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 +===== COVID-19 Case Reports Abstracts - Page 5 =====
  
 +[[oa_db:​covid19_case_reports_abstracts|Back to Table of Contents]]
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 +----------------------------------------------------------------------<​br>​
 +<​b>​[229] Title: </​b>​De Novo Status Epilepticus in patients with COVID-19.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​10.05<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-10<​br>​
 +<​b>​Publisher:​ </​b>​Annals of Clinical and Translational Neurology<​br>​
 +<​b>​Keywords:​ </b>, <br>
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​acn3.51071">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​acn3.51071</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Neurological complications are increasingly recognized with SARS-CoV-2, the causative pathogen for COVID-19. We present a single-center retrospective case series reporting the EEG and outcome of de novo status epilepticus (SE) in two African-American women with laboratory-confirmed SARS-CoV-2 virus. SE was the initial presentation in one asymptomatic individual. Patient 2 had COVID-19 pneumonia, and fluctuating mental status that raised the suspicion of subclinical SE. The patient with older age and higher comorbidities failed to recover from the viral illness that has no definitive treatment.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[230] Title: </​b>​Cutaneous side effects of hydroxychloroquine in health care workers in a COVID referral hospital - implications for clinical practice.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​10<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-22<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Dermatological Treatment<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid, antihistamines,​ hydroxychloroquine,​ maculopapular rash, prophylaxis,​ pruritis, urticaria, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.tandfonline.com/​doi/​full/​10.1080/​09546634.2020.1781041">​https://​www.tandfonline.com/​doi/​full/​10.1080/​09546634.2020.1781041</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The utility of hydroxychloroquine for the prophylaxis and treatment of alarmingly rising COVID-19 infection has been widely explored in several studies. However, its cutaneous adverse effects among health care workers and COVID patients taking prophylactic doses has not been reported. We report cases of palmoplantar among health care workers who were on prophylactic doses of hydroxychloroquine and their management with cetirizine and methylprednisolone.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[231] Title: </b>A fine balance: Immunosuppression and immunotherapy in a patient with multiple sclerosis and COVID-19.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​9.9<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-07-01<​br>​
 +<​b>​Publisher:​ </​b>​Multiple Sclerosis and Related Disorders<​br>​
 +<​b>​Keywords:​ </b>, covid-19, fingolimod, multiple sclerosis, tocilizumab<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2211034820302583">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2211034820302583</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +BACKGROUND: Treatment decisions in patients with multiple sclerosis (MS) during the coronavirus disease 2019 (COVID-19) pandemic are challenging. It is not known whether and how various disease modifying therapies, especially immunosuppressive drugs, affect COVID-19 risk and disease course. METHODS: Case report RESULTS: We report a fingolimod-treated MS patient who developed severe COVID-19 but recovered after treatment with tocilizumab. CONCLUSION: This report suggests that a brief course of tocilizumab for the treatment of severe COVID-19 may be effective while not aggravating pre-existing MS.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[232] Title: </​b>​Coronavirus Disease 2019 in the Perioperative Period of Lung Resection: A Brief Report From a Single Thoracic Surgery Department in Wuhan, People'​s Republic of China.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​9.8<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-01<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Thoracic Oncology<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, 2019 novel coronavirus disease, characteristics,​ lung resection, perioperative period, severe acute respiratory syndrome coronavirus 2, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S1556086420302987">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S1556086420302987</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Coronavirus disease 2019 (COVID-19) is an emerging infectious disease that was first reported in Wuhan, People'​s Republic of China, and has subsequently spread worldwide. Clinical information on patients who contracted severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the perioperative period is limited. Here, we report seven cases with confirmed SARS-CoV-2 infection in the perioperative period of lung resection. Retrospective analysis suggested that one patient had been infected with the SARS-CoV-2 infection before the surgery and the other six patients contracted the infection after the lung resection. Fever, lymphopenia,​ and ground-glass opacities revealed on computed tomography are the most common clinical manifestations of the patients who contracted COVID-19 after the lung resection. Pathologic studies of the specimens of these seven patients were performed. Pathologic examination of patient 1, who was infected with the SARS-CoV-2 infection before the surgery, revealed that apart from the tumor, there was a wide range of interstitial inflammation with plasma cell and macrophage infiltration. High density of macrophages and foam cells in the alveolar cavities, but no obvious proliferation of pneumocyte, was found. Three of seven patients died from COVID-19 pneumonia, suggesting lung resection surgery might be a risk factor for death in patients with COVID-19 in the perioperative period.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[233] Title: </​b>​Clinical course of COVID-19 in a liver transplant recipient on hemodialysis and response to tocilizumab therapy: A case report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​9.6<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-03<​br>​
 +<​b>​Publisher:​ </​b>​American Journal of Transplantation<​br>​
 +<​b>​Keywords:​ </​b>​Medical And Health Sciences, clinical research/​practice,​ immunosuppressant - calcineurin inhibitor: tacrolimus, immunosuppression/​immune modulation, infection and infectious agents - viral, infectious disease, liver transplantation/​hepatology,​ Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​ajt.15985">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​ajt.15985</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The novel coronavirus disease 2019 (COVID-19) is a highly infectious and rapidly spreading disease. There are limited published data on the epidemiology and outcomes of COVID-19 infection among organ transplant recipients. After initial flulike symptoms, progression to an inflammatory phase may occur, characterized by cytokine release rapidly leading to respiratory and multiorgan failure. We report the clinical course and management of a liver transplant recipient on hemodialysis,​ who presented with COVID-19 pneumonia, and despite completing a 5-day course of hydroxychloroquine,​ later developed marked inflammatory manifestations with rapid improvement after administration of off-label, single-dose tocilizumab. We also highlight the role of lung ultrasonography in early diagnosis of the inflammatory phase of COVID-19. Future investigation of the effects of immunomodulators among transplant recipients with COVID-19 infection will be important.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[234] Title: </​b>​COVID-19 in 7 multiple sclerosis patients in treatment with ANTI-CD20 therapies.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​9.55<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-09-01<​br>​
 +<​b>​Publisher:​ </​b>​Multiple Sclerosis and Related Disorders<​br>​
 +<​b>​Keywords:​ </b>, <br>
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2211034820303825">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2211034820303825</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +BACKGROUND AND AIM: In December 2019, the first cases of SARS-CoV-2 infection were detected in Wuhan. Within two months, it had begun to spread around the world in what became an unprecedented pandemic. Patients with Multiple Sclerosis (MS) in a state of immunosuppression may be considered at risk for complications in the COVID-19 pandemic, although there is increasing evidence postulating a possible protective role of selective immunosuppression. One group of such immunosuppressants used in MS comprises the anti-CD20 monoclonal antibodies (mAbs) ocrelizumab and rituximab. Anti-CD20 mAbs bind to the surface of B cells, causing their depletion. We describe our experience in seven cases of patients with multiple sclerosis who have been affected by SARS-COV-2 (with a clinical/​serological diagnosis or PCR diagnosis) and who were being treated with anti-CD20+ monoclonal antibodies. MATERIAL AND METHODS: We review the development of patients during infection as well as the resolution of their clinical picture. We also analyze the serology status against SARS-CoV-2 after resolution of the infection. RESULTS: Although the severity of the clinical pictures was variable, patients'​ development was good. Not all patients, however, developed antibodies against SARS-CoV-2. CONCLUSIONS:​ Patients treated with anti-CD20+ have adequate resolution of COVID-19 despite the fact that the presence of antibodies against SARS-CoV-2 was not detected in all cases. It is possible that the presence of humoral immunity is not always necessary fora good clinical course of SARS-CoV-2 infection.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[235] Title: </​b>​Kidney Infarction in Patients With COVID-19.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​9.55<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-01<​br>​
 +<​b>​Publisher:​ </​b>​American Journal of Kidney Diseases<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, acute kidney injury, covid-19, kidney infarction, sars-cov-2, anticoagulation,​ Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S027263862030723X">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S027263862030723X</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Coronavirus disease 2019 (COVID-19) is a contagious, life-threatening infection caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Recent findings indicate an increased risk of acute kidney injury during COVID-19. The pathophysiological mechanisms leading to acute kidney injury in COVID-19 are unclear, but may include direct cytopathic effects of the virus on kidney tubular and endothelial cells, indirect damage caused by virus-induced cytokine release, and kidney hypoperfusion due to a restrictive fluid strategy. In this case-report we propose an additional pathophysiological mechanism. We describe two cases in which patients with COVID-19 developed a decrease in kidney function due to kidney infarction. These patients did not have atrial fibrillation. One of these patients was treated with therapeutic doses of low molecular weight heparin, whereafter no further deterioration of kidney function was observed. Our findings implicate that the differential diagnosis of acute kidney injury in COVID-19 patients should include kidney infarction, which may have important preventive and therapeutic implications.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[236] Title: </​b>​Early COVID-19 infection after lung transplantation.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​9.3<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-11<​br>​
 +<​b>​Publisher:​ </​b>​American Journal of Transplantation<​br>​
 +<​b>​Keywords:​ </​b>​Medical And Health Sciences, covid-19, coronavirus,​ lung transplant, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​ajt.16097">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​ajt.16097</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +COVID-19, the clinical syndrome caused by the novel coronavirus,​ SARS-CoV-2, continues to rapidly spread, leading to significant stressors on global healthcare infrastructure. The manifestations of COVID-19 in solid organ transplant recipients are only beginning to be understood with cases reported to date in transplant recipients on chronic immunosuppression. Herein, we report the first case of COVID-19 in a lung transplant recipient in the immediate posttransplant period, and we describe the epidemiologic challenges in identifying the source of infection in this unique situation.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[237] Title: </​b>​Varicella-like exanthem associated with COVID-19 in an 8-year-old girl: A diagnostic clue?<​br><​br>​
 +<​b>​Altmetric Score: </​b>​9.28<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-19<​br>​
 +<​b>​Publisher:​ </​b>​Pediatric Dermatology<​br>​
 +<​b>​Keywords:​ </​b>​Paediatrics And Reproductive Medicine, covid-19, sars-cov-2, coronavirus,​ infection, pediatric, viral exanthem, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​pde.14201">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​pde.14201</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +It has been reported that the novel coronavirus disease (COVID-19) may be associated with a papulovesicular skin eruption predominantly involving the trunk. We hereby present a case of COVID-19-associated varicella-like exanthem in an 8-year-old girl with mild systemic symptoms.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[238] Title: </​b>​Brainstem involvement and respiratory failure in COVID-19.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​9.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-29<​br>​
 +<​b>​Publisher:​ </​b>​Neurological Sciences<​br>​
 +<​b>​Keywords:​ </​b>​Medicine & Public Health, covid-19, sars-cov-2, brainstem involvement,​ respiratory failure, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​link.springer.com/​article/​10.1007/​s10072-020-04487-2">​https://​link.springer.com/​article/​10.1007/​s10072-020-04487-2</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Respiratory failure is the most worrisome problem of COVID-19. Patients may develop severe pneumonia requiring invasive mechanical ventilation and a significant proportion of them dies. It has been suggested that brainstem might play a role in severe respiratory failure of COVID-19 patients. We described three COVID-19 patients in ICU at Federico II Hospital in Naples that, although had recovered from pneumonia, could not be weaned from invasive mechanical ventilation. Our clinical evaluation was consistent with an involvement of the brainstem and especially of respiratory centre thus possibly explaining the weaning failure in patients that were awake and had recovered from lung involvement. Our data, though limited, indicate that brainstem involvement may play a role in respiratory failure and perhaps in the high death rate of COVID-19 patients. Moreover, the weaning failure from mechanical ventilation due to central respiratory drive depression might underlie the unusual long stay in ICU reported for COVID-19 patients.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[239] Title: </​b>​Persistent viral RNA positivity during the recovery period of a patient with SARS-CoV-2 infection.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​9.08<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-02<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Medical Virology<​br>​
 +<​b>​Keywords:​ </​b>​Medical Microbiology,​ sars-cov-2, coronavirus,​ saliva, virus shedding, Health Sciences, Life Sciences, Medicine, Immunology and Microbiology<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​jmv.25940">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​jmv.25940</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +As an emerging infectious disease, the clinical course and virological course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain to be further investigated. In this case report, we described a case of SARS-CoV-2 infection with the clinical course for more than 2 months. This patient had recovered from pneumonia after treatment. The viral RNA of throat swabs became negative and the viral-specific antibodies were produced during the recovery period. However, the viral RNA reappeared and additionally persisted in throat swabs for more than 40 days. In addition, the viral RNA was detected in multiple types of specimens with extremely high titers in the saliva. In conclusion, these findings indicate that SARS-CoV-2 can cause a long clinical course. The coexistence of viral RNA and viral-specific antibodies may imply an immune evasion of SARS-CoV-2 from the host's immune system.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[240] Title: </​b>​Veno-venous extracorporeal membrane oxygenation for severe pneumonia: COVID-19 case in Japan.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​8.9<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-14<​br>​
 +<​b>​Publisher:​ </​b>​Acute Medicine & Surgery<​br>​
 +<​b>​Keywords:​ </b>, coronavirus disease 2019, japan, extracorporeal membrane oxygenation,​ lopinavir, ritonavir, severe acute respiratory syndrome coronavirus 2<br>
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​ams2.509">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​ams2.509</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Background: Veno-venous extracorporeal membrane oxygenation (VV-ECMO) is one of the ultimate treatments for acute respiratory failure. However, the effectiveness of ECMO in patients with novel coronavirus disease (COVID-19) is unknown. Case Presentation:​ A 72-year-old woman who was a passenger of a cruise ship tested positive for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) while in quarantine on board using throat swab. Three days after admission, her condition deteriorated,​ and she was subsequently intubated. On day 6, VV-ECMO was introduced. Lopinavir/​ritonavir was given; continuous renal replacement therapy was also introduced. On day 10, her chest radiography and lung compliance improved. She was weaned off ECMO on day 12. Conclusion: Treatment of severe pneumonia in COVID-19 by ECMO should recognize lung plasticity considering time to ECMO introduction and interstitial biomarkers. In Japan, centralization of ECMO patients has not been sufficient. Thus, we suggest nationwide centralization and further research to respond to the crisis caused by COVID-19.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[241] Title: </​b>​Prothrombotic state induced by COVID-19 infection as trigger for stroke in young patients: A dangerous association.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​8.85<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-09-01<​br>​
 +<​b>​Publisher:​ </​b>​eNeurologicalSci<​br>​
 +<​b>​Keywords:​ </b>, covid-19, coronavirus,​ prothrombotic state, stroke, vertebrobasilar disease<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2405650220300265">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2405650220300265</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +*COVID-19 infection could led to a pro-inflammatory and pro-thrombotic state.*Cerebrovascular involvement may occur in COVID-19 infection even in young patients.*Physicians should be aware that stroke may be the first COVID-19 manifestation.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[242] Title: </​b>​Venous thrombosis and arteriosclerosis obliterans of lower extremities in a very severe patient with 2019 novel coronavirus disease: a case report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​8.83<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-18<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Thrombosis and Thrombolysis<​br>​
 +<​b>​Keywords:​ </​b>​Cardiology,​ 2019 novel coronavirus disease, arteriosclerosis obliterans, rhabdomyolysis,​ type 2 diabetes, venous thrombosis, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​link.springer.com/​article/​10.1007/​s11239-020-02084-w">​https://​link.springer.com/​article/​10.1007/​s11239-020-02084-w</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The outbreak of 2019 novel coronavirus disease (COVID-19) began since early December 2019, and has been declared as a public health emergency by the World Health Organization. Due to the hypercoagulable state, blood stasis and endothelial injury, severe patients with COVID-19 are at high risk for thrombosis. We report a case of very severe COVID-19 complicated with venous thrombosis and arteriosclerosis obliterans of lower extremities. Risk stratification for deep vein thrombosis and peripheral arterial disease are of vital importance for the prognosis of COVID-19.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[243] Title: </​b>​Severe COVID-19 infection in a patient with multiple sclerosis treated with fingolimod.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​8.8<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-07-01<​br>​
 +<​b>​Publisher:​ </​b>​Multiple Sclerosis and Related Disorders<​br>​
 +<​b>​Keywords:​ </b>, covid-19, critical care, fingolimod, multiple sclerosis, viral infection<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S221103482030256X">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S221103482030256X</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +BACKGROUND: Fingolimod is used for immune therapy in patients with multiple sclerosis. Long-term treatment is associated with a small increase in the risk of herpes virus reactivation and respiratory tract infections. Patients with coronavirus disease 2019 (COVID-19) under Fingolimod treatment have not been described. METHODS AND RESULTS: We report a 57-year old female patient with a relapsing remitting multiple sclerosis under fingolimod treatment who experienced a severe COVID-19 infection in March 2020 (Extended Disability Status Scale: 2.0). Having peripheral lymphopenia typical for fingolimod treatment (total lymphocytes 0.39/nL [reference range 1.22-3.56]),​ the patient developed bilateral interstitial pneumonia with multiple ground-glass opacities on chest CT. Fingolimod medication was stopped. On the intensive care unit, non-invasive ventilation was used to provide oxygen and ventilation support regularly. Over the following two days, oxygenation improved, and the patient was transferred to a normal ward five days after admission. CONCLUSION: The implications fingolimod has on COVID-19 are complex. As an S1P analogue, fingolimod might enhance lung endothelial cell integrity. In addition, in case of a so-called cytokine storm, immunomodulation might be beneficial to reduce mortality. Future studies are needed to explore the risks and therapeutic effects of fingolimod in COVID-19 patients.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[244] Title: </​b>​First case of drug-induced liver injury associated with the use of tocilizumab in a patient with COVID-19.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​8.7<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-01<​br>​
 +<​b>​Publisher:​ </​b>​Liver International<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19, sars-cov-2, drug-induced liver injury, hepatotoxicity,​ tocilizumab,​ Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​liv.14516">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​liv.14516</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +BACKGROUND AND AIMS: Tocilizumab (TCZ; interleukine-6 receptor antagonist) has been proposed to treat severe forms of Coronavirus disease-19 (COVID-19) because interleukine-6 plays an important role in COVID-19-induced cytokine storm. Several clinical studies have shown very good effects of TCZ in patients with COVID-19, with a few minor side effects reported. Only eight serious liver injuries caused by TCZ were reported before being used in the treatment of patients with COVID-19. Considering the significantly increased use of TCZ for the treatment of COVID-19, we would like to warn of its rare but possible serious hepatotoxicity,​ especially when used together with other hepatotoxic drugs. METHODS: We describe a patient with COVID-19-induced cytokine storm who developed drug-induced liver injury associated with the use of TCZ. RESULTS: One day after TCZ administration,​ serum transaminase levels increased 40-fold. Nevertheless,​ TCZ had a positive effect on clinical and laboratory parameters in cytokine storm, with transaminases values normalizing in 10 days. CONCLUSIONS:​ This is the first reported case of DILI caused by TCZ in a COVID-19 patient. Intensive liver function monitoring is imperative in COVID-19 patients, because of frequent polypharmacy with potentially hepatotoxic drugs.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[245] Title: </​b>​Towards individualised and optimalised positioning of non-ventilated COVID-19 patients: Putting the affected parts of the lung(s) on top?<​br><​br>​
 +<​b>​Altmetric Score: </​b>​8.55<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-01<​br>​
 +<​b>​Publisher:​ </​b>​Diabetes & Metabolism<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, body positioning,​ covid-19, oxygen saturation, Biochemistry,​ Genetics and Molecular Biology, Health Sciences, Life Sciences, Medicine<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S1262363620300860">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S1262363620300860</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The outbreak of COVID-19 led to an unprecedented inflow of hospitalised patients with severe acute respiratory syndrome (SARS), requiring high-flow non-invasive oxygenation,​ if not invasive mechanical ventilation. While the best option in terms of non-invasive systems of oxygen delivery is still a matter of debate, it also remains unclear as to whether or not the optimal in-bed positioning of patients might also help to improve their oxygen saturation levels. On the basis of three representative cases, it is possible to propose the following hypotheses: (i) how patients are positioned has a strong influence on their oxygen saturation levels; (ii) saturation-optimalised positions are patient-specific;​ (iii) prone positions require ergonomic devices; and (iv) saturation-optimalised positions should aim to place the most affected part(s) of the lung(s) on top. Considered together, these hypotheses have led us to recommend that COVID-19 patients should undergo a specific assessment at admission to determine their saturation-optimalised in-bed position. However, further studies are still needed to assess the benefits of such a strategy on clinical outcomes.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[246] Title: </​b>​Chest Imaging in Patients Hospitalized With COVID-19 Infection - A Case Series.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​8.4<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-07-01<​br>​
 +<​b>​Publisher:​ </​b>​Current Problems in Diagnostic Radiology<​br>​
 +<​b>​Keywords:​ </b>, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0363018820300554">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0363018820300554</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +COVID-19 (Corona Virus Disease-19) is a zoonotic illness first reported in the city of Wuhan, China in December 2019, and is now officially a global pandemic as declared by the World Health Organization. The infection is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 infected patients can be asymptomatic carriers or present with mild-to-severe respiratory symptoms. Imaging, including computed tomography is not recommended to screen/​diagnose COVID-19 infections, but plays an important role in management of these patients, and to rule out alternative diagnoses or coexistent diseases. In our multicenter case series, we outline the clinical presentations and illustrate the most common imaging manifestations in patients hospitalized with COVID-19.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[247] Title: </​b>​Severe ARDS in COVID-19-infected pregnancy: obstetric and intensive care considerations.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​8.4<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-01<​br>​
 +<​b>​Publisher:​ </​b>​American Journal of Obstetrics & Gynecology MFM<​br>​
 +<​b>​Keywords:​ </b>, ards, covid-19, sars-cov-2, acute respiratory distress syndrome, coronavirus,​ pneumonia, pregnancy<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2589933320300501">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2589933320300501</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Since the emergence of a novel coronavirus (SARS-CoV-2) in Wuhan, China, at the end of December 2019, its infection - COVID-19 - has been associated with severe morbidity and mortality and has left world governments,​ healthcare systems and providers caring for vulnerable populations,​ such as pregnant women, wrestling with the optimal management strategy. Unique physiologic and ethical considerations negate a one-size-fits-all approach to the care of critically ill pregnant women with COVID-19, and few resources exist to guide the multi-disciplinary team through decisions regarding optimal maternal-fetal surveillance,​ intensive care procedures, and delivery timing. We present a case of rapid clinical decompensation and development of severe Acute Respiratory Distress Syndrome (ARDS) in a woman at 31 weeks' gestation to highlight these unique considerations and present an algorithmic approach to the disease'​s diagnosis and management.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[248] Title: </​b>​SARS-CoV-2 infection of the placenta.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​8.4<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-23<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Clinical Investigation<​br>​
 +<​b>​Keywords:​ </​b>​Medical And Health Sciences, covid-19, molecular pathology, reproductive biology, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.jci.org/​articles/​view/​139569">​https://​www.jci.org/​articles/​view/​139569</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +BACKGROUND: The effects of Covid-19 in pregnancy remain relatively unknown. We present a case of second trimester pregnancy with symptomatic Covid-19 complicated by severe preeclampsia and placental abruption. METHODS: We analyzed placenta for the presence of SARS-CoV-2 through molecular and immunohistochemical assays and by and electron microscopy, and we measured the maternal antibody response in blood to this infection. RESULTS: SARS-CoV-2 localized predominantly to syncytiotrophoblast cells at the maternal-fetal interface of the placenta. Histological examination of the placenta revealed a dense macrophage infiltrate, but no evidence for vasculopathy typically associated with preeclampsia. CONCLUSION: This case demonstrates SARS-CoV-2 invasion of the placenta, highlighting the potential for severe morbidity among pregnant women with Covid-19.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[249] Title: </​b>​Acute Type A Aortic Dissection during COVID-19 Outbreak.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​8.35<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-01<​br>​
 +<​b>​Publisher:​ </​b>​The Annals of Thoracic Surgery<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0003497520305944">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0003497520305944</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +As of April 7, 2020, approximately 1,300,000 cases and 80,000 deaths related to coronavirus disease 2019 (COVID-19) have been reported in > 180 countries/​territories. Healthcare infrastructures and resources, particularly as it relates to the care of the most critically ill patients, are currently being strained globally. In this context, however, there has been little clinical guidance or information regarding life-threatening conditions requiring emergency surgery that cannot be delayed. We herein present a case of acute type A aortic dissection with COVID-19 in order to highlight the clinical implications of a true emergent procedure during the COVID-19 outbreak.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[250] Title: </​b>​Successful remission induction therapy with gilteritinib in a patient with de novo FLT3-mutated acute myeloid leukaemia and severe COVID-19.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​8.3<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-25<​br>​
 +<​b>​Publisher:​ </​b>​British Journal of Haematology<​br>​
 +<​b>​Keywords:​ </​b>​Cardiovascular Medicine And Haematology,​ , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​bjh.16962">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​bjh.16962</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The optimal treatment for patients with newly diagnosed acute myeloid leukaemia (AML) who are infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)/​COVID-19 is unknown.(1) We report the case of a previously fit 27-year-old male who presented with a 3-day history of fever (>39 C), swollen, erythematous elbows and no respiratory symptoms. His white blood count (WBC) was 187x10(9) /L and bone marrow (Figure 1A & 1C) examination revealed normal karyotype AML with a fms related receptor tyrosine kinase 3 (FLT3) internal tandem duplication (ITD), wild-type NPM1 and no additional mutations on a next-generation sequencing panel.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[251] Title: </​b>​D-dimer and mortality in COVID-19: a self-fulfilling prophecy or a pathophysiological clue?<​br><​br>​
 +<​b>​Altmetric Score: </​b>​8.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-26<​br>​
 +<​b>​Publisher:​ </​b>​Swiss Medical Weekly<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​smw.ch/​article/​doi/​smw.2020.20293">​https://​smw.ch/​article/​doi/​smw.2020.20293</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as a global phenomenon has presented clinicians around the world with multiple challenges. Thromboembolic events are recognised complications of viral infection, but the diagnosis of an acute pulmonary thrombotic complication in the context of coronavirus disease 2019 (COVID-19) can be challenging because of the similarities of presentation,​ logistical considerations of diagnosis in a patient isolated for infection control reasons and the effects of cognitive errors in diagnostic reasoning. We present the case of a patient who was diagnosed with a pulmonary thrombotic complication during inpatient care for COVID-19. The haemostasis parameters we observed, including increased levels of von Willebrand factor and factor VIII, point towards a relevant involvement of endothelial cells in patients with severe COVID-19. We suggest that it is possible to hypothesise a spectrum of secondarily acquired, prothrombotic coagulopathy mediated by the endothelial interaction with SARS-CoV-2 as a cause of mortality in a subset of patients with a complicated clinical course of COVID-19. We support the recommendation of thromboembolic chemoprophylaxis for inpatients with COVID-19 as a very minimum in the absence of strict contraindications,​ while recognising that pulmonary thrombotic complications can occur under standard thromboprophylaxis. We suggest that higher, possibly therapeutic levels of anticoagulation might be mandatory for a further subset of patients with COVID-19 where a discrepant evolution of C-reactive protein and D-dimer is observed. Therapeutic levels of anticoagulation are obligatory where new evidence of a macrovascular thrombotic complication has been documented. More research to delineate the macro- and microvascular thrombotic complications of COVID-19, and the therapeutic implications for this patient group is required.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[252] Title: </​b>​Mediastinal Emphysema, Giant Bulla, and Pneumothorax Developed during the Course of COVID-19 Pneumonia.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​8.15<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-01-01<​br>​
 +<​b>​Publisher:​ </​b>​Korean Journal of Radiology<​br>​
 +<​b>​Keywords:​ </b>, covid-19, complication,​ coronavirus,​ pneumonia, tomography, x-ray computed, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​kjronline.org/​DOIx.php?​id=10.3348/​kjr.2020.0180">​https://​kjronline.org/​DOIx.php?​id=10.3348/​kjr.2020.0180</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The coronavirus disease 2019 (COVID-19) pneumonia is a recent outbreak in mainland China and has rapidly spread to multiple countries worldwide. Pulmonary parenchymal opacities are often observed during chest radiography. Currently, few cases have reported the complications of severe COVID-19 pneumonia. We report a case where serial follow-up chest computed tomography revealed progression of pulmonary lesions into confluent bilateral consolidation with lower lung predominance,​ thereby confirming COVID-19 pneumonia. Furthermore,​ complications such as mediastinal emphysema, giant bulla, and pneumothorax were also observed during the course of the disease.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[253] Title: </​b>​COVID-19 in a High-Risk Dual Heart and Kidney Transplant Recipient.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​8.15<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-22<​br>​
 +<​b>​Publisher:​ </​b>​American Journal of Transplantation<​br>​
 +<​b>​Keywords:​ </​b>​Medical And Health Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​ajt.15936">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​ajt.15936</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is rapidly infecting people worldwide, resulting in the infectious disease coronavirus disease 19 (COVID-19) that has been declared a pandemic. Much remains unknown about COVID-19, including its effects on solid organ transplant (SOT) recipients. Given their immunosuppressed state, SOT recipients are presumed to be at high risk of complications with viral infections such as SARS-CoV-2. Limited case reports in single SOT recipients, however, have not suggested a particularly severe course in this population. In this report, we present a dual-organ (heart/​kidney) transplant recipient who was found to have COVID-19 and, despite the presence of a number of risk factors for poor outcomes, had a relatively mild clinical course.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[254] Title: </​b>​Inside the lungs of COVID-19 disease.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​8.15<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-26<​br>​
 +<​b>​Publisher:​ </​b>​International Journal of Legal Medicine<​br>​
 +<​b>​Keywords:​ </​b>​Other Chemical Sciences, covid-19, diffuse alveolar damage, interstitial pneumonia, post-mortem,​ sars-cov-2, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​link.springer.com/​article/​10.1007/​s00414-020-02318-9">​https://​link.springer.com/​article/​10.1007/​s00414-020-02318-9</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +In the setting of the coronavirus disease 2019 (COVID-19) pandemic, only few data regarding lung pathology induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is available, especially without medical intervention interfering with the natural evolution of the disease. We present here the first case of forensic autopsy of a COVID-19 fatality occurring in a young woman, in the community. Diagnosis was made at necropsy and lung histology showed diffuse alveolar damage, edema, and interstitial pneumonia with a geographically heterogeneous pattern, mostly affecting the central part of the lungs. This death related to COVID-19 pathology highlights the heterogeneity and severity of central lung lesions after natural evolution of the disease.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[255] Title: </​b>​Respiratory Distress in Postanesthesia Care Unit: First Presentation of Coronavirus Disease 2019 in a 17-Year-Old Girl: A Case Report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​8.01<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-01<​br>​
 +<​b>​Publisher:​ </b>A & A Practice<​br>​
 +<​b>​Keywords:​ </b>, <br>
 +<​b>​DOI:​ </​b><​a href="​https://​journals.lww.com/​aacr/​FullText/​2020/​05000/​Respiratory_Distress_in_Postanesthesia_Care_Unit_.5.aspx">​https://​journals.lww.com/​aacr/​FullText/​2020/​05000/​Respiratory_Distress_in_Postanesthesia_Care_Unit_.5.aspx</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +A 17-year-old healthy girl underwent an uneventful esthetic septorhinoplasty. She was easily extubated and transferred to the postanesthesia care unit (PACU) with oxygen saturation (SpO2) of 96%. About 30 minutes after arrival in the PACU, she developed dyspnea with SpO2 of 84% and promptly received oxygen with bilevel positive airway pressure in conjunction with low-dose corticosteroid. The subsequent chest computed tomography (CT) revealed bilateral patchy infiltrates similar to the radiologic findings of Coronavirus Disease 2019 (COVID-19). Finally, a reverse transcriptase polymerase chain reaction (RT-PCR) of a pharyngeal specimen confirmed the diagnosis of COVID-19.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[256] Title: </​b>​Fatal Eosinophilic Myocarditis in a Healthy 17-Year-Old Male with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2c).<​br><​br>​
 +<​b>​Altmetric Score: </​b>​8<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-13<​br>​
 +<​b>​Publisher:​ </​b>​Fetal & Pediatric Pathology<​br>​
 +<​b>​Keywords:​ </​b>​Paediatrics And Reproductive Medicine, covid 19, sars-cov-2, coronavirus disease 2019, eosinophilic myocarditis,​ severe respiratory syndrome coronavirus 2, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.tandfonline.com/​doi/​full/​10.1080/​15513815.2020.1761491">​https://​www.tandfonline.com/​doi/​full/​10.1080/​15513815.2020.1761491</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Background: Cardiac damage is frequently referred to in patients with SARS-CoV-2, is usually diagnosed by enzyme elevations, and is generally thought to be due to underlying coronary artery disease. There are references to cardiomyopathies accompanying coronavirus,​ but there has been no histologic confirmation.Case report: A previously healthy 17 year male old presented in full cardiac arrest to the emergency department after a 2 day history of headache, dizziness, nausea and vomiting. Autopsy demonstrated an enlarged flabby heart with eosinophilic myocarditis. There was no interstitial pneumonia or diffuse alveolar damage. Postmortem nasopharyngeal swabs detected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) known to cause coronavirus disease 2019 (COVID-19). No other cause for the eosinophilic myocarditis was elucidated.Conclusion:​ Like other viruses, SARS-CoV-2 may be associated with fulminant myocarditis.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[257] Title: </​b>​Humidifier Use and Prone Positioning in a Patient with Severe COVID-19 Pneumonia and Endotracheal Tube Impaction Due to Highly Viscous Sputum.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​8<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-15<​br>​
 +<​b>​Publisher:​ </​b>​Cureus<​br>​
 +<​b>​Keywords:​ </b>, coronavirus 2019 (covid-19), coronavirus disease 2019, covid-19 respiratory failure high altitude pulmonary edema high flow nasal cannula acute respiratory distress syndrome, invasive mechanical ventilation,​ key words corona, sars cov-2, sars-cov-2 (severe acute respiratory syndrome coronavirus -2), tube impaction<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.cureus.com/​articles/​32620-humidifier-use-and-prone-positioning-in-a-patient-with-severe-covid-19-pneumonia-and-endotracheal-tube-impaction-due-to-highly-viscous-sputum">​https://​www.cureus.com/​articles/​32620-humidifier-use-and-prone-positioning-in-a-patient-with-severe-covid-19-pneumonia-and-endotracheal-tube-impaction-due-to-highly-viscous-sputum</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +COVID-19 can lead to severe pneumonia, requiring mechanical ventilation. While increased sputum secretion could cause airway obstruction during mechanical ventilation,​ there are few reported cases in the literature. We report a case of a 65-year-old man with diabetes and severe COVID-19 pneumonia requiring mechanical ventilation and treated with hydroxychloroquine,​ azithromycin,​ nafamostat, and prone positioning. Initially, mechanical ventilation consisted of a heat moisture exchanger, endotracheal tube aspiration, and subglottic secretion drainage using a closed suction system. However, endotracheal tube impaction by highly viscous sputum occurred during this mechanical ventilation system. Replacing the endotracheal tube, the use of a humidifier instead of a heat moisture exchanger, and prone positioning contributed to the patient being weaned off mechanical ventilation. Although anti-aerosol measures are important for severe COVID-19 pneumonia, attention should be given to potential endotracheal tube impaction during mechanical ventilation.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[258] Title: </​b>​2019 Novel Coronavirus (COVID-19) Pneumonia with Hemoptysis as the Initial Symptom: CT and Clinical Features.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​7.83<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-01-01<​br>​
 +<​b>​Publisher:​ </​b>​Korean Journal of Radiology<​br>​
 +<​b>​Keywords:​ </b>, 2019 novel coronavirus,​ atypical imaging features, atypical symptoms, covid-19, hemoptysis, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​kjronline.org/​DOIx.php?​id=10.3348/​kjr.2020.0181">​https://​kjronline.org/​DOIx.php?​id=10.3348/​kjr.2020.0181</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Recently, some global cases of 2019 novel coronavirus (COVID-19) pneumonia have been caused by second- or third-generation transmission of the viral infection, resulting in no traceable epidemiological history. Owing to the complications of COVID-19 pneumonia, the first symptom and imaging features of patients can be very atypical and early diagnosis of COVID-19 infections remains a challenge. It would aid radiologists and clinicians to be aware of the early atypical symptom and imaging features of the disease and contribute to the prevention of infected patients being missed.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[259] Title: </​b>​Significance of serology testing to assist timely diagnosis of SARS-CoV-2 infections: implication from a family cluster.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​7.83<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-13<​br>​
 +<​b>​Publisher:​ </​b>​Emerging Microbes & Infections<​br>​
 +<​b>​Keywords:​ </b>, <br>
 +<​b>​DOI:​ </​b><​a href="​https://​www.tandfonline.com/​doi/​full/​10.1080/​22221751.2020.1752610">​https://​www.tandfonline.com/​doi/​full/​10.1080/​22221751.2020.1752610</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Confirmative diagnosis of SARS-CoV-2 infections has been challenged due to unsatisfactory positive rate of molecular assays. Here we identified a family cluster of SARS-CoV-2 infections, with five of six family members were SARS-CoV-2-specific immunoglobin serology testing positive, while molecular assays only detected two of this five patients even repeated twice. We comprehensively analyzed this familial cluster of cases based on the clinical characteristics,​ chest CT images, SARS-CoV-2 molecular detection results, and serology testing results. At last, two patients were diagnosed with COVID-19, two were suspected of COVID-19, and two were considered close contacts. Our results emphasized the significance of serology testing to assist timely diagnosis of SARS-CoV-2 infections, especially for COVID-19 close contacts screening.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[260] Title: </​b>​18F-FDG PET/CT and Serial Chest CT Findings in a COVID-19 Patient With Dynamic Clinical Characteristics in Different Period.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​7.76<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-01<​br>​
 +<​b>​Publisher:​ </​b>​Clinical Nuclear Medicine<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​journals.lww.com/​nuclearmed/​FullText/​2020/​06000/​18F_FDG_PET_CT_and_Serial_Chest_CT_Findings_in_a.25.aspx">​https://​journals.lww.com/​nuclearmed/​FullText/​2020/​06000/​18F_FDG_PET_CT_and_Serial_Chest_CT_Findings_in_a.25.aspx</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Neurological symptoms and gastrointestinal symptoms were rare at onset in COVID-19. Here we report a 37-year-old man with vertigo, fever, and diarrhea symptoms as the first manifestation. F-FDG PET/CT spotted multiple ground glass opacity (GGO) lesions in the lungs, with increased tracer uptake in both lung GGOs and the whole colon. Serial CT examinations showed the emersion and dissipation of lung GGOs. We illustrate the symptoms initiation, the laboratory test results, the imaging examination,​ and the treatment strategy in the duration of COVID-19 with a timeline chart.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[261] Title: </​b>​Perioperative Presentation of COVID-19 Disease in a Liver Transplant Recipient.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​7.7<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-03-27<​br>​
 +<​b>​Publisher:​ </​b>​Hepatology<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​resolve/​doi?​DOI=10.1002/​hep.31257">​https://​onlinelibrary.wiley.com/​resolve/​doi?​DOI=10.1002/​hep.31257</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Coronavirus disease 2019 (COVID-19) is highly contagious. It may rapidly progress to acute respiratory distress syndrome (ARDS) and result in multiorgan dysfunction or death in some cases.((1,​2)) Here, we report the case of a patient with hepatocellular carcinoma (HCC) who underwent liver transplantation and experienced COVID-19 infection during the perioperative period. This case may help clinicians by alerting them to potential COVID-19 infection in transplant recipients during the outbreak.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[262] Title: </​b>​Interleukin-6 Blockade Treatment for COVID-19 associated Cytokine Release Syndrome in a Patient with Poorly Controlled Chronic Myeloid Leukaemia.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​7.65<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-01<​br>​
 +<​b>​Publisher:​ </​b>​British Journal of Haematology<​br>​
 +<​b>​Keywords:​ </​b>​Cardiovascular Medicine And Haematology,​ , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​bjh.16901">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​bjh.16901</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +In December 2019, a novel coronavirus pneumonia, coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was reported in Wuhan, China. A hyperinflammatory immune response, or cytokine release syndrome (CRS) is observed in critically unwell patients with SARS-CoV-2 globally. Severe lymphopenia,​ hyperactivated pro-inflammatory T cells(1) and decreased regulatory T cells(2) are seen in these critically ill patients, suggesting dysregulated immune responses.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[263] Title: </b>A report of clinical diagnosis and treatment of nine cases of coronavirus disease 2019.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​7.55<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-03-16<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Medical Virology<​br>​
 +<​b>​Keywords:​ </​b>​Medical Microbiology,​ covid-19, sars-cov-2, respiratory symptoms, Health Sciences, Life Sciences, Medicine, Immunology and Microbiology<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​jmv.25755">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​jmv.25755</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 has become an important public health issue in the world. More than 118 000 cases were confirmed around the world. The main clinical manifestations were respiratory symptoms and occasional gastrointestinal symptoms. However, there is no unified standard for the diagnosis and treatment of COVID-19. In the retrospective analysis, we report nine cases of COVID-19, describe the history of contact, clinical manifestations,​ the course of diagnosis and clinical treatment before, during and after treatment.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[264] Title: </​b>​Severe Acute Respiratory Syndrome Coronavirus 2 Infection and the Upper Limb Deep Vein Thrombosis Risk.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​7.51<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-07-01<​br>​
 +<​b>​Publisher:​ </​b>​Annals of Vascular Surgery (Science Direct)<​br>​
 +<​b>​Keywords:​ </b>, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0890509620303563">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0890509620303563</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Little or nothing is known about the correlation between the upper limb deep vein thrombosis (UL-DVT) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We describe the increased risk of UL-DVT in 3 patients with SARS-CoV-2 who require continuous positive airway pressure with a hood and the need for early adequate antithrombotic prophylaxis.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[265] Title: </​b>​Family cluster of three recovered cases of pneumonia due to severe acute respiratory syndrome coronavirus 2 infection.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​7.51<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-04<​br>​
 +<​b>​Publisher:​ </​b>​BMJ Case Reports<​br>​
 +<​b>​Keywords:​ </b>, infectious diseases, respiratory medicine<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​casereports.bmj.com/​lookup/​doi/​10.1136/​bcr-2020-235302">​https://​casereports.bmj.com/​lookup/​doi/​10.1136/​bcr-2020-235302</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The coronavirus disease (COVID-19) outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan, China, in late 2019 and has affected more than 1 270 000 people worldwide. The numbers of reported cases continue to rise and threaten global health. Transmissions among family members are frequently observed, although the route of transmission is partially known. Here we report three cases of SARS-CoV-2 infection within one family. Sequencing of the S gene of the viral genome showed 100% identity among samples, suggesting that the same strain caused the infection. Following treatment with oseltamivir and short-term methylprednisolone combined with symptomatic management, all three patients recovered within 3 weeks, as evidenced by the disappearance of their symptoms, clearance of pulmonary infiltrates and consecutive negative molecular diagnostic test findings. Our observations suggest the importance of preventing family transmission and the efficacy of current integrated treatment for mild/​moderate pneumonia in COVID-19 cases.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[266] Title: </​b>​Isolated sudden onset anosmia in COVID-19 infection. A novel syndrome?<​br><​br>​
 +<​b>​Altmetric Score: </​b>​7.5<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-02<​br>​
 +<​b>​Publisher:​ </​b>​Rhinology<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​doi.org/​10.4193/​rhin20.114">​https://​doi.org/​10.4193/​rhin20.114</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +BACKGROUND: The amelioration of the current COVID pandemic relies on swift and efficient case finding as well as stringent social distancing measures. Current advice suggests that fever or new onset dry cough are the commonest presenting complaints. METHODOLOGY:​ We present a case report and case series as well as other evidence that there is an important fourth presenting syndrome, namely isolated sudden onset anosmia (ISOA), which should be considered highly suspicious for SARS-CoV-2. RESULTS: A patient presenting with ISOA who went on to test positive for infection with COVID-19 and did not develop any further symptoms as well as a case series of similar patients although limited by the lack of reliable testing at the moment. CONCLUSIONS:​ We posit the existence of a fourth common syndrome of COVID-19 infection: isolated sudden onset anosmia (ISOA) and urge the international community to consider this presentation in current management advice.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[267] Title: </​b>​Collateral damage of COVID-19 pandemic: Delayed medical care.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​7.5<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-17<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Cardiac Surgery<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19, coronary artery disease, postinfarction ventricular septal defect, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​jocs.14638">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​jocs.14638</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +During the COVID-19 pandemic, emergency room visits have drastically decreased for non-COVID conditions such as appendicitis,​ heart attack, and stroke. Patients may be avoiding seeking medical attention for fear of catching the deadly condition or as an unintended consequence of stay-at-home orders. This delay in seeking care can lead to increased morbidity and mortality, which has not been figured in the assessment of the extent of damage caused by this pandemic. This case illustrates an example of "​collateral damage"​ caused by the COVID-19 pandemic. What would have been a standard ST-elevation myocardial infarction treated with timely and successful stenting of a dominant right coronary artery occlusion, became a much more dangerous postinfarction ventricular septal defect; all because of a 2-day delay in seeking medical attention by an unsuspecting patient.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[268] Title: </​b>​Low Barrier Tele-Buprenorphine in the Time of COVID-19: A Case Report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​7.5<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-20<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Addiction Medicine<​br>​
 +<​b>​Keywords:​ </​b>​Public Health And Health Services, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​journals.lww.com/​journaladdictionmedicine/​Abstract/​9000/​Low_Barrier_Tele_Buprenorphine_in_the_Time_of.99229.aspx">​https://​journals.lww.com/​journaladdictionmedicine/​Abstract/​9000/​Low_Barrier_Tele_Buprenorphine_in_the_Time_of.99229.aspx</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +BACKGROUND: To reduce the spread of coronavirus disease 2019 (COVID-19), many substance use disorder treatment programs have transitioned to telemedicine. Emergency regulatory changes allow buprenorphine initiation without an in-person visit. We describe the use of videoconferencing for buprenorphine initiation combined with street outreach to engage 2 patients experiencing homelessness with severe opioid use disorder (OUD). CASE PRESENTATION:​ Patient 1 was a 30-year-old man with severe OUD who had relapsed to injection heroin/​fentanyl after incarceration. A community drop-in center outreach harm reduction specialist facilitated a videoconference with an addiction specialist at an OUD bridge clinic. The patient completed a community buprenorphine/​naloxone initiation and self-titrated to his prior dose, 8/2 mg twice daily. One week later, he reconnected with the outreach team for a follow-up videoconference visit. Patient 2, a 36-year-old man with severe OUD, connected to the addiction specialist via a syringe service program harm reduction specialist. He had been trying to connect to a community buprenorphine/​naloxone provider, but access was limited due to COVID-19, so he was using diverted buprenorphine/​naloxone to reduce opioid use. He was restarted on his previous dose of 12/3 mg daily which was continued via phone follow-up 16 days later. CONCLUSIONS:​ COVID-19-related regulatory changes allow buprenorphine initiation via telemedicine. We describe 2 cases where telemedicine was combined with street outreach to connect patients experiencing homelessness with OUD to treatment. These cases highlight an important opportunity to provide access to life-saving OUD treatment for vulnerable patients in the setting of a pandemic that mandates reduced face-to-face clinical interactions.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[269] Title: </​b>​Case report: use of lenzilumab and tocilizumab for the treatment of coronavirus disease 2019.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​7.35<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-17<​br>​
 +<​b>​Publisher:​ </​b>​Immunotherapy<​br>​
 +<​b>​Keywords:​ </b>, covid-19, gm-csf, il-6, cytokine-release syndrome, inflammatory markers, lenzilumab, monoclonal antibody, pneumonia, severe acute respiratory distress syndrome, tocilizumab<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.futuremedicine.com/​doi/​10.2217/​imt-2020-0136">​https://​www.futuremedicine.com/​doi/​10.2217/​imt-2020-0136</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Background: Coronavirus disease 2019 (COVID-19) is a novel disease associated with a cytokine-mediated,​ severe, acute respiratory syndrome. Tocilizumab and lenzilumab are recombinant monoclonal antibodies against IL-6 and granulocyte macrophage colony-stimulating factor, respectively,​ and have been proposed as a potential treatment for acute, hypoxic respiratory failure associated with COVID-19. Results & methodology:​ We present the case of a 68-year-old man with COVID-19 who was initially treated with hydroxychloroquine and lenzilumab, but continued to develop hypoxemia, requiring an increase in respiratory support with an associated rise in serum inflammatory markers. He was subsequently treated with tocilizumab with marked clinical improvement and a decrease in acute phase reactants within 48 h. Discussion & conclusion: This case demonstrates the effective use of tocilizumab in the treatment of COVID-19 and suggests the superiority of tocilizumab over lenzilumab in the management of this cytokine-mediated syndrome.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[270] Title: </​b>​Dynamic change process of target genes by RT-PCR testing of SARS-Cov-2 during the course of a Coronavirus Disease 2019 patient.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​7.33<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-07-01<​br>​
 +<​b>​Publisher:​ </​b>​Clinica Chimica Acta<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19, coronavirus,​ nucleocapsid,​ rt-pcr testing, sars-cov-2, Biochemistry,​ Genetics and Molecular Biology, Health Sciences, Life Sciences, Medicine<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0009898120301340">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0009898120301340</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We report the dynamic change process of target genes by RT-PCR testing of SARS-Cov-2 during the course of a COVID-19 patient: from successive negative results to successive single positive nucleocapsid gene, to two positive target genes (orf1ab and nucleocapsid) by RT-PCR testing of SARS-Cov-2, and describe the diagnosis, clinical course, and management of the case. In this case, negative results of RT-PCR testing was not excluded to diagnose a suspected COVID-19 patient, clinical signs and symptoms, other laboratory findings, and chest CT images should be taken into account for the absence of enough positive evidence. This case highlights the importance of successive sampling and testing SARS-Cov-2 by RT-PCR as well as the increased value of single positive target gene from pending to positive in two specimens to diagnose laboratory-confirmed COVID-19.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[271] Title: </​b>​Erythema multiforme and Kawasaki disease associated with COVID-19 infection in children.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​7.33<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-26<​br>​
 +<​b>​Publisher:​ </​b>​Journal of the European Academy of Dermatology & Venereology<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19, kawasaki disease, coranovirus,​ erythema multiforme, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​jdv.16666">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​jdv.16666</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We read with interest the publications in the JEADV which reported dermatological manifestations associated with COVID-19, such as pityriasis rosea, urticaria, rash, vascular signs, or chilblain-like lesions. Herein, we report two life-threatening cases of children presenting with fever and eruptions with mucous membrane involvement - erythema multiforme and Kawasaki disease - associated with COVID-19.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[272] Title: </​b>​Concomitant brain arterial and venous thrombosis in a COVID-19 patient.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​7.33<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-05<​br>​
 +<​b>​Publisher:​ </​b>​European Journal of Neurology<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Health Sciences, Life Sciences, Medicine, Neuroscience<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​ene.14380">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​ene.14380</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +COVID-19 infection can cause a severe pneumonia which, in some cases, can lead to admission in intensive care unit for respiratory support.(1) In severe cases, systemic thrombotic complication has been described, including cerebrovascular disease (5.7-23% of cases).(2,​3).<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[273] Title: </​b>​Emergency cesarean section on severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) confirmed patient.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​7.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-03-31<​br>​
 +<​b>​Publisher:​ </​b>​Korean Journal of Anesthesiology<​br>​
 +<​b>​Keywords:​ </b>, covid-19, cesarean section, pandemics, pregnant women, severe acute respiratory syndrome coronavirus 2<br>
 +<​b>​DOI:​ </​b><​a href="​https://​ekja.org/​journal/​view.php?​doi=10.4097/​kja.20116">​https://​ekja.org/​journal/​view.php?​doi=10.4097/​kja.20116</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Background: Since the first case of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) occurred in Wuhan in December 2019, the virus has spread globally. The World Health Organization declared the virus outbreak a pandemic on March 11, 2020. On January 19, 2020, a 35-year-old woman who returned from China was confirmed as the first SARS-CoV-2 infected case in Korea. Since then, it has spread all over Korea. Case: We report the first case of a SARS-CoV-2 positive woman delivering a baby through cesarean section at 37+6 weeks of pregnancy in the Republic of Korea. Conclusions:​ This case suggested that negative pressure operating room, skillful medical team, and enhanced personal protective equipment including N95 masks, surgical cap, double gown, double gloves, shoe covers, and powered air-purifying respirator are required at the hospital for safe delivery in such a case.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[274] Title: </​b>​Clinicopathologic and Immunohistochemical Findings from Autopsy of Patient with COVID-19, Japan.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​7.2<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-09-01<​br>​
 +<​b>​Publisher:​ </​b>​Emerging Infectious Diseases<​br>​
 +<​b>​Keywords:​ </​b>​Medical Microbiology,​ covid-19, japan, sars-cov-2, autopsy, coronavirus disease, cruise, diffuse alveolar damage, electron microscopy, immunohistochemistry,​ next-generation sequencing, respiratory infections, severe acute respiratory syndrome coronavirus 2, viruses, zoonoses, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​wwwnc.cdc.gov/​eid/​404.html?​aspxerrorpath=/​eid/​article/​26/​9/​20-1353_article">​https://​wwwnc.cdc.gov/​eid/​404.html?​aspxerrorpath=/​eid/​article/​26/​9/​20-1353_article</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +An autopsy of a patient in Japan with coronavirus disease indicated pneumonia lung pathology, manifested as diffuse alveolar damage. We detected severe acute respiratory syndrome coronavirus 2 antigen in alveolar epithelial cells and macrophages. Coronavirus disease is essentially a lower respiratory tract disease characterized by direct viral injury of alveolar epithelial cells.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[275] Title: </​b>​Ethical and Logistical Considerations of Caring for Older Adults on Inpatient Psychiatry During the COVID-19 Pandemic.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​7.05<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-01<​br>​
 +<​b>​Publisher:​ </​b>​American Journal of Geriatric Psychiatry: Official Journal of the American Association for Geriatric Psychiatry<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19, ethics, geropsychiatry,​ infection, inpatient, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S1064748120303286">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S1064748120303286</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The coronavirus disease 2019 (COVID-19) pandemic has brought challenges to delivery of care for older adults on inpatient psychiatry. We describe two cases: patient A, a 62-year-old woman who initially refused screening for potential COVID-19, bringing up questions about threshold for capacity when public health is at risk and questions about whether screening for infection should be different in older adults. The other case, patient B, is that of an 83-year-old man who was on the unit when patient A tested positive, and brought up concerns for risk of dissemination in the context of wandering, spitting behaviors, and inability to adhere to room isolation or masking measures. We review measures taken to decrease risk of transmission and improve screening for infection in older adults.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[276] Title: </​b>​Evidence from two cases of asymptomatic infection with SARS-CoV-2: Are 14 days of isolation sufficient?<​br><​br>​
 +<​b>​Altmetric Score: </​b>​7<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-01<​br>​
 +<​b>​Publisher:​ </​b>​International Journal of Infectious Diseases<​br>​
 +<​b>​Keywords:​ </​b>​Microbiology,​ , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S1201971220301739">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S1201971220301739</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Among 78 laboratory-confirmed cases, we found two asymptomatic infections. One patient was discharged within 14 days after treatment. Another patient was discharged 25 days after treatment, and his RT-PCR test was still positive on the 15th day. We found that there may be virus carriers in the asymptomatic population with an epidemiological contact history. After 14 days of isolation, those with asymptomatic infection may still carry the virus, which means a risk of transmission,​ presenting a new challenge for the management of home isolation.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[277] Title: </​b>​Neurological Complications of Coronavirus Disease (COVID-19): Encephalopathy.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​7<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-03-21<​br>​
 +<​b>​Publisher:​ </​b>​Cureus<​br>​
 +<​b>​Keywords:​ </b>, covid-19, encephalopathy<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.cureus.com/​articles/​29414-neurological-complications-of-coronavirus-disease-covid-19-encephalopathy">​https://​www.cureus.com/​articles/​29414-neurological-complications-of-coronavirus-disease-covid-19-encephalopathy</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Coronavirus disease 2019 (COVID-19) is a pandemic. Neurological complications of COVID-19 have not been reported. Encephalopathy has not been described as a presenting symptom or complication of COVID-19. We report a case of a 74-year-old patient who traveled from Europe to the United States and presented with encephalopathy and COVID-19.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[278] Title: </​b>​Pseudo acute myocardial infarction in a young COVID-19 patient.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​7<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-01<​br>​
 +<​b>​Publisher:​ </​b>​JACC:​ Case Reports<​br>​
 +<​b>​Keywords:​ </b>, acute respiratory distress syndrome, ards, cardiac troponin i, ctni, computed tomography, ct, coronary ct angiogram, ccta, coronary artery disease, cad, coronavirus disease 2019, covid-19, electrocardiogram,​ ekg, nucleic-acid amplification test, naat, severe acute respiratory syndrome, sars, transthoracic echocardiogram,​ tte<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2666084920303764">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2666084920303764</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +A 29 year old man tested positive for COVID-19 and developed acute respiratory distress syndrome (ARDS). While mechanically ventilated, his electrocardiogram (EKG) showed inferior ST segment elevations, with normal serial cardiac troponin I and transthoracic echocardiograms. He was treated conservatively,​ with complete clinical recovery and resolution of his EKG abnormalities.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[279] Title: </​b>​COVID-19:​ A case report from Bangladesh perspective.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​7<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-01-01<​br>​
 +<​b>​Publisher:​ </​b>​Respiratory Medicine Case Reports<​br>​
 +<​b>​Keywords:​ </b>, <br>
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2213007120301738">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2213007120301738</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +A 34-year-old man without any significant medical history or comorbidities,​ suddenly developed fever, and shortness of breath, thereby admitted to the emergency department of a tertiary care hospital, Dhaka, Bangladesh. He had neither a history of traveling to Coronavirus disease (COVID) prone areas nor a direct contact of COVID positive patients. His chest X-ray revealed ground-glass opacity in the right middle and lower zone of the lung. The first polymerase chain reaction (PCR) test on throat and nasal swabs for the COVID upon admission was negative. Based on the chest X-ray result, RT-PCR was done again resulted positive. The patient was primarily treated with chloroquine and azithromycin. On full recovery, he was discharged from the hospital on day 12, after two subsequent throat swab samples tested negative by PCR (24 hours apart). He was encouraged to maintain home quarantine for at least the next 14 days. SARS-CoV-2 RNA by swab remained negative and the blood sample shows the presence of antibody (both IgM and IgG) in his follow-up visit (after 7 days of hospital discharge).<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[280] Title: </​b>​Clinically significant anticardiolipin antibodies associated with COVID-19.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​7<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-10-01<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Critical Care<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, anticardiolipin,​ antiphospholipid syndrome, coagulopathy,​ coronarvirus,​ covid-19, critical care, icu, infarct, peripheral arterial disease, sars-cov-2, stroke, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S088394412030575X">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S088394412030575X</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The novel coronavirus strain known as SARS-CoV-2 has rapidly spread around the world creating distinct challenges to the healthcare workforce. Coagulopathy contributing to significant morbidity in critically ill patients with SARS-CoV-2 has now been well documented. We discuss two cases selected from patients requiring critical care in April 2020 in New York City with a unique clinical course. Both cases reveal significant thrombotic events noted on imaging during their hospital course. Obtaining serial inflammatory markers in conjunction with anti-phospholipid antibody testing revealed clinically significant Antiphospholipid syndrome (APS). This case series reviews the details preceding APS observed in SARS-CoV-2 and aims to report findings that could potentially further our understanding of the disease.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[281] Title: </​b>​Early transmission patterns of coronavirus disease 2019 (COVID-19) in travellers from Wuhan to Thailand, January 2020.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​6.95<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-02-27<​br>​
 +<​b>​Publisher:​ </​b>​Eurosurveillance<​br>​
 +<​b>​Keywords:​ </b>, covid-19, sars-cov-2, wuhan, coronavirus,​ transmission,​ traveller, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.eurosurveillance.org/​content/​10.2807/​1560-7917.ES.2020.25.8.2000097">​https://​www.eurosurveillance.org/​content/​10.2807/​1560-7917.ES.2020.25.8.2000097</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We report two cases of coronavirus disease 2019 (COVID-19) in travellers from Wuhan, China to Thailand. Both were independent introductions on separate flights, discovered with thermoscanners and confirmed with RT-PCR and genome sequencing. Both cases do not seem directly linked to the Huanan Seafood Market in Hubei but the viral genomes are identical to four other sequences from Wuhan, suggesting early spread within the city already in the first week of January.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[282] Title: </​b>​Mild COVID-19 infection despite chronic B cell depletion in a patient with aquaporin-4-positive neuromyelitis optica spectrum disorder.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​6.9<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-09-01<​br>​
 +<​b>​Publisher:​ </​b>​Multiple Sclerosis and Related Disorders<​br>​
 +<​b>​Keywords:​ </b>, covid-19, multiple sclerosis, neuromyelitis optica spectrum disorder (nmosd), sars-cov-2, coronaviruses,​ pandemic<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2211034820302753">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2211034820302753</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Coronavirus disease 2019 (COVID-19) is caused by the novel coronavirus SARS-CoV-2, which affects the lung and other organs. After an incubation period of 3-14 days, the infection presents with symptoms of variable severity, from mild flu-like disease to severe pneumonia and cytokine storm with increased mortality. Immunosuppressed patients may have higher risk of adverse outcomes; hence, there is an urgent need to evaluate the immune response and clinical outcomes of SARS-CoV-2 infection in these patients. Here, we report a 59-year-old woman with aquaporin-4-positive (AQPR4+) neuromyelitis Optica treated with rituximab who developed mild respiratory symptoms with COVID-19, despite B cell depletion at the time of infection.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[283] Title: </​b>​COVID-19 pneumonia with hemoptysis: Acute segmental pulmonary emboli associated with novel coronavirus infection.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​6.8<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-01<​br>​
 +<​b>​Publisher:​ </​b>​American Journal of Emergency Medicine<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19, coronavirus,​ pulmonary embolism, sars-cov-2, venous thromboembolism,​ Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0735675720302394">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0735675720302394</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Recent retrospective studies from Wuhan, China suggest Novel Coronavirus Disease 2019 (COVID-19) may be associated with a hypercoagulable state and increased risk for venous thromboembolism. The overlap in the signs and symptoms of COVID-19 associated Acute Respiratory Distress Syndrome (ARDS) and COVID-19 with concurrent pulmonary embolism creates a diagnostic challenge for emergency medicine physicians in patients already at risk for renal impairment. However, identifying features atypical for COVID-19 alone may play a role in the judicious use of Computed Tomography Angiography among these patients. Hemoptysis is seen in roughly 13% of pulmonary embolism cases and infrequently reported among COVID-19 infections. Additionally,​ the presence of right heart strain on electrocardiography (EKG) is a well described clinical presentations of pulmonary embolism not reported commonly with COVID-19 infections.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[284] Title: </​b>​Coronavirus Disease 19 (COVID-19) complicated with pneumonia in a patient with rheumatoid arthritis receiving conventional disease-modifying antirheumatic drugs.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​6.75<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-20<​br>​
 +<​b>​Publisher:​ </​b>​Rheumatology International<​br>​
 +<​b>​Keywords:​ </​b>​Medicine & Public Health, covid-19, coronavirus,​ disease-modifying antirheumatic drugs, pneumonia, rheumatoid arthritis, Health Sciences, Life Sciences, Medicine, Immunology and Microbiology<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​link.springer.com/​article/​10.1007/​s00296-020-04584-7">​https://​link.springer.com/​article/​10.1007/​s00296-020-04584-7</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +In December 2019, numerous coronavirus disease 2019 (COVID-19) cases were reported in Wuhan, China, which has since spread throughout the world. However, its impact on rheumatoid arthritis (RA) patients is unknown. Herein, we report a case of COVID-19 pneumonia in a 61-year-old female RA patient who was receiving conventional disease-modifying antirheumatic drugs (cDMARDs). The patient presented with a 4-day history of myalgia and febrile sensation. COVID-19 was confirmed by real-time polymerase chain reaction (PCR). Chest X-ray showed increased opacity on the right lower lung area, and C-reactive protein level was slightly elevated. The patient was treated with antiviral agents (lopinavir/​ritonavir),​ and treatment with cDMARDs was discontinued except hydroxychloroquine. Her symptoms and laboratory results gradually improved. Three weeks later, real-time PCR for COVID-19 showed negative conversion, and the patient was discharged without any complications.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[285] Title: </​b>​Robotic-assisted percutaneous coronary intervention in a COVID-19 patient.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​6.75<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-20<​br>​
 +<​b>​Publisher:​ </​b>​Catheterization and Cardiovascular Interventions (Formerly Catheterization and Cardiovascular Diagnosis)<​br>​
 +<​b>​Keywords:​ </​b>​Cardiovascular Medicine And Haematology,​ covid-19, coronary intervention,​ interventional devices/​innovation,​ robot assisted, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​ccd.28982">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​ccd.28982</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Coronavirus disease-2019 (COVID-19) pandemic is the biggest global health threat in the 21st century. We describe a case of a patient with suspected COVID-19 who needed urgent coronary artery interrogation,​ in which we utilized robotic assistance to minimize the risk of exposure to COVID-19 and reduced personal protective equipment needed by the procedural team.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[286] Title: </​b>​Novel coronavirus in a 15-day-old neonate with clinical signs of sepsis, a case report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​6.5<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-01<​br>​
 +<​b>​Publisher:​ </​b>​Infectious Diseases<​br>​
 +<​b>​Keywords:​ </b>, covid-19, neonates, novel coronavirus,​ sepsis<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.tandfonline.com/​doi/​full/​10.1080/​23744235.2020.1747634">​https://​www.tandfonline.com/​doi/​full/​10.1080/​23744235.2020.1747634</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Introduction:​ Novel coronavirus or coronavirus disease (COVID-19) can affect all age groups. The clinical course of the disease in children and infants is milder than in adults. It should be noted that, although typical symptoms may be present in children, non-specific symptoms could be noted in the neonate. The disease is rare in the neonate, so, its suspicion in this group can help to make a quick diagnose.Case report: A 15-day-old neonate was admitted with fever, lethargy, cutaneous mottling, and respiratory distress without cough. His mother had symptoms of Novel coronavirus. So Reverse-Transcription Polymerase Chain Reaction (RT-PCR) assay was done for the neonate and showed to be positive. The newborn was isolated and subjected to supportive care. Antibiotic and antiviral treatment was initiated. Eventually, the baby was discharged in good general condition.Conclusion:​ When a newborn presents with non-specific symptoms of infection with an added history of COVID-19 in his/her parents, it indicates the need for PCR testing for Novel coronavirus.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[287] Title: </​b>​Guillain-Barre syndrome in a patient with antibodies against SARS-COV-2.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​6.5<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-12<​br>​
 +<​b>​Publisher:​ </​b>​European Journal of Neurology<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Health Sciences, Life Sciences, Medicine, Neuroscience<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​ene.14388">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​ene.14388</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +There are now several reports on neurologic features of SARS-CoV-2 infection.(1 2) In a recent study of 214 patients with COVID-19, 78 (36.4%) patients had neurological manifestations,​ including headache, dizziness, acute cerebrovascular diseases, and impaired consciousness.(2).<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[288] Title: </​b>​Hemorrhagic Posterior Reversible Encephalopathy Syndrome as a Manifestation of COVID-19 Infection.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​6.3<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-21<​br>​
 +<​b>​Publisher:​ </​b>​American Journal of Neuroradiology<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​http://​www.ajnr.org/​content/​early/​2020/​05/​21/​ajnr.A6595">​http://​www.ajnr.org/​content/​early/​2020/​05/​21/​ajnr.A6595</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We describe 2 hospitalized patients with confirmed coronavirus 19 (COVID-19) infection in whom brain imaging showed hemorrhagic posterior reversible encephalopathy syndrome, and we discuss the possible reasons for these findings and their relationship to the infection.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[289] Title: </​b>​Persisting SARS-CoV-2 viremia after rituximab therapy: Two cases with fatal outcome and a review of literature.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​6.3<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-22<​br>​
 +<​b>​Publisher:​ </​b>​British Journal of Haematology<​br>​
 +<​b>​Keywords:​ </​b>​Cardiovascular Medicine And Haematology,​ covid-19, pneumonia, rituximab, sars-cov-2, viremia, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​bjh.16896">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​bjh.16896</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +BACKGROUND: COVID-19 is an emerging infectious disease caused by SARS-CoV-2. The role of immunosuppression in disease course is not clear. Here we describe the lethal disease course in two SARS-CoV-2 infected patients after rituximab therapy. METHODS: Clinical data and laboratory findings of two SARS-CoV-2 infected rituximab treated patients were collected. SARS-CoV-2 RNA was detected in blood. RESULTS: Both patients developed severe respiratory failure. SARS-CoV-2 viremia persisted in both patients until they died on day 22 and 26 after admission. CONCLUSION: Rituximab therapy leads to severe combined immunodeficiency and these two cases indicate a high risk for fatal outcome after SARS-CoV-2 infection.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[290] Title: </​b>​Digital Ischemia in COVID-19 Patients: Case Report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​6.2<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-01<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Hand Surgery - American Edition<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19, critical care, digital ischemia, hand, hypercoagulability,​ Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0363502320302288">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0363502320302288</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +As coronavirus 2019 (COVID-19) continues to cause an immense burden on the global health care systems, it is crucial to understand the breadth of this disease process. Recent reports identified hypercoagulability in a subset of critically ill patients and extremity ischemia in an even smaller cohort. Because abnormal coagulation parameters and extremity ischemia have been shown to correlate with poor disease prognosis, understanding how to treat these patients is crucial. To better describe the identification and management of this phenomenon, we present 2 cases of critically ill patients with COVID-19 who developed fingertip ischemia while in the intensive care unit.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[291] Title: </​b>​Positive RT-PCR in urine from an asymptomatic patient with novel coronavirus 2019 infection: a case report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​6.2<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-18<​br>​
 +<​b>​Publisher:​ </​b>​Infectious Diseases<​br>​
 +<​b>​Keywords:​ </b>, novel coronavirus disease 2019, asymptomatic patient, urine<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.tandfonline.com/​doi/​full/​10.1080/​23744235.2020.1766105">​https://​www.tandfonline.com/​doi/​full/​10.1080/​23744235.2020.1766105</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Introduction:​ With the emergence of novel coronavirus disease 2019 (COVID-19) in many countries, medical resources currently focus on the treatment of confirmed patients and screening of suspected cases. Asymptomatic patients may be contagious, which makes epidemic control difficult. We describe an asymptomatic patient with a positive real-time polymerase chain reaction (RT-PCR) test in urine.Case report: An asymptomatic girl was identified during the epidemiological investigation of a confirmed COVID-19 patient. When admitted to the hospital on 24 February 2020, she had no clinical manifestations. A throat swab was negative for RT-PCR, but urine was positive. She was given antiviral and symptomatic supportive treatment. On 26 February, a throat swab RT-PCR was positive. RT-PCR in throat swabs and urine were negative on 3 and 5 March, and on 9 and 12 March, throat swabs were still negative. At follow-up on 26 March, she felt well, throat swab RT-PCR was negative, and isolation was lifted.Conclusion:​ The urine of asymptomatic patients may be contagious. RT-PCR in urine might be a useful supplement in screening when the RT-PCR is negative in throat swabs.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[292] Title: </​b>​COVID-19 complicated by acute myocardial infarction with extensive thrombus burden and cardiogenic shock.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​6<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-19<​br>​
 +<​b>​Publisher:​ </​b>​Catheterization and Cardiovascular Interventions (Formerly Catheterization and Cardiovascular Diagnosis)<​br>​
 +<​b>​Keywords:​ </​b>​Cardiovascular Medicine And Haematology,​ covid-19, cardiogenic shock, myocardial infarction, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​ccd.28992">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​ccd.28992</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +A patient with coronavirus disease 19 (COVID-19) developed acute myocardial infarction (AMI) complicated by extensive coronary thrombosis and cardiogenic shock. She underwent percutaneous coronary intervention and placement of a mechanical circulatory support device but subsequently died from shock. This report illustrates the challenges in managing patients with COVID-19, AMI, and cardiogenic shock.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +
 +</​html>​
oa_db/covid19_case_reports_abstracts_pg5.txt · Last modified: 2020/06/28 05:18 by bpwhite