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oa_db:covid19_case_reports_abstracts_pg7 [2020/06/28 05:22] (current)
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 +===== COVID-19 Case Reports Abstracts - Page 7 =====
  
 +[[oa_db:​covid19_case_reports_abstracts|Back to Table of Contents]]
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 +----------------------------------------------------------------------<​br>​
 +<​b>​[356] Title: </​b>​COVID-19 infection in a paucisymptomatic infant: Raising the index of suspicion in epidemic settings.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2.95<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-06<​br>​
 +<​b>​Publisher:​ </​b>​Pediatric Pulmonology<​br>​
 +<​b>​Keywords:​ </​b>​Paediatrics And Reproductive Medicine, covid-19, sars-cov-2, coronavirus,​ coronavirus disease 19, epidemic, epidemiology,​ infant, paediatric, severe acute respiratory syndrome coronavirus 2, viral infections, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​ppul.24754">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​ppul.24754</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Few children have been reported to have been affected by novel coronavirus disease 2019 (COVID-19); it is unclear whether children are less likely to be infected or rather display fewer symptoms. We present the case of a 32-day-old boy infected by COVID-19 that presented with an upper air way infection which resolved spontaneously and did not require any therapy. We argue that in epidemic settings children presenting with any mild symptom potentially attributable to COVID-19 should be considered contagious until proven otherwise, and that management must be guided by clinical conditions.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[357] Title: </​b>​Co-infection of SARS CoV-2 and influenza A in a Pediatric Patient in Germany.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2.95<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-11<​br>​
 +<​b>​Publisher:​ </​b>​Klinische P䤩atrie<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.thieme-connect.de/​products/​ejournals/​abstract/​10.1055/​a-1163-7385">​https://​www.thieme-connect.de/​products/​ejournals/​abstract/​10.1055/​a-1163-7385</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +In December 2019 a novel coronavirus was firstly encountered in Wuhan/China with a massive outbreak of fatal pneumonia leading to a pandemic declared by the World Health Organization in March 2020 (WHO Dashboard COVID-19. [WHO web site]. Available from: https://​www.who.int/​emergencies/​diseases/​novel-coronavirus-2019),​ affecting mainly elderly adults with underlying co-morbidities. Clinical course in children below the age of 10 years is considered to be mild or even with subclinical signs (Sinha IP, Ha et al. The Lancet Respiratory medicine 2020;​27;​S2213-2600(20) 30152-1). We describe a 4 month old infant with co-infection of SARS CoV-2 and influenza A virus.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[358] Title: </​b>​Point-of-Care Lung Ultrasound findings in novel coronavirus disease-19 pnemoniae: a case report and potential applications during COVID-19 outbreak.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2.85<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-03-01<​br>​
 +<​b>​Publisher:​ </​b>​European review for medical and pharmacological sciences<​br>​
 +<​b>​Keywords:​ </b>, <br>
 +<​b>​DOI:​ </​b><​a href="​https://​www.europeanreview.org/​article/​20549">​https://​www.europeanreview.org/​article/​20549</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +An outbreak of a novel coronavirus disease-19 (nCoV-19) infection began in December 2019 in Wuhan, China, and now involved the whole word. Several health workers have been infected in different countries. We report the case of a young man with documented nCoV-19 infection evaluated with lung ultrasound and discuss potential applications of lung ultrasound in this setting. Lung ultrasound allowed the identification of nCoV-19 infection at bed-side. Moreover, lung ultrasound can have several other advantages, such as reduced health worker exposition to infected patients, repeatability during follow-up, low-costs and easier application in low-resource settings.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[359] Title: </b>A case of coronavirus disease 2019-infected liver transplant donor.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2.85<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-12<​br>​
 +<​b>​Publisher:​ </​b>​American Journal of Transplantation<​br>​
 +<​b>​Keywords:​ </​b>​Medical And Health Sciences, covid-19, liver transplantation,​ Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​ajt.15997">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​ajt.15997</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Coronavirus disease 2019 (COVID-19) is a novel infectious disease that continues to spread on a global scale. There has been growing concern about donor-derived transmissions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Herein, we present the case of a patient who underwent ABO-incompatible living donor liver transplantation without knowing that the liver donor was infected with COVID-19 during the donation procedure. In this case, the donor-derived transmission to the recipient was not identified, and the liver donor was found to be recovering from a COVID-19 infection. The donor-derived transmission was not identified.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[360] Title: </​b>​SARS-COV-2 infection presenting as ST-elevationmyocardial infarction.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2.85<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-30<​br>​
 +<​b>​Publisher:​ </​b>​Catheterization and Cardiovascular Interventions (Formerly Catheterization and Cardiovascular Diagnosis)<​br>​
 +<​b>​Keywords:​ </​b>​Cardiovascular Medicine And Haematology,​ acute myocardial infarction/​stemi,​ angiography,​ coronary, cardiomyopathy,​ Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​ccd.28974">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​ccd.28974</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We describe a patient presenting with chest discomfort, anterolateral ST elevation, and developing acute cardiogenic shock secondary to SARS-COV-2infection-patient zero presenting to our institution'​s cardiac catheterization laboratory. The emergent presentation with limited clinical information led to exposure of personnel. The diagnosis was complicated by two negative tests for SARS-COV-2, and high-clinical suspicion from the patient'​s occupational history led to additional testing in order to confirm the diagnosis.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[361] Title: </​b>​Unlikely SARS-CoV-2 vertical transmission from mother to child: A case report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2.75<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-01<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Infection and Public Health<​br>​
 +<​b>​Keywords:​ </​b>​Public Health And Health Services, covid-19, neonate, sars-cov-2, vertical transmission,​ Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S1876034120304391">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S1876034120304391</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +As the 2019 novel coronavirus disease (COVID-19) rapidly spread across China and to more than 70 countries, an increasing number of pregnant women were affected. The vertical transmission potential of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is of great concern to the obstetrics, neonatologists,​ and public health agencies. Though some studies indicated the risk of vertical transmission is low, few cases have been reported with comprehensive serial tests from multiple specimens. In this case, a female preterm infant was born to a mother with confirmed COVID-19. She presented with mild respiratory distress and received general management and a short period of nasal continuous positive airway pressure support. During her stay at the hospital, a series of SARS-CoV-2 nucleic test from her throat and anal swab, serum, bronchoalveolar lavage fluid, and urine were negative. The nucleic acid test from the mother'​s amniotic fluid, vaginal secretions, cord blood, placenta, serum, anal swab, and breast milk were also negative. The most comprehensively tested case reported to date confirmed that the vertical transmission of COVID is unlikely, but still, more evidence is needed.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[362] Title: </​b>​Detection of SARS-CoV-2 by bronchoscopy after negative nasopharyngeal testing: Stay vigilant for COVID-19.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2.75<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-01-01<​br>​
 +<​b>​Publisher:​ </​b>​Respiratory Medicine Case Reports<​br>​
 +<​b>​Keywords:​ </b>, <br>
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2213007120303154">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2213007120303154</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Purpose: Real-time polymerase chain reaction (RT-PCR) detection of severe acute respiratory syndrome coronavirus (SARS-CoV-2) is required for diagnosis of coronavirus disease 2019 (COVID-19). Sensitivity of RT-PCR nasopharyngeal (NP) testing is presumed to be high, but there is no gold standard against which this has been determined. The objective was to determine whether lower respiratory tract infection (LRTI), detected in bronchoalveolar lavage fluid (BALF), occurs in the absence of upper respiratory tract infection with clinical testing of both specimen types. Methods: Between March 26, 2020 and April 17, 2020 at the University of Washington Medical Center all patients with BALF specimens clinically tested for SARS-CoV-2 were identified. We assessed the proportion of patients with positive RT-PCR for SARS-CoV-2 in BALF after negative NP testing. We describe 3 cases with positive testing in BALF. Results: Among 16 patients with BALF samples, 3 cases (19%) had SARS-CoV-2 detected in BALF. In Case 1, negative NP testing occurred early in the infection and respiratory symptoms may have been missed due to neurologic injury. In Case 2, outpatient diagnosis was aspiration pneumonia, but clinical suspicion remained high for COVID-19 at hospitalization based on epidemiological and clinical features. All 3 cases involved older adults (age >65 years), one of whom was immunosuppressed in the setting of lung transplantation (Case 3). Conclusions:​ These data demonstrate that SARS-CoV-2 LRTI occurs in the presence of negative NP testing. NP testing may underestimate the prevalence of COVID-19 and has implications for spread of SARS-CoV2 in the community and healthcare setting.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[363] Title: </​b>​Severe SARS-CoV-2 pneumonia in a 58-year-old patient with HIV: a clinical case report from the Republic of Cyprus.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2.7<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-25<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Medical Virology<​br>​
 +<​b>​Keywords:​ </​b>​Medical Microbiology,​ retrovirus < virus classification,​ sars coronavirus < virus classification,​ sexually transmitted disease < epidemiology,​ Health Sciences, Life Sciences, Medicine, Immunology and Microbiology<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​jmv.26053">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​jmv.26053</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +HIV and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) co-infection is a major challenge for the clinicians as it urged the importance of developing an optimal pharmaceutical scheme and patient'​s management. The reports that have been recently published regarding the course of SARS-CoV-2 in patients with HIV are sparse. In this brief report we describe, our first single-centre experience from a 58-year-old Caucasian male patient with HIV who developed a severe SARS-CoV-2 infection, including clinical characteristics,​ treatment, and outcomes. This article is protected by copyright. All rights reserved.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[364] Title: </​b>​Working in the dark: Interaction with a sub clinical COVID-19 subject and lessons learned.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2.7<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-08-01<​br>​
 +<​b>​Publisher:​ </​b>​European Journal of Cancer (1965)<​br>​
 +<​b>​Keywords:​ </​b>​Oncology And Carcinogenesis,​ covid-19, subclinical infection, Biochemistry,​ Genetics and Molecular Biology, Health Sciences, Life Sciences, Medicine<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0959804920302744">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0959804920302744</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Subclinical COVID-19 subjects pose a significant challenge. We present a very close clinical interaction with a subclinical COVID-19 subject that met the "​standard screening criteria"​ and is unique in several ways. Learning from our experience, we suggest close attention should be paid to any unexpected findings such as groundglass opacity on CT as it could help early identification of subclinical COVID-19 infection.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[365] Title: </​b>​Clinical characteristics and management of a liver transplanted patient admitted with SARS-CoV-2 infection.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2.7<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-01<​br>​
 +<​b>​Publisher:​ </​b>​Clinics and Research in Hepatology and Gastroenterology<​br>​
 +<​b>​Keywords:​ </b>, covid-19, hydroxychloroquine,​ immunosuppression,​ lopinavir, low-dose ct scan<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2210740120301595">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2210740120301595</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We present here the case of a 62-year-old man, who was referred to the emergency department with fever and cough for 3 days. He underwent liver transplantation 4 years earlier due to HCV and NASH-related cirrhosis with hepatocellular carcinoma. At admission he was in reduced general conditions. Nasopharyngeal smear specimen resulted positive for SARS-CoV-2 infection. Pulmonary low-dose CT-scan revealed bilateral subpleural ground-glass infiltrates. O2 saturation was 93%. A treatment with lopinavir/​ritonavir and hydroxychloroquine twice daily was started. The patient received also cefepime and remained in isolation. Seven days later imaging showed a progression of the pulmonary infiltrates. Cefepime was replaced by meropenem. During the following 3 days the fever resolved, and the general conditions of the patient significantly improved. Consequently,​ treatment with lopinavir/​ritonavir and hydroxychloroquine was stopped. The evolution of SARS-CoV-2 interstitial pneumonia in this immunosuppressed patient was moderate to severe and liver injury was not clinically significant. Despite its limitations,​ this case report confirm that the liver may be only mildly affected during SARS-CoV-2 infection, also in liver transplanted patients. Further studies are needed to assess whether the outcome of SARS-CoV-2 infection is worse in immunosuppressed patients than in the general population.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[366] Title: </​b>​Olfactory and Gustatory Dysfunction in a COVID-19 Patient with Ankylosing Spondylitis Treated with Etanercept: Case Report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2.6<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-03-26<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Korean Medical Science<​br>​
 +<​b>​Keywords:​ </b>, neurologic manifestations,​ severe acute respiratory syndrome coronavirus 2, tumor necrosis factor-alpha,​ Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​jkms.org/​DOIx.php?​id=10.3346/​jkms.2020.35.e201">​https://​jkms.org/​DOIx.php?​id=10.3346/​jkms.2020.35.e201</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The neurologic manifestations concerning coronavirus disease 2019 (COVID-19) are highly penetrated. Anosmia and ageusia are one of the common acute neurologic symptoms, which develop in the early stage of COVID-19. However, it is not reported that how immunosuppressive agents affect these symptoms. We report olfactory and gustatory dysfunctions in a patient with ankylosing spondylitis (AS) treated with etanercept during COVID-19. A 53-year-old female showing AS controlled with tumor necrosis factor-alpha inhibitor, etanercept, had been diagnosed with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, presenting cough and rhinorrhea. One month after diagnosis, she complained about hyposmia and hypogeusia two days before the seronegative conversion of SARS-CoV-2, which were confirmed by a neurological examination. We speculate that the etanercept may have delayed the development of olfactory and gustatory dysfunction in the patient.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[367] Title: </​b>​Neurovascular Complications in COVID-19 Infection: Case Series.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2.6<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-11<​br>​
 +<​b>​Publisher:​ </​b>​American Journal of Neuroradiology<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​http://​www.ajnr.org/​content/​early/​2020/​06/​11/​ajnr.A6655">​http://​www.ajnr.org/​content/​early/​2020/​06/​11/​ajnr.A6655</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We present a series of 10 hospitalized patients with confirmed coronavirus 2019 infections who developed severe neurovascular complications and discuss the possible reasons for these findings and their relationship to the novel Severe Acute Respiratory Syndrome coronavirus 2 infection.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[368] Title: </​b>​Guillain-Barre syndrome after SARS-CoV-2 infection.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2.6<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-13<​br>​
 +<​b>​Publisher:​ </​b>​European Journal of Neurology<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19, guillain-barre syndrome, sars-cov-2, polyradiculoneuropathy,​ post-infectious,​ Health Sciences, Life Sciences, Medicine, Neuroscience<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​ene.14398">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​ene.14398</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Since the first reports in December 2019 in Wuhan, China, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly developed into a pandemic associated with substantial morbidity and mortality. Guillain-Barre syndrome (GBS) is an acute immune-mediated polyradiculoneuropathy that may be triggered by various bacterial and viral infections. Reports on possible neurological manifestations of SARS-CoV-2 are still scarce. Hereby, we report a case of GBS after an infection with SARS-CoV-2.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[369] Title: </​b>​Postmortem Lung Findings in an Asthmatic Patient With Coronavirus Disease 2019.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2.5<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-01<​br>​
 +<​b>​Publisher:​ </​b>​CHEST<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, asthma, coronavirus,​ diffuse alveolar damage, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0012369220307753">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0012369220307753</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Asthma is increasingly recognized as an underlying risk factor for severe respiratory disease in patients with coronavirus disease 2019 (COVID-19), particularly in the United States. Here, we report the postmortem lung findings from a 37-year-old man with asthma, who met the clinical criteria for severe acute respiratory distress syndrome and died of COVID-19 less than 2 weeks after presentation to the hospital. His lungs showed mucus plugging and other histologic changes attributable to asthma, as well as early diffuse alveolar damage and a fibrinous pneumonia. The presence of diffuse alveolar damage is similar to descriptions of autopsy lung findings from patients with severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus,​ and the absence of a neutrophil-rich acute bronchopneumonia differs from the histologic changes typical of influenza. The relative contribution of mucus plugging to his hypoxemia is unknown.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[370] Title: </​b>​Case Report: Right Bundle Brunch Block and QTc Prolongation in a Patient with Novel Coronavirus Disease (COVID-19) Treated with Hydroxychloroquine.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2.5<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-07<​br>​
 +<​b>​Publisher:​ </​b>​The American Journal of Tropical Medicine and Hygiene<​br>​
 +<​b>​Keywords:​ </​b>​Medical And Health Sciences, , Health Sciences, Life Sciences, Medicine, Immunology and Microbiology<​br>​
 +<​b>​DOI:​ </​b><​a href="​http://​www.ajtmh.org/​content/​journals/​10.4269/​ajtmh.20-0376">​http://​www.ajtmh.org/​content/​journals/​10.4269/​ajtmh.20-0376</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Novel coronavirus disease (COVID-19) is a highly contagious disease caused by severe adult respiratory syndrome-coronavirus-2 that has resulted in the current global pandemic. Currently, there is no available treatment proven to be effective against COVID-19, but multiple medications,​ including hydroxychloroquine (HCQ), are used off label. We report the case of a 60-year-old woman without any cardiac history who developed right bundle brunch block and critically prolonged corrected electrocardiographic QT interval (QTc 631 ms) after treatment for 3 days with HCQ, which resolved on discontinuation of the medication. This case highlights a significant and potentially life-threatening complication of HCQ use.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[371] Title: </​b>​Novel coronavirus 2019 (COVID-19): A case report and review of treatments.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2.5<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-01<​br>​
 +<​b>​Publisher:​ </​b>​Medicine<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​journals.lww.com/​md-journal/​FullText/​2020/​05080/​Novel_coronavirus_2019__COVID_19___A_case_report.93.aspx">​https://​journals.lww.com/​md-journal/​FullText/​2020/​05080/​Novel_coronavirus_2019__COVID_19___A_case_report.93.aspx</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +RATIONALE: Novel coronavirus 2019 (COVID-19) also known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, non-segmented positive-sense RNA virus belonging to the beta-coronaviridae family. This virus is known to cause severe bilateral pneumonia and acute respiratory distress syndrome (ARDS) which can lead to difficulty breathing requiring mechanical ventilation and intensive care unit management. PATIENT CONCERNS: A 77-year-old female with a history of hypertension and hyperlipidemia who presented as a transfer to our hospital facility with worsening fevers, cough, and respiratory distress. DIAGNOSIS: Chest X-rays revealed bilateral infiltrates worse at the lung bases and CT scan of the chest showed bilateral ground-glass opacities consistent with COVID-19. While our testing revealed a negative COVID-19 result at our institution,​ the result at a previous hospital returned a positive result. INTERVENTIONS:​ She was being treated aggressively in the intensive care unit with high dose intravenous ascorbic acid, hydroxychloroquine,​ and anti-interleukin-6 monoclonal antibody. She also received a loading dose of remdesivir however was unable to complete the course due to organ failure and requirement of vasopressors for hemodynamic stability. OUTCOMES: She remained critically ill and was eventually placed on comfort care as per the family'​s wishes and passed away. LESSONS: With a rapidly growing death rate and more than 200,000 confirmed cases worldwide, COVID-19 has become a global pandemic and major hit to our healthcare systems. While several companies have already begun vaccine trials and healthcare facilities have been using a wide-range of medications to treat the virus and symptoms, there is not yet an approved medication regimen for COVID-19 infections. The alarming increase in cases per day adds additional pressure to find a cure and decrease the global health burden and mortality rate.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[372] Title: </​b>​High-dose,​ short-term corticosteroids for ARDS caused by COVID-19: a case series.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2.5<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-04<​br>​
 +<​b>​Publisher:​ </​b>​Respirology Case Reports<​br>​
 +<​b>​Keywords:​ </b>, ards, covid-19, corticosteroid therapy, mechanical ventilation<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​rcr2.596">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​rcr2.596</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We report a case series of seven mechanically ventilated patients with acute respiratory distress syndrome (ARDS) caused by coronavirus disease (COVID-19) who received early treatment with high-dose, short-term systemic corticosteroids to prevent cytokine overproduction. Of the seven patients, four were male and median age was 69 years. They were intubated within seven days after admission when their respiratory status rapidly worsened. At that time, we administered 1000 or 500 mg/day for three days of methylprednisolone intravenously,​ followed by 1 mg/kg and tapered off. The median duration for the total administration of corticosteroids was 13 days. This high-dose, short-term corticosteroid therapy enabled extubation of the patients within seven days. Many questions on the clinical management of COVID-19 remain unanswered, and data on corticosteroid therapy as a choice of treatment are mixed. We present the clinical course of our cases, review the previous evidence, and discuss management.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[373] Title: </b>A case of COVID-19 patient with the diarrhea as initial symptom and literature review.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2.45<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-01<​br>​
 +<​b>​Publisher:​ </​b>​Clinics and Research in Hepatology and Gastroenterology<​br>​
 +<​b>​Keywords:​ </b>, diarrhea, novel coronavirus<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2210740120300851">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2210740120300851</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Since Dec 2019, a cluster of pneumonia outbreak in Wuhan, Hubei province, China, and soon spread to all province of China. The pathogen was proved to be a novel betacoronavirus called 2019 novel coronavirus (officially named by the World Health Organization as COVID-19). The typical clinical manifestations were fever, cough, dyspnea, and myalgia or fatigue. Less common symptoms included headache, diarrhea, nausea and vomiting. However diarrhea as the first symptom is rarely reported. Here we reported a case of 2019 novel coronavirus-infected patient (NCIP) with diarrhea as the initial symptom. Image of CT scan and laboratory examination and careful collected as well as detection of viral RNA in pharynx. The case demonstrate that gastrointestinal symptoms ware not rare in NCIP, and diarrhea could be the initial symptom.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[374] Title: </​b>​Fatal SARS-CoV-2 infection in a renal transplant recipient.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2.45<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-20<​br>​
 +<​b>​Publisher:​ </​b>​CEN Case Reports<​br>​
 +<​b>​Keywords:​ </​b>​Medicine & Public Health, covid-19, renal transplantation,​ treatment<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​link.springer.com/​article/​10.1007/​s13730-020-00496-4">​https://​link.springer.com/​article/​10.1007/​s13730-020-00496-4</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2) caused a pandemic that first discovered in Wuhan, China. While 10% of the patients have asymptomatic infection, 15-20% have lung involvement,​ 5-10% have multiple organ failure, and macrophage activation syndrome. Chronic respiratory diseases, diabetes mellitus, hypertension,​ and cancer are risk factors for mortality. Prognosis or optimal treatment strategy for renal transplant recipients in SARS-CoV-2 infection is still unknown. Besides fatal cases, there were also milder case reports. In addition, COVID-19 treatment and the maintenance immunosuppression strategy is still under debate. Antiviral therapies and drug interactions are special topics for these patients. To the best of our knowledge, favipiravir and anti-cytokine treatments have not been previously reported in a kidney transplant recipient with SARS-CoV-2 infection before. We report a case of SARS-CoV-2 infection in a kidney transplant recipient with fatal outcomes.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[375] Title: </​b>​CT Manifestations of Novel Coronavirus Pneumonia: A Case Report<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2.35<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-12<​br>​
 +<​b>​Publisher:​ </​b>​Balkan Medical Journal<​br>​
 +<​b>​Keywords:​ </b>, influenza, novel coronavirus pneumonia, pulmonary complications,​ computed tomography, diagnosis<​br>​
 +<​b>​DOI:​ </​b><​a href="​http://​balkanmedicaljournal.org/​uploads/​pdf/​pdf_BMJ_2192.pdf">​http://​balkanmedicaljournal.org/​uploads/​pdf/​pdf_BMJ_2192.pdf</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Background: Since December 2019, the outbreak of the novel coronavirus has impacted nearly >90,000 people in more than 75 countries. In this case report, we aim to define the chest computed tomography findings of 2019-novel coronavirus associated with pneumonia and its successful resolution after treatment. Case Report: A fifty-year-old female patient, who is a businesswoman,​ presented with chief complaints of "fever for one week, diarrhea, anorexia, and asthenia."​ Initially, she was given Tamiflu. The influenza A virus serology was negative. Three days later, levofloxacin was started because the patient'​s symptoms did not improve. The novel coronavirus nucleic acid test was negative. It was noted that before the onset of the disease, the patient went to Wuhan on a business trip. Despite the given treatment, her body temperature rose to 39.2 degrees C and she was referred to our clinic for further evaluation. Then, chest computed tomography was performed and showed bilateral multifocal ground glass opacities with consolidation which suggested viral pneumonia as a differential diagnosis, and the subsequent 2019-novel coronavirus pneumonia nucleic acid test was positive. Conclusion: Chest computed tomography offers fast and convenient evaluation of patients with suspected 2019-novel coronavirus pneumonia.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[376] Title: </​b>​Management of the difficult airway in the COVID-19 pandemic: Illustrative complex head and neck cancer scenario.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2.35<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-22<​br>​
 +<​b>​Publisher:​ </​b>​Head & Neck<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19, airway rapid response, difficult airway, head and neck cancer, personal protective equipment, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​hed.26175">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​hed.26175</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +BACKGROUND: This case highlights challenges in the assessment and management of the "​difficult airway"​ patient in the SARS-CoV-2 (COVID-19) pandemic era. METHODS: A 60-year-old male with history of recent transoral robotic surgery resection, free flap reconstruction,​ and tracheostomy for p16+ squamous cell carcinoma presented with stridor and dyspnea 1 month after decannulation. Careful planning by a multidisciplinary team allowed for appropriate staffing and personal protective equipment, preparations for emergency airway management, evaluation via nasopharyngolaryngoscopy,​ and COVID testing. The patient was found to be COVID negative and underwent imaging which revealed new pulmonary nodules and a tracheal lesion. RESULTS: The patient was safely transorally intubated in the operating room. The tracheal lesion was removed endoscopically and tracheostomy was avoided. CONCLUSIONS:​ This case highlights the importance of careful and collaborative decision making for the management of head and neck cancer and other "​difficult airway"​ patients during the COVID-19 epidemic.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[377] Title: </​b>​Recovery from COVID-19 in two patients with coexisted HIV infection.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2.35<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-13<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Medical Virology<​br>​
 +<​b>​Keywords:​ </​b>​Medical Microbiology,​ covid-19, hiv, case report, outcome, Health Sciences, Life Sciences, Medicine, Immunology and Microbiology<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​jmv.26006">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​jmv.26006</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +COVID-19 has become a global health concern. HIV-infected patients are particularly vulnerable to COVID-19 due to their immune-compromised status. The clinical manifestations and clinical outcomes of these patients are not clear. In this report, we presented two special COVID-19 patients with HIV infection and other comorbidities. We described the clinical characteristics,​ clinical manifestations,​ treatments and clinical outcomes of both patients. One patient with prior HIV-infection continued anti-HIV treatment when diagnosed with COVID-19. The other patient was newly diagnosed with HIV-infection when diagnosed with COVID-19 and had not begun anti-HIV treatment. Both patients were treated with anti-viral, antibiotics,​ oxygen treatment and supportive care and recovered from severe pneumonia. The experience of these two cases suggested that COVID-19 patients with HIV infection could still have satisfactory clinical outcomes following proper medical care. This article is protected by copyright. All rights reserved.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[378] Title: </​b>​Stroke in patients with SARS-CoV-2 infection: case series.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2.35<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-20<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Neurology<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, brain hemorrhage, covid-19, cerebrovascular disease, coronavirus,​ encephalitis,​ neurological complications,​ Health Sciences, Life Sciences, Medicine, Neuroscience<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​link.springer.com/​article/​10.1007/​s00415-020-09885-2">​https://​link.springer.com/​article/​10.1007/​s00415-020-09885-2</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +BACKGROUND: Italy is one of the most affected countries by the coronavirus disease 2019 (COVID-19). The responsible pathogen is named severe acute respiratory syndrome coronavirus (SARS-CoV-2). The clinical spectrum ranges from asymptomatic infection to severe pneumonia, leading to intensive care unit admission. Evidence of cerebrovascular complications associated with SARS-CoV-2 is limited. We herein report six patients who developed acute stroke during COVID-19 infection. METHODS: A retrospective case series of patients diagnosed with COVID-19 using reverse-transcriptase polymerase chain reaction (RT-PCR) on nasopharyngeal swabs, who developed clinical and neuroimaging evidence of acute stroke during SARS-CoV-2 infection. RESULTS: Six patients were identified (5 men); median age was 69 years (range 57-82). Stroke subtypes were ischemic (4, 67%) and hemorrhagic (2, 33%). All patients but one had pre-existing vascular risk factors. One patient developed encephalopathy prior to stroke, characterized by focal seizures and behavioral abnormalities. COVID-19-related pneumonia was severe (i.e., requiring critical care support) in 5/6 cases (83%). Liver enzyme alteration and lactate dehydrogenase (LDH) elevation were registered in all cases. Four patients (67%) manifested acute kidney failure prior to stroke. Four patients (67%) had abnormal coagulation tests. The outcome was poor in the majority of the patients: five died (83%) and the remaining one (17%) remained severely neurologically affected (mRS: 4). CONCLUSIONS:​ Both ischemic and hemorrhagic stroke can complicate the course of COVI-19 infection. In our series, stroke developed mostly in patients with severe pneumonia and multiorgan failure, liver enzymes and LDH were markedly increased in all cases, and the outcome was poor.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[379] Title: </​b>​Asymptomatic COVID-19 infection in a child with nasal foreign body.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2.35<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-08-01<​br>​
 +<​b>​Publisher:​ </​b>​International Journal of Pediatric Otorhinolaryngology<​br>​
 +<​b>​Keywords:​ </​b>​Paediatrics And Reproductive Medicine, asymptomatic infection, covid-19, sars-cov-2, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0165587620302354">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0165587620302354</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +While children, particularly infants, are susceptible to severe and critical COVID-19 disease, over 55% of pediatric cases are present in asymptomatic or mildly symptomatic children. Aerosolized SARS-CoV-2 viral particles remain viable for up to 3 hours, raising concern about risk to healthcare workers during aerosol generating procedures (APGs) in the airway and nasopharynx. Herein we describe the first case of a nasal foreign body in an asymptomatic child with SARS-CoV-2 infection. We discuss management of this child and highlight the importance of considering asymptomatic infection and preoperative testing when planning procedures of the airway in the COVID-19 era.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[380] Title: </​b>​COVID-19 and Acute Lupus Pneumonitis:​ Diagnostic and Treatment Dilemma.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2.35<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-05<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Investigative Medicine High Impact Case Reports<​br>​
 +<​b>​Keywords:​ </b>, covid-19, lupus, pneumonia, pneumonitis<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​journals.sagepub.com/​doi/​10.1177/​2324709620933438">​https://​journals.sagepub.com/​doi/​10.1177/​2324709620933438</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +In this article, we present a case of a young female patient with previously diagnosed lupus pneumonitis,​ now with a flare and new superimposed COVID-19 infection that was treated with intravenous steroids. On computed tomography scans, she had extensive interstitial lung fibrosis in addition to a positive COVID-19 polymerase chain reaction test requiring 6 L of oxygen via nasal cannula on admission. After administration of methylprednisolone,​ the patient improved and was weaned off her oxygen requirements and was discharged home.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[381] Title: </​b>​Respiratory Distress in SARS-CoV-2 without Lung Damage: Phrenic Paralysis Should Be Considered in COVID-19 Infection.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2.35<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-01-01<​br>​
 +<​b>​Publisher:​ </​b>​2020<​br>​
 +<​b>​Keywords:​ </b>, covid-19, neurotropism,​ phrenic paralysis, respiratory distress<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.ejcrim.com/​index.php/​EJCRIM/​article/​view/​1728">​https://​www.ejcrim.com/​index.php/​EJCRIM/​article/​view/​1728</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We describe an overweight COVID-19 patient with respiratory distress preceded by anosmia/​dysgeusia with no lung injury shown on CT, angio-CT or ventilation/​perfusion scans. Orthopnoea and paradoxical abdominal respiration were identified. Phrenic paralysis, demonstrated by examination of patient breathing, and on x-ray while standing breathing in and out, explained the respiratory distress. This is a rare and previously undescribed neurological complication of COVID-19 infection caused by vagus nerve injury. LEARNING POINTS: Phrenic paralysis must be kept in mind as a rare neurological complication of COVID-19.Vagus nerve palsy is a neurological manifestation as anosmia and dysgeusia, that were already identified in the olfactory system of COVID-19 patients.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[382] Title: </​b>​Neuroimaging Findings in Patients with COVID-19.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2.35<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-11<​br>​
 +<​b>​Publisher:​ </​b>​American Journal of Neuroradiology<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​http://​www.ajnr.org/​content/​early/​2020/​06/​11/​ajnr.A6630">​http://​www.ajnr.org/​content/​early/​2020/​06/​11/​ajnr.A6630</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Little is known about the neurologic sequelae of coronavirus disease 2019 (COVID-19). We assessed neuroimaging findings in 4 patients positive for COVID-19. All had abnormal mental status, deranged coagulation parameters, and markedly elevated D-dimer levels. CT/MR imaging showed a common pattern of multifocal subcortical/​cortical petechial-type hemorrhages,​ while SWI showed more extensive multifocal abnormalities. The appearances are consistent with a thrombotic microangiopathy and may be due to the heightened level of thrombosis in patients with COVID-19.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[383] Title: </​b>"​COVID-19-related acute genital ulcers"​.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2.35<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-13<​br>​
 +<​b>​Publisher:​ </​b>​Journal of the European Academy of Dermatology & Venereology<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19, lipschutz, aphthae, coronavirus,​ ulcer, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​resolve/​doi?​DOI=10.1111/​jdv.16740">​https://​onlinelibrary.wiley.com/​resolve/​doi?​DOI=10.1111/​jdv.16740</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +A wide variety of cutaneous manifestations has recently been reported as COVID-19-related skin lesions, such as erythematous rash, acro-ischemia or chilblain-like lesions (1, 2) , which can be useful for the clinical diagnosis of COVID-19. Case reports of other less frequent COVID-19-related skin disorders such as pytiriasis rosea (3) or livedo reticularis (4) have been also described. In order to report a new clinical manifestation of SARS-Coronavirus-2,​ we present a case of acute reactive genital ulcers in a COVID-19 patient.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[384] Title: </​b>​Dynamic changes in routine blood parameters of a severe COVID-19 case.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-09-01<​br>​
 +<​b>​Publisher:​ </​b>​Clinica Chimica Acta<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19, dynamic, routine blood parameters, Biochemistry,​ Genetics and Molecular Biology, Health Sciences, Life Sciences, Medicine<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0009898120301881">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0009898120301881</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +BACKGROUND: Novel coronavirus infectious disease (COVID-19) has been spreading worldwide, and tracking laboratory indexes during the diagnosis and treatment of patients with severe COVID-19 can provide a reference for patients in other countries and regions. METHODS: We closely tracked the epidemiological history, diagnosis and treatment process, as well as dynamic changes in routine blood indicators, of a severe COVID-19 patient who was hospitalized for 26 days. RESULTS: Our study found that the patient'​s condition worsened in the first week after admission, white blood cells (WBCs), neutrophils,​ lymphocytes,​ monocytes, eosinophils,​ red blood cells (RBCs), hemoglobin, neutrophil lymphocyte ratio (NLR), platelets (PLT) and platelet lymphocyte ratio (PLR) decreased. On the 7th day of admission, the levels of these cells decreased to their lowest values, though the red blood cell distribution width (RDW) and C-reactive protein (CRP) level remained at high values. From 8 to 14 days of admission, the patient'​s condition improved, hypoxemia was corrected, and mechanical ventilation was discontinued. The number of WBCs, neutrophils,​ monocytes, eosinophils and lymphocytes increased gradually, and the erythrocyte parameters stopped declining and stabilized in a certain range; CRP decreased rapidly. On the 20th day of admission, the nucleic acid test was negative, WBC, neutrophil, CRP, NLR and PLR decreased gradually, and monocyte, lymphocyte, and eosinophil counts increased. Although RBCs and hemoglobin (Hb) levels continued to decrease, RDW gradually increased, indicating the recovery of hematopoiesis. In addition, it should be noted that monocytes and eosinophils were at extremely low levels within 10 days after admission; the recovery time of eosinophils was approximately 12 days after admission, which was earlier than other parameters, which might be of great value in judging the progress of the disease. CONCLUSIONS:​ Dynamic changes in routine blood parameters might be helpful for the prognosis of COVID-19 patients and evaluation of the treatment effect.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[385] Title: </​b>​Pediatric COVID-19-associated rhabdomyolysis:​ a case report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-23<​br>​
 +<​b>​Publisher:​ </​b>​Pediatric Nephrology<​br>​
 +<​b>​Keywords:​ </​b>​Medicine & Public Health, children, coronavirus,​ creatine kinase, sars-cov-2, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​link.springer.com/​article/​10.1007/​s00467-020-04617-0">​https://​link.springer.com/​article/​10.1007/​s00467-020-04617-0</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +COVID-19 is the illness caused by infection with the novel coronavirus SARS-CoV-2. Although myalgia is common in adults, it has not been noted as a common symptom in children. There have been a few reported cases of COVID-19-associated rhabdomyolysis in adults. This case report describes a 16-year-old boy who presented with fever, myalgias, mild shortness of breath with exertion, and dark-colored urine. COVID-19 PCR was positive. His initial creatinine kinase (CK) level was 427,656 U/L. Serum creatinine was normal for age. He was treated with isotonic intravenous fluids containing sodium bicarbonate to maintain urine output of 100-200 mL/h and urine pH > 7.0. His serum creatinine remained normal throughout the hospital stay and he was discharged on hospital day 12 with a CK of 6526 U/L. To our knowledge, no pediatric cases of COVID-19-associated rhabdomyolysis have been previously reported. Adult cases of rhabdomyolysis have been reported and a few reports have noted patients with elevated CK levels without rhabdomyolysis. Given this pediatric case of COVID-19-associated rhabdomyolysis,​ pediatric clinicians should be aware of this complication and manage fluids appropriately in order to prevent acute kidney injury.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[386] Title: </​b>​Plasmapheresis treatment in COVID-19-related autoimmune meningoencephalitis:​ Case series.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2.2<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-07-01<​br>​
 +<​b>​Publisher:​ </​b>​Brain,​ Behavior & Immunity<​br>​
 +<​b>​Keywords:​ </​b>​Immunology,​ autoimmune, covid-19, encephalitis,​ plasmapheresis,​ Life Sciences, Immunology and Microbiology,​ Neuroscience<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0889159120308035">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0889159120308035</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Severe SARS-CoV-2 (COVID-19) infection has the potential for a high mortality rate. In this paper, we report the results of plasmapheresis treatment in a series of severely ill patients with COVID-19-related autoimmune meningoencephalitis in the Intensive Care Unit (ICU).<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[387] Title: </​b>​Successful treatment of COVID-19 using extracorporeal membrane oxygenation,​ a case report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2.1<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-03-01<​br>​
 +<​b>​Publisher:​ </​b>​European review for medical and pharmacological sciences<​br>​
 +<​b>​Keywords:​ </b>, <br>
 +<​b>​DOI:​ </​b><​a href="​https://​www.europeanreview.org/​article/​20705">​https://​www.europeanreview.org/​article/​20705</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Since the end of 2019, COVID-19 has been prevalent in Wuhan, China, and has been rapidly spreading to mainland China. Currently, more than 80,000 people have been infected, of which over 10,000 were severely ill and had characteristics of dyspnea and hypoxemia about one week after onset. Severe patients had rapidly progressed to acute respiratory distress syndrome (ARDS), causing multiple organ failures and even death, with a mortality rate of nearly 4.3%. The treatment of severe COVID-19 patients has been rarely reported. This study reported a successful example of a severe COVID-19 patient with extracorporeal membrane oxygenation (ECMO) technology in our hospital. This experience revealed that the early application of ECMO can dramatically promote the recovery of severe COVID-19 patients.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[388] Title: </b>A Recovered Case of COVID-19 Myocarditis and ARDS Treated with Corticosteroids,​ Tocilizumab,​ and Experimental AT-001.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2.1<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-01<​br>​
 +<​b>​Publisher:​ </​b>​JACC:​ Case Reports<​br>​
 +<​b>​Keywords:​ </b>, 2019-ncov, ards, covid-19, sars-cov-2, aldose reductase inhibitor, cardiac mri, cardiogenic shock, corticosteroids,​ myocarditis,​ tocilizumab<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2666084920304319">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2666084920304319</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We describe the case of a critically-ill patient with myocarditis and severe ARDS related to COVID-19 infection. This case highlights management strategies including the use of corticosteroids,​ an IL-6 inhibitor, and an aldose reductase inhibitor resulting in complete clinical recovery.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[389] Title: </​b>​Spontaneous coronary artery dissection of the left anterior descending artery in a patient with COVID-19 infection.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2.1<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-07<​br>​
 +<​b>​Publisher:​ </​b>​Catheterization and Cardiovascular Interventions (Formerly Catheterization and Cardiovascular Diagnosis)<​br>​
 +<​b>​Keywords:​ </​b>​Cardiovascular Medicine And Haematology,​ catheterization diagnostic, coronary angiography,​ coronary artery disease, coronary dissection, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​ccd.28960">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​ccd.28960</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +A 48-year-old woman with a past medical history of migraines and hyperlipidemia presented due to severe retrosternal chest pain with no other associated signs or symptoms. The patient was hemodynamically stable and was found to have an elevated troponin with electrocardiogram showing no ischemic changes. Computed tomography of the coronary arteries showed a left dominant system with dissection extending from the mid-to-distal left anterior descending (LAD) artery. The patient was subsequently discharged on medical therapy but returned 3 days later due to worsening chest pain. Electrocardiogram revealed inferior and anteroseptal ST segment changes with peak troponin of 14.9 ng/ml (reference range <0.80 ng/ml). Coronavirus disease 2019 (COVID-19) nasopharyngeal swab was performed prior to urgent coronary angiogram. Coronary angiogram was performed with full personal protective equipment for respiratory and droplet precautions due to pending COVID-19 testing results. Angiogram revealed spontaneous coronary artery dissection (SCAD) extending from the ostium of the LAD to the distal vessel. COVID-19 testing returned positive while in intensive care unit. The patient was not a percutaneous coronary intervention candidate due to the extent of the dissection and was not a surgical candidate due to a lack of graftable target and medical management was continued. To our knowledge, this case is the first in which SCAD has been reported in the LAD in a patient with COVID-19 with no other symptoms of respiratory illness or symptoms classically associated with the novel coronavirus. SCAD should be considered on the differential as one of the various cardiac manifestations of COVID-19 infection.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[390] Title: </​b>​Mild course of Coronavirus disease 2019 and spontaneous severe acute respiratory syndrome coronavirus 2 clearance in a patient with depleted peripheral blood B-cells due to treatment with rituximab.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2.1<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-26<​br>​
 +<​b>​Publisher:​ </​b>​Arthritis & Rheumatology<​br>​
 +<​b>​Keywords:​ </b>, <br>
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​art.41380">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​art.41380</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Over 4 million cases of Coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been confirmed worldwide. Up to 20% of cases develop severe disease and the fatality rate are high.[1] Little is known however on the course of the infection in immunosuppressed patients. We therefore report the case of a patient with COVID-19 under immunosuppression with rituximab. This 77-year-old woman was admitted to the hospital with a 5-week history of unclear fever (up to 38.5 degrees C), hypotension (80 mmHg systolic on self-measurement),​ occasional mild shortness of breath and intermittent dry cough.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[391] Title: </​b>​Histology of skin lesions establishes that the vesicular rash associated with COVID-19 is not "​varicella-like"​.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2.1<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-05<​br>​
 +<​b>​Publisher:​ </​b>​Journal of the European Academy of Dermatology & Venereology<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19, sars-cov-2, acantholysis,​ coronavirus,​ skin rash, varicella, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​jdv.16706">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​jdv.16706</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Several articles recently reported a "​varicella-like"​ rash in patients with COVID-19 [1,2]. We observed similar cases at our institution. However, although we agree that the clinical picture is original, we reject that "​varicella-like"​ denomination since clinical presentation,​ as well as some histologic features that we wish to report here for the first time, make it clearly different from varicella. Three patients with a vesicular rash associated with COVID-19 (RT-PCR test on a nasopharyngeal swab specimen positive for SARS-CoV-2 ARN) were seen at our institution in April, 2020. A biopsy of a vesicle was performed in each. Multiple levels with H&E stain were done; the slides were reviewed independently by two pathologists;​ only concordant data were validated. A test for SARS-CoV-2 was performed on a vesicle in two patients, and a direct immunofluorescence test on perilesional skin in one.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[392] Title: </​b>​Covid-19 in a patient with multiple sclerosis treated with natalizumab:​ May the blockade of integrins have a protective role?<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2.1<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-09-01<​br>​
 +<​b>​Publisher:​ </​b>​Multiple Sclerosis and Related Disorders<​br>​
 +<​b>​Keywords:​ </b>, covid-19, integrins, multiple sclerosis, natalizumab,​ sars-cov-2<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2211034820303266">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2211034820303266</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The disease caused by the new coronavirus SARS-CoV-2 (COVID-19) is currently spread worldwide . Recent data supports SARS-CoV-2 may use integrins to enter human cells. Therefore, anti-integrins therapies might be an alternative against the infection . Natalizumab,​ approved for Multiple Sclerosis (MS) treatment, acts blocking alpha4-integrin. We report a MS patient treated with natalizumab who develops COVID-19, with excellent recovery and repeated negative results in 5 consecutive microbiological studies. We postulate this may be due to the blockade of integrins induced by natalizumab.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[393] Title: </​b>​Could HIV infection alter the clinical course of SARS-CoV-2 infection? When less is better.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-15<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Medical Virology<​br>​
 +<​b>​Keywords:​ </​b>​Medical Microbiology,​ human immunodeficiency virus, protease inhibitor, sars coronavirus,​ Health Sciences, Life Sciences, Medicine, Immunology and Microbiology<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​resolve/​doi?​DOI=10.1002/​jmv.25881">​https://​onlinelibrary.wiley.com/​resolve/​doi?​DOI=10.1002/​jmv.25881</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Recently, the first case of HIV and SARS-CoV-2 infection was reported in the literature. With this letter, we proposed a hypothesis that could explain the interaction between HIV infection and the clinical course of SARS-CoV-2 infection. This article is protected by copyright. All rights reserved.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[394] Title: </​b>​First COVID-19 infections in the Philippines:​ a case report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-14<​br>​
 +<​b>​Publisher:​ </​b>​Tropical Medicine & Health<​br>​
 +<​b>​Keywords:​ </​b>​Infectious Diseases, covid-19, case report, coronavirus,​ manila, philippines,​ sars-cov-2<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​tropmedhealth.biomedcentral.com/​articles/​10.1186/​s41182-020-00203-0">​https://​tropmedhealth.biomedcentral.com/​articles/​10.1186/​s41182-020-00203-0</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Background: The novel coronavirus (COVID-19) is responsible for more fatalities than the SARS coronavirus,​ despite being in the initial stage of a global pandemic. The first suspected case in the Philippines was investigated on January 22, 2020, and 633 suspected cases were reported as of March 1. We describe the clinical and epidemiological aspects of the first two confirmed COVID-19 cases in the Philippines,​ both admitted to the national infectious disease referral hospital in Manila. Case presentation:​ Both patients were previously healthy Chinese nationals on vacation in the Philippines travelling as a couple during January 2020. Patient 1, a 39-year-old female, had symptoms of cough and sore throat and was admitted to San Lazaro Hospital in Manila on January 25. Physical examination was unremarkable. Influenza B, human coronavirus 229E, Staphylococcus aureus and Klebsiella pneumoniae were detected by PCR on initial nasopharyngeal/​oropharyngeal (NPS/OPS) swabs. On January 30, SARS-CoV-2 viral RNA was reported to be detected by PCR on the initial swabs and she was identified as the first confirmed COVID-19 case in the Philippines. Her symptoms resolved, and she was discharged. Patient 2, a 44-year-old male, had symptoms of fever, cough, and chills. Influenza B and Streptococcus pneumoniae were detected by PCR on initial NPS/OPS swabs. He was treated for community-acquired pneumonia with intravenous antibiotics,​ but his condition deteriorated and he required intubation. On January 31, SARS-CoV-2 viral RNA was reported to be detected by PCR on the initial swabs, and he was identified as the 2nd confirmed COVID-19 infection in the Philippines. On February 1, the patient'​s condition deteriorated,​ and following a cardiac arrest, it was not possible to revive him. He was thus confirmed as the first COVID-19 death outside of China. Conclusions:​ This case report highlights several important clinical and public health issues. Despite both patients being young adults with no significant past medical history, they had very different clinical courses, illustrating how COVID-19 can present with a wide spectrum of disease. As of March 1, there have been three confirmed COVID-19 cases in the Philippines. Continued vigilance is required to identify new cases.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[395] Title: </​b>​New type of corona virus induced acute otitis media in adult.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-01<​br>​
 +<​b>​Publisher:​ </​b>​American Journal of Otolaryngology<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19, coronavirus,​ otitis media, reverse transcriptase-polymerase chain reaction, x-ray, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0196070920301691">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0196070920301691</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Since late December 2019, a new type of coronavirus (CIVID-19) causing a cluster of respiratory infections was first identified in Wuhan-China. And it disseminated to all countries. Generally, COVID-19 cases have fever, cough, respiratory distress findings (dyspnoea, intercostal retraction, cyanosis etc.). In this paper, we have presented an adult otitis media case whom infected with COVID-19, but she have not any classical COVID-19 symptoms.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[396] Title: </​b>​Persistent hiccups as an atypical presenting complaint of COVID-19.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-01<​br>​
 +<​b>​Publisher:​ </​b>​American Journal of Emergency Medicine<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0735675720302746">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0735675720302746</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Hiccups (singultus) are reflex inspiratory movements that involve the swallowing reflex arc and can be classified as acute (<48 h) or persistent (>48 h). A 62-year-old man with no history of malignancy or pulmonary disease presented to the Emergency Department with a four-day history of persistent hiccups. Other than episodic hiccupping, his physical examination was otherwise unremarkable. An abnormal chest X-ray led to a CT scan of the chest with IV contrast, which demonstrated regional, peripheral groundglass opacities of the upper lobes with small focal groundglass opacities scattered throughout the lungs. He was tested for COVID-19 per admission protocol, started on hydroxychloroquine,​ his hiccups improved, and he was discharged to home after 3 days. An emergency medicine physician should keep COVID-19 on the differential and be vigilant of exposure in atypical presentations.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[397] Title: </​b>​Cutaneous manifestations of COVID-19: Report of three cases and a review of literature.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-01<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Dermatological Science<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19, cutaneous manifestations,​ review, skin, Biochemistry,​ Genetics and Molecular Biology, Health Sciences, Life Sciences, Medicine<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0923181120301493">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0923181120301493</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +BACKGROUND: Various cutaneous manifestations have been observed in patients with COVID-19 infection. However, overall similarities in the clinical presentation of these dermatological manifestations have not yet been summarized. OBJECTIVE: This review aims to provide an overview of various cutaneous manifestations in patients with COVID-19 through three case reports and a literature review. METHODS: A literature search was conducted using PubMed, OVID, and Google search engines for original and review articles. Studies written in the English language that mentioned cutaneous symptoms and COVID-19 were included. RESULTS: Eighteen articles and three additional cases reported in this paper were included in this review. Of these studies, 6 are case series and 12 are case report studies. The most common cutaneous manifestation of COVID-19 was found to be maculopapular exanthem (morbilliform),​ presenting in 36.1% (26/72) patients. The other cutaneous manifestations included: a papulovesicular rash (34.7%, 25/72), urticaria (9.7%, 7/72), painful acral red purple papules (15.3%, 11/72) of patients, livedo reticularis lesions (2.8%, 2/72) and petechiae (1.4%, 1/72). Majority of lesions were localized on the trunk (66.7%, 50/72), however, 19.4% (14/72) of patients experienced cutaneous manifestations in the hands and feet. Skin lesion development occurred before the onset of respiratory symptoms or COVID-19 diagnosis in 12.5% (9/72) of the patients, and lesions spontaneously healed in all patients within 10 days. Majority of the studies reported no correlation between COVID-19 severity and skin lesions. CONCLUSION: Infection with COVID-19 may result in dermatological manifestations with various clinical presentations,​ which may aid in the timely diagnosis of this infection.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[398] Title: </​b>​The use of convalescent plasma therapy and remdesivir in the successful management of a critically ill obstetric patient with novel coronavirus 2019 infection: A case report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-07-01<​br>​
 +<​b>​Publisher:​ </​b>​Case Reports in Women'​s Health<​br>​
 +<​b>​Keywords:​ </b>, covid-19, convalescent plasma, coronavirus,​ pregnancy, remdesivir, sars cov-2<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2214911220300515">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2214911220300515</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Remdesivir is a novel therapeutic with known activity against SARS CoV-2 and related coronaviruses. Remdesivir, as well as convalescent plasma therapy, are currently under investigation as potential therapies for patients with Coronavirus Disease 19 (COVID-19). In this case report we summarize the use of convalescent plasma therapy and then remdesivir as a late addition in the treatment of a critically ill obstetric patient with COVID-19. The patient subsequently improved, was extubated 5days after initiation of remdesivir, was transitioned to room air 24h later, and discharged at the completion of remdesivir therapy.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[399] Title: </​b>​Three cases of treatment with Nafamostat in elderly patients with COVID-19 pneumonia who need oxygen therapy.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-07-01<​br>​
 +<​b>​Publisher:​ </​b>​International Journal of Infectious Diseases<​br>​
 +<​b>​Keywords:​ </​b>​Microbiology,​ covid-19, nafamostat, pneumonia, oxygen treatment, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S1201971220303799">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S1201971220303799</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +No effective treatment for COVID-19 has been well established yet. Nafamostat, known as anticoagulant,​ has potential anti-inflammatory and anti-viral activities against COVID-19. We report three cases of COVID-19 pneumonia who progressed while using antiviral drugs and needed supplementary oxygen therapy, improved after treatment with nafamostat. These preliminary findings show the possibility that Nafamostat can be considered to be used in elderly patients with COVID-19 pneumonia who need oxygen therapy. The effectiveness of nafamostat should be evaluated in further studies.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[400] Title: </​b>​Effectiveness of Tocilizumab in a COVID-19 Patient with Cytokine Release Syndrome.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-01-01<​br>​
 +<​b>​Publisher:​ </​b>​European journal of case reports in internal medicine<​br>​
 +<​b>​Keywords:​ </b>, covid-19, tocilizumab,​ cytokine release syndrome<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.ejcrim.com/​index.php/​EJCRIM/​article/​view/​1731">​https://​www.ejcrim.com/​index.php/​EJCRIM/​article/​view/​1731</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Cytokine release syndrome (CRS) is a systemic inflammatory response that can be triggered by many factors such as infections. CRS in patients with coronavirus disease 2019 (COVID-19) is life-threatening and can occur very rapidly after COVID-19 diagnosis. Tocilizumab (TCZ), an interleukin-6 (IL-6) inhibitor, may ameliorate the CRS associated with severe COVID-19 and thus improve clinical outcomes. We present a case of life-threatening CRS caused by COVID-19 infection successfully treated with TCZ. LEARNING POINTS: Cytokine release syndrome (CRS) is a systemic inflammatory response that can be triggered by COVID-19.CRS can be life-threatening in severe COVID-19.Tocilizumab may have a role in treating severe COVID-19 patients with CRS.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[401] Title: </​b>​Peripheral "Swiss Cheese"​ Appearance in a COVID-19 Patient with Chronic Obstructive Pulmonary Disease.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-12<​br>​
 +<​b>​Publisher:​ </​b>​The American Journal of Tropical Medicine and Hygiene<​br>​
 +<​b>​Keywords:​ </​b>​Medical And Health Sciences, , Health Sciences, Life Sciences, Medicine, Immunology and Microbiology<​br>​
 +<​b>​DOI:​ </​b><​a href="​http://​www.ajtmh.org/​content/​journals/​10.4269/​ajtmh.20-0605">​http://​www.ajtmh.org/​content/​journals/​10.4269/​ajtmh.20-0605</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Peripheral "Swiss Cheese"​ Appearance in a COVID-19 Patient with Chronic Obstructive Pulmonary Disease.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[402] Title: </​b>​Clinical Characteristics and Outcome for Four SARS-CoV-2-infected Cancer Patients Treated with Immune Checkpoint Inhibitors.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-01<​br>​
 +<​b>​Publisher:​ </​b>​European Urology<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19, cancer, immune checkpoint inhibition, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0302283820303705">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0302283820303705</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Preliminary data suggest that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with higher mortality among cancer patients, particularly in those on systemic therapy. It is unclear whether this applies to patients receiving immune checkpoint inhibitors (ICIs). In this case series, 74 patients from a single institution with genitourinary (GU) cancer on ICI were followed up during a 12-wk period. During this period, 11 patients (15%) developed symptoms consistent with coronavirus disease 2019 (COVID-19) and four (5%) tested positive. Two patients had metastatic urothelial cancer (treated with atezolizumab) and two had metastatic renal cancer (treated with ipilimumab and nivolumab). All had additional risk factors associated with COVID-19 mortality and two received steroids within 1 mo of infection. Two patients developed symptoms requiring hospitalisation. All four are alive 32-45 d after their first symptoms and 28-38 d after testing positive. These patients all had multiple risk factors associated with severe COVID-19. These data suggest that the higher risk of COVID-19 death associated with systemic therapy in cancer may not apply to patients on ICIs. Assessment of COVID-19 severity in these patients can be complicated by the underlying cancer and its treatment.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[403] Title: </​b>​Sentinel Case of COVID-19 at Fort Stewart, GA in a National Guard Soldier Participating in Annual Training: A Case Report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-22<​br>​
 +<​b>​Publisher:​ </​b>​Military Medicine<​br>​
 +<​b>​Keywords:​ </​b>​Public Health And Health Services, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​http://​doi.org/​10.1093/​milmed/​usaa144">​http://​doi.org/​10.1093/​milmed/​usaa144</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +For healthcare providers, specifically military and federal public health personnel, prompt and accurate diagnosis and isolation of SARS-CoV-2 novel coronavirus patients provide a two-fold benefit: (1) directing appropriate treatment to the infected patient as early as possible in the progression of the disease to increase survival rates and minimize the devastating sequelae following recovery and remission of symptoms; (2) provide critical information requirements that enable commanders and public health officials to best synchronize policy, regulations,​ and troop movement restrictions while best allocating scarce resources in the delicate balance of risk mitigation versus mission readiness. Simple personal protective measures and robust testing and quarantine procedures, instituted and enforced aggressively by senior leaders, physicians, and healthcare professionals at all levels are an essential aspect of the battle against the COVID-19 pandemic that will determine the success or failure of the overall effort. As consideration,​ the authors respectfully submit this vignette of the first confirmed positive COVID-19 case presenting to the Emergency Department at Winn Army Community Hospital, Fort Stewart, Georgia.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[404] Title: </​b>​The Difficult Airway and Aerosol-Generating Procedures in COVID-19: Timeless Principles for Uncertain Times.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​1.95<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-23<​br>​
 +<​b>​Publisher:​ </​b>​Otolaryngology-Head & Neck Surgery<​br>​
 +<​b>​Keywords:​ </b>, covid-19, sars-cov-2, aerosol-generating procedures, coronavirus,​ difficult airway, flexible fiberoptic laryngoscopy,​ intubation, laryngotracheal stenosis, novel coronavirus,​ pandemic, subglottic stenosis, tracheal stenosis, ultrasound, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​journals.sagepub.com/​doi/​10.1177/​0194599820936615">​https://​journals.sagepub.com/​doi/​10.1177/​0194599820936615</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The impact of the COVID-19 pandemic on otolaryngology practice is nowhere more evident than in acute airway management. Considerations of preventing SARS-CoV-2 transmission,​ conserving personal protective equipment, and prioritizing care delivery based on acuity have dictated clinical decision making in the acute phase of the pandemic. With transition to a more chronic state of pandemic, heightened vigilance is necessary to recognize how deferral of care in patients with tenuous airways and COVID-19 infection may lead to acute airway compromise. Furthermore,​ it is critical to respect the continuing importance of flexible laryngoscopy in diagnosis. Safely managing airways during the pandemic requires thoughtful multidisciplinary planning. Teams should consider trade-offs among aerosol-generating procedures involving direct laryngoscopy,​ supraglottic airway use, fiberoptic intubation, and tracheostomy. We share clinical cases that illustrate enduring principles of acute airway management. As algorithms evolve, time-honored approaches for diagnosis and management of acute airway pathology remain essential in ensuring patient safety.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[405] Title: </​b>​Gross examination report of a COVID-19 death autopsy.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​1.85<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-02-25<​br>​
 +<​b>​Publisher:​ </​b>​Fa yi xue za zhi<​br>​
 +<​b>​Keywords:​ </b>, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​http://​www.fyxzz.cn/​CN/​10.12116/​j.issn.1004-5619.2020.01.005">​http://​www.fyxzz.cn/​CN/​10.12116/​j.issn.1004-5619.2020.01.005</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Abstract:<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[406] Title: </​b>​Novel coronavirus (SARS-CoV-2) infection in a renal transplant recipient: Case report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​1.85<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-08<​br>​
 +<​b>​Publisher:​ </​b>​American Journal of Transplantation<​br>​
 +<​b>​Keywords:​ </​b>​Medical And Health Sciences, clinical decision-making,​ clinical research/​practice,​ immunosuppressive regimens-maintenance,​ infection and infectious agents-viral,​ infectious disease, kidney transplantation/​nephrology,​ Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​ajt.15897">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​ajt.15897</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +An ongoing outbreak of pneumonia associated with the severe acute respiratory coronavirus 2 (SARS-CoV-2) started in Wuhan, China, with cases now confirmed in multiple countries. The clinical course of patients remains to be fully characterized,​ clinical presentation ranges from asymptomatic infection to acute respiratory distress syndrome and acute renal failure, and no pharmacological therapies of proven efficacy yet exist. We report a case of SARS-CoV-2 infection in a renal transplant recipient with excellent outcome. This case states the importance of close monitoring of the concentration of cyclosporine in patients treated with lopinavir/​ritonavir;​ the routine treatment of corticosteroid can be continued. This is a rare report of SARS-CoV-2 infection in a renal transplant recipient. Further data are needed to achieve better understanding of the impact of immunosuppressive therapy on the clinical presentation,​ severity, and outcome of SARS-CoV-2 infections in solid organ transplant recipients.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[407] Title: </​b>​COVID-19 pneumonia patient without clear epidemiological history outside Wuhan: An analysis of the radiographic and clinical features.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​1.85<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-09-01<​br>​
 +<​b>​Publisher:​ </​b>​Clinical Imaging<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19, epidemiological history, hrct, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0899707120301352">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0899707120301352</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The purpose of this case report is to describe the radiographic and clinical features of a COVID-19 pneumonia patient without clear epidemiological history outside Wuhan, China.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[408] Title: </​b>​Mild COVID-19 in a pediatric renal transplant recipient.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​1.85<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-08<​br>​
 +<​b>​Publisher:​ </​b>​American Journal of Transplantation<​br>​
 +<​b>​Keywords:​ </​b>​Medical And Health Sciences, covid-19, clinical research/​practice,​ immunosuppressant,​ immunosuppression,​ infection and infectious agents - viral, infectious disease, kidney transplantation/​nephrology,​ lung disease: infectious, pediatric, pediatrics, renal transplantation,​ Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​ajt.16003">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​ajt.16003</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +As of mid-April 2020, the coronavirus disease of 2019 (COVID-19) pandemic has affected more than 2 million people and caused 135 000 deaths worldwide. Not much is known about the effect of this disease in immunosuppressed children with renal transplantation (RT). Here we report a 13-year-old child with multiple comorbidities who acquired COVID-19 5 years post-RT in the United States. Maintenance immunosuppression (IS) consisted of sirolimus and mycophenolate. There was no history of travel or exposure to sick contacts. The presenting features were fever, cough, rhinorrhea, and hypoxemia. Diarrhea was the only extrapulmonary manifestation. Chest X-ray was normal. He did not require intensive care unit care or ventilation. There was a transient rise in his serum creatinine without change in urine output; dialysis was not required. Slight reduction in IS was done. He had an excellent clinical recovery within 4 days and was able to be discharged home. His respiratory symptoms resolved but the diarrhea persisted during a 4-week follow-up period. This report provides a brief perspective on the short-term COVID-19 clinical course in an immunosuppressed child. More reports will add valuable information on the potential variety of spectrum of the illness in this subset of children.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[409] Title: </​b>​Clinical and histological characterization of late appearance maculopapular eruptions in association with the coronavirus disease 2019. A case series of seven patients.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​1.85<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-04<​br>​
 +<​b>​Publisher:​ </​b>​Journal of the European Academy of Dermatology & Venereology<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19, maculopapular eruptions, sars-cov-2, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​jdv.16707">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​jdv.16707</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Since the first report of cutaneous manifestations of the coronavirus disease 2019 (COVID-19) by Recalcati et al(1) , there has been described five clinical patterns including pseudo-chilblain lesions, vesicular eruptions, urticarial lesions, livedo and necrosis and maculopapular eruptions(2) . Several clinical reports have been published recently describing these clinical patterns although there is still a lack of information regarding histopathology of maculopapular eruptions. We designed a retrospective study of patients attended in our department over the course of three weeks. We collected clinical data and pictures, and performed a biopsy when possible.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[410] Title: </​b>​Combination of thrombolytic and immunosuppressive therapy for coronavirus disease 2019: A case report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​1.85<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-08-01<​br>​
 +<​b>​Publisher:​ </​b>​International Journal of Infectious Diseases<​br>​
 +<​b>​Keywords:​ </​b>​Microbiology,​ acute respiratory distress syndrome, coronavirus disease 2019, d-dimer, recombinant tissue plasminogen activator, tocilizumab,​ Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S1201971220304252">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S1201971220304252</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +In a proportion of patients, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a multisystem syndrome characterized by hyperinflammation,​ acute respiratory distress syndrome (ARDS), and hypercoagulability. A 68-year-old man with coronavirus disease 2019 (COVID-19) was admitted to the intensive care unit with respiratory failure, cytokine release syndrome (CRS), and skin ischemia - microthrombosis. Specific coagulation and inflammatory markers (D-dimer, ferritin, and C-reactive protein), along with the clinical picture, triggered the trial of recombinant tissue plasminogen activator (rt-PA) and tocilizumab. This was followed by resolution of the skin ischemia and CRS, while respiratory parameters improved. No major complications associated with rt-PA or tocilizumab occurred. The combination of rt-PA with targeted anti-inflammatory treatment could be a new therapeutic option for patients with COVID-19, ARDS, hyperinflammation,​ and increased blood viscosity.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[411] Title: </​b>​Severe bleeding in a patient with Factor XIII deficiency and COVID-19.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​1.85<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-24<​br>​
 +<​b>​Publisher:​ </​b>​Haemophilia<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​hae.14088">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​hae.14088</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Since the outbreak in last December of the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in Wuhan, China, scientific literature is providing essential contributions to elucidate the pathophysiological and clinical features of the Coronavirus disease 2019 (COVID-19).(1) Consistent evidence shows that COVID-19 is associated with significant changes in coagulation laboratory testing, mainly prolonged prothrombin time and elevated D-dimer.(2).<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[412] Title: </​b>​Large pulmonary cavity in COVID-19 cured patient case report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​1.85<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-01<​br>​
 +<​b>​Publisher:​ </​b>​Annals of Palliative Medicine<​br>​
 +<​b>​Keywords:​ </b>, coronavirus disease 2019 (covid-19), case report, pulmonary cavity, severe acute respiratory syndrome coronavirus 2 (sarscov-2)<​br>​
 +<​b>​DOI:​ </​b><​a href="​http://​apm.amegroups.com/​article/​view/​44376">​http://​apm.amegroups.com/​article/​view/​44376</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Coronavirus Disease 2019 (COVID-19) is a pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The outbreak began in Wuhan, China, and spread rapidly, with many cases confirmed in multiple countries. Usually, after viral pneumonia were clinical cured, the pulmonary lesions of majority patients will gradually be absorbed to complete dissipation,​ very few severe patients may retain pulmonary interstitial inflammation and fibrosis (1-3). In this case, we described one unique COVID-19 patient, the symptoms were: dry cough, fatigue, poor appetite and subjective fever, moreover, the patient was a non-smoker, had no pulmonary bullous, no history of tuberculosis,​ and also no hypertension or diabetes. The patient received antiviral therapy, antibacterial therapy, recombinant human interferon-alpha2a,​ vitamin C and oxygen inhalation. After two weeks of treatment and observation,​ the patient was clinical cured and discharged. However, two days later, the patient had a sudden chest stuffiness, CT images indicted: his lung didn't heal like others, but developed a large pulmonary cavity in the lower lobe of right lung. In hospital, the patient showed no symptoms of infection for another 14 days, and the pulmonary cavity remain unchanged. This case suggested: it is important to follow convalescent COVID-19 patients, especially their lung CT images, to make sure a fully recovery.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[413] Title: </​b>​An Innovative Way to Achieve Safe Lung Deflation During One-Lung Ventilation in a Potential Coronavirus Disease 2019 Patient: A Case Report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​1.85<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-01<​br>​
 +<​b>​Publisher:​ </​b>​A&​A Practice<​br>​
 +<​b>​Keywords:​ </b>, <br>
 +<​b>​DOI:​ </​b><​a href="​https://​doi.org/​10.1213/​xaa.0000000000001244">​https://​doi.org/​10.1213/​xaa.0000000000001244</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +A novel coronavirus pandemic may be particularly hazardous to health care workers. Airway management is an aerosol-producing high-risk procedure. To minimize the production of airborne droplets, including pathogens such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),​ from the endotracheal tube during procedures requiring lung deflation, we devised a technique to mitigate the risk of infection transmission to health care personnel.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[414] Title: </​b>​Immune monitoring of a child with autoimmune hepatitis and type 1 diabetes during COVID-19 infection.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​1.85<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-16<​br>​
 +<​b>​Publisher:​ </​b>​European journal of gastroenterology & hepatology<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​journals.lww.com/​eurojgh/​Abstract/​9000/​Immune_monitoring_of_a_child_with_autoimmune.97545.aspx">​https://​journals.lww.com/​eurojgh/​Abstract/​9000/​Immune_monitoring_of_a_child_with_autoimmune.97545.aspx</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Immunocompromised patients may be at increased risk to develop COVID-19 during the 2019 beta-coronavirus infection. We present the unique opportunity we had to monitor the liver, IL-6 and immune cell course before, during and after COVID-19 in a boy with autoimmune hepatitis (AIH) and type 1 diabetes (T1D). CD4 and CD8 T cells frequencies decreased because of prednisolone,​ followed by a plateauing increase whereas CD19CD20 B cell increased strongly and was unaffected by COVID-19 infection. Moreover, the percentage of activated CD8 T cells expressing HLA-DR (CD8HLA-DR) increased during COVID-19 and subsided after its clearance. Total regulatory T cells (Tregs: CD4CD25CD127FOXP3) remained stable. Although activated Tregs (CD4CD45RAFOXP3) strongly increased upon prednisolone,​ it decreased afterwards. Furthermore,​ regulatory B cells (Bregs: CD19CD20CD24CD38) declined sharply owing to prednisolone. Serum IL-6 remained undetectable at all times. We demonstrated for the first time immune monitoring in a child with AIH and T1D before, during and after COVID-19. We hypothesize that continuing with low level of prednisolone without azathioprine may have abrogated activated Tregs, Bregs and IL-6 production and therefore permitting the activation of CD8 T cells, clearing the virus.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[415] Title: </​b>​Orbital cellulitis, sinusitis and intracranial abnormalities in two adolescents with COVID-19.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​1.75<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-18<​br>​
 +<​b>​Publisher:​ </​b>​Orbit<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19, sars-cov-2, hemorrhage, orbital cellulitis, thrombosis, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.tandfonline.com/​doi/​full/​10.1080/​01676830.2020.1768560">​https://​www.tandfonline.com/​doi/​full/​10.1080/​01676830.2020.1768560</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We review two cases of adolescents with orbital cellulitis, sinusitis and SARS- CoV-2 infection presenting to emergency departments within a 24 hour period. SARS-CoV-2 samples obtained within 24 hours were positive, supporting prior infection despite relatively limited early symptoms of COVID-19. Unusual clinical and radiographic characteristics included hemorrhagic abscess with blood of varying age in the first, intracranial epidural abscess in the second, radiographic signal consistent with hemorrhagic or thrombotic phenomena, retro-maxillary antral fat changes, and meningeal enhancement or extension in both cases. Radiographic findings thereby mimic fungal infection, although final cultures and ancillary investigation for allergic and invasive fungal disease have remained negative. These cases highlight two unusual orbital presentations of cellulitis occurring in the context of SARS-CoV-2 co-infection.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[416] Title: </​b>​Early Outcomes with Utilization of Tissue Plasminogen Activator in COVID-19 Associated Respiratory Distress: A series of five cases.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​1.75<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-21<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Trauma and Acute Care Surgery, The<​br>​
 +<​b>​Keywords:​ </b>, <br>
 +<​b>​DOI:​ </​b><​a href="​https://​journals.lww.com/​jtrauma/​Abstract/​9000/​Early_Outcomes_with_Utilization_of_Tissue.97876.aspx">​https://​journals.lww.com/​jtrauma/​Abstract/​9000/​Early_Outcomes_with_Utilization_of_Tissue.97876.aspx</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +BACKGROUND: Coronavirus patients demonstrate varying degrees of respiratory insufficiency;​ many will progress to respiratory failure with a severe version of acute respiratory distress syndrome (ARDS) refractory to traditional supportive strategies. Providers must consider alternative therapies to deter or prevent the cascade of decompensation to fulminant respiratory failure. METHODS: This is a case-series of five COVID-19 positive patients who demonstrated severe hypoxemia, declining respiratory performance,​ and escalating oxygen requirements. Patients met the following criteria: COVID-19 positivity, worsening respiratory performance,​ severe hypoxemia (PaO2<​80) despite traditional supportive measures, escalating supplemental oxygen requirements and D-dimer greater than 1.5mug/mL. All patients received protocol directed thrombolytic therapy with Tissue Plasminogen Activator (tPA). RESULTS: All five patients improved without deleterious effects of thrombolytic therapy. Patient one was on maximum ventilator support, paralytics, and prone positioning without improvement. During tPA administration his P/F ratio improved from 69 to 127. Ventilator support was weaned immediately on post-treatment day 1 and he was extubated on post treatment day 12. Our second through fifth patients were not intubated at time of initiation of tPA therapy. These patients each required significant oxygen supplementation trending toward intubation. After tPA therapy, all patients demonstrated a noticeable increase in PaO2 values overtime. Three of these patients avoided intubation due to COVID-19 associated respiratory failure. CONCLUSIONS:​ Administration of thrombolytics was followed by overall improvement in patients'​ oxygen requirements,​ and in three cases, prevented progression to mechanical ventilation,​ without deleterious effects. Clinical trials of thrombolytic therapy would further serve to underscore the efficacy and utility of this therapy. LEVEL OF EVIDENCE: Level V- Case series of therapeutic effect.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +
 +</​html>​
oa_db/covid19_case_reports_abstracts_pg7.txt · Last modified: 2020/06/28 05:22 by bpwhite