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 +===== COVID-19 Case Reports Abstracts - Page 10 =====
  
 +[[oa_db:​covid19_case_reports_abstracts|Back to Table of Contents]]
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 +[[oa_db:​covid19_case_reports_abstracts_pg9|Page 9]] | [[oa_db:​covid19_case_reports_abstracts_pg11|Page 11]]
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 +----------------------------------------------------------------------<​br>​
 +<​b>​[532] Title: </​b>​Neuroleptic malignant syndrome in patients with COVID-19.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.5<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-01<​br>​
 +<​b>​Publisher:​ </​b>​American Journal of Emergency Medicine<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19, fever, neuroleptic malignant syndrome, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0735675720303843">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0735675720303843</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We report the first two cases of Coronavirus Disease 2019 (COVID-19) who were receiving intensive care including favipiravir,​ and were clinically diagnosed with neuroleptic malignant syndrome (NMS) to focus attention on NMS in COVID-19 management. Case 1: A 46-year-old-man with acute respiratory distress syndrome (ARDS) caused by COVID-19 infection was being administered favipiravir. Fentanyl, propofol, and rocuronium were also given. On day 3, midazolam administration was initiated for deep sedation. On day 5, his high body temperature increased to 41.2 degrees C, creatine kinase level elevated, and he developed tachycardia,​ tachypnea, altered consciousness,​ and diaphoresis. NMS was suspected, and supportive therapy was initiated. High-grade fever persisted for 4days and subsided on day 9. Case 2: A 44-year-old-man with ARDS caused by COVID-19 infection was being treated with favipiravir. On day 5, risperidone was started for delirium. On day 7, his body temperature suddenly increased to 40.8 degrees C, his CK level elevated, and he developed tachycardia,​ tachypnea, altered consciousness,​ and diaphoresis. NMS diagnosis was confirmed, and both, favipiravir and risperidone were discontinued on day 8. On the same day, his CK levels decreased, and his body temperature normalized on day 9. Patients with COVID-19 infection frequently require deep sedation and develop delirium; therefore, more attention should be paid to the development of NMS in patients who are being administered such causative agents. The mechanism underlying the occurrence of NMS in COVID-19 patients treated with favipiravir remains unknown. Therefore, careful consideration of NMS development is necessary in the management of COVID-19 patients.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[533] Title: </b>A case report with COVID-19 during perioperative period of lobectomy.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.5<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-29<​br>​
 +<​b>​Publisher:​ </​b>​Medicine<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​journals.lww.com/​md-journal/​FullText/​2020/​05290/​A_case_report_with_COVID_19_during_perioperative.26.aspx">​https://​journals.lww.com/​md-journal/​FullText/​2020/​05290/​A_case_report_with_COVID_19_during_perioperative.26.aspx</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +RATIONALE: Currently, COVID-19 has made a significant impact on many countries in the world. However, there have been no reported cases of pulmonary lobectomy with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) infection. We are the first to report such a case. PATIENT CONCERNS: We report a 63-year-old Wuhan male patient with smoking history of 40 cigarettes per day for 40 years. He sought medical consultation for right lower lung nodules found by CT scan. DIAGNOSES AND INTERVENTIONS:​ The patient'​s postoperative pathological diagnosis was squamous cell carcinoma of the right lower lung. On the fourth day after the operation, the real-time reverse transcription polymerase chain reaction test showed a positive result. After the operation, we routinely give symptomatic treatments such as anti-infection,​ nebulization and oxygen inhalation. We also change antibiotics several times depending on the patient'​s condition. OUTCOMES: The patient'​s condition continued to deteriorate. On the fifth day after surgery, the patient died despite medical treatment. LESSONS: We are the first to report the diagnosis and treatment process of patients with COVID-19 during perioperative period of lobectomy. It provides a case for the postoperative management of such patients.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[534] Title: </b>A 55-year-old COVID-19-positive man managed with self-regulation of high-flow oxygen by high-velocity nasal insufflation therapy.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.5<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-21<​br>​
 +<​b>​Publisher:​ </​b>​Respirology Case Reports<​br>​
 +<​b>​Keywords:​ </b>, covid-19, ppe, vapotherm, nasal insufflation,​ patient control<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​rcr2.591">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​rcr2.591</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Management of critically ill coronavirus disease 2019 (COVID-19) patients remains both risky and technically challenging. A 55-year-old male COVID-19-positive patient with obstructive sleep apnoea (OSA), diabetes, and obesity presented with cough and shortness of breath, escalating to requiring high-flow oxygen therapy by high-velocity nasal insufflation. The patient'​s flow rate and oxygen fraction remained labile throughout much of the hospitalization. This lability required frequent clinician interactions and use of personal protective equipment. The patient was alert and oriented and was instructed on the operation of the high-flow system, specifically the adjustment of both flow rate and oxygen percentage. The patient was instructed to modify oxygen to maintain an SpO2 (peripheral capillary oxygen saturation) target range, and flow rate to address dyspnoea as well as reduction of flow as tolerated when other staff entered the room. The patient was successfully self-regulated for 10 days and was discharged on 2 L/min nasal cannula on day 14 of his illness.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[535] Title: </​b>​Failed antibody response in a renal transplant recipient with SARS-CoV-2 infected.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.5<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-25<​br>​
 +<​b>​Publisher:​ </​b>​Transplant Infectious Disease<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​tid.13349">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​tid.13349</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +In late December 2019, severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) has been identified as a novel pathogen causing Coronavirus Disease 2019 (COVID-19) in Wuhan, China, subsequently spread to the rest of China and has been demonstrating a rapid global spread. Nucleic acid testing (NAT, tested by real-time polymerase chain reaction) of SARS-CoV-2 virus in oropharyngeal/​nasal swab samples has been described to be extremely sensitive for the diagnose of SARS-CoV-2 infection, but false-negative results have been reported. Recent months, researches demonstrated the importance of IgM/IgG antibody detecting due to the unsatisfied positive rate of NAT, and the increasement IgM/IgG antibody was considered as a confirmed criteria of diagnosis in the official guides of the diagnosis and treatment of COVID-19 in China (7(th) Edition) .<br>
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[536] Title: </​b>​Gross and histopathological pulmonary findings in a COVID-19 associated death during self-isolation.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.5<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-05<​br>​
 +<​b>​Publisher:​ </​b>​International Journal of Legal Medicine<​br>​
 +<​b>​Keywords:​ </​b>​Other Chemical Sciences, covid-19, coronavirus,​ diffuse alveolar damage, forensic autopsy, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​link.springer.com/​article/​10.1007/​s00414-020-02319-8">​https://​link.springer.com/​article/​10.1007/​s00414-020-02319-8</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Forensic investigations generally contain extensive morphological examinations to accurately diagnose the cause of death. Thus, the appearance of a new disease often creates emerging challenges in morphological examinations due to the lack of available data from autopsy- or biopsy-based research. Since late December 2019, an outbreak of a novel seventh coronavirus disease has been reported in China caused by "​severe acute respiratory syndrome coronavirus 2" (SARS-CoV-2). On March 11, 2020, the new clinical condition COVID-19 (Corona-Virus-Disease-19) was declared a pandemic by the World Health Organization (WHO). Patients with COVID-19 mainly have a mild disease course, but severe disease onset might result in death due to proceeded lung injury with massive alveolar damage and progressive respiratory failure. However, the detailed mechanisms that cause organ injury still remain unclear. We investigated the morphological findings of a COVID-19 patient who died during self-isolation. Pathologic examination revealed massive bilateral alveolar damage, indicating early-phase "acute respiratory distress syndrome"​ (ARDS). This case emphasizes the possibility of a rapid severe disease onset in previously mild clinical condition and highlights the necessity of a complete autopsy to gain a better understanding of the pathophysiological changes in SARS-CoV-2 infections.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[537] Title: </​b>​COVID-19 in a severe eosinophilic asthmatic receiving benralizumab - a case study.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.5<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-18<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Asthma<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, acq-6, act, il-5, il-5r, monoclonal antibody, sars-cov-2, asthma control, asthma control questionnaire 6-item scale, asthma control test, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.tandfonline.com/​doi/​full/​10.1080/​02770903.2020.1781165">​https://​www.tandfonline.com/​doi/​full/​10.1080/​02770903.2020.1781165</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Introduction:​ Only little is known about COVID-19 in patients with asthma. There is no data on COVID-19 in patients with severe asthma or patients with asthma who are treated with monoclonal antibodies.Case Study: Here, we present the case of a severe eosinophilic asthmatic in whom benralizumab treatment, an anti-IL-5R monoclonal antibody, was initiated 2 years ago. Prior to benralizumab treatment, every viral infection had resulted in a prolonged course of oral corticosteroids (OCS). Since initiation of benralizumab,​ the patient has had good asthma control. Mid-March 2020, the patient developed high fever.Results:​ A SARS-CoV-2-PCR (nasopharyngeal swab) was positive. The patient'​s symptoms subsided after few days. No OCS was needed. The asthma control questionnaire 6-item scale worsened moderately in the week of the infection and returned to normal levels thereafter. The asthma control test, measuring longer term asthma control, showed no decline.Conclusion:​ The course of COVID-19 was very mild in this particular patient with severe eosinophilic asthma. So far, there is no evidence that would suggest a more severe course of COVID-19 in patients with asthma. It is worth noting, that prior to the initiation of benralizumab this patient had multiple exacerbations per year triggered by viral infections (4/year), which all required OCS. Whilst only anecdotal, this case study provides the first evidence to support the current recommendation of continuing monoclonal antibodies in patients with severe asthma during the COVID-19 pandemic.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[538] Title: </​b>​Incidental COVID-19 Pneumonia on 18F-Fluorocholine PET/​CT.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.5<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-08<​br>​
 +<​b>​Publisher:​ </​b>​Clinical Nuclear Medicine<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​doi.org/​10.1097/​rlu.0000000000003189">​https://​doi.org/​10.1097/​rlu.0000000000003189</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We present the case of a patient who underwent F-fluorocholine PET/CT for biochemical recurrence of prostate cancer in which bilateral pneumonia was diagnosed. In the current state of COVID-19 pandemic, a high prevalence of incidental pneumonia may be expected, even with previous clinical triage, explained by a nondefined number of patients who were asymptomatic or minimally symptomatic for infectious process. Therefore, nuclear medicine physicians should be prepared to recognize and diagnose incidental COVID-19 pneumonia manifestation on F-fluorocholine PET/CT, due to the crucial epidemiological implications.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[539] Title: </​b>​Thoracoscopic Bullectomy for Persistent Air Leak in a 14-Year-Old Child with COVID-19 Bilateral Pulmonary Disease.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.5<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-11<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Laparoendoscopic & Advanced Surgical Techniques<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, sars-cov-2, coronavirus,​ lung, minimally invasive surgery, pneumothorax,​ thoracoscopy,​ Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.liebertpub.com/​doi/​10.1089/​lap.2020.0289">​https://​www.liebertpub.com/​doi/​10.1089/​lap.2020.0289</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Introduction:​ Thoracic surgery in children with coronavirus disease-19 (COVID-19) pulmonary disease is rare, as very limited virus-related lung lesions require intervention. However, some patients may suffer from other pulmonary abnormalities that can be worsened by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and they may consequently require lung surgery. COVID-19 affects the indications,​ surgical procedure, and postsurgical care of these patients. Background: We present a case of a 14-year-old girl with COVID-19 pulmonary disease and persistent air leak due to right apical bullae that required resection. Clinical, surgical, and safety implications are discussed. The role of thoracic minimally invasive surgery under COVID-19 conditions is also analyzed. Materials and Methods: The thoracoscopic procedure was scheduled earlier than normally expected. The surgery was performed in a COVID-19 reserved theatre with neutral pressure and only the necessary personnel was allowed inside. The use of the required personal protective equipment was supervised by an expert nurse before and after the intervention. Results: The surgeons used a three-port technique to resect the bullae with an endostapler and no mechanical pleural abrasion was added to the procedure. Electrocautery and CO2 insufflation were avoided, and a chest drain with a closed-circuit aspiration system was installed before removing the ports. The child was discharged home 3 days later after the removal of the chest drain. Conclusions:​ COVID-19 has an impact on the standard indications,​ surgical strategies and postoperative care of some conditions requiring intervention. Extra safety measures are needed in the operating room to limit the chance of transmission. Minimally invasive surgery for thoracic surgery remains safe if the current safety guidelines are followed closely.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[540] Title: </​b>​Duration of viral shedding in asymptomatic or mild cases of novel coronavirus disease 2019 (COVID-19) from a cruise ship: A single-hospital experience in Tokyo, Japan.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.5<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-01<​br>​
 +<​b>​Publisher:​ </​b>​International Journal of Infectious Diseases<​br>​
 +<​b>​Keywords:​ </​b>​Microbiology,​ asymptomatic,​ coronavirus disease 2019, polymerase chain reaction., severe acute respiratory syndrome coronavirus 2, viral shedding, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S1201971220304562">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S1201971220304562</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),​ which is the cause of novel coronavirus disease 2019 (COVID-19) first reported in Wuhan, China, has spread across the world, and has been characterized as a global pandemic. The propagation from asymptomatic polymerase chain reaction (PCR)-positive individuals represents a complicating factor in the efforts to control the COVID-19 pandemic. We examined the course of PCR assays and duration of viral shedding in 23 asymptomatic or mild COVID-19 patients from the cruise ship who were admitted to our hospital. Among these 23 cases, the median duration of viral shedding was 19 days (range, 6-37 days) from initial viral detection. Eight cases (35%) had another positive PCR result after testing negative once. Although the duration of viral shedding was approximately 3 weeks, the infectivity and transmissibility period from asymptomatic and mild COVID-19 cases is unclear. Further studies are needed to determine how long such asymptomatic and mild COVID-19 cases have the infectivity.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[541] Title: </​b>​Mechanical Ventilation in Pregnancy Due to COVID-19: A Cohort of Three Cases.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.5<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-16<​br>​
 +<​b>​Publisher:​ </​b>​American Journal of Perinatology<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.thieme-connect.de/​products/​ejournals/​abstract/​10.1055/​s-0040-1713664">​https://​www.thieme-connect.de/​products/​ejournals/​abstract/​10.1055/​s-0040-1713664</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We describe our experience with three pregnant women with novel coronavirus disease 2019 (COVID-19) who required mechanical ventilation. Recent data suggest a mortality of 88% in nonpregnant patients with COVID-19 who require intubation and mechanical ventilation. The three women we report were intubated and mechanically ventilated during pregnancy due to respiratory failure and pneumonia resulting from COVID-19. After several days of ventilation,​ all three were successfully weaned off mechanical ventilation and extubated, and are continuing their pregnancies with no demonstrable adverse effects. Our experience suggests that the mortality in pregnant women with COVID-19 requiring mechanical ventilation is not necessarily as high as in nonpregnant patients with COVID-19. KEY POINTS: . Coronavirus disease 2019 (COVID-19) is now a pandemic.. . COVID-19 may cause pneumonia or respiratory failure in pregnant women.. . Approximately 5% of women with COVID-19 will develop severe or critical disease.. . Mechanical ventilation in pregnant women may not necessarily result in high mortality rates..<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[542] Title: </​b>​COVID-19 Neurologic Complication with CNS Vasculitis-Like Pattern.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.5<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-18<​br>​
 +<​b>​Publisher:​ </​b>​American Journal of Neuroradiology<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​http://​www.ajnr.org/​content/​early/​2020/​06/​18/​ajnr.A6651">​http://​www.ajnr.org/​content/​early/​2020/​06/​18/​ajnr.A6651</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Coronavirus disease 2019 (COVID-19) is a viral infection caused by the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2),​ which spreads rapidly from person to person and manifests in most symptomatic patients as a respiratory illness, similar to prior SARS viruses. Neurologic manifestations of COVID-19 are uncommon; those so far reported include encephalopathy,​ stroke from large-vessel occlusion, and polyneuropathy. We report a unique neurologic complication of COVID-19 in a patient who had extensive cerebral small-vessel ischemic lesions resembling cerebral vasculitis in a characteristic combined imaging pattern of ischemia, hemorrhage, and punctuate postcontrast enhancement. Also, a characteristic lower extremity skin rash was present in our patient. Our observation lends support to the increasingly suspected mechanism of "​endotheliitis"​ associated with this novel coronavirus.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[543] Title: </​b>​COVID-19 cardiac involvement in a 38-day old infant.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.5<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-18<​br>​
 +<​b>​Publisher:​ </​b>​Pediatric Pulmonology<​br>​
 +<​b>​Keywords:​ </​b>​Paediatrics And Reproductive Medicine, sars-cov-2, coronavirus disease 2019, heart, inflammation,​ severe acute respiratory syndrome coronavirus 2, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​ppul.24895">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​ppul.24895</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The spectrum of clinical manifestations of coronavirus disease 2019 in children is yet to be fully elucidated. We report the case of an infant who tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and developed mild cardiovascular inflammation,​ a novelty for patients of very young age, that contributes to defining the puzzling nature of this disease in pediatric patients. The potential cardiovascular involvement of SARS-CoV-2 in children should always be taken into account.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[544] Title: </b>A case of an Infant with SARS-CoV-2 hepatitis early after liver transplantation.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.5<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-25<​br>​
 +<​b>​Publisher:​ </​b>​Pediatric Transplantation<​br>​
 +<​b>​Keywords:​ </​b>​Paediatrics And Reproductive Medicine, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​petr.13778">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​petr.13778</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We present a case of a pediatric liver transplant recipient diagnosed with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection four days after receiving a living donor liver allograft from her mother. The recipient was a 6-month-old with end stage liver disease due to biliary atresia and failed Kasai. The infant had an uncomplicated implantation,​ excellent graft function and down-trending liver enzymes until developing fevers, diarrhea and moderate respiratory distress requiring non-invasive respiratory support. SARS-CoV-2 testing (nasal swab Polymerase Chain Reaction) was positive on post-operative day (POD) 4. Liver enzymes peaked ~ 1000 U/L (5-fold higher than the previous day) on POD 6. Histology demonstrated a mixed picture of moderate acute hepatitis and classical elements of mild to moderate acute cellular rejection. Her hepatitis and respiratory symptoms improved coincident with completing treatment with hydroxychloroquine,​ reduced immunosuppression and intravenous gamma globulin (IVIG).<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[545] Title: </b>A complex COVID-19 case with rheumatoid arthritis treated with tocilizumab.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.5<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-19<​br>​
 +<​b>​Publisher:​ </​b>​Clinical Rheumatology<​br>​
 +<​b>​Keywords:​ </​b>​Medicine & Public Health, coronavirus disease 2019, rheumatoid arthritis, secondary opportunistic infection, tocilizumab,​ Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​link.springer.com/​article/​10.1007/​s10067-020-05234-w">​https://​link.springer.com/​article/​10.1007/​s10067-020-05234-w</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Recurrences of COVID-19 were observed in a patient with long-term usage of hydroxychloroquine,​ leflunomide,​ and glucocorticoids due to her 30-year history of rheumatoid arthritis (RA). Tocilizumab was applied and intended to target both COVID-19 and RA. However, disease of this patient aggravated after usage of tocilizumab. After the discussion of a multiple disciplinary team (MDT) including rheumatologists,​ antimicrobial treatments were applied to target the potential opportunistic infections (Pneumocystis jirovecii and Aspergillus fumigatus), which were authenticated several days later via high throughput sequencing. As an important cytokine in immune responses, IL-6 can be a double-edged sword: interference in the IL-6-IL-6 receptor signaling may save patients from cytokine release storm (CRS), but can also weaken the anti-infectious immunity, particularly in rheumatic patients, who may have received a long-term treatment with immunosuppressive/​modulatory agents. Thus, we suggest careful considerations before and close monitoring in the administration of tocilizumab in rheumatic patients with COVID-19. Besides tocilizumab,​ several disease-modifying antirheumatic drugs (DMARDs) can also be applied in the treatment of COVID-19. Therefore, we also reviewed and discussed the application of these DMARDs in COVID-19 condition.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[546] Title: </​b>​Case series and review of liver dysfunction in COVID-19 patients.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.5<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-19<​br>​
 +<​b>​Publisher:​ </​b>​European journal of gastroenterology & hepatology<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​journals.lww.com/​eurojgh/​Abstract/​9000/​Case_series_and_review_of_liver_dysfunction_in.97529.aspx">​https://​journals.lww.com/​eurojgh/​Abstract/​9000/​Case_series_and_review_of_liver_dysfunction_in.97529.aspx</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Coronoviraus disease 2019 (COVID-19) has infected over two million people worldwide and the number keeps growing every day. While the pulmonary complications of COVID-19 are obvious, the effect of the virus on the other organs and the chronicity of the organ dysfunction remain unknown. The virus causes a debilitating infection with multiorgan injury and has a high mortality rate estimated to be around 3.70%. Several hypotheses are formulated to explain the liver dysfunction in COVID-19 patients which include collateral damage from cytokine storm, drug-induced liver injury, viral-induced hepatitis and hypoxia-induced damage. Through this case series, we would like to highlight that liver enzyme abnormalities are often seen in COVID-19 patients and would like to highlight that physicians need to serially monitor biochemical testing until the liver enzymes return to baseline. Physicians also need to be vigilant of liver enzyme abnormalities in these patients, especially before starting new medications.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[547] Title: </​b>​Three Novel COVID-19 Pneumonia Cases Successfully Treated With Lopinavir/​Ritonavir.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.5<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-19<​br>​
 +<​b>​Publisher:​ </​b>​Frontiers in Medicine<​br>​
 +<​b>​Keywords:​ </b>, covid-19, lopinavir, ritonavir, cruise ship, elderly patient, hyponatremia<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.frontiersin.org/​articles/​10.3389/​fmed.2020.00241/​full">​https://​www.frontiersin.org/​articles/​10.3389/​fmed.2020.00241/​full</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Following the first case of Coronavirus Disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-Cov-2),​ in Wuhan, China, in December 2019, it has spread worldwide. An outbreak in Japan occurred on a cruise ship, and this was followed by community-acquired COVID-19. Herein, we report three cases of COVID-19 that presented pneumonia following admission to Kitasato University Hospital. Patients were admitted based on the positive result of real-time reverse transcriptase-polymerase chain reaction (RT-PCR) tests for COVID-19 nucleic acid. All patients were diagnosed as suffering from non-severe COVID-19 pneumonia and were successfully treated with Lopinavir/​Ritonavir (LPV/r). LPV/r could be an option for treating non-severe COVID-19 pneumonia in general and even in elderly patients.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[548] Title: </b>A 95-year-old patient with unexpected coronavirus disease 2019 masked by aspiration pneumonia: a case report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.5<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-23<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Medical Case Reports<​br>​
 +<​b>​Keywords:​ </​b>​Other Medical And Health Sciences, covid-19, elderly, older, pneumonia, sars-cov-2, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​jmedicalcasereports.biomedcentral.com/​articles/​10.1186/​s13256-020-02432-7">​https://​jmedicalcasereports.biomedcentral.com/​articles/​10.1186/​s13256-020-02432-7</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +BACKGROUND: Severe acute respiratory syndrome coronavirus-2 infection has become a pandemic disease (coronavirus disease 2019). The infection has moved from China to the rest of the world and Italy represents one of the most affected countries. Older adults are more susceptible to develop complications with the consequent highest mortality rates. CASE PRESENTATION:​ We report a case of a 95-year-old Caucasian woman affected by pneumonia, initially defined as common aspiration pneumonia in a bedridden patient with vascular dementia, which later turned out to be coronavirus disease 2019 pneumonia during the initial spread of severe acute respiratory syndrome coronavirus-2 in our district. Some features of a computed tomography scan of her chest and her clinical history with known dysphagia had led at first to a different diagnosis with a consequent exposure of health professionals to infectious risk in two distinct hospitals. In this case report, we describe the clinical/​imaging features of coronavirus disease 2019 pneumonia and the diagnostic process that led to a correct diagnosis in a nonagenarian with multiple comorbidities. CONCLUSIONS:​ This case report highlights both the possible pitfalls in diagnosing coronavirus disease 2019 pneumonia in very old patients with comorbidities and the greater than expected spread of the infection, even in individuals with reduced interpersonal contacts and no defined epidemiological link.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[549] Title: </b>A familial cluster, including a kidney transplant recipient, of Coronavirus Disease 2019 (COVID-19) in Wuhan, China.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-17<​br>​
 +<​b>​Publisher:​ </​b>​American Journal of Transplantation<​br>​
 +<​b>​Keywords:​ </​b>​Medical And Health Sciences, covid-19, kidney, novel coronavirus,​ pneumonia, transplantation,​ treatment, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​ajt.15903">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​ajt.15903</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +In December 2019, an outbreak of COVID-19 occurred in Wuhan, China, and spread to the whole of China and to multiple countries worldwide. Unlike SARS and MERS, where secondary transmission mostly occurred in hospital settings, COVID-19 transmission occurs in large numbers within families. Herein we report three cases of a familial cluster with one family member being a kidney transplant recipient. The initial clinical symptoms of COVID-19 in these three patients were the same, but their progression was different. Based on the severity of clinical symptoms, chest computer tomography findings and SARS-Cov-2 RNA test results, we admitted the husband to the respiratory intensive care unit (RICU) and used a treatment consisting of immunosuppressant reduction/​cessation and low dose methylprednisolone-based therapy, and his wife to the respiratory isolation ward. In contrast, the son received in-home isolation and home-based care. All three family members made a full recovery.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[550] Title: </​b>​Dynamic Chest CT Evaluation in Three Cases of 2019 Novel Coronavirus Pneumonia.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-01<​br>​
 +<​b>​Publisher:​ </​b>​Archives of Iranian Medicine (AIM)<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, 2019-novel coronavirus pneumonia, chest computed tomography, clinical characteristics,​ coronavirus disease 2019, dynamic evaluation, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​http://​www.aimjournal.ir/​Article/​aim-15643">​http://​www.aimjournal.ir/​Article/​aim-15643</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +A recent outbreak of pneumonia in Wuhan, China, was caused by the 2019 novel coronavirus (2019-nCoV). There have been some reports of imaging findings regarding the disease'​s characteristic features. Here, we report three cases of coronavirus disease 2019 (COVID-19) with dynamic pulmonary CT evaluation. The CT scan showed multiple regions of ground-glass opacities and patchy consolidation in COVID-19 patients and the CT scan was useful in tracking the progression or regression of COVID-19.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[551] Title: </​b>​Influenza-like illnesses caused by a cluster of imported Italian COVID-19.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-13<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Medical Virology<​br>​
 +<​b>​Keywords:​ </​b>​Medical Microbiology,​ covid-19, imported italian cases, influenza-like illness, Health Sciences, Life Sciences, Medicine, Immunology and Microbiology<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​resolve/​doi?​DOI=10.1002/​jmv.25869">​https://​onlinelibrary.wiley.com/​resolve/​doi?​DOI=10.1002/​jmv.25869</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The ongoing pandemic of 2019 corona-virus disease (COVID-19) is caused by an emerging family of SARS-CoV-2, threatening human health worldwide. Here we report a cluster of Italian COVID-19 imported to Lishui City, China. Of all the eight patients, 7 consistently display cough, a representative sign of influenza-like illness (ILI), and the remaining one is a cryptic case. This further our understanding a full spectrum of COVID-19 repertoire. This article is protected by copyright. All rights reserved.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[552] Title: </​b>​[Bronchoalveolar lavage fluid was used to diagnose two cases of 2019-nCoV infection].<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-12<​br>​
 +<​b>​Publisher:​ </​b>​Zhonghua jie he he hu xi za zhi Zhonghua jiehe he huxi zazhi Chinese journal of tuberculosis and respiratory diseases<​br>​
 +<​b>​Keywords:​ </b>, 2019-ncov, bronchoalveolar lavage fluid, throat swab, viral nucleic acid testing, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​http://​journal.yiigle.com/​PartnerAdmin/​HttpError/​NotFound">​http://​journal.yiigle.com/​PartnerAdmin/​HttpError/​NotFound</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The case reports 2 cases of novel coronavirus pneumonia diagnosed by concurrent bronchoalveolar lavage in our hospital, 1 case had a history of epidemiology,​ clinical symptoms and high imaging suspicion, but repeated negative throat swabs. One patient was diagnosed 2019-nCoV. Before the patient was discharged, the clinical symptoms disappeared,​ the chest CT showed significant improvement,​ and the pharynx swab was twice negative, reaching the discharge standard.We detected the ORF 1ab gene, the N gene and the nucleic acid of the new coronavirus in the broncho-alveolar lavage fluid of 2 patients. The results showed that the positive rate of bronchoalveolar lavage for detection of new coronavirus nucleic acid was high, and bronchoalveolar lavage for suspected or confirmed new coronavirus pneumonia patients with negative detection of nucleic acid in pharynx swabs but still residual lung lesions was helpful for early diagnosis, treatment and prognosis.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[553] Title: </​b>​Coronavirus-19 disease (COVID-19): A case series of early suspected cases reported and the implications towards the response to the pandemic in Zimbabwe.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-01<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Microbiology,​ Immunology and Infection<​br>​
 +<​b>​Keywords:​ </​b>​Immunology,​ africa, covid-19, coronavirus,​ emergency preparedness and response, zimbabwe, Health Sciences, Life Sciences, Medicine, Immunology and Microbiology<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S1684118220300967">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S1684118220300967</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Zimbabwe is among the countries that have been identified to be at risk of the COVID-19 pandemic. As of the 15(th) of March 2020, there was no confirmed case of the virus. Official reports of suspected cases were used to appraise the general screening, case management, and the emergency preparedness and response of the country towards the COVID-19 pandemic. In terms of the surveillance and capacity to screen at the ports of entry, the country seems to be faring well. The country might not be screening optimally, considering the number of COVID-19 tests conducted to date and the suspected cases who missed testing. Three of the suspected cases faced mental, social, and psychological consequences due to them being suspected cases of COVID-19. There is a need to enhance the screening process and infrastructure at all the ports of entry. More COVID-19 diagnostic tests should be procured to increase the testing capacity. Training and awareness on mental, social, and psychological consequences of COVID-19 should be offered to the health care workers and the general public. More financial resources should be sourced to enable the country control the pandemic.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[554] Title: </​b>​CT imaging of the COVID-19.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-01<​br>​
 +<​b>​Publisher:​ </​b>​Journal of the Formosan Medical Association<​br>​
 +<​b>​Keywords:​ </​b>​Medical And Health Sciences, covid-19, computed tomography, imaging, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S092966462030142X">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S092966462030142X</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +COVID-19 pneumonia presented with certain characteristic chest CT imaging features, which are helpful to the radiologist in the early detection and diagnosis of this emerging global health emergency. In this report, we present chest CT findings from five patients with COVID-19. Except for one case with normal lung appearance, all the other four cases had certain characteristics,​ including ground-glass opacity (GGO), consolidation and atoll sign. The lesions were mainly distributed in the peripheral portion of lung.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[555] Title: </​b>​Small Solitary Ground-Glass Nodule on CT as an Initial Manifestation of Coronavirus Disease 2019 (COVID-19) Pneumonia.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-01-01<​br>​
 +<​b>​Publisher:​ </​b>​Korean Journal of Radiology<​br>​
 +<​b>​Keywords:​ </b>, covid-19, ground-glass,​ pneumonia, viral, solitary pulmonary nodule, tomography, x-ray computed, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​kjronline.org/​DOIx.php?​id=10.3348/​kjr.2020.0240">​https://​kjronline.org/​DOIx.php?​id=10.3348/​kjr.2020.0240</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The 2019 novel coronavirus (2019-nCoV) outbreak in Wuhan, Hubei Province, China in 2019 led to large numbers of people being infected and developing atypical pneumonia (coronavirus disease 2019, COVID-19). Typical imaging manifestations of patients infected with 2019-nCoV has been reported, but we encountered an atypical radiological manifestation on baseline computed tomography (CT) images in three patients from Wuhan, China infected with the 2019-nCoV. Surprisingly,​ the only similar CT finding was a solitary sub-centimeter ground-glass nodule adjacent to bronchovascular bundles, which could be easily overlooked. In addition, the follow-up images in these patients showed how COVID-19 pneumonia evolved from these small nodules. The radiologic manifestation of the three cases will expand contemporary understanding of COVID-19.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[556] Title: </​b>​Coronavirus Disease 2019 (COVID-19) Complicated by Acute Respiratory Distress Syndrome: An Internist'​s Perspective.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-03-31<​br>​
 +<​b>​Publisher:​ </​b>​Cureus<​br>​
 +<​b>​Keywords:​ </b>, acute respiratory distress syndrome, ards, coronavirus disease 2019, corticosteroids,​ covid-19, nebulizer, pandemic<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.cureus.com/​articles/​29830-coronavirus-disease-2019-covid-19-complicated-by-acute-respiratory-distress-syndrome-an-internists-perspective">​https://​www.cureus.com/​articles/​29830-coronavirus-disease-2019-covid-19-complicated-by-acute-respiratory-distress-syndrome-an-internists-perspective</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +A pandemic outbreak of a novel coronavirus disease (COVID-19) that began in Wuhan, China, in December 2019 has spread rapidly to multiple countries. In the United States, the first confirmed case was reported on January 20, 2020, and since then, the number of cases is rising exponentially on a daily basis. We report a case of COVID-19 infection that presented with symptoms suggestive of pneumonia. Due to the major backlog with an immense number of pending tests, it took 48 hours for the result to come back positive, while the patient went into acute respiratory distress syndrome. We provide an internist'​s perspective of the difficulties encountered in terms of the available management options, as the patient progressively deteriorated on the regular medical floor prompting transfer to the intensive care unit.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[557] Title: </​b>​The novel coronavirus (COVID-19) pneumonia with negative detection of viral ribonucleic acid from nasopharyngeal swabs: a case report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-30<​br>​
 +<​b>​Publisher:​ </​b>​BMC Infectious Diseases<​br>​
 +<​b>​Keywords:​ </​b>​Microbiology,​ bronchoalveolar-lavage fluid, covid-19, coronavirus,​ pneumonia, tracheoscopy,​ Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​bmcinfectdis.biomedcentral.com/​articles/​10.1186/​s12879-020-05045-z">​https://​bmcinfectdis.biomedcentral.com/​articles/​10.1186/​s12879-020-05045-z</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +BACKGROUND: The novel coronavirus disease 2019 (COVID-19) outbreak started in Wuhan, Hubei, China since Dec 2019 and cases of infection have been continuously reported in various countries. It is now clear that the SARS-COV-2 coronavirus is transmissible from human to human. Nucleic acid detection is considered as the gold standard for the diagnosis of COVID-19. In this case report, we describe our experience in detection of SARS-COV-2 from a confirmed patient using nucleic acid test of bronchoalveolar-lavage fluid (BALF) samples but not nasopharyngeal swabs. CASE PRESENTATION:​ We present a case of severely ill SARS-COV-2 infected 46-year-old man with fever, coughing and chest tightness. We performed viral detection using his BALF samples and imaging method (CT) for confirmation. The patient received combination of interferonalfa-1b and ribavirin, lopinavir and ritonavir for antiviral treatment at different stages. Other medication was also given to him in combination for anti-inflammation,​ intestinal microbial regulation, phlegm elimination,​ liver protection and pulmonary fibrosis prevention purposes. We provided oxygen supply to him using BIPAP ventilator and high-flow humidification oxygen therapy instrument to facilitate respiration. The patient was cured and discharged. CONCLUSION: This case report described an effective supportive medication scheme to treat SARS-COV-2 infected patient and emphasized the necessity of detection of the viral genome using BALF samples and its significance in the diagnosis and prognosis of the disease.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[558] Title: </​b>​COVID-19 and clinical mimics. Correct diagnosis is the key to appropriate therapy.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-06<​br>​
 +<​b>​Publisher:​ </​b>​Monaldi archives for chest disease Archivio Monaldi per le malattie del torace<​br>​
 +<​b>​Keywords:​ </b>, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.monaldi-archives.org/​index.php/​macd/​article/​view/​1327">​https://​www.monaldi-archives.org/​index.php/​macd/​article/​view/​1327</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +As of 29 April 2020, across the globe, there are 3,216,353 confirmed Coronavirus disease 2019 (COVID-19 disease) with 227,894 deaths. The health care infrastructure of most of the countries is overwhelmed due to the gigantic upsurge of the new cases within a short time period. Most of the beds in the regular wards and critical care units are currently occupied by either people under investigation (PUI) or COVID-19 confirmed cases. We hereby discuss the challenges faced while approaching any case of shortness of breath, or other common upper respiratory symptoms during the current COVID-19 pandemic era.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[559] Title: </b>A child with household transmitted COVID-19.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-07<​br>​
 +<​b>​Publisher:​ </​b>​BMC Infectious Diseases<​br>​
 +<​b>​Keywords:​ </​b>​Microbiology,​ covid-19, children, sars-cov-2, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​bmcinfectdis.biomedcentral.com/​articles/​10.1186/​s12879-020-05056-w">​https://​bmcinfectdis.biomedcentral.com/​articles/​10.1186/​s12879-020-05056-w</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +BACKGROUND: Although people of all ages are susceptible to the novel coronavirus infection, which is presently named "​Coronavirus Disease 2019" (COVID-19), there has been relatively few cases reported among children. Therefore, it is necessary to understand the clinical characteristics of COVID-19 in children and the differences from adults. CASE PRESENTATION:​ We report one pediatric case of COVID-19. A 14-month-old boy was admitted to the hospital with a symptom of fever, and was diagnosed with a mild form of COVID-19. The child'​s mother and grandmother also tested positive for SARS-CoV-2 RNA. However, the lymphocyte counts were normal. The chest computed tomography (CT) revealed scattered ground glass opacities in the right lower lobe close to the pleura and resorption after the treatment. The patient continued to test positive for SARS-CoV-2 RNA in the nasopharyngeal swabs and stool at 17 days after the disappearance of symptoms. CONCLUSION: The present pediatric case of COVID-19 was acquired through household transmission,​ and the symptoms were mild. Lymphocyte counts did not significantly decrease. The RNA of SARS-CoV-2 in stool and nasopharyngeal swabs remained positive for an extended period of time after the disappearance of symptoms. This suggests that attention should be given to the potential contagiousness of pediatric COVID-19 cases after clinical recovery.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[560] Title: </​b>​Severe COVID-19 infection in pregnancy requiring intubation without preterm delivery: A case report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-07-01<​br>​
 +<​b>​Publisher:​ </​b>​Case Reports in Women'​s Health<​br>​
 +<​b>​Keywords:​ </b>, acute respiratory distress, covid-19, corona virus, intubation, maternal fetal medicine, pregnancy<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2214911220300473">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2214911220300473</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Background: Coronavirus-2019 (COVID-19) is a global health crisis, but there is limited guidance for the critical care management of pregnant patients experiencing respiratory collapse. We describe our management of a peri-viable pregnant patient requiring intubation; discussion includes pharmacologic interventions,​ mechanical ventilation adjustments,​ and consideration of fetal interventions,​ including delivery timing. Case: A 36-year-old,​ gravida 2, para 1 woman positive for COVID-19 at 23weeks of gestation with severe disease required admission to the intensive care unit and intubation. She completed 5days of hydroxychloroquine and 7days of prednisone. She was successfully intubated after 8days and discharged home in a stable condition without preterm delivery on hospital day 11. Conclusion: Fortunately,​ the patient responded to aggressive respiratory support with intubation and mechanical ventilation early upon presentation. It is unclear whether our institution'​s empiric use of hydroxychloroquine and prednisone facilitated her recovery. We hope that our report helps other institutions navigate the complex care surrounding pregnant patients with severe COVID-19 pneumonia requiring intensive care.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[561] Title: </​b>​SARS-CoV-2 Infection with Different Radiological Insights.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-07<​br>​
 +<​b>​Publisher:​ </​b>​Diagnostics<​br>​
 +<​b>​Keywords:​ </b>, acute respiratory distress syndrome, lung acute embolism, severe acute respiratory syndrome-coronavirus-2<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.mdpi.com/​2075-4418/​10/​5/​283">​https://​www.mdpi.com/​2075-4418/​10/​5/​283</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Severe acute respiratory syndrome-Coronavirus-2 (SARS-CoV-2) is a novel viral infection characterized by several symptoms range from mild to severe clinical conditions that could lead to death. We report two different radiological findings on computed tomography (CT) in two patients affected by SARS-CoV-2: a lung acute embolism (APE) in the first case and a radiological picture of acute respiratory distress syndrome (ARDS) in the second case. This is an important issue to be identified in order to provide more specific therapy earlier, including both antiviral and anti-inflammatory drugs associated with anti anticoagulant therapy.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[562] Title: </​b>​Successful COVID-19 rescue therapy by extra-corporeal membrane oxygenation (ECMO) for respiratory failure: a case report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-08<​br>​
 +<​b>​Publisher:​ </​b>​Patient Safety in Surgery<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19, coronavirus,​ extra-corporeal membrane oxygenation,​ lung injury, remdesivir treatment, sars-cov-2<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​pssjournal.biomedcentral.com/​articles/​10.1186/​s13037-020-00245-7">​https://​pssjournal.biomedcentral.com/​articles/​10.1186/​s13037-020-00245-7</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Background: The value of extracorporeal membrane oxygenation (ECMO) for patients suffering from novel coronavirus disease 2019 (COVID-19) as a rescue therapy for respiratory failure remains controversial and associated with high mortality rates of 50 to 82% in early reports from Wuhan, China. We hypothesized that patient outcomes would be improved at our tertiary cardiothoracic surgery referral center with a protocolized team-approach for ECMO treatment of patients with severe COVID-19 disease. Case presentation:​ A 51-year-old healthy female developed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) bilateral pneumonia while vacationing in Colorado with her family. She was transferred to our facility for a higher level of care. Her respiratory status continued to deteriorate despite maximized critical care, including prone positioning ventilation and nitric oxide inhalation therapy. Veno-venous ECMO was initiated on hospital day 7 in conjunction with a 10-day course of compassionate use antiviral treatment with remdesivir. The patient'​s condition improved significantly and she was decannulated from ECMO on hospital day 17 (ECMO day 11). She was successfully extubated and eventually discharged to rehabilitation on hospital day 28. Conclusion: This case report demonstrates a positive outcome in a young patient with COVID-19 treated by the judicious application of ECMO in conjunction with compassionate use antiviral treatment (remdesivir). Future prospective multi-center studies are needed to validate these findings in a larger cohort of patients.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[563] Title: </​b>​2019 novel coronavirus pneumonia with onset of dizziness: a case report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-01<​br>​
 +<​b>​Publisher:​ </​b>​Annals of Translational Medicine<​br>​
 +<​b>​Keywords:​ </b>, coronavirus pneumonia (cov), case report, diagnosis, dizziness, nervous system symptoms<​br>​
 +<​b>​DOI:​ </​b><​a href="​http://​atm.amegroups.com/​article/​view/​39774/​html">​http://​atm.amegroups.com/​article/​view/​39774/​html</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The 2019 novel coronavirus (2019-nCoV) epidemic continues, with the number of infections and deaths increasing. The respiratory tract is the main route of transmission of the virus, and the majority of symptoms are respiratory relative. Until now, there has been no reports concerning the nervous system onset. We present a 2019-nCoV patient with the onset of simple dizziness, accompanied by dry throat, no fever, no cough, no headache, no mental abnormality,​ and no obvious abnormality in the nuclear magnetic resonance imaging (MRI) of the head. Meanwhile, chest computed tomography (CT) scans showed multiple small spot shadows and interstitial changes in the early stage, especially in the extrapulmonary zone. There was a development of multiple ground-glass shadows and infiltrative shadows in both lungs with mild pleural effusion. The nucleic acid gene detection was positive, and thus the diagnosis of 2019-nCoV was confirmed. At last, the prognosis was good after active treatment. After antiviral and anti-infective treatment, the symptoms recovered. We presume that 2019-nCoV can also manifest in the nervous system alone, and lung CT, which has relative specificity,​ should be used as a routine screening method.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[564] Title: </​b>​First Case of Coronavirus Disease 2019 in Childhood Leukemia in China.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-12<​br>​
 +<​b>​Publisher:​ </​b>​The Pediatric Infectious Disease Journal<​br>​
 +<​b>​Keywords:​ </​b>​Paediatrics And Reproductive Medicine, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​journals.lww.com/​pidj/​FullText/​2020/​07000/​First_Case_of_Coronavirus_Disease_2019_in.32.aspx">​https://​journals.lww.com/​pidj/​FullText/​2020/​07000/​First_Case_of_Coronavirus_Disease_2019_in.32.aspx</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We report the first case of coronavirus disease 2019 (COVID-19) comorbid with leukemia in a patient hospitalized in Beijing, China. The patient showed a prolonged manifestation of symptoms and a protracted diagnosis period of COVID-19. It is necessary to extend isolation time, increase the number of nucleic acid detections and conduct early symptomatic treatment for children with both COVID-19 and additional health problems.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[565] Title: </​b>​Coronavirus disease 2019 in renal transplant recipients: report of two cases.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-16<​br>​
 +<​b>​Publisher:​ </​b>​Transplant Infectious Disease<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19, sars-cov-2, immunosuppressant,​ methylprednisolone,​ renal transplant recipient, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​tid.13329">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​tid.13329</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Coronavirus disease 2019 (COVID-19) has been a pandemic worldwide. The data about COVID-19 in renal transplant recipient is deficiency. Herein we report two COVID-19 cases in renal transplant recipients. Both cases were discharged following a treatment regimen including discontinued immunosuppressant and low-dose methylprednisolone-based therapy. There were no signs of rejection during the treatment. These successfully treated cases can provide helpful information about the management of COVID-19 in renal transplant recipients.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[566] Title: </​b>​Autopsy Report with Clinical Pathological Correlation.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-18<​br>​
 +<​b>​Publisher:​ </​b>​Archives of Pathology & Laboratory Medicine<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Medicine, Health Professions,​ Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.archivesofpathology.org/​doi/​10.5858/​arpa.2020-0217-SA">​https://​www.archivesofpathology.org/​doi/​10.5858/​arpa.2020-0217-SA</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Since making its debut on the global stage in December 2019, Coronavirus Disease 2019 (COVID-19) has afflicted nearly four million people and caused hundreds of thousands of deaths. Case reports and case series depicting the clinical effects of the causative virus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) have been published, yet few demonstrate the cytopathologic alterations of this disease. We present a clinical-pathological correlation report of a previously healthy Hispanic woman with laboratory-confirmed COVID-19 who had typical features of acute respiratory distress syndrome (ARDS), and also showed cardiac abnormalities thought to represent fulminant viral myocarditis. Congruent with the ARDS clinical impression, autopsy findings were remarkable for extensive and markedly severe acute lung injury consistent with viral pneumonia, characterized by diffuse alveolar damage, pulmonary infarction, severe pulmonary edema, desquamation of pneumocytes with intraalveolar aggregation,​ and pneumocyte morphological alterations suspicious for viral cytopathic effect. However, there was incongruence between the clinical impression and the cardiovascular pathology findings in that viral myocarditis was not detected on histopathologic evaluation. This case highlights the importance of pathologic corroboration of the clinical impression and, in addition, illuminates the key role autopsy plays during a pandemic by providing valuable insight into viral pathology in tissues.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[567] Title: </​b>​Interleukin-1 receptor antagonist anakinra in association with remdesivir in severe Coronavirus disease 2019: A case report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-01<​br>​
 +<​b>​Publisher:​ </​b>​International Journal of Infectious Diseases<​br>​
 +<​b>​Keywords:​ </​b>​Microbiology,​ anakinra, cytokine-release syndrome, interleukin-1 receptor antagonist, novel coronavirus disease 2019 (covid-19), remdesivir, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S120197122030357X">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S120197122030357X</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We report the first successful treatment with the IL-1 receptor antagonist anakinra, in association with the most promising and available antiviral therapy, of a severe case of novel coronavirus disease 2019 (COVID-19). We describe the diagnosis, clinical course, and management of the case, including the respiratory failure at presentation,​ the progression to a scenario characterized by profound inflammatory dysregulation similar to that observed during macrophage activation syndrome, and the clinical improvement after treatment with the IL-1 receptor antagonist anakinra. This case highlights the high tolerability and the interesting immunomodulatory profile of the IL-1 receptor antagonist anakinra in the setting of severe COVID-19 associated with remdesivir therapy. Further studies are needed to confirm the safety and efficacy of this combination strategy in the treatment of this emerging infection.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[568] Title: </​b>​Early manifestation of ARDS in COVID-19 infection in a 51- year-old man affected by Mounier-Kuhn Syndrome.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-01<​br>​
 +<​b>​Publisher:​ </​b>​Heart & Lung<​br>​
 +<​b>​Keywords:​ </​b>​Cardiovascular Medicine And Haematology,​ coivd-19, computed tomography, mounier-kuhn syndrome,​lung,​ Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0147956320302314">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0147956320302314</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We present the first patient of a 51-year-old man with fever, dyspnea and deterioration of his chronic coughs, who was referred to the Mounier-Kuhn syndrome (MKS). Chest computed tomography (CT) scan revealed increased diameter of his trachea (39 mm), right (30 mm) and left (26 mm) main bronchi, because of MKS. Then, COIVD-19 infection was eventually confirmed by RT-PCR. To our knowledge, COIVD-19 has not been reported in patients with the MKS.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[569] Title: </​b>​Encephalopathy as the Sentinel Sign of a Cortical Stroke in a Patient Infected With Coronavirus Disease-19 (COVID-19).<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-14<​br>​
 +<​b>​Publisher:​ </​b>​Cureus<​br>​
 +<​b>​Keywords:​ </b>, cerebrovascular accidents, coronavirus,​ coronavirus disease 2019, covid 19, cva, ischemic cva, ischemic stroke, mca, sars-cov-2, stroke systems of care<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.cureus.com/​articles/​32367-encephalopathy-as-the-sentinel-sign-of-a-cortical-stroke-in-a-patient-infected-with-coronavirus-disease-19-covid-19">​https://​www.cureus.com/​articles/​32367-encephalopathy-as-the-sentinel-sign-of-a-cortical-stroke-in-a-patient-infected-with-coronavirus-disease-19-covid-19</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The novel coronavirus has challenged medical systems worldwide to provide optimal medical care in the setting of limited resources. Although we are uncovering many facets of its disease spectrum, with rapidly emerging data, there is still limited knowledge of the sequelae of this infection, making treatment guidelines incomplete and resulting in serious unpredictable outcomes in patients at seemingly low risk, especially ones afflicted by neurological consequences. We present a case of a cortical stroke in a 31-year-old coronavirus disease-19 (COVID-19) positive female with otherwise no stroke risk factors. We noted a correlation between cytokine release, encephalopathy,​ and the onset of stroke symptoms. Patients with marked pro-thrombotic and inflammatory markers may benefit from closer neurological monitoring and thromboprophylaxis at therapeutic doses. The establishment of acute care pathways to manage critically ill patients with neurological consequences may reverse the suboptimal outcome trends seen during the pandemic.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[570] Title: </​b>​Encephalopathy in patients with COVID-19: '​Causality or coincidence?'<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-19<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Medical Virology<​br>​
 +<​b>​Keywords:​ </​b>​Medical Microbiology,​ coronavirus,​ nervous system, sars coronavirus,​ Health Sciences, Life Sciences, Medicine, Immunology and Microbiology<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​jmv.26027">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​jmv.26027</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The main tropism of the novel coronavirus disease 2019 (COVID-19) is respiratory. Increasing evidences show that SARS-CoV-2 is not always confined to the respiratory tract but can also invade the central nervous system (CNS) and induce neurological diseases. We report two cases illustrating this phenomenon. This article is protected by copyright. All rights reserved.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[571] Title: </​b>​SARS-CoV-2 identification in lungs, heart and kidney specimens by transmission and scanning electron microscopy.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-01<​br>​
 +<​b>​Publisher:​ </​b>​European review for medical and pharmacological sciences<​br>​
 +<​b>​Keywords:​ </b>, <br>
 +<​b>​DOI:​ </​b><​a href="​https://​www.europeanreview.org/​article/​21217">​https://​www.europeanreview.org/​article/​21217</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +From two COVID-19-related deaths, samples of lung, heart and kidney were collected and processed for Transmission and Scanning Electron Microscopy (TEM and SEM) with the aim of identifying the virus. Virions of SARS-CoV-2 were found in all tissues by TEM and SEM, corroborating the hypothesis that the virus enters the cells of different organs. This is the first report identifying SARS-CoV-2 in different human tissues by TEM and SEM.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[572] Title: </​b>​Cutaneous small vessel vasculitis secondary to COVID-19 infection: A case report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-22<​br>​
 +<​b>​Publisher:​ </​b>​Journal of the European Academy of Dermatology & Venereology<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19, cutaneous small vessel vasculitis, leukocytoclastic vasculitis, sars-cov-2, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​jdv.16670">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​jdv.16670</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We present a case of an 83-year-old woman with a history of hypertension,​ transient ischemic attack (TIA), atrial fibrillation,​ chronic renal impairment presented to our dermatology emergency room on April 9, 2020, for evaluation of purple palpable papules and serohaematic blisters on both her lower legs, feet and toes that had appeared 5 days earlier (Figure 1).<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[573] Title: </​b>​SARS-CoV-2 pneumonia with subcutaneous emphysema, mediastinal emphysema, and pneumothorax:​ A case report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-15<​br>​
 +<​b>​Publisher:​ </​b>​Medicine<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​journals.lww.com/​md-journal/​FullText/​2020/​05150/​SARS_CoV_2_pneumonia_with_subcutaneous_emphysema,​.61.aspx">​https://​journals.lww.com/​md-journal/​FullText/​2020/​05150/​SARS_CoV_2_pneumonia_with_subcutaneous_emphysema,​.61.aspx</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +INTRODUCTION:​ Since the end of 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has affected more than 1,000,000 population in the world. Subcutaneous emphysema and pneumothorax are uncommon complications of SARS-CoV-2 pneumonia. Herein, we describe a fatal case of SARS-CoV-2 pneumonia with subcutaneous emphysema and pneumothorax. PATIENT CONCERNS: Subcutaneous emphysema was found in neck, bilateral chest walls, abdomen wall, groin area, and scrotum of a 67-year-old man. Extensive air-space opacities, subcutaneous emphysema and a small amount of pneumothorax were found in his chest X-ray scan. Echocardiography showed left ventricular enlargement with ejection fraction 20%. DIAGNOSIS: This resident of Wuhan with laboratory-confirmed SARS-CoV-2 infection had chronic pulmonary and cardiac diseases. Liver dysfunction,​ myocardial injury, and coagulation disorder were suggested by laboratory findings. Pneumonia, subcutaneous emphysema, and pneumothorax were confirmed with chest X-ray. Heart failure was revealed by echocardiography. INTERVENTIONS:​ He was transferred to intensive care unit, where invasive ventilation was used for him during the whole hospitalization. Prone position ventilation,​ vasoconstrictor,​ antibacteria,​ and antiviral therapy were given. OUTCOMES: He died on the twelfth day after admission. CONCLUSIONS:​ Subcutaneous emphysema and pneumothorax may occur in patients with SARS-CoV-2 pneumonia and chronic pulmonary disease. Chronic cardiac disease might be aggravated by SARS-CoV-2 infection, and develop heart failure.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[574] Title: </​b>​Are patients with Down syndrome vulnerable to life-threatening COVID-19?<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-22<​br>​
 +<​b>​Publisher:​ </​b>​Acta neurologica Belgica<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19, down syndrome, infection, intellectual disability, pneumonia, viral disease, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​link.springer.com/​article/​10.1007/​s13760-020-01373-8">​https://​link.springer.com/​article/​10.1007/​s13760-020-01373-8</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Patients with Down syndrome are at increased risk of respiratory syncytial virus- and H1N1-related death. Literature on COVID-19 in Down syndrome patients is unavailable thus far. We describe the clinical course of 4 patients with Down syndrome during an outbreak of COVID-19. In all four patients, disease course was severe, warranting hospital care in three patients, with fatal outcome in one patient. Another patient receives supportive care in our institution. Our case series is the first report on probable increased risk of life-threatening disease course of COVID-19 in patients with Down syndrome. Proper surveillance,​ the adherence of social distancing, and the use of personal protective equipment will be essential in reducing morbidity and mortality in our patients.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[575] Title: </​b>​Prosthetic aortic valve endocarditis complicated by COVID-19 and hemorrhage.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-22<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Cardiac Surgery<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19, cardiac surgery, endocarditis,​ Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​jocs.14643">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​jocs.14643</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The novel coronavirus,​ now termed SARS-CoV-2, has caused a significant global impact in the space of 4 months. Almost all elective cardiac surgical operations have been postponed with only urgent and emergency operations being considered in order to maximise resource utilisation. We present a case of a 69-year old lady with an infected prosthetic aortic valve for consideration of urgent inpatient surgery. Despite being asymptomatic and testing negative initially for COVID-19 RT-PCR swab, further investigations with CT revealed suspicious findings. She subsequently tested positive on a repeat swab and unfortunately deteriorated rapidly with complications including gastro-intestinal and intracerebral haemorrhage.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[576] Title: </​b>​Novel Coronavirus-Induced Right Ventricular Failure and Point of Care Echocardiography:​ A Case Report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-25<​br>​
 +<​b>​Publisher:​ </​b>​Cardiology<​br>​
 +<​b>​Keywords:​ </​b>​Cardiovascular Medicine And Haematology,​ cor pulmonale, coronavirus disease 2019, novel coronavirus,​ point of care echocardiography,​ Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.karger.com/​Article/​FullText/​508527">​https://​www.karger.com/​Article/​FullText/​508527</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Various cardiovascular complications have been reported in patients with coronavirus disease 2019. Common complications include acute myocardial injury, myocarditis,​ arrhythmia, pericarditis,​ heart failure, and shock. We present a case of cor pulmonale diagnosed with serial point of care ultrasound. Given the current shortage of personal protective equipment (PPE) and high infectivity of this virus, we acknowledge the utility of this tool in obtaining important clinical information while minimizing exposure and PPE consumption.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[577] Title: </​b>​Cutaneous small-vessel vasculitis associated with novel 2019 coronavirus SARS-CoV-2 infection (COVID-19).<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-26<​br>​
 +<​b>​Publisher:​ </​b>​Journal of the European Academy of Dermatology & Venereology<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, coronavirus,​ dermatology,​ outbreak, travelers health, vasculitis, virus, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​jdv.16663">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​jdv.16663</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly become a global health issue. Although it is known to produce diverse cutaneous manifestations,​ some of them have yet to be described. This letter reports new dermatologic findings associated with a confirmed COVID-19 case.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[578] Title: </​b>​Two False Negative Test Results in a Symptomatic Patient with a Confirmed Case of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and Suspected Stevens-Johnson Syndrome/​Toxic Epidermal Necrolysis (SJS/​TEN).<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-19<​br>​
 +<​b>​Publisher:​ </​b>​Cureus<​br>​
 +<​b>​Keywords:​ </b>, burn surgery, covid-19, false-negative,​ patient under investigation,​ rt-pcr, sjs/​ten<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.cureus.com/​articles/​31470-two-false-negative-test-results-in-a-symptomatic-patient-with-a-confirmed-case-of-severe-acute-respiratory-syndrome-coronavirus-2-sars-cov-2-and-suspected-stevens-johnson-syndrometoxic-epidermal-necrolysis-sjsten">​https://​www.cureus.com/​articles/​31470-two-false-negative-test-results-in-a-symptomatic-patient-with-a-confirmed-case-of-severe-acute-respiratory-syndrome-coronavirus-2-sars-cov-2-and-suspected-stevens-johnson-syndrometoxic-epidermal-necrolysis-sjsten</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The recent outbreak of COVID-19 has put significant strain on the current health system and has exposed dangers previously overlooked. The pathogen known as severe acute respiratory syndrome coronavirus 2 (SARS-COV-2),​ is notable for attacking the pulmonary system causing acute respiratory distress, but it can also severely affect other systems in at-risk individuals including cardiovascular compromise, gastrointestinal distress, acute kidney injury, coagulopathies,​ cutaneous manifestations,​ and ultimately death from multi-organ failure. Unfortunately,​ the reliability of negative test results is questionable and the high infectious burden of the virus calls for extended safety precautions,​ especially in symptomatic patients. We present a confirmed COVID-19 case that was transferred to our burn center for concern of Steven Johnson syndrome/​toxic epidermal necrolysis (SJS/TEN) overlap syndrome after having two negative confirmatory COVID-19 tests at an outside hospital. A 58-year-old female with a history of morbid obesity, HTN, gout, CML managed with imatinib, and chronic kidney disease presented as a transfer from a community hospital to our burn center. The patient was admitted to her community hospital with febrile, acute respiratory distress. Imaging and clinical presentation was consistent with COVID-19 and lab tests for the pathogen were ordered. During observation,​ while waiting for results, she was placed under patient under investigation (PUI) protocol. Once negative results were obtained, the PUI protocol was abandoned despite ongoing symptoms. Subsequently,​ dermatological symptoms developed and transfer to our burn center was initiated. After a second negative test result, the symptomatic patient was transferred to our burn center for expert wound management. Given the lack of resolve of respiratory symptoms and concern for the burn patient population, the patient was placed in PUI protocol and an internal COVID-19 was ordered. The patient'​s initial exam under standard COVID-19 airborne precautions revealed 5% total body surface area of loss of epidermis affecting bilateral thighs, bilateral arms, and face. A dermatopathological biopsy suggested a bullous drug reaction with an erythema multiform-like reaction pattern versus SJS/TEN. Moreover, the internal COVID-19 test returned positive. The delayed positive test results and complicated hospital course with our patient required us to scale back and notify every patient and staff member whom they came in contact with, across multiple institutions. We suggest that whenever a suspected COVID-19 patient is transferred to a specialized center, they should be isolated and re-checked before joining the new patient population for treatment of the unique condition.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[579] Title: </​b>​COVID-19 in a melanoma patient under treatment with checkpoint-inhibition.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-26<​br>​
 +<​b>​Publisher:​ </​b>​Journal of the European Academy of Dermatology & Venereology<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​jdv.16661">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​jdv.16661</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +SARS-CoV-2 poses new challenges in all aspects of healthcare. Patients with preexisting cardio-vascular conditions are at higher risk of developing severe symptoms and worse outcome. Data also suggest that cancer patients are particularly vulnerable, but differences between tumor entities and cancer treatments may exist. Little is known how cancer treatment engaging immune checkpoints affects the course of COVID-19.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[580] Title: </​b>​Late onset of acral necrosis after SARS-CoV-2 infection resolution.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-22<​br>​
 +<​b>​Publisher:​ </​b>​Journal of the European Academy of Dermatology & Venereology<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, acro-ischemia,​ covid-19, sars-cov-2, acral necrosis, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​jdv.16668">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​jdv.16668</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +SARS-CoV-2 has been hypothesized as the aetiologic agent of CLL, on the basis of the temporal correlation between the "​burst"​ of skin manifestations and the viral pandemic, even though we have scarce evidence of swab-confirmed infections. Authors have therefore suggested some pathogenetic mechanisms such as a delayed immune-mediated reaction to the virus in genetically-predisposed patients(1) or an early IFN-I response in young patients, muting early viral replication but also inducing microangiopathic changes.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[581] Title: </​b>​80-year-old man with dyspnoea and bilateral groundglass infiltrates:​ an elusive case of COVID-19.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-27<​br>​
 +<​b>​Publisher:​ </​b>​BMJ Case Reports<​br>​
 +<​b>​Keywords:​ </b>, pneumonia (respiratory medicine), respiratory system<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​casereports.bmj.com/​lookup/​doi/​10.1136/​bcr-2020-236069">​https://​casereports.bmj.com/​lookup/​doi/​10.1136/​bcr-2020-236069</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +COVID-19 is a novel viral infection caused by severe acute respiratory syndrome-coronavirus-2 virus, first identified in Wuhan, China in December 2019. COVID-19 has spread rapidly and is now considered a global pandemic. We present a case of a patient with minimal respiratory symptoms but prominent bilateral groundglass opacities in a 'crazy paving'​ pattern on chest CT imaging and a negative initial infectious workup. However, given persistent dyspnoea and labs suggestive of COVID-19 infection, the patient remained hospitalised for further monitoring. Forty-eight hours after initial testing, the PCR test was repeated and returned positive for COVID-19. This case illustrates the importance of clinical vigilance to retest patients for COVID-19, particularly in the absence of another compelling aetiology. As COVID-19 testing improves to rapidly generate results, selective retesting of patients may uncover additional COVID-19 cases and strengthen measures to minimise the spread of COVID-19.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[582] Title: </​b>​COVID-19-RELATED AORTIC THROMBOSIS: A REPORT OF FOUR CASES.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-01<​br>​
 +<​b>​Publisher:​ </​b>​Annals of Vascular Surgery (Science Direct)<​br>​
 +<​b>​Keywords:​ </b>, aortic thrombosis, covid-19, coagulopathy,​ complications,​ coronavirus disease 2019, thrombosis, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0890509620304386">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0890509620304386</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +COVID-19 may predispose patients to an increased risk of thrombotic complications through various pathophysiological mechanisms. Most of the reports on a high incidence of thrombotic complications are in relation to deep vein thrombosis and pulmonary embolism, while the evidence about arterial thrombosis in patients with COVID-19 is limited. We describe four cases of aortic thrombosis and associated ischemic complications in patients with severe SARS-CoV-2 infection.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[583] Title: </​b>​Acute pulmonary embolism in COVID-19 related hypercoagulability.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-30<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Thrombosis and Thrombolysis<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19, case report, coagulation,​ interstitial pneumonia, pulmonary embolism, sars-cov-2, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​link.springer.com/​article/​10.1007/​s11239-020-02160-1">​https://​link.springer.com/​article/​10.1007/​s11239-020-02160-1</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Since December 2019, a novel Coronavirus (SARS-CoV-2) was confirmed as the etiologic agent of a worldwide outbreak of a pneumonia that can result in severe respiratory failure. This clinical entity seems to be associated with a marked hypercoagulable state that causes both arterial and venous thromboembolic complications. Therefore, an adequate anti-thrombotic prophylaxis is recommended in hospitalized COVID-19 patients. Although rapidly worsening respiratory symptoms in a patient with SARS-CoV-2 respiratory infection may correlate with worsening pneumonia itself, it may also mask a pulmonary embolism. We report the case of a 50-year-old man affected by SARS-CoV-2 pneumonia, who developed acute pulmonary embolism.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[584] Title: </​b>​COVID-19:​ how it can look on the skin. Clinical and pathological features in twenty COVID-19 patients observed in Bologna, northeastern Italy.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-25<​br>​
 +<​b>​Publisher:​ </​b>​Journal of the European Academy of Dermatology & Venereology<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​jdv.16693">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​jdv.16693</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Global public health is currently dealing with the explosive spread of the novel Coronavirus disease 2019 (COVID-19) [1]. This new type of viral pneumonia, spread from its first focus in Wuhan (Hubei, China) to across all the world, until a pandemic condition was declared. Clinically. the most common symptoms of the disease are cough and fever. More than 80% of patients have asymptomatic to moderate disease, but about 15% get severe pneumonia and 5% develope a multi-organ failure [2].<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[585] Title: </​b>​Tocilizumab in the treatment of a critical COVID-19 patient: a case report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-01<​br>​
 +<​b>​Publisher:​ </​b>​European review for medical and pharmacological sciences<​br>​
 +<​b>​Keywords:​ </b>, <br>
 +<​b>​DOI:​ </​b><​a href="​https://​www.europeanreview.org/​article/​21372">​https://​www.europeanreview.org/​article/​21372</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +In December 2019, Coronavirus disease 2019 (COVID-19) emerged in Wuhan and rapidly spread throughout China and the rest of the world. COVID-19 is currently a global pandemic. There are cytokine storms in severe COVID-19 patients. Interleukin-6 plays an important role in cytokine storm. Tocilizumab is a blocker of interleukin-6 receptor, which is likely to become an effective drug for patients with severe COVID-19. Here, we reported a case in which tocilizumab was effective for a critical COVID-19 patient.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[586] Title: </b>A case report of serious haemolysis in a glucose-6-phosphate dehydrogenase-deficient COVID-19 patient receiving hydroxychloroquine.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-04<​br>​
 +<​b>​Publisher:​ </​b>​Infectious Diseases<​br>​
 +<​b>​Keywords:​ </b>, covid-19, adverse event, evidence-based medicine, glucose-6-phosphate dehydrogenase (g6pd) deficiency, haemolysis, hydroxychloroquine<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.tandfonline.com/​doi/​full/​10.1080/​23744235.2020.1774644">​https://​www.tandfonline.com/​doi/​full/​10.1080/​23744235.2020.1774644</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +While the COVID-19 epidemic occurred since December 2019, as of end April 2020, no treatment has been validated or invalidated by accurate clinical trials. Use of hydroxychloroquine has been popularised on mass media and put forward as a valid treatment option without strong evidence of efficacy. Hydroxychloroquine (HCQ) has its own side effects, some of which are very serious like acute haemolysis in glucose-6-phosphate dehydrogenase (G6PD) deficient patients. Side effects may be worse than the disease itself. Belgian national treatment guidelines recommend the use of HCQ in mild to severe COVID-19 disease. As opinions, politics, media and beliefs are governing COVID-19 therapy, performance of randomised controlled blinded clinical trials became difficult. Results of sound clinical trials are eagerly awaited. We report a case of acute haemolysis leading to admission in intensive care unit and renal failure in a patient with uncovered G6PD deficiency.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[587] Title: </​b>​Influenza and COVID-19 Co-infection:​ Report of 6 cases and review of the Literature.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-04<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Medical Virology<​br>​
 +<​b>​Keywords:​ </​b>​Medical Microbiology,​ covid-19, co-infection,​ influenza, Health Sciences, Life Sciences, Medicine, Immunology and Microbiology<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​jmv.26125">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​jmv.26125</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +COVID-19 pandemic caused infection in a season when influenza is still prevalent. Both viruses have similar transmission characteristics and common clinical manifestations. Influenza has been described to cause respiratory infection with some other respiratory pathogens. However the information of COVID-19 and influenza co-infection is limited. In this study, we reported our co-infected cases and reviewed the literature. We included all COVID-19 diagnosed patients. All patients with a presumed diagnosis of COVID-19 were routinely screened for influenza. Their thorax radiology was reviewed for COVID-19 -influenza differentiation. During the study period, 1103 patients have been diagnosed COVID-19. Among them, 6 patients (0.54%) were diagnosed co-infected with influenza. There have been 28 more co-infected patients reported. Laboratory-based,​ screening studies reported more patients. Thorax radiology findings were compatible with COVID-19 in 5 and with influenza in 1 one of our patients. Our cases were mild-to-moderate in severity. The reported cases in the literature included patients died (n=2) and those living ventilator dependent or under mechanical ventilation. COVID-19 and influenza co-infection is rare. Screening studies report more cases, suggesting that unless screening COVID-19 patients, the co-infection remains undiagnosed and underestimated. Increasing experience in thoracic radiology may contribute to diagnose the responsible virus(es) from the clinical illness. Influenza vaccine for larger population groups can be recommended to simplify clinicians'​ work. This article is protected by copyright. All rights reserved.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[588] Title: </​b>​Feedback to Prepare EMS Teams to Manage Infected Patients with COVID-19: A Case Series.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​0.25<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-08<​br>​
 +<​b>​Publisher:​ </​b>​Prehospital and disaster medicine<​br>​
 +<​b>​Keywords:​ </​b>​Medical And Health Sciences, covid-19, ems, emergency, personnel protection equipment, providers'​ contamination,​ Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.cambridge.org/​core/​journals/​prehospital-and-disaster-medicine/​article/​feedback-to-prepare-ems-teams-to-manage-infected-patients-with-covid19-a-case-series/​450F661EC708369BB7D18B0EF95B0D53">​https://​www.cambridge.org/​core/​journals/​prehospital-and-disaster-medicine/​article/​feedback-to-prepare-ems-teams-to-manage-infected-patients-with-covid19-a-case-series/​450F661EC708369BB7D18B0EF95B0D53</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Coronavirus Disease 2019 (COVID-19), a new respiratory disease, is spreading globally. In France, Emergency Medical Service (EMS) teams are mobile medicalized resuscitation teams composed of emergency physician, nurse or anesthesiologist nurse, ambulance driver, and resident. Four types of clinical cases are presented here because they have led these EMS teams to change practices in their management of patients suspected of COVID-19 infection: cardiac arrest, hypoxia on an acute pneumonia, acute chronic obstructive pulmonary disease (COPD) exacerbation with respiratory and hemodynamic disorders, and upper function disorders in a patient in a long-term care facility. The last case raised the question of COVID-19 cases with atypical forms in elderly subjects. Providers were contaminated during the management of these patients. These cases highlighted the need to review the way these EMS teams are responding to the COVID-19 pandemic, in view of heightening potential for early identification of suspicious cases, and of reinforcing the application of staff protection equipment to limit risk of contamination.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +
 +</​html>​
oa_db/covid19_case_reports_abstracts_pg10.txt · Last modified: 2020/06/28 05:26 by bpwhite