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 +===== COVID-19 Case Reports Abstracts - Page 11 =====
  
 +[[oa_db:​covid19_case_reports_abstracts|Back to Table of Contents]]
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 +[[oa_db:​covid19_case_reports_abstracts_pg10|Page 10]]
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 +----------------------------------------------------------------------<​br>​
 +<​b>​[589] Title: </​b>​COVID-19 in Refractory Myasthenia Gravis- A Case Report of Successful Outcome.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-02<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Neuromuscular Diseases<​br>​
 +<​b>​Keywords:​ </b>, covid-19, plasmapheresis,​ refractory myasthenia gravis, immunosuppression,​ outcome<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.medra.org/​servlet/​aliasResolver?​alias=iospress&​doi=10.3233/​JND-200520">​https://​www.medra.org/​servlet/​aliasResolver?​alias=iospress&​doi=10.3233/​JND-200520</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +This is a brief report of a patient who has refractory Myasthenia Gravis, on multiple long-term immunosuppressive therapies and contracted COVID-19 during this 2020 pandemic. She was quarantined for total of 14 days and recovered successfully without any complications (no myasthenia exacerbation or crisis, no COVID-19 related complications),​ with no changes to her immunosuppressive therapy. Treatment of MG patients with COVID-19 needs to be tailored to individual patient.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[590] Title: </​b>​Oral cavity lesions as a manifestation of the novel virus (COVID-19): a letter-to-editor.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-08<​br>​
 +<​b>​Publisher:​ </​b>​Oral Diseases<​br>​
 +<​b>​Keywords:​ </​b>​Dentistry,​ covid-19, histopathology,​ oral cavity ulcer, oral manifestation,​ Medicine, Dentistry, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​odi.13465">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​odi.13465</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +In early December 2019, the acute respiratory illness began in the Wuhan, China, which quickly spread around the world, that today known as COVID-19. (Sun, Qie, Liu, Ren, & Xi, 2020) Preliminary studies have shown that hospitalized patients have different symptoms, including myalgia, whooping cough, fatigue, and dyspnea and gastrointestinal complains. (Guo et al., 2020; Zhang et al., 2020) In more recent studies, skin manifestations have also been reported in covid-19 patients.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[591] Title: </​b>​Symmetrical polyneuropathy in coronavirus disease 2019 (COVID-19).<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-01-01<​br>​
 +<​b>​Publisher:​ </​b>​IDCases<​br>​
 +<​b>​Keywords:​ </b>, covid-19, nervous system, pneumonia, polyneuropathy,​ sars-cov-2<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2214250920301232">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2214250920301232</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The outbreak of the novel coronavirus that began in late December 2019 was announced as a pandemic by the World Health Organization as the number of cases is increasing exponentially throughout the globe. We presented a patient with confirmed SARS-CoV-2 pneumonia developing symmetric polyneuropathy. To our knowledge, extrapulmonary clinical presentations of 2019 novel coronavirus disease (COVID-19) have rarely been reported. This case highlights the possible association between SARS-CoV-2 infection and nervous system involvement.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[592] Title: </​b>​[Biological therapy after COVID-19 infection : No reactivation of a COVID-19 infection with positive SARS-CoV-2 antibody status under biological therapy].<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-08<​br>​
 +<​b>​Publisher:​ </​b>​Zeitschrift für Rheumatologie<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, biological therapy, covid-19 infection, immunsuppression,​ positive antibody status sars-cov2, rheumatoid arthritis, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​link.springer.com/​article/​10.1007/​s00393-020-00824-0">​https://​link.springer.com/​article/​10.1007/​s00393-020-00824-0</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +A case with rheumatoid arthritis and insufficient compensation under disease-modifying combined long-term therapy with methotrexate and leflunomide is reported. After recovery from a COVID-19 infection, a tumor necrosis factor (TNF) inhibitor therapy was initiated. Until now no reactivation of the COVID-19 infection with positive SARS-CoV2 antibody status has occurred.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[593] Title: </​b>​Colon cancer during the coronavirus pandemic - recovery from COVID-19 pneumonia of an elderly woman with multiple co-morbidities<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-01<​br>​
 +<​b>​Publisher:​ </​b>​Orvosi Hetilap<​br>​
 +<​b>​Keywords:​ </b>, covid-19, covid-19, case report, colon cancer, esetismertetes,​ pneumonia, tudogyulladas,​ vastagbeldaganat,​ Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​doi.org/​10.1556/​650.2020.31866">​https://​doi.org/​10.1556/​650.2020.31866</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +COVID-19, caused by the new coronavirus,​ can lead to acute respiratory failure or even sepsis. Patients with multiple co-morbidities are more likely to develop these severe forms of the disease. The aim of this report is to highlight cases the analysis of which might help discover factors that influence the course and mortality of COVID-19 pneumonia. The past medical history of our elderly patient (75-year-old female) includes rectum resection with intraoperative cardiac arrest and successful resuscitation. In January 2020, the patient was diagnosed with adenocarcinoma of the ascending colon and concomittant pulmonary embolism. Following 6 weeks of therapeutic dose low-molecular-weight heparin (LMWH) treatment, the cancerous colonic section was resected. The patient arrested intraoperatively but was successfully resuscitated. On post-operative day 15, the patient developed arterial anastomosis bleed, which necessitated acute right-sided hemicolectomy. Post-operatively she became pyrexial and COVID-19 was confirmed, but later became apyrexial with symptomatic treatment. Subsequently,​ the patient developed partial anastomosis insufficiency,​ which resolved with conservative management. Following three negative SARS-CoV-2 tests, she was successfully discharged from hospital. It is worthy of note that due to the active anastomosis bleed the angiotensin-converting enzyme (ACE)-inhibitor treatment was stopped, and later the patient got infected with SARS-CoV-2. A long-lasting LMWH therapy was performed. The timely management of colorectal carcinoms remains important even during an epidemic. The appropriate treatment of these patients during the pandemic presents a great challenge for all doctors, but, as shown in our case report, surgical treatment of even those with multiple co-morbidities can be successful. Orv Hetil. 2020; 161(25): 1059-1062.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[594] Title: </​b>​Incidental Discovery of a COVID-19 Infection on a Reevaluation FDG PET/CT in a Patient Treated for Hodgkin Lymphoma.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-08<​br>​
 +<​b>​Publisher:​ </​b>​Clinical Nuclear Medicine<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​doi.org/​10.1097/​rlu.0000000000003144">​https://​doi.org/​10.1097/​rlu.0000000000003144</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We report the results of F-FDG PET/CT in an asymptomatic case of COVID-19 infection. A 27-year-old woman underwent FDG PET/CT for revaluation of a stage IIIE B Hodgkin lymphoma after the fourth cycle of chemotherapy. It showed intense avid FDG subpleural mixed ground-glass and consolidative lesions, especially in the left lung. Because of this morpho-metabolic aspect and the epidemic context, a viral pneumopathy was suspected. The patient who was initially asymptomatic was admitted for fever 28 hours after the PET/CT. The nasopharyngeal swab was positive for COVID-19, and the outcome was favorable.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[595] Title: </​b>​PET/​CT of COVID-19 as an Organizing Pneumonia.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-08<​br>​
 +<​b>​Publisher:​ </​b>​Clinical Nuclear Medicine<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​doi.org/​10.1097/​rlu.0000000000003174">​https://​doi.org/​10.1097/​rlu.0000000000003174</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +An 85-year-old woman with history of melanoma is referred for a follow-up F-FDG PET/CT. F-FDG PET/CT scan showed bilateral and peripheral ground-glass opacities in upper and lower pulmonary lobes surrounded by consolidations of crescent shape with increased FDG uptake, findings compatible with organizing pneumonia. Following further inquiry, the patient reported low-grade fever, sore throat, and fatigue for the past 6 days. Because of the ongoing COVID-19 pandemic, the patient was tested for SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), which resulted positive.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[596] Title: </​b>​Atypical Presentation of COVID-19 Incidentally Detected at 18F-FDG PET/CT in an Asymptomatic Oncological Patient.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-08<​br>​
 +<​b>​Publisher:​ </​b>​Clinical Nuclear Medicine<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​doi.org/​10.1097/​rlu.0000000000003175">​https://​doi.org/​10.1097/​rlu.0000000000003175</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The incidence of COVID-19, a severe acute respiratory syndrome caused by SARS-CoV-2, is rapidly growing worldwide. In this pandemic period, the chance of incidental pulmonary findings suggestive of COVID-19 at F-FDG PET/CT in asymptomatic oncological patients is not negligible. To suspect COVID-19 is more demanding whether its presentation is atypical. We describe the incidental PET/CT detection of an F-FDG-avid isolated centrilobular pulmonary consolidation in an asymptomatic lymphoma patient, which later resulted in an unexpected and atypical COVID-19 presentation. The nuclear medicine physicians should be prepared to suspect COVID-19 even in asymptomatic patients presenting with a "​far-from-COVID-19"​ finding at PET/​CT.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[597] Title: </​b>​Pneumatosis intestinalis in COVID-19.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-09<​br>​
 +<​b>​Publisher:​ </​b>​BMJ Open Gastroenterology<​br>​
 +<​b>​Keywords:​ </b>, bacterial overgrowth, clinical decision making, colonic diseases, colonic microflora, infectious disease<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​bmjopengastro.bmj.com/​lookup/​doi/​10.1136/​bmjgast-2020-000434">​https://​bmjopengastro.bmj.com/​lookup/​doi/​10.1136/​bmjgast-2020-000434</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +INTRODUCTION:​ COVID-19 is a respiratory illness due to novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),​ described in December 2019 in Wuhan (China) and rapidly evolved into a pandemic. Gastrointestinal (GI) tract can also be involved. CASE PRESENTATION:​ A 44-year-old man was hospitalised for COVID-19-associated pneumonia. A rapid recovery of respiratory and general symptoms was observed after 1 week of treatment with lopinavir/​ritonavir plus hydroxychloroquine and broad-spectrum antibiotics (piperacillin-tazobactam plus teicoplanin). No GI symptoms were reported during hospitalisation,​ but a lung contrast-enhancement CT (CE-CT) excluding thromboembolism showed, as collateral finding, intraperitoneal free bubbles not present on a previous CT examination;​ the subsequent abdominal CE-CT described pneumatosis intestinalis (PI) involving the caecum and the right colon. Ciprofloxacin plus metronidazole was started, and the 2-week follow-up CT showed the complete resolution of PI. DISCUSSION: The pathogenesis of PI is poorly understood. PI involving the caecum and right colon has been described for HIV and Cytomegalovirus infections, but, to our best knowledge, never before in COVID-19. We hypothesise a multifactorial aetiopathogenesis for PI, with a possible role of the bowel wall damage and microbiota impairment due to SARS-CoV-2 infection, and we suggest a conservative management in the absence of symptoms.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[598] Title: </​b>​Multidisciplinary team management and cesarean delivery for a Jordanian woman infected with SARS-COV-2: A case report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-07-01<​br>​
 +<​b>​Publisher:​ </​b>​Case Reports in Women'​s Health<​br>​
 +<​b>​Keywords:​ </b>, covid-19, cesarean delivery, hydroxychloroquine,​ jordan, pregnancy<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2214911220300424">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2214911220300424</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The SARS-COV-2 virus appears to have originated in Hubei Province in China towards the end of 2019 and has spread worldwide. Currently, there is little literature on COVID-19, and even less on its effect on pregnant mothers and infants. At this time, there are no clear recommendations specific to pregnant women with COVID-19. We report the multidisciplinary team management of a cesarean delivery for a woman infected with SARS-COV-2, including her pre-delivery care, intraoperative considerations,​ and post-delivery recommendations for the mother and baby. We also discuss the currently available recommendations and guidelines on the management of such cases.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[599] Title: </​b>​Incidental COVID-19 in a Heart-Kidney Transplant Recipient with Malnutrition and Recurrent Infections: Implications for the SARS-CoV-2 Immune Response.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-13<​br>​
 +<​b>​Publisher:​ </​b>​Transplant Infectious Disease<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19, immunosuppression,​ sars-cov-2, simultaneous heart-kidney transplant, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​tid.13367">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​tid.13367</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The clinical course and outcomes of immunocompromised patients, such as transplant recipients, with COVID-19 remains unclear. It has been postulated that a substantial portion of the disease burden seems to be mediated by the host immune activation to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Herein, we present a simultaneous heart-kidney transplant (SHKT) recipient who was hospitalized for the management of respiratory failure from volume overload complicated by failure to thrive, multiple opportunistic infections, and open non-healing wounds in the setting of worsening renal dysfunction weeks prior to the first case of SARS-CoV-2 being detected in the state of Connecticut. After his third endotracheal intubation, routine nucleic acid testing (NAT) for SARS-CoV-2, in anticipation of a planned tracheostomy,​ was positive. His hemodynamics,​ respiratory status and ventilator requirements remained stable without any worsening for 4 weeks until he had a negative NAT test. It is possible that the immunocompromised status of our patient may have prevented significant immune activation leading up to clinically-significant cytokine storm that could have resulted in acute respiratory distress syndrome and multisystem organ failure.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[600] Title: </​b>​Cutaneous manifestations of hospitalized COVID-19 patients: A report of six cases with clinicopathologic features and viral RNA in situ hybridization.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-13<​br>​
 +<​b>​Publisher:​ </​b>​Journal of the European Academy of Dermatology & Venereology<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, coronavirus disease 2019 (covid-19), cutaneous manifestations,​ histopathologic features, severe acute respiratory syndrome coronavirus 2 (sars-cov-2),​ viral rna in situ hybridization,​ Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​jdv.16741">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​jdv.16741</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Novel coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was declared a global pandemic on March, 2020.(1) Recalcati et al. reported cutaneous manifestations in 20.4% of COVID-19 patients.(2) We identified six patients (five female, one male) with COVID-19-associated cutaneous manifestations in April 2020 on the inpatient dermatology consultation service. The mean age was 51 years (range, 28-71 years).<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[601] Title: </​b>​COVID-19 in a young man with hypertension:​ A case study of missed opportunities in intensive progression.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-01<​br>​
 +<​b>​Publisher:​ </​b>​Intensive & Critical Care Nursing<​br>​
 +<​b>​Keywords:​ </​b>​Nursing,​ covid-19, enteral feeding, heart failure, hypertension,​ pneumonia, viral, Health Sciences, Nursing<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0964339720301014">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0964339720301014</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We report the case of a young patient diagnosed with coronavirus disease 2019 with a history of hypertension. The patient improved after antiviral treatment but eventually developed severe respiratory distress syndrome and cardiac insufficiency. His respiratory secretions were tested for nucleic acids and returned negative twice. Computed tomography imaging of the patient showed evidence of viral pneumonia on the 11th day of onset and continued to worsen. The patient was finally intubated and transferred to a higher-level care centre for further treatment. We were very focused on infectious disease protection throughout the treatment, however, suboptimal treatment was provided due to the switch in antihypertensive medication, lack of early nutritional support and fluid restriction management.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[602] Title: </​b>​COVID-19 infection presenting as pancreatitis in a pregnant woman: A case report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-07-01<​br>​
 +<​b>​Publisher:​ </​b>​Case Reports in Women'​s Health<​br>​
 +<​b>​Keywords:​ </b>, covid-19, coronavirus 2019, pancreatitis,​ pregnancy, type 1 diabetes mellitus<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2214911220300588">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2214911220300588</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Background: The coronavirus 2019 (COVID-19) pandemic has posed unique challenges in healthcare. In obstetrics, there is little information available to guide practice. As new data emerge, the spectrum of initial presenting symptoms has expanded from fever, cough, and dyspnea to gastrointestinal and other symptoms in both pregnant and non-pregnant patients. Case: A 36-year-old woman, G4P2, at 33 weeks of gestation presented very early in the COVID-19 course with four days of cough and fever, without recent travel or known exposure. She appeared well, with stable vital signs, and was sent home to self-quarantine after a specimen for COVID-19 testing was collected. Two days later, she presented with nausea, vomiting, and abdominal pain, and was diagnosed with acute pancreatitis. Conclusion: To date, no cases of human pancreatitis have been identified as related to a COVID-19 infection, although multiple other gastrointestinal symptoms have been described. Given the lack of other etiology, we consider the possibility that patient'​s acute pancreatitis could be secondary to COVID-19 infection.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[603] Title: </​b>​Extensive pneumatosis intestinalis and portal venous gas mimicking mesenteric ischaemia in a patient with SARS-CoV-2.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-15<​br>​
 +<​b>​Publisher:​ </​b>​Annals of the Royal College of Surgeons of England<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19, mesenteric ischaemia, pneumatosis intestinalis,​ sars-cov-2, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​publishing.rcseng.ac.uk/​doi/​10.1308/​rcsann.2020.0145">​https://​publishing.rcseng.ac.uk/​doi/​10.1308/​rcsann.2020.0145</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We present the case of a critically ill 47-year-old man diagnosed with SARS-CoV-2 (COVID-19) who developed extensive pneumatosis intestinalis and portal venous gas in conjunction with an acute abdomen during the recovery phase of his acute lung injury. A non-surgical conservative approach was taken as the definitive surgical procedure; a complete small-bowel resection was deemed to be associated with an unacceptably high long-term morbidity. However, repeat computed tomography four days later showed complete resolution of the original computed tomography findings. Pneumatosis intestinalis from non-ischaemic origins has been described in association with norovirus and cytomegalovirus. To our knowledge, this is the first time that this has been described in COVID-19.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[604] Title: </​b>​Acute Necrotizing Encephalitis in Viral Respiratory Tract Infection: An Autopsy Case Report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-12<​br>​
 +<​b>​Publisher:​ </​b>​Cureus<​br>​
 +<​b>​Keywords:​ </b>, acute necrotizing encephalitis,​ morphology, pathology, respiratory tract infections<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.cureus.com/​articles/​31793-acute-necrotizing-encephalitis-in-viral-respiratory-tract-infection-an-autopsy-case-report">​https://​www.cureus.com/​articles/​31793-acute-necrotizing-encephalitis-in-viral-respiratory-tract-infection-an-autopsy-case-report</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Acute necrotizing encephalitis (ANE) is a rare complication of viral respiratory tract infections, with specific histological changes. The condition is most commonly described in the pediatric population, however, it can also develop in the elderly, with some genetic factors being described as contributory. Herein, we report the autopsy finding of a patient with a viral respiratory tract infection, complicated with ANE. The patient was a 77-year-old female with multiple comorbidities living in a social home. For the two months prior, she had been hospitalized with cerebral infarction, respiratory tract infection, and exacerbation of chronic cardiac failure and concomitant hypertension and type 2 diabetes. On gross examination,​ the brain was edematous, with ground-glass opacity meninges a focus of encephalomalacia in the right cerebral hemisphere and multiple petechial hemorrhages. Histology revealed diffuse foci of encephalitis,​ with large areas of neuronal necrosis (coagulative-like necrosis) around the blood vessels and a sharp border with the surrounding healthy parenchyma - ANE. The patients tested negative for coronavirus disease 2019 (COVID-19).<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[605] Title: </b>A Case Report of Suicide Attempt Caused by Acute and Transient Psychotic Disorder during the COVID-19 Outbreak.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-28<​br>​
 +<​b>​Publisher:​ </​b>​Case Reports in Psychiatry<​br>​
 +<​b>​Keywords:​ </b>, <br>
 +<​b>​DOI:​ </​b><​a href="​https://​www.hindawi.com/​journals/​crips/​2020/​4320647/">​https://​www.hindawi.com/​journals/​crips/​2020/​4320647/</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We reported a case of suicide attempt caused by acute and transient psychotic disorder during the COVID-19 outbreak, which broke out in December 2019 in Wuhan. An epidemic of infectious diseases brought great psychological pressure to the public. During this period, a 20-year-old man went to the hospital repeatedly because he suspected that he was infected, with suspicious auditory hallucinations,​ self-laughter,​ primary delusions, victimization delusions, relationship delusions, and suicide attempts. He was diagnosed with Acute Transient Psychotic Disorder. 0.1 g bid Quetiapine was given orally, then gradually increased to 0.4 g per day, supplemented by cognitive therapy. The patient was discharged from hospital in relief of symptoms on February 9th. Conclusion. During the epidemic period, in addition to strengthening the protection work, we should also monitor the mental and psychological state of the population to prevent mental illness caused by coronavirus.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[606] Title: </​b>​COVID-19 in a Patient with beta-Thalassemia Major and Severe Pulmonary Arterial Hypertension.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-18<​br>​
 +<​b>​Publisher:​ </​b>​Hemoglobin<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, angiotensin ii receptor blockers (arbs), sildenafil, coronavirus disease-19 (covid-19), pulmonary arterial hypertension (pah), thalassemic syndromes, Biochemistry,​ Genetics and Molecular Biology, Health Sciences, Life Sciences, Medicine<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.tandfonline.com/​doi/​full/​10.1080/​03630269.2020.1779082">​https://​www.tandfonline.com/​doi/​full/​10.1080/​03630269.2020.1779082</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We here report the successful recovery from coronavirus disease-19 (COVID-19) pneumonia in a patient with beta-thalassemia major (beta-TM) and severe pulmonary arterial hypertension (PAH), focusing on the patient'​s comorbidities,​ therapeutic course and drug interaction.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[607] Title: </​b>​Antibodies in the breast milk of a maternal woman with COVID-19.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-18<​br>​
 +<​b>​Publisher:​ </​b>​Emerging Microbes & Infections<​br>​
 +<​b>​Keywords:​ </b>, antibodies, breastmilk, covid-19, maternal woman<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.tandfonline.com/​doi/​full/​10.1080/​22221751.2020.1780952">​https://​www.tandfonline.com/​doi/​full/​10.1080/​22221751.2020.1780952</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +A maternal woman was positive for SARS-CoV-2 tested in throat swabs but negative tested in other body fluids, and she had IgG and IgA detected in breast milk. Her infant negative for SARS-CoV-2 at birth had elevated IgG in serum but quickly decayed. These findings suggest that breastfeeding might have the potential benefit to the neonates.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[608] Title: </​b>​Non-optimal effectiveness of convalescent plasma transfusion and hydroxychloroquine in treating COVID-19: a case report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-19<​br>​
 +<​b>​Publisher:​ </​b>​Virology Journal<​br>​
 +<​b>​Keywords:​ </​b>​Medical Microbiology,​ covid-19, convalescent plasma, cycle threshold, hydroxychloroquine,​ sars-cov-2, Health Sciences, Life Sciences, Medicine, Immunology and Microbiology<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​virologyj.biomedcentral.com/​articles/​10.1186/​s12985-020-01354-6">​https://​virologyj.biomedcentral.com/​articles/​10.1186/​s12985-020-01354-6</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +BACKGROUND: Convalescent plasma (CP) transfusion was reported to be effective in treating critically ill patients with COVID-19, and hydroxychloroquine could potently inhibit SARS-CoV-2 in vitro. Herein, we reported a case receiving combination therapy with CP transfusion and hydroxychloroquine for the first time. CASE PRESENTATION:​ Laboratory findings showed high lactic acid level (2.1 mmol/L) and C-reactive protein (CRP, 48.8 mg/L), and low white blood cell count (1.96 x 10(9)/L) in a 65-year-old Chinese man, who was diagnosed with severe COVID-19. CP was intravenously given twice, and hydroxychloroquine was orally administrated for a week (0.2 g, three times a day). The lactic acid and C-reactive protein levels remained high (2.1 mmol/L and 73.23 mg/L, respectively),​ while the arterial oxyhemoglobin saturation decreased to 86% with a low oxygenation index (OI, 76 mmHg) on day 4 after CP transfusion. His temperature returned to normal and the OI ascended above 300 on day 11. Moreover, the RNA test remained positive in throat swab, and computed tomography revealed severe pulmonary lesions on day 11 after admission. CONCLUSION: These findings suggested that the effectiveness of combination therapy with CP and hydroxychloroquine may be non-optimal,​ and specific therapy needs to be explored.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[609] Title: </b>A COVID-19 case report from asymptomatic contact: implication for contact isolation and incubation management.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-19<​br>​
 +<​b>​Publisher:​ </​b>​Infectious Diseases of Poverty<​br>​
 +<​b>​Keywords:​ </​b>​Infectious Diseases, covid-19, coronavirus,​ infection, particular contacting<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​idpjournal.biomedcentral.com/​articles/​10.1186/​s40249-020-00686-3">​https://​idpjournal.biomedcentral.com/​articles/​10.1186/​s40249-020-00686-3</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +BACKGROUND: As of 2 March, 2020, at least 80 151 coronavirus disease 2019 (COVID-19) cases were reported in China. Most of the patients had a history of visiting Hubei Province or contacting with people who had ever stayed in or passed by Hubei Province or were exposed to symptoms. Some patients got infected through only asymptomatic contact. This study aimed to report the epidemic features and lab identification of a patient confirmed with COVID-19 infection through only asymptomatic contact. CASE PRESENTATION:​ A 44-year-old man, who lived in Nanchang, Jiangxi Province, China until 6 March 2020, suffered from cough on 27 January 2020. Fever symptoms appeared on 28 January, with a maximum temperature of 38.8 degrees C, accompanied by cough, sore throat, headache, fatigue, muscle ache, joint ache, and other symptoms. The symptoms continued until he was hospitalized on 30 January. Coronavirus conventional polymerase chain reaction assay was positive for the throat swab sample. The patient, along with his wife and son, drove from Nanchang to back to Honghu City, Hubei Province, on 23 January 2020. After staying with his parents and brother'​s family for 3 days, the patient drove back to Nanchang and arrived on 25 January. On the way back home, they stopped by Tongshan service area, Hubei Province, without any close contact with other people. After arriving home in Nanchang City, Jiangxi Province, none of them left their residence. In addition, his parents stayed at home for 20 days with his younger brother'​s family before they got back. His younger brother and one of his brother'​s children visited Wuhan on 5 January and came home on 6 January 2020. CONCLUSIONS:​ This report suggested that, in the early phase of COVID-19 pneumonia, routine screening could miss patients who were virus carriers. Highlighting travel history is of paramount importance for the early detection and isolation of severe acute respiratory syndrome coronavirus 2 cases.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[610] Title: </​b>​Az elso ket sikeres, convalescens friss fagyasztott plazmaval torteno terapia hazai alkalmazasa intenziv osztalyon kezelt, kritikus allapotu, COVID-19-fertozesben szenvedo betegekben.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-07-01<​br>​
 +<​b>​Publisher:​ </​b>​Orvosi Hetilap<​br>​
 +<​b>​Keywords:​ </b>, covid-19, covid-19, sars-cov-2, convalescens plazma, convalescent plasma, interleukin-6,​ Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​doi.org/​10.1556/​650.2020.31901">​https://​doi.org/​10.1556/​650.2020.31901</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +INTRODUCTION:​ At present, neither specific curative treatment nor vaccines for novel coronavirus 2019 (COVID-19) are available. There is an urgent need to look for alternative strategies for COVID-19 treatment especially in the case of severe and/or critically ill patients with cytokine release syndrome (CRS). AIM: Convalescent plasma proved to increase survival rates in other severe viral infections. Therefore, convalescent plasma could be a promising treatment option for severe COVID-19 patients. METHOD: In our article, we present the first two critically ill Hungarian patients with COVID-19 infection treated with convalescent fresh frozen plasma. RESULTS: At the time of plasma therapy both patients were on mechanical ventilation and received antiviral agents and a full scale of supportive care. Each patient received 3 x 200 mL of convalescent plasma of recently recovered donors with sufficient novel anti-coronavirus IgG titers. Subsequent to convalescent plasma infusion, oxygenization improved and inflammatory markers decreased in both individuals. As compared to pretransfusion,​ lymphocyte counts increased and interleukin-6 level lessened. Both patients were weaned from mechanical ventilation within 2 weeks of treatment. No severe adverse effects were observed. CONCLUSIONS:​ Our experience indicates that convalescent plasma therapy is well tolerated and could potentially improve clinical outcomes. Optimal dose and timing as well as precise assessment of clinical benefit of convalescent plasma therapy will need further investigation in larger, well-controlled trials. This is the first report of the successful use of convalescent plasma in the treatment of critically ill patients with COVID-19 infection in Hungary. Orv Hetil. 2020; 161(27): 1111-1121.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[611] Title: </​b>​Facial pressure ulcers in COVID-19 patients undergoing prone positioning:​ How to prevent an underestimated epidemic?<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-01<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Stomatology,​ Oral and Maxillofacial Surgery<​br>​
 +<​b>​Keywords:​ </b>, covid -19, facial, pressure ulcers, prone positioning<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2468785520301543">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2468785520301543</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Prone positioning is an adjuvant therapy used to treat COVID-19 pneumonia complicated by acute respiratory distress syndrome. However, prolonged pressure on facial skin at the level of the bony structures may be responsible for facial pressure ulcers. In the context of severe COVID-19 pneumonia, we hypothesized that hypoxemia, microvascular injury and thrombosis can increase the risk of pressure ulcers. We described two cases in order to emphasize the risk of facial pressure ulcers as a result of prone positioning,​ so as to discuss their physiopathology and highlight the importance of appropriate preventive measures.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[612] Title: </​b>​Protracted course of coronavirus disease with severe acute respiratory distress syndrome: a case report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-18<​br>​
 +<​b>​Publisher:​ </​b>​Acute Medicine & Surgery<​br>​
 +<​b>​Keywords:​ </b>, acute respiratory distress syndrome, covid-19, sars-cov-2, critically ill, prone ventilation<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​ams2.521">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​ams2.521</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Background: Coronavirus disease (COVID-19) is a growing concern worldwide. Approximately 5% of COVID-19 cases require intensive care. However, the optimal treatment for respiratory failure in COVID-19 patients is yet to be determined. Case presentation:​ A 79-year-old man with severe acute respiratory distress syndrome due to COVID-19 was admitted to our intensive care unit. Prone ventilation was effective in treating the patient'​s hypoxemia. Furthermore,​ the patient received lung protective ventilation with a tidal volume of 6-8 mg/kg (predicted body weight). However, the patient'​s respiratory failure did not improve and he died 16 days after admission because of multiple organ failure. Serial chest computed tomography revealed a change from ground-glass opacity to consolidation pattern in both lungs. Conclusions:​ We report a protracted case of COVID-19 in a critically ill patient in Japan. Although prone ventilation could contribute to treating hypoxemia, its efficacy in preventing mortality from COVID-19 is unknown.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[613] Title: </​b>​Abdominal Surgery in Patients with COVID-19: Detection of SARS-CoV-2 in Abdominal and Adipose Tissues.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-16<​br>​
 +<​b>​Publisher:​ </​b>​Annals of Surgery<​br>​
 +<​b>​Keywords:​ </​b>​Medical And Health Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​journals.lww.com/​annalsofsurgery/​Abstract/​9000/​Abdominal_Surgery_in_Patients_with_COVID_19_.94416.aspx">​https://​journals.lww.com/​annalsofsurgery/​Abstract/​9000/​Abdominal_Surgery_in_Patients_with_COVID_19_.94416.aspx</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +: Multiple tissue samples were obtained during emergent abdominal surgery in four patients with coronavirus disease 2019 (COVID-19) to examine for tissue involvement by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The first patient underwent a laparoscopic cholecystectomy for gallbladder empyema and died from severe respiratory failure. The second patient with Crohn'​s disease underwent emergent laparotomy for a perforation in the terminal ileum and recovered. The third patient underwent an open appendectomy and recovered. The fourth patient underwent emergent laparotomy for a perforated peptic ulcer and died from sepsis. While the SARS-CoV-2 RNA was found in the feces of three patients and in the duodenal wall of the patient with perforated peptic ulcer, RT-PCR examination of abdominal fluid was negative for the virus. The RT-PCR did not detect viral RNA in the wall of small intestine, appendix, and gallbladder,​ bile, liver, and urine. Visceral fat (omentum) and abdominal subcutaneous fat of four patients were also not infected with the SARS-CoV-2. Although this limited experience did not show direct involvement of abdominal fluid and omentum, assessment in large series is suggested to provide answers about the safety of abdominal surgery in patients with COVID-19.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[614] Title: </​b>​Clinical Characteristics of Metastatic Prostate Cancer Patients Infected with COVID-19 in South Italy.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-22<​br>​
 +<​b>​Publisher:​ </​b>​Oncology (08909091)<​br>​
 +<​b>​Keywords:​ </​b>​Oncology And Carcinogenesis,​ comorbidities,​ coronavirus disease sars-cov-2, drug interaction,​ hormonal therapy, prostate cancer, Biochemistry,​ Genetics and Molecular Biology, Health Sciences, Life Sciences, Medicine<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.karger.com/​Article/​FullText/​509434">​https://​www.karger.com/​Article/​FullText/​509434</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +BACKGROUND: To date, the clinical characteristics of coronavirus disease 19 (COVID-19)-infected urologic cancer patients are unknown. METHODS: We have analyzed all patients with prostate cancer undergoing hormonal or chemotherapy treatment and receiving telephone and in person pre-triage between March 1 and 27, 2020, at the Tortora Hospital, Pagani, Italy. RESULTS: Among 72 patients, 48 and 24 were hormone-sensitive (HS) and castration-resistant prostate cancer (CRPC), respectively;​ 0 HS and 2 (8.3%) CRPC (p < 0.05) were positive for COVID-19. Both patients were receiving LHRH agonist therapy, and 1 patient was receiving enzalutamide. Urgent intensive care unit admission was required due to clinical worsening. Blood tests showed severe lymphopenia,​ anemia, and an increase in platelets. Retroviral therapy, antibiotics,​ heparin, and chloroquine were prescribed at the beginning. One patient also received tocilizumab as a salvage treatment. After 3 weeks of hospitalization,​ the patients were discharged from the hospital. Both patients suffered from an aggressive COVID-19 course due to concomitant comorbidities. CONCLUSIONS:​ Investigating whether hormonal therapy, especially in advanced disease, acts as a protective factor or a risk factor during COVID-19 could be useful.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[615] Title: </​b>​Mortality risk in post-operative head and neck cancer patients during the SARS-Cov2 pandemic: early experiences.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-22<​br>​
 +<​b>​Publisher:​ </​b>​European Archives of Oto-Rhino-Laryngology<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19, head and neck cancer, mortality, sars-cov2, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​link.springer.com/​article/​10.1007/​s00405-020-06138-w">​https://​link.springer.com/​article/​10.1007/​s00405-020-06138-w</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +PURPOSE: The objective of this report is to outline our early experience with head and neck cancer patients in a tertiary referral center, during the SARS-Cov2 pandemic, and to describe the poor outcomes of patients who acquired the infection. METHODS: In this case series from a single-center,​ national tertiary referral center for head and neck cancer we describe three consecutive head and neck cancer patients who contracted SARS-Cov2 during their inpatient stay. RESULTS: Of the three patients described in our case series that contracted SARS-Cov2, two patients died from SARS-Cov2 related illness. CONCLUSION: We have demonstrated the significant implications that SARS-Cov2 has on head and neck cancer patients, with 3 patients acquiring SARS-Cov2 in hospital, and 2 deaths in our that cohort. We propose a complete separation in the location of where these patients are being managed, and also dedicated non-SARS-Cov2 staff for their peri-operative management. LEVEL OF EVIDENCE: IV.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[616] Title: </b>A Primary Mediastinal Large B-Cell Lymphoma Patient With COVID-19 Infection After Intensive Immunochemotherapy:​ A Case Report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-22<​br>​
 +<​b>​Publisher:​ </​b>​Frontiers in oncology<​br>​
 +<​b>​Keywords:​ </b>, covid-19, chemotherapy,​ immunotherapy,​ lymphoma, myelosuppression<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.frontiersin.org/​articles/​10.3389/​fonc.2020.00924/​full">​https://​www.frontiersin.org/​articles/​10.3389/​fonc.2020.00924/​full</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Background: The outbreak of coronavirus disease 2019 (COVID-19) had become a global public health event. Lymphoma patients need to be distinguished from the general population because of their deficient immune status and intensive anti-tumor treatment. The impacts of cancer subtypes and treatment on COVID-19 infection are unclear. Case Presentation:​ We here report the case of a primary mediastinal large B-cell lymphoma patient who was infected with COVID-19 after intensive immunochemotherapy (DA-EPOCH-R). The patient developed a neutropenic fever during chemotherapy,​ and fever was persistent, although antibiotics were used. Initial chest CT was negative, and the patient received a throat swab test since the second CT showed evidence of pneumonia. With treatment with Arbidol Hydrochloride and LianHuaQingWen capsule, his COVID-19 was cured. Conclusions:​ To the best of our knowledge, this is the first report focusing on COVID-19 infection in a lymphoma patient undergoing intensive immunochemotherapy. For those patients being treated with immunochemotherapy in epidemic areas, a reduced dose intensity of intensive chemotherapy should be considered, and the effect of immunotherapies such as rituximab on COVID-19 infection should be considered. The impacts of anti-cancer treatment on COVID-19 infection need to be explored further.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[617] Title: </​b>​Alveolar macrophage dysfunction and cytokine storm in the pathogenesis of two severe COVID-19 patients.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-07-01<​br>​
 +<​b>​Publisher:​ </​b>​EBioMedicine<​br>​
 +<​b>​Keywords:​ </b>, alveolar macrophage, cytokine storm, pathology, sars-cov-2, covid-19<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2352396420302085">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2352396420302085</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +BACKGROUND: The novel coronavirus pneumonia COVID-19 caused by SARS-CoV-2 infection could lead to a serious of clinical symptoms and severe illness, including acute respiratory distress syndrome (ARDS) and fatal organ failure. We report the fundamental pathological investigation in the lungs and other organs of fatal cases for the mechanistic understanding of severe COVID-19 and the development of specific therapy in these cases. METHODS: The autopsy and pathological investigations of specimens were performed on bodies of two deceased cases with COVID-19. Gross anatomy and histological investigation by Hematoxylin and eosin (HE) stained were reviewed on each patient. Alcian blue/​periodic acid-Schiff (AB-PAS) staining and Masson staining were performed for the examinations of mucus, fibrin and collagen fiber in lung tissues. Immunohistochemical staining were performed on the slides of lung tissues from two patients. Real-time PCR was performed to detect the infection of SARS-CoV-2. Flow cytometry analyses were performed to detect the direct binding of S protein and the expression of ACE2 on the cell surface of macrophages. FINDINGS: The main pathological features in lungs included extensive impairment of type I alveolar epithelial cells and atypical hyperplasia of type II alveolar cells, with formation of hyaline membrane, focal hemorrhage, exudation and pulmonary edema, and pulmonary consolidation. The mucous plug with fibrinous exudate in the alveoli and the dysfunction of alveolar macrophages were characteristic abnormalities. The type II alveolar epithelial cells and macrophages in alveoli and pulmonary hilum lymphoid tissue were infected by SARS-CoV-2. S protein of SARS-CoV-2 directly bound to the macrophage via the S-protein-ACE2 interaction. INTERPRETATION:​ Infection of Alveolar macrophage by SARS-CoV-2 might be drivers of the "​cytokine storm",​ which might result in damages in pulmonary tissues, heart and lung, and leading to the failure of multiple organs . FUNDING: Shanghai Guangci Translational Medical Research Development Foundation, Shanghai, China.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[618] Title: </​b>​Are They Just Two Children COVID-19 Cases Confused With Flu?<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-05<​br>​
 +<​b>​Publisher:​ </​b>​Frontiers in Pediatrics<​br>​
 +<​b>​Keywords:​ </b>, covid-19, children, influenza, nucleic acid, serum antibody of sars-cov-2<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.frontiersin.org/​articles/​10.3389/​fped.2020.00341/​full">​https://​www.frontiersin.org/​articles/​10.3389/​fped.2020.00341/​full</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +COVID-19, an emerging infectious disease, has quickly spread all over the world. All human populations are susceptible to this disease. Here we present two pediatric COVID-19 cases, both of whom exhibited negative SARS-CoV-2 nucleic acid tests upon nasopharyngeal swab and were initially diagnosed with influenza A infection. COVID-19 was later confirmed in both patients by serum antibodies of SARS-CoV-2 and nucleic acid test on stool samples. Because children are susceptible to many respiratory pathogens, especially influenza, we concluded that children can be coinfected with multiple pathogens, and more attention should be paid to the exploration of SARS-CoV-2 during the pandemic of COVID-19. This report shows the possibility of misdiagnosis or missed diagnosis of children with COVID-19. We suggest that highly suspected pediatric COVID-19 cases with negative nucleic acid tests on nasopharyngeal swabs should be further checked by performing a nucleic acid test on stool samples and testing serum for antibodies against SARS-CoV-2.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[619] Title: </​b>​COVID-19 in Recent Heart Transplant Recipients: Clinicopathologic Features and Early Outcomes.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-24<​br>​
 +<​b>​Publisher:​ </​b>​Transplant Infectious Disease<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​tid.13382">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​tid.13382</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +BACKGROUND: The impact of COVID-19 on heart transplant (HTx) recipients remains unclear, particularly in the early post-transplant period. METHODS: We share novel insights from our experience in five HTx patients with COVID-19 (three within two-months post-transplant) from our institution at the epicenter of the pandemic. RESULTS: All five exhibited moderate (requiring hospitalization,​ n=3) or severe (requiring ICU and/or mechanical ventilation,​ n=2) illness. Both cases with severe illness were transplanted approximately six weeks before presentation and acquired COVID-19 through community spread. All five patients were on immunosuppressive therapy with mycophenolate mofetil (MMF) and tacrolimus and three that were transplanted within the prior two months were additionally on prednisone. The two cases with severe illness had profound lymphopenia with markedly elevated C-reactive protein, procalcitonin,​ and ferritin. All had bilateral ground-glass opacities on chest imaging. MMF was discontinued in all five, and both severe cases received convalescent plasma. All three recent transplants underwent routine endomyocardial biopsies, revealing mild (n=1) or no acute cellular rejection (n=2), and no visible viral particles on electron microscopy. Within 30 days of admission, the two cases with severe illness remain hospitalized but have clinically improved, while the other three have been discharged. CONCLUSIONS:​ COVID-19 appears to negatively impact outcomes early after heart transplantation.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +
 +</​html>​
oa_db/covid19_case_reports_abstracts_pg11.txt · Last modified: 2020/06/28 05:27 by bpwhite