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 +===== COVID-19 Case Reports Abstracts - Page 3 =====
  
 +[[oa_db:​covid19_case_reports_abstracts|Back to Table of Contents]]
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 +<​b>​[110] Title: </​b>​Benign COVID-19 in an immunocompromised cancer patient - the case of a married couple.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​37.1<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-11<​br>​
 +<​b>​Publisher:​ </​b>​Swiss Medical Weekly<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​smw.ch/​article/​doi/​smw.2020.20246">​https://​smw.ch/​article/​doi/​smw.2020.20246</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Respiratory failure in COVID-19 is a common feature in fatal cases and has been considered as a failure of the immune system to control the virus. Here we report the case of COVID-19 affecting an immunocompromised women and her presumably immunocompetent spouse. A married couple (age 60 years) was simultaneously admitted to the emergency department on 10 March 2020 because of dyspnoea and fever, consistent with COVID-19. The wife (patient 1) was partially immunocompromised as a consequence of a recently started chemotherapy with fulvestrant and abemaciclid for recurring breast cancer, her husband (patient 2) had been healthy except for a history of controlled arterial hypertension. Both patients were treated with darunavir/​cobicistat and hydroxychloroquine. The clinical course of the immunocompromised partner was benign, without need of intensive care. She was able to leave the hospital on day 6 after admission. In contrast, her husband needed intensive care and his recovery was slow, although eventually successful too. These findings suggest that the course of COVID-19 is not necessarily ominous in the presence of a compromised immune response and tend to reinforce the emerging therapeutic concepts of a controlled mitigation of the immune cascade following SARS CoV-2 infection.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[111] Title: </​b>​Perinatal Transmission of COVID-19 Associated SARS-CoV-2: Should We Worry?<​br><​br>​
 +<​b>​Altmetric Score: </​b>​36.55<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-03-17<​br>​
 +<​b>​Publisher:​ </​b>​Clinical Infectious Diseases<​br>​
 +<​b>​Keywords:​ </​b>​Biological Sciences, covid-19, sars-cov-2, pregnancy outcome, vertical transmission,​ Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​http://​doi.org/​10.1093/​cid/​ciaa226">​http://​doi.org/​10.1093/​cid/​ciaa226</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We presented two cases of COVID-19 associated SARS-CoV-2 infection during third trimester of pregnancy. Both mothers and newborns had excellent outcomes. We failed to identify SARS-CoV-2 in all the products of conception and the newborns. This report provided evidence of low risk of intrauterine infection by vertical transmission of SARS-CoV-2.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[112] Title: </​b>​COVID-19 in Hemodialysis Patients: A Report of 5 Cases.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​35.7<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-07-01<​br>​
 +<​b>​Publisher:​ </​b>​American Journal of Kidney Diseases<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19, hemodialysis,​ sars-cov-2, case report, chest radiograph, coronavirus,​ diarrhea, end-stage renal disease (esrd), symptoms, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0272638620306120">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0272638620306120</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +In December 2019, an outbreak of coronavirus disease 2019 (COVID-19) due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in China and spread rapidly worldwide. It is unknown whether hemodialysis patients represent a distinct group of patients with certain characteristics that may make them susceptible to infection or severe disease. In this case report, we describe the clinical and epidemiologic features of COVID-19 infection in 201 maintenance hemodialysis patients in Zhongnan Hospital of Wuhan University, including 5 maintenance hemodialysis patients who contracted COVID-19 infection. Of the 5 patients with COVID-19 infection, one had a definite history of contact with an infected person. The age range of the patients was 47 to 67 years. Diarrhea (80%), fever (60%), and fatigue (60%) were the most common symptoms. Lymphopenia occurred in all patients. Computed tomography of the chest showed ground glass opacity in the lungs of all patients. Up to February 13, 2020, none of the patients had developed severe complications (acute respiratory distress syndrome, shock, or multiple organ dysfunction) or died.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[113] Title: </​b>​COVID-19 presenting as stroke.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​35.4<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-07-01<​br>​
 +<​b>​Publisher:​ </​b>​Brain,​ Behavior & Immunity<​br>​
 +<​b>​Keywords:​ </​b>​Immunology,​ covid-19, sars-cov2, stroke, Life Sciences, Immunology and Microbiology,​ Neuroscience<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0889159120306851">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0889159120306851</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +OBJECTIVE: Acute stroke remains a medical emergency even during the COVID-19 pandemic. Most patients with COVID-19 present with constitutional and respiratory symptoms, some patients present with atypical symptoms including gastrointestinal,​ cardiovascular,​ or neurological symptoms. Here we present a series of four COVID-19 patients with acute stroke as a presenting symptom. METHODS: We searched the hospital databases for patients presenting with acute strokes and suspected COVID-19 features. All patients that had imaging confirmed strokes and PCR confirmed COVID-19 were included in the study. Patients admitted to the hospital with PCR confirmed COVID-19 disease whose hospital course was complicated with acute stroke while inpatient were excluded from the study. Retrospective patient data were obtained from electronic medical records. Informed consent was obtained. RESULTS: We identified four patients presenting with imaging confirmed acute strokes and PCR confirmed SARS-CoV-2 infection. We elucidate the clinical characteristics,​ imaging findings, and the clinical course. CONCLUSIONS:​ Timely assessment and hyperacute treatment is the key to minimize mortality and morbidity of patients with acute stroke. Stroke teams should be wary of the fact that COVID-19 patients can present with cerebrovascular accidents and dawn appropriate personal protective equipment in every suspected patient. Further studies are urgently needed for a comprehensive understanding of the neurological pathology of COVID-19 and its effects on the nervous system.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[114] Title: </​b>​First case of COVID-19 complicated with fulminant myocarditis:​ a case report and insights.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​35.28<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-10<​br>​
 +<​b>​Publisher:​ </​b>​Infection<​br>​
 +<​b>​Keywords:​ </​b>​General Practice / Family Medicine, covid-19, coronavirus,​ echocardiography,​ fulminant myocarditis,​ infection, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​link.springer.com/​article/​10.1007/​s15010-020-01424-5">​https://​link.springer.com/​article/​10.1007/​s15010-020-01424-5</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +BACKGROUND: Coronavirus disease 2019 (COVID-19) has been demonstrated to be the cause of pneumonia. Nevertheless,​ it has not been reported as the cause of acute myocarditis or fulminant myocarditis. CASE PRESENTATION:​ A 63-year-old male was admitted with pneumonia and cardiac symptoms. He was genetically confirmed as having COVID-19 according to sputum testing on the day of admission. He also had elevated troponin I (Trop I) level (up to 11.37 g/L) and diffuse myocardial dyskinesia along with a decreased left ventricular ejection fraction (LVEF) on echocardiography. The highest level of interleukin-6 was 272.40 pg/ml. Bedside chest radiographs showed typical ground-glass changes indicative of viral pneumonia. Laboratory test results for viruses that cause myocarditis were all negative. The patient conformed to the diagnostic criteria of the Chinese expert consensus statement for fulminant myocarditis. After receiving antiviral therapy and mechanical life support, Trop I was reduced to 0.10 g/L, and interleukin-6 was reduced to 7.63 pg/mL. Moreover, the LVEF of the patient gradually recovered to 68%. The patient died of aggravation of secondary infection on the 33rd day of hospitalization. CONCLUSION: COVID-19 patients may develop severe cardiac complications such as myocarditis and heart failure. This is the first report of COVID-19 complicated with fulminant myocarditis. The mechanism of cardiac pathology caused by COVID-19 needs further study.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[115] Title: </​b>​(18)F-FDG PET/CT findings of COVID-19: a series of four highly suspected cases.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​35.15<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-02-22<​br>​
 +<​b>​Publisher:​ </​b>​European Journal of Nuclear Medicine & Molecular Imaging<​br>​
 +<​b>​Keywords:​ </​b>​Cardiology,​ 18f-fdg pet/ct, acute respiratory disease, covid-19, consolidative opacities, ground-glass opacities, infection, sars-cov-2, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​link.springer.com/​article/​10.1007/​s00259-020-04734-w">​https://​link.springer.com/​article/​10.1007/​s00259-020-04734-w</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +PURPOSE: The aim of this case series is to illustrate the (18)F-FDG PET/CT findings of patients with acute respiratory disease caused by COVID-19 in Wuhan, Hubei province of China. METHODS: We describe the (18)F-FDG PET/CT results from four patients who were admitted to the hospital with respiratory symptoms and fever between January 13 and January 20, 2020, when the COVID-19 outbreak was still unrecognized and the virus infectivity was unknown. A retrospective review of the patients'​ medical history, clinical and laboratory data, as well as imaging findings strongly suggested a diagnosis of COVID-19. RESULTS: All patients had peripheral ground-glass opacities and/or lung consolidations in more than two pulmonary lobes. Lung lesions were characterized by a high (18)F-FDG uptake and there was evidence of lymph node involvement. Conversely, disseminated disease was absent, a finding suggesting that COVID-19 has pulmonary tropism. CONCLUSIONS:​ Although (18)F-FDG PET/CT cannot be routinely used in an emergency setting and is generally not recommended for infectious diseases, our pilot data shed light on the potential clinical utility of this imaging technique in the differential diagnosis of complex cases.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[116] Title: </​b>​Use of Tocilizumab for COVID-19-Induced Cytokine Release Syndrome: A Cautionary Case Report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​33.58<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-01<​br>​
 +<​b>​Publisher:​ </​b>​CHEST<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19, critical care, cytokines, viral disease, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0012369220307649">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0012369220307649</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Novel coronavirus disease 2019 (COVID-19) emerged in late December 2019 in Wuhan, China. Since then, COVID-19 has become a pandemic affecting more than 1.5 million people worldwide. Patients with COVID-19 have a wide spectrum of manifestations,​ one being cytokine release syndrome (CRS) and its fatal correlate, secondary hemophagocytic lymphohistiocytosis (sHLH). Anti-cytokine therapy such as tocilizumab,​ an IL-6 receptor antagonist, is a potential treatment for COVID-19; however, data regarding the efficacy of this anti-IL-6 therapy are currently lacking. We report two cases of patients who received a diagnosis of COVID-19 complicated by CRS and were treated with tocilizumab. Both patients progressed to sHLH despite treatment with tocilizumab,​ and one developed viral myocarditis,​ challenging the safety and clinical usefulness of tocilizumab in the treatment of COVID-19-induced CRS. These cases highlight the need for clinical trials to determine optimal patient selection and timing for the use of tocilizumab during this disease process.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[117] Title: </​b>​Just the Facts: Recommendations on point-of-care ultrasound use and machine infection control during the coronavirus disease 2019 pandemic.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​32.6<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-09<​br>​
 +<​b>​Publisher:​ </​b>​CJEM:​ Canadian Journal of Emergency Medicine<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19, pocus, emergency medicine, pandemic, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.cambridge.org/​core/​journals/​canadian-journal-of-emergency-medicine/​article/​just-the-facts-recommendations-on-pointofcare-ultrasound-use-and-machine-infection-control-during-the-coronavirus-disease-2019-pandemic/​C0015DBD16D90009D8C12CF1CEB80480">​https://​www.cambridge.org/​core/​journals/​canadian-journal-of-emergency-medicine/​article/​just-the-facts-recommendations-on-pointofcare-ultrasound-use-and-machine-infection-control-during-the-coronavirus-disease-2019-pandemic/​C0015DBD16D90009D8C12CF1CEB80480</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The World Health Organization declared the novel coronavirus disease 2019 (COVID-19) to be a pandemic on March 11, 2020, and, currently, there are over 10,000 confirmed cases in Canada, with this number expected to grow exponentially. There has been widespread interest in the use of point-of-care ultrasound (POCUS) in the management of patients with suspected COVID-19. The CAEP Emergency Ultrasound Committee has developed recommendations on the use of POCUS in these patients, with an emphasis on machine infection control measures.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[118] Title: </​b>​COVID-19 Respiratory Failure: Targeting Inflammation on VV-ECMO Support.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​31.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-16<​br>​
 +<​b>​Publisher:​ </​b>​ASAIO Journal: A Peer-Reviewed Journal of the American Society for Artificial Internal Organs<​br>​
 +<​b>​Keywords:​ </​b>​Biomedical Engineering,​ , Materials Science, Biochemistry,​ Genetics and Molecular Biology, Medicine, Engineering,​ Chemical Engineering,​ Health Sciences, Physical Sciences, Life Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​journals.lww.com/​asaiojournal/​FullText/​2020/​06000/​COVID_19_Respiratory_Failure__Targeting.4.aspx">​https://​journals.lww.com/​asaiojournal/​FullText/​2020/​06000/​COVID_19_Respiratory_Failure__Targeting.4.aspx</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The outbreak of novel coronavirus (SARS-CoV-2) that causes the respiratory illness COVID-19 has led to unprecedented efforts at containment due to its rapid community spread, associated mortality, and lack of immunization and treatment. We herein detail a case of a young patient who suffered life-threatening disease and multiorgan failure. His clinical course involved rapid and profound respiratory decompensation such that he required support with venovenous extracorporeal membrane oxygenation (VV-ECMO). He also demonstrated hyperinflammation (C-reactive protein peak 444.6 mg/L) with severe cytokine elevation (Interleukin-6 peak > 3000 pg/ml). Through treatment targeting hyperinflammation,​ he recovered from critical COVID-19 respiratory failure and required only 160 hours of VV-ECMO support. He was extubated 4 days after decannulation,​ had progressive renal recovery, and was discharged to home on hospital day 24. Of note, repeat SARS-CoV-2 test was negative 21 days after his first positive test. We present one of the first successful cases of VV-ECMO support to recovery of COVID-19 respiratory failure in North America.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[119] Title: </​b>​Panton-Valentine Leukocidin-Secreting Staphylococcus aureus Pneumonia Complicating COVID-19.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​30.75<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-08-01<​br>​
 +<​b>​Publisher:​ </​b>​Emerging Infectious Diseases<​br>​
 +<​b>​Keywords:​ </​b>​Medical Microbiology,​ covid-19, panton-valentine leukocidin, sars-cov-2, staphylococcus aureus, bacteria, coronavirus disease, necrotizing pneumonia, severe acute respiratory syndrome coronavirus 2, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​wwwnc.cdc.gov/​eid/​404.html?​aspxerrorpath=/​eid/​article/​26/​8/​20-1413_article">​https://​wwwnc.cdc.gov/​eid/​404.html?​aspxerrorpath=/​eid/​article/​26/​8/​20-1413_article</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Necrotizing pneumonia induced by Panton-Valentine leukocidin-secreting Staphylococcus aureus is a rare but life-threatening infection that has been described in patients after they had influenza. We report a fatal case of this superinfection in a young adult who had coronavirus disease.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[120] Title: </​b>​COVID-19-related acute necrotizing encephalopathy with brain stem involvement in a patient with aplastic anemia.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​30.65<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-26<​br>​
 +<​b>​Publisher:​ </​b>​Neurology:​ Neuroimmunology and Neuroinflammation<​br>​
 +<​b>​Keywords:​ </b>, <br>
 +<​b>​DOI:​ </​b><​a href="​https://​nn.neurology.org/​content/​7/​5/​e789">​https://​nn.neurology.org/​content/​7/​5/​e789</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +OBJECTIVE: To describe a novel case of coronavirus disease 2019 (COVID-19)-associated acute necrotizing encephalopathy (ANE) in a patient with aplastic anemia where there was early brain stem-predominant involvement. METHODS: Evaluation of cause, clinical symptoms, and treatment response. RESULTS: A 59-year-old woman with a background of transfusion-dependent aplastic anemia presented with seizures and reduced level of consciousness 10 days after the onset of subjective fever, cough, and headache. Nasopharyngeal swab testing for severe acute respiratory syndrome coronavirus (SARS-CoV-2) was positive, and CT during admission demonstrated diffuse swelling of the brain stem. She required intubation and mechanical ventilation for airway protection, given her reduced level of consciousness. The patient'​s condition deteriorated,​ and MRI on day 6 demonstrated worsening brain stem swelling with symmetrical hemorrhagic lesions in the brain stem, amygdalae, putamina, and thalamic nuclei. Appearances were consistent with hemorrhagic ANE with early brain stem involvement. The patient showed no response to steroid therapy and died on the eighth day of admission. CONCLUSIONS:​ COVID-19 may be associated with an acute severe encephalopathy and, in this case, was considered most likely to represent an immune-mediated phenomenon. As the pandemic continues, we anticipate that the spectrum of neurologic presentation will broaden. It will be important to delineate the full clinical range of emergent COVID-19-related neurologic disease.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[121] Title: </​b>​Case Report: Hepatotoxicity Associated with the Use of Hydroxychloroquine in a Patient with COVID-19.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​30.13<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-03<​br>​
 +<​b>​Publisher:​ </​b>​The American Journal of Tropical Medicine and Hygiene<​br>​
 +<​b>​Keywords:​ </​b>​Medical And Health Sciences, , Health Sciences, Life Sciences, Medicine, Immunology and Microbiology<​br>​
 +<​b>​DOI:​ </​b><​a href="​http://​www.ajtmh.org/​content/​journals/​10.4269/​ajtmh.20-0276">​http://​www.ajtmh.org/​content/​journals/​10.4269/​ajtmh.20-0276</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Hydroxychloroquine (HCQ) has been used for the treatment of novel coronavirus disease (COVID-19) cases. However, evidence of efficacy remains limited, and adverse events can be associated with its use. Here, we report a case of a patient with severe COVID-19 who, after being administered HCQ, exhibited a 10-fold increase in serum levels of transaminases,​ followed by a rapid decrease after HCQ was withdrawn. Considering the significantly increased use of HCQ during the COVID-19 pandemic, this case alerts us to the potential for HCQ to be associated with hepatotoxicity and the need to monitor liver function during HCQ therapy.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[122] Title: </​b>​Azole-Resistant COVID-19-Associated Pulmonary Aspergillosis in an Immunocompetent Host: A Case Report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​29.8<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-06<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Fungi<​br>​
 +<​b>​Keywords:​ </b>, aspergillus fumigatus, capa, icu, sars-cov-2, tr34l98h, azole-resistant aspergillus,​ co-infection,​ pulmonary aspergillosis<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.mdpi.com/​2309-608X/​6/​2/​79">​https://​www.mdpi.com/​2309-608X/​6/​2/​79</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +COVID-19-associated pulmonary aspergillosis (CAPA) is a recently described disease entity affecting patients with severe pulmonary abnormalities treated in intensive care units. Delays in diagnosis contribute to a delayed start of antifungal therapy. In addition, the emergence of resistance to triazole antifungal agents puts emphasis on early surveillance for azole-resistant Aspergillus species. We present a patient with putative CAPA due to Aspergillus fumigatus with identification of a triazole-resistant isolate during therapy. We underline the challenges faced in the management of these cases, the importance of early diagnosis and need for surveillance given the emergence of triazole resistance.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[123] Title: </​b>​Case Report: Death due to COVID-19 in Three Brothers.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​29.63<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-03<​br>​
 +<​b>​Publisher:​ </​b>​The American Journal of Tropical Medicine and Hygiene<​br>​
 +<​b>​Keywords:​ </​b>​Medical And Health Sciences, , Health Sciences, Life Sciences, Medicine, Immunology and Microbiology<​br>​
 +<​b>​DOI:​ </​b><​a href="​http://​www.ajtmh.org/​content/​journals/​10.4269/​ajtmh.20-0240">​http://​www.ajtmh.org/​content/​journals/​10.4269/​ajtmh.20-0240</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We report fatal cases of novel coronavirus disease (COVID-19) in three brothers in Iran. An increased susceptibility to specific pathogens has been reported for a number of genetic defects. Considering the fact that most of them who are affected by COVID-19 recover, deaths in three brothers who lived separately and had no known underlying disease suggest genetic predisposition to COVID-19 in some individuals.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[124] Title: </​b>​Persistence of intestinal SARS-CoV-2 infection in patients with COVID-19 leads to re-admission after pneumonia resolved.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​29.6<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-01<​br>​
 +<​b>​Publisher:​ </​b>​International Journal of Infectious Diseases<​br>​
 +<​b>​Keywords:​ </​b>​Microbiology,​ covid-19, environmental sars-cov-2 contamination,​ intestinal infection, sars-cov-2, viral excretion of sars-cov-2, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S1201971220302794">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S1201971220302794</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The current reports of COVID-19 focus on the respiratory system, however, intestinal infections caused by SARS-CoV-2 are also worthy of attention. This paper reported persistence of intestinal SARS-CoV-2 infection leads to re-admission after pneumonia resolved in three cases with COVID-19.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[125] Title: </​b>​Loss of smell or taste as the only symptom of COVID-19.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​29.55<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-01-01<​br>​
 +<​b>​Publisher:​ </​b>​Tidsskrift for den Norske l槥forening tidsskrift for praktisk medicin ny r櫫e<​br>​
 +<​b>​Keywords:​ </b>, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​tidsskriftet.no/​2020/​04/​kort-kasuistikk/​covid-19-med-nedsatt-lukte-og-smakssans-som-eneste-symptom">​https://​tidsskriftet.no/​2020/​04/​kort-kasuistikk/​covid-19-med-nedsatt-lukte-og-smakssans-som-eneste-symptom</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +BACKGROUND: Olfactory and taste disorders (OTDs) have recently been reported among patients with COVID-19, and it has been hypothesised that oral and nasal tissues may contain host cells of SARS-CoV-2. We report on two cases (spouses) with SARS-CoV-2 infection with self-reported OTDs, but otherwise no typical respiratory symptoms of COVID-19. CASE PRESENTATION:​ A man in his nineties (index patient) had respiratory symptoms and dysgeusia, and was diagnosed with COVID-19. His daughter-in-law and son had no respiratory COVID-19 symptoms. However, they experienced complete loss of smell and taste, respectively,​ 7 and 10 days after their first close contact with the index patient. Both tested positive for SARS-CoV-2 RNA. INTERPRETATION:​ Our case histories support recent reports hypothesising that anosmia and ageusia may be the only symptoms of SARS-CoV-2 infection, and that SARS-CoV-2 may infect oral and nasal tissues. Together, these findings may inform future research, diagnosis, prevention and treatment of COVID-19.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[126] Title: </​b>​Takotsubo Syndrome in the Setting of COVID-19 Infection.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​29.3<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-01<​br>​
 +<​b>​Publisher:​ </​b>​JACC:​ Case Reports<​br>​
 +<​b>​Keywords:​ </b>, ards, acute respiratory distress syndrome, acute cardiac dysfunction,​ covd-19, covid-19, coronavirus disease 2019, ecg, electrocardiogram,​ ef, ejection fraction, rv, right ventricle, stemi, st-elevation myocardial infarction, stress cardiomyopathy,​ takotsubo, v-a, veno-arterial,​ v-v ecmo, veno-venous extracorporeal membrane oxygenation<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2666084920304290">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2666084920304290</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +A 58 year old woman was admitted with symptoms of COVID-19. She subsequently developed mixed shock and echocardiogram showed mid-distal left ventricular hypokinesis and apical ballooning, findings typical for stress, or Takotsubo, cardiomyopathy. Over the next few days her left ventricular function improved, further supporting reversibility of acute stress cardiomyopathy.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[127] Title: </​b>​Misdiagnosis in the COVID era: When Zebras are Everywhere, Don't Forget the Horses.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​29.05<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-01<​br>​
 +<​b>​Publisher:​ </​b>​JACC:​ Case Reports<​br>​
 +<​b>​Keywords:​ </b>, ards, acute respiratory distress syndrome, acute coronary syndrome, ecg, electrocardiogram,​ echo, echocardiogram,​ ecmo, extracorporeal membrane oxygenation,​ lad, left anterior descending artery, lcx, left circumflex artery, lv, left ventricle, myocardial infarction, rca, right coronary artery, rv, right ventricle, stemi, st-elevation myocardial infarction, cardiomypathy<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2666084920303806">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2666084920303806</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We report a patient who presented with respiratory failure, chest pain, and fever. In the COVID-19 pandemic era, the focus was diverted to the coronavirus infection, and STEMI was missed. Even though we need to be vigilant in the diagnosis of COVID-19, we should not forget about the common pathologies.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[128] Title: </​b>​Dexmedetomidine and worsening hypoxemia in the setting of COVID-19: A case report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​28.15<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-01<​br>​
 +<​b>​Publisher:​ </​b>​American Journal of Emergency Medicine<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0735675720304253">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0735675720304253</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Emergency department management of hypoxemia in the setting of COVID-19 is riddled with uncertainty. The lack of high-quality research has translated to an absence of clarity at the bedside. With disease spread outpacing treatment consensus, provider discretion has taken on a heightened role. Here, we report a case of dexmedetomidine use in the setting of worsening hypoxemia, whereby oxygenation improved and intubation was avoided. Well known pharmacologic properties of the drug, namely the lack of respiratory depression and its anti-delirium effects, as well as other possible physiologic effects, suggest potential benefit for patients being managed with a delayed intubation approach. If dexmedetomidine can improve compliance with non-invasive oxygen support (the current recommended first-line therapy) while promoting better oxygenation,​ it may also decrease the need for mechanical ventilation and thus improve mortality.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[129] Title: </​b>​Computed Tomographic Imaging of 3 Patients With Coronavirus Disease 2019 Pneumonia With Negative Virus Real-time Reverse-Transcription Polymerase Chain Reaction Test.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​27.83<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-03-31<​br>​
 +<​b>​Publisher:​ </​b>​Clinical Infectious Diseases<​br>​
 +<​b>​Keywords:​ </​b>​Biological Sciences, chest ct, covid-19 pneumonia, rt-pcr, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​http://​doi.org/​10.1093/​cid/​ciaa207">​http://​doi.org/​10.1093/​cid/​ciaa207</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We reported computed tomographic (CT) imaging findings of 3 patients with coronavirus disease 2019 (COVID-19) pneumonia with initially negative results before CT examination and finally confirmed positive for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by real-time reverse-transcription polymerase chain reaction assay.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[130] Title: </​b>​Viral Load Kinetics of SARS-CoV-2 Infection in First Two Patients in Korea.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​27.05<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-01-01<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Korean Medical Science<​br>​
 +<​b>​Keywords:​ </b>, 2019-ncov, covid-19, coronavirus,​ sars-cov-2, viral load kinetics, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​jkms.org/​DOIx.php?​id=10.3346/​jkms.2020.35.e86">​https://​jkms.org/​DOIx.php?​id=10.3346/​jkms.2020.35.e86</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +As of February 2020, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak started in China in December 2019 has been spreading in many countries in the world. With the numbers of confirmed cases are increasing, information on the epidemiologic investigation and clinical manifestation have been accumulated. However, data on viral load kinetics in confirmed cases are lacking. Here, we present the viral load kinetics of the first two confirmed patients with mild to moderate illnesses in Korea in whom distinct viral load kinetics are shown. This report suggests that viral load kinetics of SARS-CoV-2 may be different from that of previously reported other coronavirus infections such as SARS-CoV.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[131] Title: </​b>​COVID-19 complicated by Acute Pulmonary Embolism and Right-Sided Heart Failure.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​26.58<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-01<​br>​
 +<​b>​Publisher:​ </​b>​JACC:​ Case Reports<​br>​
 +<​b>​Keywords:​ </b>, covid-19, covid-19, coronavirus disease-2019,​ ekg, electrocardiogram,​ heart failure, pulmonary embolism, sars-cov-2, severe acute respiratory syndrome coronavirus-2,​ tte, transthoracic echocardiography<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2666084920303673">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2666084920303673</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +A patient with Coronavirus Disease-2019 (COVID-19) developed sudden shortness of breath and hypoxia. She was diagnosed with a massive pulmonary embolism (PE) complicated by right sided heart failure, which was successfully managed conservatively. This marks the first report of COVID-19 induced PE in association with acute heart failure.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[132] Title: </​b>​Case Report: Viral Shedding for 60 Days in a Woman with COVID-19.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​26.13<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-03<​br>​
 +<​b>​Publisher:​ </​b>​The American Journal of Tropical Medicine and Hygiene<​br>​
 +<​b>​Keywords:​ </​b>​Medical And Health Sciences, , Health Sciences, Life Sciences, Medicine, Immunology and Microbiology<​br>​
 +<​b>​DOI:​ </​b><​a href="​http://​www.ajtmh.org/​content/​journals/​10.4269/​ajtmh.20-0275">​http://​www.ajtmh.org/​content/​journals/​10.4269/​ajtmh.20-0275</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Novel coronavirus disease (COVID-19) caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has become a public health emergency of international concern. This was first noted in Wuhan, Hubei Province, China, and since then has become widespread globally. We report a 71-year-old woman with documented viral shedding (based on reverse transcription-polymerase chain reaction (RT-PCR) testing) of SARS-CoV-2 for 60 days from the onset of symptoms (55 days from her first positive test and 36 days after complete resolution of symptoms). This is to our knowledge the longest duration of viral shedding reported to date. This case demonstrates that viral shedding after COVID-19 diagnosis can be prolonged.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[133] Title: </​b>​COVID-19 in recent kidney transplant recipients.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​26<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-08<​br>​
 +<​b>​Publisher:​ </​b>​American Journal of Transplantation<​br>​
 +<​b>​Keywords:​ </​b>​Medical And Health Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​ajt.16120">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​ajt.16120</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +As coronavirus disease 2019 (COVID-19) pandemic spread across the globe, transplant programs suffered a setback. We report the first experience of COVID-19 infection within 1 month of living donor kidney transplant (LDKT). We describe 2 LDKT recipients who were detected positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection at day 19 and day 7 post-transplant. They had minimal symptoms at diagnosis and did not develop any respiratory complications or allograft dysfunction. Immunosuppression was de-escalated;​ however, nasopharyngeal swab real-time reverse transcription polymerase chain reaction (rRT-PCR) remained positive for SARS-CoV-2 for a prolonged time. Younger age, absence of other comorbidities and lower dose of anti-thymocyte globulin (ATG) used as induction possibly contributed to good outcome in our recent LDKT recipients compared with earlier published cases of recent deceased donor kidney transplant recipients with COVID-19.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[134] Title: </​b>​COVID-19 chilblain-like lesion: immunohistochemical demonstration of SARS-CoV-2 spike protein in blood vessel endothelium and sweat gland epithelium in a PCR-negative patient.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​26<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-25<​br>​
 +<​b>​Publisher:​ </​b>​British Journal of Dermatology<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​bjd.19338">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​bjd.19338</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +A 35-year-old woman with no significant previous medical history presented at the Emergency Department of Fundacion Jimenez Diaz Hospital (Madrid, Spain) on April 14(th) with acral purpuric lesions of three weeks duration. These had started as oedematous, erythematous areas and had appeared coincidentally with fever and coughing, which lasted only two days. There was no history of diarrhoea, ageusia, hyposmia or dyspnea. The patient stated that the skin of her feet acquired a bluish discoloration after standing for some time.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[135] Title: </​b>​Coronavirus Disease-19 (COVID-19) associated with severe acute pancreatitis:​ Case report on three family members.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​25.3<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-01<​br>​
 +<​b>​Publisher:​ </​b>​Pancreatology<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, acute pancreatitis,​ covid-19, sars-cov-2, severe acute pancreatitis,​ viral pancreatitis,​ Biochemistry,​ Genetics and Molecular Biology, Health Sciences, Life Sciences, Medicine<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S1424390320301472">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S1424390320301472</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +BACKGROUND/​OBJECTIVES:​ Abdominal pain is one of the known symptoms associated with coronavirus disease 2019. Little is known about the development of acute pancreatitis as a complication of severe acute respiratory syndrome coronavirus 2 infection. This case report describes the presentation of acute pancreatitis in two of three family members with severe COVID-19 infection. METHODS: Data were collected from three family members admitted with COVID-19 to the intensive care unit in March 2020. This study was reviewed and approved by the local data and ethics committee (31-1521-253). RESULTS: Two of the three family members were diagnosed with acute pancreatitis associated with SARS-CoV-2. Other causes of acute pancreatitis were excluded for both patients (including alcohol, biliary obstruction/​gall stones, drugs, trauma, hypertriglyceridemia,​ hypercalcemia,​ and hypotension). CONCLUSIONS:​ These cases highlight acute pancreatitis as a complication associated with COVID-19 and underlines the importance of measuring pancreas-specific plasma amylase in patients with COVID-19 and abdominal pain.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[136] Title: </​b>​Delirium in COVID-19: A case series and exploration of potential mechanisms for central nervous system involvement.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​24.9<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-07-01<​br>​
 +<​b>​Publisher:​ </​b>​General Hospital Psychiatry<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, akinetic mutism, covid-19, delirium, encephalopathy,​ sars-cov-2, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0163834320300694">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0163834320300694</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +INTRODUCTION:​ Neuropsychiatric manifestations of the coronavirus disease 2019 (COVID-19) have been described, including anosmia, ageusia, headache, paresthesia,​ encephalitis and encephalopathy. Little is known about the mechanisms by which the virus causes central nervous system (CNS) symptoms, and therefore little guidance is available regarding potential workup or management options. CASES: We present a series of four consecutive cases, seen by our psychiatry consultation service over a one-week period, each of which manifested delirium as a result of infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). DISCUSSION: The four cases highlighted here all occurred in older patients with premorbid evidence of cognitive decline. Unique features seen in multiple cases included rigidity, alogia, abulia, and elevated inflammatory markers. In all four cases, a change in mental status was the presenting symptom, and three of the four cases lacked significant respiratory symptoms. In addition to discussing unique features of the cases, we discuss possible pathophysiologic explanations for COVID-19 delirium. CONCLUSIONS:​ Delirium should be recognized as a potential feature of infection with SARS-CoV-2 and may be the only presenting symptom. Based on the high rates of delirium demonstrated in prior studies, hospitals should consider adding mental status changes to the list of testing criteria. Further research is needed to determine if delirium in COVID-19 represents a primary encephalopathy heralding invasion of the CNS by the virus, or a secondary encephalopathy related to systemic inflammatory response or other factors.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[137] Title: </​b>​Status of SARS-CoV-2 in cerebrospinal fluid of patients with COVID-19 and stroke.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​24.5<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-30<​br>​
 +<​b>​Publisher:​ </​b>​Journal of neurology, neurosurgery and psychiatry<​br>​
 +<​b>​Keywords:​ </b>, csf, cerebrovascular disease, infectious diseases, stroke, subarachnoid haemorrhage<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​doi.org/​10.1136/​jnnp-2020-323522">​https://​doi.org/​10.1136/​jnnp-2020-323522</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +BACKGROUND: Emergence of the novel corona virus (severe acute respiratory syndrome (SARS)-CoV-2) in December 2019 has led to the covid-19 pandemic. The extent of covid-19 involvement in the central nervous system is not well established,​ and the presence or the absence of SARS-CoV-2 particles in the cerebrospinal fluid (CSF) is a topic of debate. CASE DESCRIPTION:​ We present two patients with covid-19 and concurrent neurological symptoms. Our first patient is a 31-year-old man who had flu-like symptoms due to covid-19 and later developed an acute-onset severe headache and loss of consciousness and was diagnosed with a Hunt and Hess grade 3 subarachnoid haemorrhage from a ruptured aneurysm. Our second patient is a 62-year-old woman who had an ischaemic stroke with massive haemorrhagic conversion requiring a decompressive hemicraniectomy. Both patients'​ CSF was repeatedly negative on real-time PCR analysis despite concurrent neurological disease. CONCLUSION: Our report shows that patients'​ CSF may be devoid of viral particles even when they test positive for covid-19 on a nasal swab. Whether SARS-CoV-2 is present in CSF may depend on the systemic disease severity and the degree of the virus' nervous tissue tropism and should be examined in future studies.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[138] Title: </b>A Unique Presentation of Delirium in a Patient with Otherwise Asymptomatic COVID-19.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​24.3<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-16<​br>​
 +<​b>​Publisher:​ </​b>​Journal of the American Geriatrics Society<​br>​
 +<​b>​Keywords:​ </​b>​Medical And Health Sciences, covid-19, atypical, delirium, fall, outbreak, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​jgs.16536">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​jgs.16536</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +OBJECTIVE: Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),​ which causes coronavirus disease 2019 (COVID-19), manifests with a wide spectrum of presentations. Most reports of COVID-19 highlight fever and upper respiratory symptoms as the dominant initial presentations,​ consistent with the World Health Organization guidelines regarding suspected SARS-CoV-2 infection. However, atypical presentations of this disease have been evolving since the initial outbreak of the pandemic in December 2019. We report a case of an older male patient who presented at our hospital with an unusual manifestation of COVID-19. DESIGN: Brief report. SETTING: A university hospital in Saudi Arabia. PARTICIPANT:​ A 73-year-old man who presented with confusion in the absence of any respiratory symptoms or fever. INTERVENTION:​ The patient was initially admitted with delirium and underwent a further work-up. MEASUREMENTS:​ Given his recent history of domestic travel and the declaration of a global COVID-19 pandemic status, the patient was administered a swab test for SARS-CoV-2. RESULTS: The patient'​s positive test led to a diagnosis of COVID-19. Although he began to experience a spiking fever and mild upper respiratory symptoms, he recovered rapidly with no residual sequela. CONCLUSION: The recognition of atypical presentations of COVID-19 infection, such as delirium, is critical to the timely diagnosis, provision of appropriate care, and avoidance of outbreaks within healthcare facilities during this pandemic.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[139] Title: </​b>​Exploring Personal Protection During High-Risk PCI in a COVID-19 Patient: Impella CP Mechanical Support During ULMCA Bifurcation Stenting.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​24.2<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-01<​br>​
 +<​b>​Publisher:​ </​b>​JACC:​ Case Reports<​br>​
 +<​b>​Keywords:​ </b>, covid-19, covid-19, coronavirus disease 2019, lmca, left main coronary artery, high-risk pci, personal protection equipment<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2666084920303211">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2666084920303211</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The correct management of patients with coronavirus disease 2019 and acute coronary syndrome is still uncertain. We describe the percutaneous treatment of an unprotected left main coronary artery in a patient who is positive for coronavirus disease 2019 with unstable angina, dyspnea and fever. Particular attention will be dedicated to the measures adopted in the catheterization laboratory to protect the staff and to avoid further spread of the infection. (Level of Difficulty: Intermediate.).<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[140] Title: </​b>​Successful recovery of COVID-19 pneumonia in a patient from Colombia after receiving chloroquine and clarithromycin.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​23.85<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-24<​br>​
 +<​b>​Publisher:​ </​b>​Annals of Clinical Microbiology and Antimicrobials<​br>​
 +<​b>​Keywords:​ </​b>​Biochemistry,​ general, chloroquine,​ colombia, coronavirus disease 2019 (covid-19), latin america, severe acute respiratory syndrome coronavirus 2 (sars-cov-2),​ Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​ann-clinmicrob.biomedcentral.com/​articles/​10.1186/​s12941-020-00358-y">​https://​ann-clinmicrob.biomedcentral.com/​articles/​10.1186/​s12941-020-00358-y</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +BACKGROUND: COVID-19 pandemics is a challenge for public health and infectious diseases clinicians, especially for the therapeutical approach that is not yet adequately defined. Amid this situation, investigational agents are being used, including chloroquine. We report here the clinical features and therapeutic course of the first reported patient with confirmed COVID-19 pneumonia that recovered in Colombia, after the use of chloroquine and clarithromycin. CASE PRESENTATION:​ A 34-year-old male, returning from Spain, presented with complaints of fever, and cough, and class-II obesity, being hospitalized. The respiratory viruses and bacteria tested by FilmArray((R)) PCR were negative. Two days later, clarithromycin was started because the patient was suspected as community-acquired pneumonia. At the third day, the rRT-PCR confirmed the SARS-CoV-2 infection. A day later, chloroquine was started because of that. His chest computed tomography was performed and showed bilateral multifocal ground-glass opacities with consolidation,​ which suggested viral pneumonia as a differential diagnosis. Progressively his clinical condition improved and at day 9, patient rRT-PCR for SARS-CoV-2 became negative. The patient was discharged and isolated at home per 14 days. CONCLUSIONS:​ Our patient improved significantly. This and other COVID-19 cases are urgently demanding results from clinical trials that support evidence-based therapeutical approaches to this pandemic and the clinical management of patients, especially those at critical care.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[141] Title: </​b>​Cardiac Tamponade Secondary to COVID-19.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​23.65<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-01<​br>​
 +<​b>​Publisher:​ </​b>​JACC:​ Case Reports<​br>​
 +<​b>​Keywords:​ </b>, covid-19, covid-19, coronavirus disease 2019, ecg, electrocardiogram,​ ldh, lactate dehydrogenase,​ lvef, left ventricular ejection fraction, nicm, non-ischemic cardiomyopathy,​ pericardial effusion, rr, reference range, sars-cov-2, severe acute respiratory syndrome coronavirus 2, ttc, takotsubo cardiomyopathy,​ tte, transthoracic echocardiogram,​ takotsubo cardiomyopathy,​ tamponade, ctni, cardiac troponin i<br>
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2666084920303685">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2666084920303685</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +A 67-year-old female presented with upper respiratory symptoms and was diagnosed with COVID-19. She was found to have a large hemorrhagic pericardial effusion with echocardiographic signs of tamponade and mild left ventricular impairment. Clinical course was complicated by development of Takotsubo cardiomyopathy. She was treated with pericardiocentesis,​ colchicine, corticosteroids and hydroxychloroquine with improvement in symptoms.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[142] Title: </​b>​Generalized myoclonus in COVID-19.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​23.65<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-21<​br>​
 +<​b>​Publisher:​ </​b>​Neurology<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​n.neurology.org/​content/​early/​2020/​06/​04/​WNL.0000000000009829">​https://​n.neurology.org/​content/​early/​2020/​06/​04/​WNL.0000000000009829</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +OBJECTIVE: To report 3 patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who developed generalized myoclonus. METHODS: Patient data were obtained from medical records from the University Hospital "12 de Octubre,"​ Madrid, Spain. RESULTS: Three patients (2 men and 1 woman, aged 63-88 years) presented with mild hypersomnia and generalized myoclonus following the onset of the so-called inflammatory phase of coronavirus disease 2019 (COVID-19). All of them had presented previously with anosmia. Myoclonus was generalized with both positive and negative jerks, predominantly involving the facial, trapezius, sternocleidomastoid,​ and upper extremities muscles. These myoclonic jerks occurred spontaneously and were extremely sensitive to multisensory stimuli (auditive and tactile) or voluntary movements, with an exaggerated startle response. Other causes of myoclonus were ruled out, and none of the patients had undergone respiratory arrest or significant prolonged hypoxia. All of them improved, at least partially, with immunotherapy. CONCLUSIONS:​ Our 3 cases highlight the occurrence of myoclonus during the COVID-19 pandemic as a post- or para-infectious immune-mediated disorder. However, we cannot rule out that SARS-CoV-2 may spread transneuronally to first- and second-order structures connected with the olfactory bulb. Further investigation is required to clarify the full clinical spectrum of neurologic symptoms and optimal treatment.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[143] Title: </​b>​Multisystem Inflammatory Syndrome in Children (MIS-C) Related to COVID-19: A New York City Experience.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​22.95<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-25<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Medical Virology<​br>​
 +<​b>​Keywords:​ </​b>​Medical Microbiology,​ covid-19, kawasaki disease, sars-cov-2, hyperinflammatory syndrome, Health Sciences, Life Sciences, Medicine, Immunology and Microbiology<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​jmv.26224">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​jmv.26224</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +In December 2019, the 2019 novel coronavirus disease (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) first emerged in Wuhan, China. This has now spread worldwide and was declared a pandemic by March 2020. Initially, the pediatric population was described as low risk for severe COVID-19. However, reports have emerged recently of cases of COVID-19 in children with a systemic inflammatory disease, with features that overlap with Kawasaki Disease (KD). We describe the first 15 cases with multi-system inflammatory syndrome in children (MIS-C), temporally related to COVID-19, who presented for care to a tertiary pediatric referral center in New York City. We discuss the disproportionate burden of disease among Hispanic/​Latino and black/​African-American ancestry, the distinct cytokine signature across the disease spectrum (IL-1/​IL-6),​ and the potential role and pathogenesis of SARS-CoV-2 in this new clinical entity. This article is protected by copyright. All rights reserved.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[144] Title: </​b>​Triage of Acute Ischemic Stroke in Confirmed COVID-19: Large Vessel Occlusion Associated With Coronavirus Infection.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​22.87<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-21<​br>​
 +<​b>​Publisher:​ </​b>​Frontiers in Neurology<​br>​
 +<​b>​Keywords:​ </​b>​Neurosciences,​ covid-19, disease transmission,​ large vessel occlusion (lvo), stroke-diagnosis,​ therapy, triage<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.frontiersin.org/​articles/​10.3389/​fneur.2020.00353/​full">​https://​www.frontiersin.org/​articles/​10.3389/​fneur.2020.00353/​full</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The outbreak of COVID-19 has posed a significant challenge to global healthcare. Acute stroke care requires rapid bedside attendance, imaging, and intervention. However, for acute stroke patients who have a diagnosis of or are under investigation for COVID-19, the concern for nosocomial transmission moderates operational procedures for acute stroke care. We present our experience with an in-hospital stroke code called on a COVID-19-positive patient with a left middle cerebral artery syndrome and the challenges faced for timely examination,​ imaging, and decision to intervene. The outlook for the ongoing COVID-19 pandemic necessitates the development of protocols to sustain timely and effective acute stroke care while mitigating healthcare-associated transmission.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[145] Title: </​b>​Conjunctivitis can be the only presenting sign and symptom of COVID-19.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​22.8<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-01-01<​br>​
 +<​b>​Publisher:​ </​b>​IDCases<​br>​
 +<​b>​Keywords:​ </b>, acute conjunctivitis,​ covid 19, eyes, sars-cov-2 virus pandemic<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2214250920300822">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2214250920300822</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Five cases of non-remitting conjunctivitis turned out to be the sole presenting sign and symptom of COVID-19. These patients tested positive on RT-PCR of naso-pharyngeal swabs and developed no fever, malaise, or respiratory symptoms throughout the course of their illness. They all fully recovered. In the current efforts to fight the spread of this virus, authors want to emphasize that atypical clinical presentations of COVID-19 can occur and a high level of suspicion should be maintained. Ocular involvement and transmission of SARS-CoV-2 should never be overlooked. In fact, conjunctival mucosae are susceptible to respiratory viruses and remain an important point of entry. For this reason, eye protection in the form of goggles or a face shield should be considered essential for all healthcare providers, even when taking care of patients who are not showing typical symptoms of COVID-19.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[146] Title: </​b>​Abdominal Visceral Infarction in 3 Patients with COVID-19.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​22.67<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-08-01<​br>​
 +<​b>​Publisher:​ </​b>​Emerging Infectious Diseases<​br>​
 +<​b>​Keywords:​ </​b>​Medical Microbiology,​ 2019 novel coronavirus disease, covid-19, sars-cov-2, abdominal viscera, coronavirus,​ infarction, respiratory infections, severe acute respiratory syndrome coronavirus 2, viruses, zoonoses, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​wwwnc.cdc.gov/​eid/​404.html?​aspxerrorpath=/​eid/​article/​26/​8/​20-1161_article">​https://​wwwnc.cdc.gov/​eid/​404.html?​aspxerrorpath=/​eid/​article/​26/​8/​20-1161_article</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +A high incidence of thrombotic events has been reported in patients with coronavirus disease (COVID-19), which is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. We report 3 clinical cases of patients in Italy with COVID-19 who developed abdominal viscera infarction, demonstrated by computed tomography.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[147] Title: </​b>​Contrast-Enhanced Ultrasound in Patients With COVID-19: Pneumonia, Acute Respiratory Distress Syndrome, or Something Else?<​br><​br>​
 +<​b>​Altmetric Score: </​b>​22.45<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-12<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Ultrasound in Medicine<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19, contrast-enhanced ultrasound, lung ultrasound, Medicine, Health Professions,​ Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​jum.15338">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​jum.15338</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Coronavirus disease 2019 (COVID-19) represents a very heterogeneous disease. Some aspects of COVID-19 pneumonia question the real nature of ground glass opacities and its consolidative lesions. It has been hypothesized that COVID-19 lung involvement could represent not only a viral effect but also an immune response induced by the infection, causing epithelial/​endothelial lesions and coagulation disorders. We report 3 cases of COVID-19 pneumonia in which contrast-enhanced ultrasound was suggestive of consolidations with perfusion defects, at least in part caused by ischemic or necrotic changes and not only by inflammatory or atelectasis events.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[148] Title: </​b>​Characteristic of COVID-19 infection in pediatric patients: early findings from two Italian Pediatric Research Networks.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​22.35<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-03<​br>​
 +<​b>​Publisher:​ </​b>​European Journal of Pediatrics<​br>​
 +<​b>​Keywords:​ </​b>​Medicine & Public Health, adolescents,​ covid-19, children, italy, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​link.springer.com/​article/​10.1007/​s00431-020-03683-8">​https://​link.springer.com/​article/​10.1007/​s00431-020-03683-8</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Detailed data on clinical presentations and outcomes of children with COVID-19 in Europe are still lacking. In this descriptive study, we report on 130 children with confirmed COVID-19 diagnosed by 28 centers (mostly hospitals), in 10 regions in Italy, during the first months of the pandemic. Among these, 67 (51.5%) had a relative with COVID-19 while 34 (26.2%) had comorbidities,​ with the most frequent being respiratory,​ cardiac, or neuromuscular chronic diseases. Overall, 98 (75.4%) had an asymptomatic or mild disease, 11 (8.5%) had moderate disease, 11 (8.5%) had a severe disease, and 9 (6.9%) had a critical presentation with infants below 6 months having significantly increased risk of critical disease severity (OR 5.6, 95% CI 1.3 to 29.1). Seventy-five (57.7%) children were hospitalized,​ 15 (11.5%) needed some respiratory support, and nine (6.9%) were treated in an intensive care unit. All recovered.Conclusion:​This descriptive case series of children with COVID-19, mostly encompassing of cases enrolled at hospital level, suggest that COVID-19 may have a non-negligible rate of severe presentations in selected pediatric populations with a relatively high rates of comorbidities. More studies are needed to further understand the presentation and outcomes of children with COVID-19 in children with special needs.What is Known:* There is limited evidence on the clinical presentation and outcomes of children with COVID-19 in Europe, and almost no evidence on characteristics and risk factors of severe cases.What is New:* Among a case series of 130 children, mostly diagnosed at hospital level, and with a relatively high rate (26.2%) of comorbidities,​ about three-quarter had an asymptomatic or mild disease.* However, 57.7% were hospitalized,​ 11.5% needed some respiratory support, and 6.9% were treated in an intensive care unit.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[149] Title: </​b>​Therapeutic potential of ciclesonide inahalation for COVID-19 pneumonia: Report of three cases.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​22.3<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-01<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Infection & Chemotherapy<​br>​
 +<​b>​Keywords:​ </​b>​Pharmacology And Pharmaceutical Sciences, ciclesonide,​ coronavirus disease 2019, inhalation, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S1341321X20301318">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S1341321X20301318</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +No specific and effective anti-viral treatment has been approved for COVID-19 so far. Systemic corticosteroid has been sometimes administered to severe infectious diseases combined with the specific treatment. However, as lack of the specific anti-SARS-CoV-2 drug, systemic steroid treatment has not been recommended for COVID-19. We report here three cases of the COVID-19 pneumonia successfully treated with ciclesonide inhalation. Rationale of the treatment is to mitigate the local inflammation with inhaled steroid that stays in the lung and to inhibit proliferation of the virus by antiviral activity. Larger and further studies are warranted to confirm the result of these cases.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[150] Title: </​b>​Chilblain-like lesions in children following suspected COVID-19 infection.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​22.08<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-01<​br>​
 +<​b>​Publisher:​ </​b>​Pediatric Dermatology<​br>​
 +<​b>​Keywords:​ </​b>​Paediatrics And Reproductive Medicine, infection-viral,​ skin signs of systemic disease, vasculitis, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​pde.14210">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​pde.14210</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +During the COVID-19 pandemic, chilblain-like lesions have been reported in mildly symptomatic children and adolescents. We present four children investigated for suspected COVID-19 infection who presented with acral skin findings and mild systemic symptoms. Histology from one case showed signs of vasculitis with evident fibrin thrombus.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[151] Title: </b>A case of SARS-CoV-2 pneumonia with successful antiviral therapy in a 77-year-old man with a heart transplant.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​22<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-11<​br>​
 +<​b>​Publisher:​ </​b>​American Journal of Transplantation<​br>​
 +<​b>​Keywords:​ </​b>​Medical And Health Sciences, antibiotic: antiviral, clinical research/​practice,​ heart transplantation/​cardiology,​ immunosuppressant - calcineurin inhibitor: tacrolimus, immunosuppression/​immune modulation, infection and infectious agents - viral, infectious disease, lung disease: infectious, off-label drug use, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​ajt.15932">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​ajt.15932</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The SARS-CoV-2 infection can be seen as a single disease, but it also affects patients with relevant comorbidities who may have an increased risk of a severe course of infection. In this report, we present a 77-year-old patient with a heart transplant receiving relevant immunosuppressive therapy who tested positive for SARS-CoV-2 after several days of dyspnea, dry cough, and light general symptoms. Computed tomography confirmed interstitial pneumonia. The patient received antiviral therapy with hydroxychloroquine and showed no further deterioration of the clinical state. After 12 days of hospitalization,​ the patient was released; he was SARS-CoV-2 negative and completely asymptomatic.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[152] Title: </​b>​First case of Coronavirus Disease 2019 (COVID-19) pneumonia in Taiwan.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​21.48<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-03-01<​br>​
 +<​b>​Publisher:​ </​b>​Journal of the Formosan Medical Association<​br>​
 +<​b>​Keywords:​ </​b>​Medical And Health Sciences, covid-19, first case, pneumonia, taiwan, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0929664620300449">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0929664620300449</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +An outbreak of respiratory illness proved to be infected by a 2019 novel coronavirus,​ officially named Coronavirus Disease 2019 (COVID-19), was notified first in Wuhan, China, and has spread rapidly in China and to other parts of the world. Herein, we reported the first confirmed case of novel coronavirus pneumonia (NCP) imported from China in Taiwan. This case report revealed a natural course of NCP with self-recovery,​ which may be a good example in comparison with medical treatments.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[153] Title: </​b>​COVID-19 and intracerebral haemorrhage:​ causative or coincidental?<​br><​br>​
 +<​b>​Altmetric Score: </​b>​21.35<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-01<​br>​
 +<​b>​Publisher:​ </​b>​New Microbes and New Infections<​br>​
 +<​b>​Keywords:​ </b>, covid-19, central nervous system, extrapulmonary,​ intracerebral haemorrhage,​ involvement,​ symptoms<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2052297520300214">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2052297520300214</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Pneumonia appears to be the most common manifestation of coronavirus disease 2019 (COVID-19), but some extrapulmonary involvement,​ such as gastrointestinal,​ cardiac and renal, has been reported. The limited clinical data about the virus'​s behavior to date, especially extrapulmonary symptoms, suggest that we should be aware of the possibility of initial cerebrovascular manifestations of COVID-19.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[154] Title: </​b>​First successful treatment of COVID-19 induced refractory cardiogenic plus vasoplegic shock by combination of pVAD and ECMO - a case report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​21.3<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-16<​br>​
 +<​b>​Publisher:​ </​b>​ASAIO Journal: A Peer-Reviewed Journal of the American Society for Artificial Internal Organs<​br>​
 +<​b>​Keywords:​ </​b>​Biomedical Engineering,​ , Materials Science, Biochemistry,​ Genetics and Molecular Biology, Medicine, Engineering,​ Chemical Engineering,​ Health Sciences, Physical Sciences, Life Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​journals.lww.com/​asaiojournal/​FullText/​2020/​06000/​First_Successful_Treatment_of_Coronavirus_Disease.5.aspx">​https://​journals.lww.com/​asaiojournal/​FullText/​2020/​06000/​First_Successful_Treatment_of_Coronavirus_Disease.5.aspx</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The novel coronavirus SARS-CoV-2 is infecting hundreds of thousands of humans around the globe. The coronavirus disease COVID-19 is known to generate mild as well as critical courses. Complications on the intensive care units include acute respiratory distress syndrome, acute cardiac- and kidney injury as well as shock.Here, we present the first case report of a successful treatment of a COVID-19 patient presenting with ARDS plus refractory combined cardiogenic and vasoplegic shock, which could be successfully stabilized after implantation of a percutaneous ventricular assist device (pVAD) plus an extracorporeal membrane oxygenation (ECMO).While such intense treatment might not be feasible in case of a health care disaster as described for the hot spots of the COVID-19 pandemic, it might encourage treatment of younger patients on intensive care units not overcrowded by critically ill patients.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[155] Title: </​b>​First Successful Treatment of Coronavirus Disease 2019 Induced Refractory Cardiogenic Plus Vasoplegic Shock by Combination of Percutaneous Ventricular Assist Device and Extracorporeal Membrane Oxygenation:​ A Case Report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​21.3<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-16<​br>​
 +<​b>​Publisher:​ </​b>​ASAIO Journal: A Peer-Reviewed Journal of the American Society for Artificial Internal Organs<​br>​
 +<​b>​Keywords:​ </​b>​Biomedical Engineering,​ , Materials Science, Biochemistry,​ Genetics and Molecular Biology, Medicine, Engineering,​ Chemical Engineering,​ Health Sciences, Physical Sciences, Life Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​journals.lww.com/​asaiojournal/​FullText/​2020/​06000/​First_Successful_Treatment_of_Coronavirus_Disease.5.aspx">​https://​journals.lww.com/​asaiojournal/​FullText/​2020/​06000/​First_Successful_Treatment_of_Coronavirus_Disease.5.aspx</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The novel coronavirus severe acute respiratory syndrome coronavirus 2 is infecting hundreds of thousands of humans around the globe. The coronavirus disease 2019 (COVID-19) is known to generate mild as well as critical courses. Complications on the intensive care units include acute respiratory distress syndrome, acute cardiac, and kidney injury as well as shock. Here, we present the first case report of a successful treatment of a COVID-19 patient presenting with adult respiratory distress syndrome plus refractory combined cardiogenic and vasoplegic shock, which could be successfully stabilized after implantation of a percutaneous ventricular assist device plus an extracorporeal membrane oxygenation. Although such intense treatment might not be feasible in case of a health care disaster as described for the hot spots of the COVID-19 pandemic, it might encourage treatment of younger patients on intensive care units not overcrowded by critically ill patients.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[156] Title: </​b>​Successful treatment of plasma exchange followed by intravenous immunogloblin in a critically ill patient with 2019 novel coronavirus infection.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​20.93<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-01<​br>​
 +<​b>​Publisher:​ </​b>​International Journal of Antimicrobial Agents<​br>​
 +<​b>​Keywords:​ </​b>​Medical Microbiology,​ diarrhoea, immunogloblin,​ novel coronavirus,​ plasma exchange, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S092485792030131X">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S092485792030131X</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We report a case of a laboratory-confirmed 2019 novel coronavirus infected (known as COVID-19) patient who developed respiratory failure and shock accompanied by persistent diarrhoea despite conventional therapeutic interventions. The patient avoided mechanical ventilation and acquired an immediate clinical and radiological improvement,​ after treatment of intensive plasma exchange (PE) followed by intravenous immunogloblin (IVIG). Successful therapeutic strategies in our case suggest timely initiating PE treatment followed by IVIG in critically ill patients with COVID-19 may prevent the disease from worsening and help to reduce the requirements for mechanical ventilation and intensive supportive care. What's more, it may improve poor clinical outcomes of these patients.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[157] Title: </​b>​First Pediatric Case of Coronavirus Disease 2019 in Korea.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​20.75<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-01-01<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Korean Medical Science<​br>​
 +<​b>​Keywords:​ </b>, covid-19, children, coronavirus,​ sars-cov-2, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​jkms.org/​DOIx.php?​id=10.3346/​jkms.2020.35.e124">​https://​jkms.org/​DOIx.php?​id=10.3346/​jkms.2020.35.e124</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The large outbreak of coronavirus disease 2019 (COVID-19) that started in Wuhan, China has now spread to many countries worldwide. Current epidemiologic knowledge suggests that relatively few cases are seen among children, which limits opportunities to address pediatric specific issues on infection control and the children'​s contribution to viral spread in the community. Here, we report the first pediatric case of COVID-19 in Korea. The 10-year-old girl was a close contact of her uncle and her mother who were confirmed to have COVID-19. In this report, we present mild clinical course of her pneumonia that did not require antiviral treatment and serial viral test results from multiple specimens. Lastly, we raise concerns on the optimal strategy of self-quarantine and patient care in a negative isolation room for children.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[158] Title: </​b>​Concomitant neurological symptoms observed in a patient diagnosed with coronavirus disease 2019.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​19.49<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-15<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Medical Virology<​br>​
 +<​b>​Keywords:​ </​b>​Medical Microbiology,​ covid-19, meningitis, neurological symptoms, Health Sciences, Life Sciences, Medicine, Immunology and Microbiology<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​resolve/​doi?​DOI=10.1002/​jmv.25888">​https://​onlinelibrary.wiley.com/​resolve/​doi?​DOI=10.1002/​jmv.25888</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +There has been a global outbreak of coronavirus disease 2019 (COVID-19) since December 2019. In clinical practice, not only fever and respiratory tract symptoms but also multiple organ symptoms are observed in patients diagnosed with COVID-19. Herein, we report a rare case of a patient diagnosed with COVID-19 who manifested with concomitant neurological symptoms. The patient developed fever and respiratory symptoms at disease onset, followed by muscle soreness, and subsequently altered consciousness and psychiatric symptoms, with positive signs based on neurological examination. The patient tested positive for the severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) nucleic acid (throat swab). Further, chest computed tomography (CT) revealed typical COVID-19 findings, and head CT did not reveal significant abnormalities. The patient recovered after treatment and was discharged. This rare case indicates that SARS-CoV-2 can invade the central nervous system, thus causing neurological symptoms and signs. This article is protected by copyright. All rights reserved.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[159] Title: </​b>​Macrothrombosis and stroke in patients with mild Covid-19 infection.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​19.2<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-25<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Thrombosis & Haemostasis<​br>​
 +<​b>​Keywords:​ </​b>​Cardiovascular Medicine And Haematology,​ carotid artery thrombosis, coronavirus,​ infection, stroke, thrombosis, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​jth.14938">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​jth.14938</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Coronavirus disease 2019 (COVID-19) is a pandemic disease currently affecting millions of people worldwide. Its neurological implications are poorly understood, and further study is urgently required. A hypercoagulable state has been reported in patients with severe COVID-19, but nothing is known about coagulopathy in patients with milder disease. We describe cases of patients in New York City presenting with stroke secondary to large vessel thrombosis without occlusion, incidentally found to have COVID-19 with only mild respiratory symptoms. This is in contrast to the venous thrombosis and microangiopathy that has been reported in patients with severe COVID-19. Our cases suggest that even in the absence of severe disease, patients with COVID-19 may be at increased risk of thrombus formation leading to stroke, perhaps due to viral involvement of the endothelium. Further systematic study is needed, since this may have implications for primary and secondary stroke prevention in patients with COVID-19.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[160] Title: </b>A Case of COVID-19 Pneumonia in a Young Male with Full Body Rash as a Presenting Symptom.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​19.08<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-03-28<​br>​
 +<​b>​Publisher:​ </​b>​Clinical Practice and Cases in Emergency Medicine<​br>​
 +<​b>​Keywords:​ </b>, <br>
 +<​b>​DOI:​ </​b><​a href="​https://​escholarship.org/​uc/​item/​29j8q4pm">​https://​escholarship.org/​uc/​item/​29j8q4pm</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +BACKGROUND: In December 2019 the coronavirus disease of 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2, was identified in Wuhan, China. In the ensuing months, the COVID-19 pandemic has spread globally and case load is exponentially increasing across the United States. Emergency departments have adopted screening and triage procedures to identify potential cases and isolate them during evaluation. CASE PRESENTATION:​ We describe a case of COVID-19 pneumonia requiring hospitalization that presented with fever and extensive rash as the primary presenting symptoms. Rash has only been rarely reported in COVID-19 patients, and has not been previously described.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[161] Title: </​b>​Co-infection of Coronavirus Disease 2019 and Influenza A: A Report from Iran.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​19<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-01<​br>​
 +<​b>​Publisher:​ </​b>​Archives of Iranian Medicine (AIM)<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19, coinfection,​ coronavirus disease 2019, influenza, severe acute respiratory syndrome coronavirus 2, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​http://​www.aimjournal.ir/​Article/​aim-15650">​http://​www.aimjournal.ir/​Article/​aim-15650</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +BACKGROUND: In late December 2019, a viral pneumonia known as coronavirus disease 2019 (COVID-19) originated from China and spread very rapidly in the world. Since then, COVID-19 has become a global concern and health problem. METHODS: We present four patients in this study, selected from among patients who presented with pneumonia symptoms and were suspicious for COVID-19. They were referred to the intended centers for COVID-19 diagnosis and management of Shiraz University of Medical Sciences in southern Iran. Two nasopharyngeal and oropharyngeal throat swab samples were collected from each patient and tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using real-time reverse-transcriptase- polymerase-chain-reaction (RT-PCR). The samples were also tested for influenza viruses and the complete respiratory panel. RESULTS: In the present report, four patients were diagnosed in the starting days of COVID-19 disease in our center in southern Iran with co-infection of SARS-CoV-2 and influenza A virus. CONCLUSION: This co-infection of COVID-19 and influenza A highlights the importance of considering SARS-CoV-2 PCR assay regardless of other positive findings for other pathogens in the primary test during the epidemic.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[162] Title: </​b>​COVID-19 presenting as acute pancreatitis.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​18.9<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-01<​br>​
 +<​b>​Publisher:​ </​b>​Pancreatology<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, acute pancreatitis,​ atlanta classification,​ covid-19, pandemic, sars-cov-2, Biochemistry,​ Genetics and Molecular Biology, Health Sciences, Life Sciences, Medicine<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S142439032030154X">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S142439032030154X</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The ongoing pandemic of Coronavirus disease-2019 (COVID-19) has spread over 200 countries worldwide, affecting >2 million people and >120,000 deaths. COVID-19 is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The most common symptoms include cough, shortness of breath, and fever. However, gastrointestinal manifestations of COVID-19 are increasingly being recognized. Herein, we report a case of COVID-19 who presented with acute pancreatitis (AP) without any other risk factors.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[163] Title: </​b>​Acute Generalized Exanthematous Pustulosis with Erythema Multiforme-Like lesions in a COVID-19 woman.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​18.8<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-09<​br>​
 +<​b>​Publisher:​ </​b>​Journal of the European Academy of Dermatology & Venereology<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, acute generalized exanthematous pustulosis (agep), covid-19, drug reaction, hydroxychloroquine (hcq), skin, severe acute respiratory syndrome coronavirus 2 (sars-cov-2),​ Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​jdv.16613">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​jdv.16613</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The antimalarials,​ Chloroquine and Hydroxychloroquine (HCQ), and the antivirals Lopinavir/​Ritonavir have been recently recorded as having anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) effects.(1) In particular, regarding Italy, one of the countries most affected by the pandemic, the Italian Society of Infectious and Tropical disease (Lombardy section) has recommended the use of HCQ for treatment of coronavirus disease 2019 (COVID-19).<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[164] Title: </​b>​Acute Cerebral Stroke with Multiple Infarctions and COVID-19, France, 2020.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​18.55<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-09-01<​br>​
 +<​b>​Publisher:​ </​b>​Emerging Infectious Diseases<​br>​
 +<​b>​Keywords:​ </​b>​Medical Microbiology,​ 2019 novel coronavirus disease, covid-19, coronavirus diseases, france, sars-cov-2, central nervous system, infarction, pneumonia, respiratory diseases, severe acute respiratory syndrome coronavirus 2, stroke, viruses, zoonoses, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​wwwnc.cdc.gov/​eid/​article/​26/​9/​20-1791_article">​https://​wwwnc.cdc.gov/​eid/​article/​26/​9/​20-1791_article</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We describe 2 cases in coronavirus disease patients in France involving presumed thrombotic stroke that occurred during ongoing anticoagulation treatment for atrial fibrillation stroke prophylaxis;​ 1 patient had positive antiphospholipid antibodies. These cases highlight the severe and unique consequences of coronavirus disease-associated stroke.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[165] Title: </​b>​Fever without a source in a young infant due to SARS-CoV-2.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​18.5<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-22<​br>​
 +<​b>​Publisher:​ </​b>​Journal of the Pediatric Infectious Diseases Society<​br>​
 +<​b>​Keywords:​ </b>, covid-19, sars-cov-2, fever, infant<​br>​
 +<​b>​DOI:​ </​b><​a href="​http://​doi.org/​10.1093/​jpids/​piaa044">​http://​doi.org/​10.1093/​jpids/​piaa044</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +A 5-week-old infant admitted for fever without a source subsequently tested positive for SARS-CoV-2. She had a mild hospital course without respiratory distress. This unexpected presentation changed regional hospital screening for COVID-19 and personal protective equipment use by medical providers evaluating infants with fever without a source.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[166] Title: </​b>​Guillain-Barre syndrome following COVID-19: a newly emerging post-infectious complication.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​18.5<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-14<​br>​
 +<​b>​Publisher:​ </​b>​BMJ Case Reports<​br>​
 +<​b>​Keywords:​ </b>, infectious diseases, intensive care, neurology, neuromuscular disease<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​casereports.bmj.com/​lookup/​doi/​10.1136/​bcr-2020-236182">​https://​casereports.bmj.com/​lookup/​doi/​10.1136/​bcr-2020-236182</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +A 57-year-old man presented with a progressive flaccid symmetrical motor and sensory neuropathy following a 1-week history of cough and malaise. He was diagnosed with Guillain-Barre syndrome secondary to COVID-19 and started on intravenous immunoglobulin. He proceeded to have worsening respiratory function and needed intubation and mechanical ventilation. This is the first reported case of this rare neurological complication of COVID-19 in the UK, but it adds to a small but growing body of international evidence to suggest a significant association between these two conditions. Increasing appreciation of this by clinicians will ensure earlier diagnosis, monitoring and treatment of patients presenting with this.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[167] Title: </​b>​Cerebral Venous Sinus Thrombosis as a Presentation of COVID-19.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​18.45<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-01-01<​br>​
 +<​b>​Publisher:​ </​b>​European journal of case reports in internal medicine<​br>​
 +<​b>​Keywords:​ </b>, covid-19, anticoagulation,​ cerebral venous sinus thrombosis, stroke<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.ejcrim.com/​index.php/​EJCRIM/​article/​view/​1691">​https://​www.ejcrim.com/​index.php/​EJCRIM/​article/​view/​1691</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Coronavirus disease 19 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We describe the case of a 59-year-old man who presented with headache, hypertension and a single episode of fever with no other symptoms. He subsequently developed unilateral weakness. Computer tomography identified a cerebral venous sinus thrombosis (CVST). A subsequent test for COVID-19 was positive. This is the first report of CVST as a presenting symptom of COVID-19 infection. LEARNING POINTS: Thrombotic events may be the initial presenting symptom of COVID-19.These thrombotic events include stroke, venous thromboembolism,​ pulmonary embolism and cardiac complications.Clinicians should carefully consider the risk of thrombosis in patients positive for COVID-19, including prophylaxis and treatment beyond discharge.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[168] Title: </​b>​Lung Ultrasound Can Influence the Clinical Treatment of Pregnant Women With COVID-19.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​18.35<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-01<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Ultrasound in Medicine<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19, lung ultrasound, pneumonia, pregnancy, severe acute respiratory syndrome novel coronavirus 2, Medicine, Health Professions,​ Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​jum.15367">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​jum.15367</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Lung ultrasound (LUS) is an effective tool to detect and monitor patients infected with 2019 coronavirus disease (COVID-19). The use of LUS on pregnant women is an emerging trend, considering its effectiveness during the outbreak. Eight pregnant women with a diagnosis of COVID-19 confirmed by nasal/​throat real-time reverse transcription polymerase chain reaction testing who underwent point-of-care LUS examinations after routine obstetric ultrasound are described. A routinely performed LUS examination revealed serious lung involvement in 7 cases: 2 were initially asymptomatic;​ 3 have chest computed tomography; 1 had initial negative real-time reverse transcription polymerase chain reaction results; and 1 had initial negative computed tomographic findings. Treatment for COVID-19 was either commenced or changed in 87.5% of the patients (n = 7 of 8) on LUS findings. Among patients with abnormal LUS findings, treatment was commenced in 5 patients (71.5%) and changed in 2 patients (28.5%). One normal and 7 abnormal LUS cases indicate the impact of routine LUS on the clinical outcome and treatment of pregnant women.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[169] Title: </​b>​Neurologically Devastating Intraparenchymal Hemorrhage in COVID-19 Patients on Extracorporeal Membrane Oxygenation:​ A Case Series.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​18.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-19<​br>​
 +<​b>​Publisher:​ </​b>​Neurosurgery<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19, extracorporeal membrane oxygenation,​ intracranial hemorrhage, intraparenchymal hemorrhage, patient selection, resource allocation, sars-cov-2, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​http://​doi.org/​10.1093/​neuros/​nyaa198">​http://​doi.org/​10.1093/​neuros/​nyaa198</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +BACKGROUND AND IMPORTANCE: Extracorporeal membrane oxygenation (ECMO) represents a life-saving therapy in cases of refractory hypoxia and has been utilized in patients suffering from the most severe forms of coronavirus disease 2019 (COVID-19). A strikingly high mortality rate of 94% was described in early reports of patients with COVID-19 transitioned to ECMO. Later case reports and series demonstrating successful recovery from COVID-19 after ECMO have revived interest in this therapeutic modality, including the recent approval of ECMO for COVID-19 patients by the Food and Drug Administration (FDA). Here, we present the first reports of devastating intracranial hemorrhage as a complication of veno-venous (VV) ECMO in two COVID-19 patients. CLINICAL PRESENTATION:​ We performed a retrospective analysis of 2 cases of devastating intracranial hemorrhage in patients on VV-ECMO for the treatment of COVID-19. Collected data included clinical history, laboratory results, treatment, and review of all available imaging. Both patients demonstrated activated partial thromboplastin times (aPTT) within an appropriate therapeutic range. No risk factors that clearly predicted likelihood of this complication were identified. CONCLUSION: Understanding the complications of ECMO in this cohort and developing therapeutic algorithms to aid in optimal patient selection will be critical in the limited resource setting experienced as a result of global pandemic. We propose the use of head computed tomography (CT) to identify devastating neurological complications as early as possible, aiding in the resource allocation of ECMO machines to the most appropriately selected patients.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +
 +</​html>​
oa_db/covid19_case_reports_abstracts_pg3.txt · Last modified: 2020/06/28 03:09 by bpwhite