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 +===== COVID-19 Case Reports Abstracts - Page 1 =====
  
 +[[oa_db:​covid19_case_reports_abstracts|Back to Table of Contents]]
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 +[[oa_db:​covid19_case_reports_abstracts_pg2|Page 2]]
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 +----------------------------------------------------------------------<​br>​
 +<​b>​[1] Title: </​b>​First Case of 2019 Novel Coronavirus in the United States.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​9905.74<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-03-05<​br>​
 +<​b>​Publisher:​ </​b>​New England Journal of Medicine<​br>​
 +<​b>​Keywords:​ </​b>​Medical And Health Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.nejm.org/​doi/​10.1056/​NEJMoa2001191">​https://​www.nejm.org/​doi/​10.1056/​NEJMoa2001191</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +An outbreak of novel coronavirus (2019-nCoV) that began in Wuhan, China, has spread rapidly, with cases now confirmed in multiple countries. We report the first case of 2019-nCoV infection confirmed in the United States and describe the identification,​ diagnosis, clinical course, and management of the case, including the patient'​s initial mild symptoms at presentation with progression to pneumonia on day 9 of illness. This case highlights the importance of close coordination between clinicians and public health authorities at the local, state, and federal levels, as well as the need for rapid dissemination of clinical information related to the care of patients with this emerging infection.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[2] Title: </​b>​SARS-CoV-2 was already spreading in France in late December 2019.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​6029.01<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-01<​br>​
 +<​b>​Publisher:​ </​b>​International Journal of Antimicrobial Agents<​br>​
 +<​b>​Keywords:​ </​b>​Medical Microbiology,​ covid-19, coronavirus disease 2019, france, intensive care unit, sars-cov-2, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0924857920301643">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0924857920301643</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The COVID-19 epidemic is believed to have started in late January 2020 in France. Here we report a case of a patient hospitalised in December 2019 in an intensive care unit in a hospital in the north of Paris for haemoptysis with no aetiological diagnosis. RT-PCR was performed retrospectively on the stored respiratory sample and confirmed the diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Based on this result, it appears that the COVID-19 epidemic started much earlier in France.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[3] Title: </​b>​Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​2763.08<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-03-13<​br>​
 +<​b>​Publisher:​ </​b>​Nature Medicine<​br>​
 +<​b>​Keywords:​ </​b>​Medical And Health Sciences, , Biochemistry,​ Genetics and Molecular Biology, Health Sciences, Life Sciences, Medicine<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.nature.com/​articles/​s41591-020-0817-4">​https://​www.nature.com/​articles/​s41591-020-0817-4</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We report epidemiological and clinical investigations on ten pediatric SARS-CoV-2 infection cases confirmed by real-time reverse transcription PCR assay of SARS-CoV-2 RNA. Symptoms in these cases were nonspecific and no children required respiratory support or intensive care. Chest X-rays lacked definite signs of pneumonia, a defining feature of the infection in adult cases. Notably, eight children persistently tested positive on rectal swabs even after nasopharyngeal testing was negative, raising the possibility of fecal-oral transmission.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[4] Title: </​b>​Infectious SARS-CoV-2 in Feces of Patient with Severe COVID-19.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​1852.97<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-08-01<​br>​
 +<​b>​Publisher:​ </​b>​Emerging Infectious Diseases<​br>​
 +<​b>​Keywords:​ </​b>​Medical Microbiology,​ covid-19, sars-cov-2, coronavirus,​ coronavirus disease, feces, respiratory infections, severe acute respiratory syndrome coronavirus 2, transmission,​ virus isolation, viruses, zoonoses, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​wwwnc.cdc.gov/​eid/​404.html?​aspxerrorpath=/​eid/​article/​26/​8/​20-0681_article">​https://​wwwnc.cdc.gov/​eid/​404.html?​aspxerrorpath=/​eid/​article/​26/​8/​20-0681_article</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Severe acute respiratory syndrome coronavirus 2 was isolated from feces of a patient in China with coronavirus disease who died. Confirmation of infectious virus in feces affirms the potential for fecal-oral or fecal-respiratory transmission and warrants further study.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[5] Title: </b>A first case of meningitis/​encephalitis associated with SARS-Coronavirus-2.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​1841.22<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-01<​br>​
 +<​b>​Publisher:​ </​b>​International Journal of Infectious Diseases<​br>​
 +<​b>​Keywords:​ </​b>​Microbiology,​ covid-19, infections, meningitis, polymerase chain reaction, sars-cov-2, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S1201971220301958">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S1201971220301958</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Novel coronavirus (SARS-Coronavirus-2:​SARS-CoV-2) which emerged in Wuhan, China, has spread to multiple countries rapidly. We report the first case of meningitis associated with SARS-CoV-2 who was brought in by ambulance due to a convulsion accompanied by unconsciousness. He had never been to any foreign countries. He felt generalized fatigue and fever (day 1). He saw doctors nearby twice (day 2 and 5) and was prescribed Laninamivir and antipyretic agents, His family visited his home and found that he was unconsciousness and lying on the floor in his vomit. He was immediately transported to this hospital by ambulance (day 9). Under emergency transport, he had transient generalized seizures that lasted about a minute. He had obvious neck stiffness. The specific SARS-CoV-2 RNA was not detected in the nasopharyngeal swab but was detected in a CSF. Anti- HSV 1 and varicella-zoster IgM antibodies were not detected in serum samples. A brain MRI showed hyperintensity along the wall of right lateral ventricle and hyperintense signal changes in the right mesial temporal lobe and hippocampus,​ suggesting the possibility of SARS-CoV-2 meningitis. This case warns the physicians of patients who have CNS symptoms.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[6] Title: </​b>​Epidemiology of Covid-19 in a Long-Term Care Facility in King County, Washington.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​1427.77<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-21<​br>​
 +<​b>​Publisher:​ </​b>​New England Journal of Medicine<​br>​
 +<​b>​Keywords:​ </​b>​Medical And Health Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.nejm.org/​doi/​10.1056/​NEJMoa2005412">​https://​www.nejm.org/​doi/​10.1056/​NEJMoa2005412</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +BACKGROUND: Long-term care facilities are high-risk settings for severe outcomes from outbreaks of Covid-19, owing to both the advanced age and frequent chronic underlying health conditions of the residents and the movement of health care personnel among facilities in a region. METHODS: After identification on February 28, 2020, of a confirmed case of Covid-19 in a skilled nursing facility in King County, Washington, Public Health-Seattle and King County, aided by the Centers for Disease Control and Prevention, launched a case investigation,​ contact tracing, quarantine of exposed persons, isolation of confirmed and suspected cases, and on-site enhancement of infection prevention and control. RESULTS: As of March 18, a total of 167 confirmed cases of Covid-19 affecting 101 residents, 50 health care personnel, and 16 visitors were found to be epidemiologically linked to the facility. Most cases among residents included respiratory illness consistent with Covid-19; however, in 7 residents no symptoms were documented. Hospitalization rates for facility residents, visitors, and staff were 54.5%, 50.0%, and 6.0%, respectively. The case fatality rate for residents was 33.7% (34 of 101). As of March 18, a total of 30 long-term care facilities with at least one confirmed case of Covid-19 had been identified in King County. CONCLUSIONS:​ In the context of rapidly escalating Covid-19 outbreaks, proactive steps by long-term care facilities to identify and exclude potentially infected staff and visitors, actively monitor for potentially infected patients, and implement appropriate infection prevention and control measures are needed to prevent the introduction of Covid-19.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[7] Title: </​b>​Infants Born to Mothers With a New Coronavirus (COVID-19).<​br><​br>​
 +<​b>​Altmetric Score: </​b>​1364.51<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-03-16<​br>​
 +<​b>​Publisher:​ </​b>​Frontiers in Pediatrics<​br>​
 +<​b>​Keywords:​ </b>, covid-19 infected mothers, china, clinical course, newborns, vertical transmission<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.frontiersin.org/​articles/​10.3389/​fped.2020.00104/​full">​https://​www.frontiersin.org/​articles/​10.3389/​fped.2020.00104/​full</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +A novel viral respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),​ is responsible for an epidemic of the coronavirus disease 2019 (COVID-19) in cases in China and worldwide. Four full-term, singleton infants were born to pregnant women who tested positive for COVID-19 in the city of Wuhan, the capital of Hubei province, China, where the disease was first identified. Of the three infants, for who consent to be diagnostically tested was provided, none tested positive for the virus. None of the infants developed serious clinical symptoms such as fever, cough, diarrhea, or abnormal radiologic or hematologic evidence, and all four infants were alive at the time of hospital discharge. Two infants had rashes of unknown etiology at birth, and one had facial ulcerations. One infant had tachypnea and was supported by non-invasive mechanical ventilation for 3 days. One had rashes at birth but was discharged without parental consent for a diagnostic test. This case report describes the clinical course of four live born infants, born to pregnant women with the COVID-19 infection.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[8] Title: </​b>​First known person-to-person transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the USA.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​1135.28<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-01<​br>​
 +<​b>​Publisher:​ </​b>​The Lancet<​br>​
 +<​b>​Keywords:​ </​b>​Medical And Health Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0140673620306073">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0140673620306073</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +BACKGROUND: Coronavirus disease 2019 (COVID-19) is a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),​ first detected in China in December, 2019. In January, 2020, state, local, and federal public health agencies investigated the first case of COVID-19 in Illinois, USA. METHODS: Patients with confirmed COVID-19 were defined as those with a positive SARS-CoV-2 test. Contacts were people with exposure to a patient with COVID-19 on or after the patient'​s symptom onset date. Contacts underwent active symptom monitoring for 14 days following their last exposure. Contacts who developed fever, cough, or shortness of breath became persons under investigation and were tested for SARS-CoV-2. A convenience sample of 32 asymptomatic health-care personnel contacts were also tested. FINDINGS: Patient 1-a woman in her 60s-returned from China in mid-January,​ 2020. One week later, she was hospitalised with pneumonia and tested positive for SARS-CoV-2. Her husband (Patient 2) did not travel but had frequent close contact with his wife. He was admitted 8 days later and tested positive for SARS-CoV-2. Overall, 372 contacts of both cases were identified; 347 underwent active symptom monitoring, including 152 community contacts and 195 health-care personnel. Of monitored contacts, 43 became persons under investigation,​ in addition to Patient 2. These 43 persons under investigation and all 32 asymptomatic health-care personnel tested negative for SARS-CoV-2. INTERPRETATION:​ Person-to-person transmission of SARS-CoV-2 occurred between two people with prolonged, unprotected exposure while Patient 1 was symptomatic. Despite active symptom monitoring and testing of symptomatic and some asymptomatic contacts, no further transmission was detected. FUNDING: None.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[9] Title: </b>A Familial Cluster of Infection Associated With the 2019 Novel Coronavirus Indicating Possible Person-to-Person Transmission During the Incubation Period.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​1101.38<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-02-18<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Infectious Diseases<​br>​
 +<​b>​Keywords:​ </​b>​Medical And Health Sciences, 2019-ncov, family cluster, incubation period, infectivity,​ Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​http://​doi.org/​10.1093/​infdis/​jiaa077">​http://​doi.org/​10.1093/​infdis/​jiaa077</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +An ongoing outbreak of pneumonia associated with 2019 novel coronavirus was reported in China. It is unclear whether the virus is infective exists during the incubation period, although person-to-person transmission has been reported elsewhere. We report the epidemiological features of a familial cluster of 4 patients in Shanghai, including an 88-year-old man with limited mobility who was exposed only to asymptomatic family members whose symptoms developed later. The epidemiological evidence has shown possible transmission of 2019 novel coronavirus during the incubation period.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[10] Title: </b>A Well Infant with Coronavirus Disease 2019 (COVID-19) with High Viral Load.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​1066.26<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-02-28<​br>​
 +<​b>​Publisher:​ </​b>​Clinical Infectious Diseases<​br>​
 +<​b>​Keywords:​ </​b>​Biological Sciences, 2019 novel coronavirus,​ covid-19, sars-cov-2, infant, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​http://​doi.org/​10.1093/​cid/​ciaa201">​http://​doi.org/​10.1093/​cid/​ciaa201</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +A well 6-month-old infant with coronavirus disease 2019 (COVID-19) had persistently positive nasopharyngeal swabs to day 16 of admission. This case highlights the difficulties in establishing the true incidence of COVID-19 as asymptomatic individuals can excrete the virus. These patients may play important roles in human-to-human transmission in the community.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[11] Title: </​b>​Cardiac Involvement in a Patient With Coronavirus Disease 2019 (COVID-19).<​br><​br>​
 +<​b>​Altmetric Score: </​b>​976.06<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-03-27<​br>​
 +<​b>​Publisher:​ </​b>​JAMA Cardiology<​br>​
 +<​b>​Keywords:​ </b>, <br>
 +<​b>​DOI:​ </​b><​a href="​http://​doi.org/​10.1001/​jamacardio.2020.1096">​http://​doi.org/​10.1001/​jamacardio.2020.1096</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Importance: Virus infection has been widely described as one of the most common causes of myocarditis. However, less is known about the cardiac involvement as a complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Objective: To describe the presentation of acute myocardial inflammation in a patient with coronavirus disease 2019 (COVID-19) who recovered from the influenzalike syndrome and developed fatigue and signs and symptoms of heart failure a week after upper respiratory tract symptoms. Design, Setting, and Participant:​ This case report describes an otherwise healthy 53-year-old woman who tested positive for COVID-19 and was admitted to the cardiac care unit in March 2020 for acute myopericarditis with systolic dysfunction,​ confirmed on cardiac magnetic resonance imaging, the week after onset of fever and dry cough due to COVID-19. The patient did not show any respiratory involvement during the clinical course. Exposure: Cardiac involvement with COVID-19. Main Outcomes and Measures: Detection of cardiac involvement with an increase in levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitivity troponin T, echocardiography changes, and diffuse biventricular myocardial edema and late gadolinium enhancement on cardiac magnetic resonance imaging. Results: An otherwise healthy 53-year-old white woman presented to the emergency department with severe fatigue. She described fever and dry cough the week before. She was afebrile but hypotensive;​ electrocardiography showed diffuse ST elevation, and elevated high-sensitivity troponin T and NT-proBNP levels were detected. Findings on chest radiography were normal. There was no evidence of obstructive coronary disease on coronary angiography. Based on the COVID-19 outbreak, a nasopharyngeal swab was performed, with a positive result for SARS-CoV-2 on real-time reverse transcriptase-polymerase chain reaction assay. Cardiac magnetic resonance imaging showed increased wall thickness with diffuse biventricular hypokinesis,​ especially in the apical segments, and severe left ventricular dysfunction (left ventricular ejection fraction of 35%). Short tau inversion recovery and T2-mapping sequences showed marked biventricular myocardial interstitial edema, and there was also diffuse late gadolinium enhancement involving the entire biventricular wall. There was a circumferential pericardial effusion that was most notable around the right cardiac chambers. These findings were all consistent with acute myopericarditis. She was treated with dobutamine, antiviral drugs (lopinavir/​ritonavir),​ steroids, chloroquine,​ and medical treatment for heart failure, with progressive clinical and instrumental stabilization. Conclusions and Relevance: This case highlights cardiac involvement as a complication associated with COVID-19, even without symptoms and signs of interstitial pneumonia.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[12] Title: </​b>​Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​847.87<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-01<​br>​
 +<​b>​Publisher:​ </​b>​Translational Research: The Journal of Laboratory & Clinical Medicine<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S1931524420300700">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S1931524420300700</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Acute respiratory failure and a systemic coagulopathy are critical aspects of the morbidity and mortality characterizing infection with severe acute respiratory distress syndrome-associated coronavirus-2,​ the etiologic agent of Coronavirus disease 2019 (COVID-19). We examined skin and lung tissues from 5 patients with severe COVID-19 characterized by respiratory failure (n= 5) and purpuric skin rash (n=3). COVID-19 pneumonitis was predominantly a pauci-inflammatory septal capillary injury with significant septal capillary mural and luminal fibrin deposition and permeation of the interalveolar septa by neutrophils. No viral cytopathic changes were observed and the diffuse alveolar damage (DAD) with hyaline membranes, inflammation,​ and type II pneumocyte hyperplasia,​ hallmarks of classic acute respiratory distress syndrome, were not prominent. These pulmonary findings were accompanied by significant deposits of terminal complement components C5b-9 (membrane attack complex), C4d, and mannose binding lectin (MBL)-associated serine protease (MASP)2, in the microvasculature,​ consistent with sustained, systemic activation of the complement pathways. The purpuric skin lesions similarly showed a pauci-inflammatory thrombogenic vasculopathy,​ with deposition of C5b-9 and C4d in both grossly involved and normally-appearing skin. In addition, there was co-localization of COVID-19 spike glycoproteins with C4d and C5b-9 in the interalveolar septa and the cutaneous microvasculature of 2 cases examined. In conclusion, at least a subset of sustained, severe COVID-19 may define a type of catastrophic microvascular injury syndrome mediated by activation of complement pathways and an associated procoagulant state. It provides a foundation for further exploration of the pathophysiologic importance of complement in COVID-19, and could suggest targets for specific intervention.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[13] Title: </​b>​COVID-19 Autopsies, Oklahoma, USA.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​795.08<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-10<​br>​
 +<​b>​Publisher:​ </​b>​American Journal of Clinical Pathology<​br>​
 +<​b>​Keywords:​ </​b>​Medical And Health Sciences, acute lung injury, autopsy, covid-19, coronavirus,​ diffuse alveolar damage, pulmonary pathology, sars-cov-2, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​http://​doi.org/​10.1093/​ajcp/​aqaa062">​http://​doi.org/​10.1093/​ajcp/​aqaa062</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +OBJECTIVES: To report the methods and findings of two complete autopsies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive individuals who died in Oklahoma (United States) in March 2020. METHODS: Complete postmortem examinations were performed according to standard procedures in a negative-pressure autopsy suite/​isolation room using personal protective equipment, including N95 masks, eye protection, and gowns. The diagnosis of coronavirus disease 2019 (COVID-19) was confirmed by real-time reverse transcriptase polymerase chain reaction testing on postmortem swabs. RESULTS: A 77-year-old obese man with a history of hypertension,​ splenectomy,​ and 6 days of fever and chills died while being transported for medical care. He tested positive for SARS-CoV-2 on postmortem nasopharyngeal and lung parenchymal swabs. Autopsy revealed diffuse alveolar damage and chronic inflammation and edema in the bronchial mucosa. A 42-year-old obese man with a history of myotonic dystrophy developed abdominal pain followed by fever, shortness of breath, and cough. Postmortem nasopharyngeal swab was positive for SARS-CoV-2; lung parenchymal swabs were negative. Autopsy showed acute bronchopneumonia with evidence of aspiration. Neither autopsy revealed viral inclusions, mucus plugging in airways, eosinophils,​ or myocarditis. CONCLUSIONS:​ SARS-CoV-2 testing can be performed at autopsy. Autopsy findings such as diffuse alveolar damage and airway inflammation reflect true virus-related pathology; other findings represent superimposed or unrelated processes.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[14] Title: </​b>​Clinical Characteristics of 5 COVID-19 Cases With Non-respiratory Symptoms as the First Manifestation in Children.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​771.42<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-12<​br>​
 +<​b>​Publisher:​ </​b>​Frontiers in Pediatrics<​br>​
 +<​b>​Keywords:​ </b>, clinical characteristics,​ first manifestation,​ non-respiratory symptoms, novel coronavirus disease 2019, pediatrics<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.frontiersin.org/​articles/​10.3389/​fped.2020.00258/​full">​https://​www.frontiersin.org/​articles/​10.3389/​fped.2020.00258/​full</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +An outbreak of the novel coronavirus disease 2019 (COVID-19) occurred in Wuhan, China, in December 2019, which then rapidly spread to more than 80 countries. However, detailed information on the characteristics of COVID-19 in children is still scarce. Five patients with non-respiratory symptoms as the first manifestation were hospitalized from the emergency department, and were later confirmed to have COVID-19, between 23 January and 20 February 2020, at the Wuhan Children'​s Hospital. SARS-CoV-2 nucleic acid detection was positive for all the patients. Four of the patients were male and one was female, and their ages ranged from 2-months to 5.6 years. All lived in Wuhan. One patient had a clear history of exposure to SARS-CoV-2, one had a suspected history of exposure, while the others had no exposure history. For three of the five patients, the primary onset disease required an emergency operation or treatment, and included intussusception,​ acute suppurative appendicitis perforation with local peritonitis,​ and traumatic subdural hemorrhage with convulsion, while for the other two it was acute gastroenteritis (including one patient with hydronephrosis and a stone in his left kidney). During the course of the disease, four of the five patients had a fever, whereas one case had no fever or cough. Two patients had leukopenia, and one also had lymphopenia. In the two cases of severe COVID-19, the levels of CRP, PCT, serum ferritin, IL-6, and IL-10 were significantly increased, whereas the numbers of CD3+, CD4+, CD8+ T lymphocytes,​ and CD16 + CD56 natural killer cells were decreased. We also found impaired liver, kidney, and myocardial functions; the presence of hypoproteinemia,​ hyponatremia,​ and hypocalcemia;​ and, in one case, abnormal coagulation function. Except for one patient who had a rotavirus infection, all patients tested negative for common pathogens, including the influenza virus, parainfluenza virus, respiratory syncytial virus, adenovirus, enterovirus,​ mycoplasma, Chlamydia, and Legionella. Chest CT images of all the patients showed patches or ground-glass opacities in the lung periphery or near the pleura, even large consolidations. This case series is the first report to describe the clinical features of COVID-19 with non-respiratory symptoms as the first manifestation in children.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[15] Title: </​b>​SARS-CoV-2 shedding and seroconversion among passengers quarantined after disembarking a cruise ship: a case series.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​715.3<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-01<​br>​
 +<​b>​Publisher:​ </​b>​Lancet Infectious Diseases<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S1473309920303649">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S1473309920303649</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +BACKGROUND: A cruise ship is a closed-off environment that simulates the basic functioning of a city in terms of living conditions and interpersonal interactions. Thus, the Diamond Princess cruise ship, which was quarantined because of an onboard outbreak of COVID-19 in February, 2020, provides an opportunity to define the shedding pattern of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and patient antibody responses before and after the onset of symptoms. METHODS: We recruited adult (>/=18 years) passengers from Hong Kong who had been on board the Diamond Princess cruise ship docked in Yokohama, Japan in February, 2020. All participants had been found to be negative for SARS-CoV-2 by RT-PCR 4 days before disembarking and were transferred to further quarantine in a public estate in Hong Kong, where they were recruited. Participants were prospectively screened by quantitative RT-PCR (RT-qPCR) of nasopharyngeal and throat swabs, and serum IgG and IgM against internal nucleoprotein and the surface spike receptor-binding protein (RBD) of SARS-CoV-2 at baseline (upon entering quarantine) and on days 4, 8, and 12 of quarantine. FINDINGS: On Feb 22, 2020, 215 adults were recruited, of whom nine (4%; 95% CI 2-8) were positive for SARS-CoV-2 by RT-qPCR or serology and were hospitalised. Of these nine patients, nasopharyngeal swab RT-qPCR was positive in eight patients (89%; 57-99) at baseline. All nine patients were positive for anti-RBD IgG by day 8. Eight (89%; 57-99) were simultaneously positive for nasopharyngeal swab RT-PCR and anti-RBD IgG. One patient who was positive for anti-RBD IgG and had a negative viral load had multifocal peripheral ground-glass changes on high-resolution CT that were typical of COVID-19. Five patients (56%; 27-81) with ground-glass changes on high-resolution CT were found to have higher anti-nucleoprotein-IgG OD values on day 8 and 12 and anti-RBD IgG OD value on day 12 than patients without ground-glass changes. Six (67%; 35-88) patients remained asymptomatic throughout the 14-day quarantine period. INTERPRETATION:​ Patients with COVID-19 can develop asymptomatic lung infection with viral shedding and those with evidence of pneumonia on imaging tend to have an increased antibody response. Positive IgG or IgM confirmed infection of COVID-19 in both symptomatic and asymptomatic patients. A combination of RT-PCR and serology should be implemented for case finding and contact tracing to facilitate early diagnosis, prompt isolation, and treatment. FUNDING: Shaw Foundation Hong Kong; Sanming-Project of Medicine (Shenzhen); High Level-Hospital Program (Guangdong Health Commission).<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[16] Title: </​b>​COVID-19 in 2 Persons with Mild Upper Respiratory Tract Symptoms on a Cruise Ship, Japan.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​710.64<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-01<​br>​
 +<​b>​Publisher:​ </​b>​Emerging Infectious Diseases<​br>​
 +<​b>​Keywords:​ </​b>​Medical Microbiology,​ covid-19, japan, pcr, sars-cov-2, coronavirus,​ cruise ship, global health, respiratory infections, severe acute respiratory syndrome coronavirus 2, travelers health, viruses, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​wwwnc.cdc.gov/​eid/​article/​26/​6/​20-0452_article">​https://​wwwnc.cdc.gov/​eid/​article/​26/​6/​20-0452_article</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We describe 2 cases of coronavirus disease in patients with mild upper respiratory symptoms. Both patients worked on a cruise ship quarantined off the coast of Japan. One patient had persistent, low-grade upper respiratory tract symptoms without fever. The other patient had rapid symptom cessation but persistent viral RNA detection.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[17] Title: </​b>​Encephalopathy and Encephalitis Associated with Cerebrospinal Fluid Cytokine Alterations and Coronavirus Disease, Atlanta, Georgia, USA, 2020.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​638.83<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-09-01<​br>​
 +<​b>​Publisher:​ </​b>​Emerging Infectious Diseases<​br>​
 +<​b>​Keywords:​ </​b>​Medical Microbiology,​ atlanta, covid-19, csf, georgia, sars-cov-2, united states, cerebrospinal fluid, coronavirus disease, coronaviruses,​ cytokines, encephalitis,​ encephalopathy,​ meningitis/​encephalitis,​ respiratory infections, serologic analysis, severe acute respiratory syndrome coronavirus 2, viruses, zoonoses, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​wwwnc.cdc.gov/​eid/​article/​26/​9/​20-2122_article">​https://​wwwnc.cdc.gov/​eid/​article/​26/​9/​20-2122_article</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +There are few detailed investigations of neurologic complications in severe acute respiratory syndrome coronavirus 2 infection. We describe 3 patients with laboratory-confirmed coronavirus disease who development of encephalopathy and encephalitis. Neuroimaging showed nonenhancing unilateral, bilateral, and midline changes not readily attributable to vascular causes. All 3 patients had increased cerebrospinal fluid (CSF) levels of anti-S1 IgM. One patient who died also had increased levels of anti-envelope protein IgM. CSF analysis also showed markedly increased levels of interleukin (IL)-6, IL-8, and IL-10, but severe acute respiratory syndrome coronavirus 2 was not identified in any CSF sample. These changes provide evidence of CSF periinfectious/​postinfectious inflammatory changes during coronavirus disease with neurologic complications.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[18] Title: </​b>​Potential Presymptomatic Transmission of SARS-CoV-2, Zhejiang Province, China, 2020.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​628.18<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-01<​br>​
 +<​b>​Publisher:​ </​b>​Emerging Infectious Diseases<​br>​
 +<​b>​Keywords:​ </​b>​Medical Microbiology,​ 2019 novel coronavirus disease, covid-19, china, sars-cov-2, zhejiang, asymptomatic,​ cluster, coronavirus,​ respiratory infections, severe acute respiratory syndrome coronavirus 2, viruses, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​wwwnc.cdc.gov/​eid/​404.html?​aspxerrorpath=/​eid/​article/​26/​5/​20-0198_article">​https://​wwwnc.cdc.gov/​eid/​404.html?​aspxerrorpath=/​eid/​article/​26/​5/​20-0198_article</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We report a 2-family cluster of persons infected with severe acute respiratory syndrome coronavirus 2 in the city of Zhoushan, Zhejiang Province, China, during January 2020. The infections resulted from contact with an infected but potentially presymptomatic traveler from the city of Wuhan in Hubei Province.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[19] Title: </​b>​Co-infection with SARS-CoV-2 and Influenza A Virus in Patient with Pneumonia, China.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​626.29<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-01<​br>​
 +<​b>​Publisher:​ </​b>​Emerging Infectious Diseases<​br>​
 +<​b>​Keywords:​ </​b>​Medical Microbiology,​ 2019 novel coronavirus disease, covid-19, china, sars-cov-2, co-detection,​ co-infection,​ influenza, influenza a, pneumonia, severe acute respiratory syndrome coronavirus 2, viruses, zoonoses, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​wwwnc.cdc.gov/​eid/​404.html?​aspxerrorpath=/​eid/​article/​26/​6/​20-0299_article">​https://​wwwnc.cdc.gov/​eid/​404.html?​aspxerrorpath=/​eid/​article/​26/​6/​20-0299_article</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We report co-infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza A virus in a patient with pneumonia in China. The case highlights possible co-detection of known respiratory viruses. We noted low sensitivity of upper respiratory specimens for SARS-CoV-2, which could further complicate recognition of the full extent of disease.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[20] Title: </b>A Case Series of children with 2019 novel coronavirus infection: clinical and epidemiological features.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​564.62<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-01-01<​br>​
 +<​b>​Publisher:​ </​b>​Clinical Infectious Diseases<​br>​
 +<​b>​Keywords:​ </​b>​Biological Sciences, 2019 novel coronavirus,​ children, coronavirus diseases, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​http://​doi.org/​10.1093/​cid/​ciaa198">​http://​doi.org/​10.1093/​cid/​ciaa198</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We first described the 2019 novel coronavirus infection in 10 children occurring in areas other than Wuhan. The coronavirus diseases in children are usually mild and epidemiological exposure is a key clue to recognize pediatric case. Prolonged virus shedding is observed in respiratory tract and feces at the convalescent stage.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[21] Title: </​b>​Subacute Thyroiditis After Sars-COV-2 Infection.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​432.01<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-21<​br>​
 +<​b>​Publisher:​ </​b>​The Journal of Clinical Endocrinology & Metabolism<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19, sars-cov-2, coronavirus,​ subacute thyroiditis,​ thyroid, virus, Biochemistry,​ Genetics and Molecular Biology, Health Sciences, Life Sciences, Medicine<​br>​
 +<​b>​DOI:​ </​b><​a href="​http://​doi.org/​10.1210/​clinem/​dgaa276">​http://​doi.org/​10.1210/​clinem/​dgaa276</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +CONTEXT: Subacute thyroiditis (SAT) is a thyroid disease of viral or postviral origin. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that began in Wuhan, China, has spread rapidly worldwide and Italy has been severely affected by this outbreak. OBJECTIVES: The objective of this work is to report the first case of SAT related to SARS-CoV-2 infection. METHODS: We describe the clinical, laboratory, and imaging features of an 18-year-old woman who came to our attention for fever, neck pain radiated to the jaw, and palpitations occurring 15 days after a SARS-CoV-2-positive oropharyngeal swab. Coronavirus disease 2019 (COVID-19) had been mild and the patient had completely recovered in a few days. RESULTS: At physical examination the patient presented with a slightly increased heart rate and a painful and enlarged thyroid on palpation. At laboratory exams free thyroxine and free triiodothyronine were high, thyrotropin undetectable,​ and inflammatory markers and white blood cell count elevated. Bilateral and diffuse hypoechoic areas were detected at neck ultrasound. One month earlier, thyroid function and imaging both were normal. We diagnosed SAT and the patient started prednisone. Neck pain and fever recovered within 2 days and the remaining symptoms within 1 week. Thyroid function and inflammatory markers normalized in 40 days. CONCLUSIONS:​ We report the first case of SAT after a SARS-CoV-2 infection. We alert clinicians to additional and unreported clinical manifestations associated with COVID-19.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[22] Title: </​b>​Myocardial localization of coronavirus in COVID-19 cardiogenic shock.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​429.48<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-11<​br>​
 +<​b>​Publisher:​ </​b>​European Journal of Heart Failure<​br>​
 +<​b>​Keywords:​ </​b>​Cardiovascular Medicine And Haematology,​ cardiac injury, cardiogenic shock, coronavirus,​ extracorporeal membrane oxygenation,​ myocardial inflammation,​ sars-cov-2, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​ejhf.1828">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​ejhf.1828</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We describe the first case of acute cardiac injury directly linked to myocardial localization of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a 69-year-old patient with flu-like symptoms rapidly degenerating into respiratory distress, hypotension,​ and cardiogenic shock. The patient was successfully treated with venous-arterial extracorporeal membrane oxygenation (ECMO) and mechanical ventilation. Cardiac function fully recovered in 5 days and ECMO was removed. Endomyocardial biopsy demonstrated low-grade myocardial inflammation and viral particles in the myocardium suggesting either a viraemic phase or, alternatively,​ infected macrophage migration from the lung.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[23] Title: </​b>​2019-novel Coronavirus severe adult respiratory distress syndrome in two cases in Italy: An uncommon radiological presentation.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​351.6<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-01<​br>​
 +<​b>​Publisher:​ </​b>​International Journal of Infectious Diseases<​br>​
 +<​b>​Keywords:​ </​b>​Microbiology,​ covid-19, ct-scan, crazy-paving,​ enlarged pulmonary vessels, ground glass opacities, sars-cov2, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S1201971220301016">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S1201971220301016</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +INTRODUCTION:​ Several recent case reports have described common early chest imaging findings of lung pathology caused by 2019 novel Coronavirus (SARS-COV2) which appear to be similar to those seen previously in SARS-CoV and MERS-CoV infected patients. OBJECTIVE: We present some remarkable imaging findings of the first two patients identified in Italy with COVID-19 infection travelling from Wuhan, China. The follow-up with chest X-Rays and CT scans was also included, showing a progressive adult respiratory distress syndrome (ARDS). RESULTS: Moderate to severe progression of the lung infiltrates,​ with increasing percentage of high-density infiltrates sustained by a bilateral and multi-segmental extension of lung opacities, were seen. During the follow-up, apart from pleural effusions, a tubular and enlarged appearance of pulmonary vessels with a sudden caliber reduction was seen, mainly found in the dichotomic tracts, where the center of a new insurgent pulmonary lesion was seen. It could be an early alert radiological sign to predict initial lung deterioration. Another uncommon element was the presence of mediastinal lymphadenopathy with short-axis oval nodes. CONCLUSIONS:​ Although only two patients have been studied, these findings are consistent with the radiological pattern described in literature. Finally, the pulmonary vessels enlargement in areas where new lung infiltrates develop in the follow-up CT scan, could describe an early predictor radiological sign of lung impairment.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[24] Title: </​b>​RNA based mNGS approach identifies a novel human coronavirus from two individual pneumonia cases in 2019 Wuhan outbreak.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​318.2<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-02-05<​br>​
 +<​b>​Publisher:​ </​b>​Emerging Microbes & Infections<​br>​
 +<​b>​Keywords:​ </b>, 2019-ncov, wuhan pneumonia, metagenomic next-generation sequencing, phylogenetic analyses, virus evolution<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.tandfonline.com/​doi/​full/​10.1080/​22221751.2020.1725399">​https://​www.tandfonline.com/​doi/​full/​10.1080/​22221751.2020.1725399</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +From December 2019, an outbreak of unusual pneumonia was reported in Wuhan with many cases linked to Huanan Seafood Market that sells seafood as well as live exotic animals. We investigated two patients who developed acute respiratory syndromes after independent contact history with this market. The two patients shared common clinical features including fever, cough, and multiple ground-glass opacities in the bilateral lung field with patchy infiltration. Here, we highlight the use of a low-input metagenomic next-generation sequencing (mNGS) approach on RNA extracted from bronchoalveolar lavage fluid (BALF). It rapidly identified a novel coronavirus (named 2019-nCoV according to World Health Organization announcement) which was the sole pathogens in the sample with very high abundance level (1.5% and 0.62% of total RNA sequenced). The entire viral genome is 29,881 nt in length (GenBank MN988668 and MN988669, Sequence Read Archive database Bioproject accession PRJNA601736) and is classified into beta-coronavirus genus. Phylogenetic analysis indicates that 2019-nCoV is close to coronaviruses (CoVs) circulating in Rhinolophus (Horseshoe bats), such as 98.7% nucleotide identity to partial RdRp gene of bat coronavirus strain BtCoV/4991 (GenBank KP876546, 370 nt sequence of RdRp and lack of other genome sequence) and 87.9% nucleotide identity to bat coronavirus strain bat-SL-CoVZC45 and bat-SL-CoVZXC21. Evolutionary analysis based on ORF1a/1b, S, and N genes also suggests 2019-nCoV is more likely a novel CoV independently introduced from animals to humans.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[25] Title: </​b>​Efficacy of glutathione therapy in relieving dyspnea associated with COVID-19 pneumonia: A report of 2 cases.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​298.5<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-01-01<​br>​
 +<​b>​Publisher:​ </​b>​Respiratory Medicine Case Reports<​br>​
 +<​b>​Keywords:​ </b>, ards, covid 19, glutathione,​ n-acetyl-cysteine,​ nfkappab, pneumonia<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2213007120301350">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2213007120301350</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Purpose: Infection with COVID-19 potentially can result in severe outcomes and death from "​cytokine storm syndrome",​ resulting in novel coronavirus pneumonia (NCP) with severe dyspnea, acute respiratory distress syndrome (ARDS), fulminant myocarditis and multiorgan dysfunction with or without disseminated intravascular coagulation. No published treatment to date has been shown to adequately control the inflammation and respiratory symptoms associated with COVID-19, apart from oxygen therapy and assisted ventilation. We evaluated the effects of using high dose oral and/or IV glutathione in the treatment of 2 patients with dyspnea secondary to COVID-19 pneumonia. Methods: Two patients living in New York City (NYC) with a history of Lyme and tick-borne co-infections experienced a cough and dyspnea and demonstrated radiological findings consistent with novel coronavirus pneumonia (NCP). A trial of 2g of PO or IV glutathione was used in both patients and improved their dyspnea within 1h of use. Repeated use of both 2000 mg of PO and IV glutathione was effective in further relieving respiratory symptoms. Conclusion: Oral and IV glutathione,​ glutathione precursors (N-acetyl-cysteine) and alpha lipoic acid may represent a novel treatment approach for blocking NFKappaB and addressing "​cytokine storm syndrome"​ and respiratory distress in patients with COVID-19 pneumonia.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[26] Title: </​b>​Pulmonary Pathology of Early-Phase 2019 Novel Coronavirus (COVID-19) Pneumonia in Two Patients With Lung Cancer.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​282.63<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-01<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Thoracic Oncology<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19 pneumonia, coronavirus,​ pathology, sars-cov-2, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S1556086420301325">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S1556086420301325</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +There is currently a lack of pathologic data on the novel coronavirus (severe acute respiratory syndrome coronavirus 2) pneumonia, or coronavirus disease 2019 (COVID-19), from autopsy or biopsy. Two patients who recently underwent lung lobectomies for adenocarcinoma were retrospectively found to have had COVID-19 at the time of the operation. These two cases thus provide important first opportunities to study the pathology of COVID-19. Pathologic examinations revealed that apart from the tumors, the lungs of both patients exhibited edema, proteinaceous exudate, focal reactive hyperplasia of pneumocytes with patchy inflammatory cellular infiltration,​ and multinucleated giant cells. Hyaline membranes were not prominent. Because both patients did not exhibit symptoms of pneumonia at the time of operation, these changes likely represent an early phase of the lung pathology of COVID-19 pneumonia.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[27] Title: </b>A case report of neonatal COVID-19 infection in China.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​276.48<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-03-12<​br>​
 +<​b>​Publisher:​ </​b>​Clinical Infectious Diseases<​br>​
 +<​b>​Keywords:​ </​b>​Biological Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​http://​doi.org/​10.1093/​cid/​ciaa225">​http://​doi.org/​10.1093/​cid/​ciaa225</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +In December 2019, the 2019 novel coronavirus disease (COVID-19) caused by SARS-CoV-2 emerged in China and now has spread in many countries. Pregnant women are susceptible population of COVID-19 which are more likely to have complications and even progresse to severe illness. We report a case of neonatal COVID-19 infection in China with pharyngeal swabs tested positive by rRT-PCR assay 36 hours after birth. However, whether the case is a vertical transmission from mother to child remains to be confirmed.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[28] Title: </​b>​Fatal Invasive Aspergillosis and Coronavirus Disease in an Immunocompetent Patient.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​266.71<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-07-01<​br>​
 +<​b>​Publisher:​ </​b>​Emerging Infectious Diseases<​br>​
 +<​b>​Keywords:​ </​b>​Medical Microbiology,​ aspergillus,​ covid-19, sars, sars-cov-2, aspergillosis,​ coronavirus,​ coronavirus disease, fungal superinfection,​ fungi, intensive care unit, mechanical ventilation,​ severe acute respiratory syndrome coronavirus 2, viruses, zoonoses, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​wwwnc.cdc.gov/​eid/​404.html?​aspxerrorpath=/​eid/​article/​26/​7/​20-1603_article">​https://​wwwnc.cdc.gov/​eid/​404.html?​aspxerrorpath=/​eid/​article/​26/​7/​20-1603_article</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Invasive pulmonary aspergillosis is a complication in critically ill patients with acute respiratory distress syndrome, especially those with severe influenza pneumonia. We report a fatal case of invasive pulmonary aspergillosis in an immunocompetent patient in France who had severe coronavirus disease-associated pneumonia.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[29] Title: </​b>​Lack of Vertical Transmission of Severe Acute Respiratory Syndrome Coronavirus 2, China.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​265.08<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-01<​br>​
 +<​b>​Publisher:​ </​b>​Emerging Infectious Diseases<​br>​
 +<​b>​Keywords:​ </​b>​Medical Microbiology,​ 2019 novel coronavirus disease, covid-19, china, sars-cov-2, severe acute respiratory syndrome coronavirus 2, coronaviruses,​ pregnancy, respiratory infections, vertical transmission,​ viruses, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​wwwnc.cdc.gov/​eid/​404.html?​aspxerrorpath=/​eid/​article/​26/​6/​20-0287_article">​https://​wwwnc.cdc.gov/​eid/​404.html?​aspxerrorpath=/​eid/​article/​26/​6/​20-0287_article</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +A woman with coronavirus disease in her 35th week of pregnancy delivered an infant by cesarean section in a negative-pressure operating room. The infant was negative for severe acute respiratory coronavirus 2. This case suggests that mother-to-child transmission is unlikely for this virus.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[30] Title: </​b>​SARS-CoV-2 endothelial infection causes COVID-19 chilblains: histopathological,​ immunohistochemical and ultraestructural study of 7 paediatric cases.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​252.1<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-20<​br>​
 +<​b>​Publisher:​ </​b>​British Journal of Dermatology<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​bjd.19327">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​bjd.19327</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +BACKGROUND: Chilblains ("​COVID toes") are being seen with increasing frequency in children and young adults during the COVID-19 pandemic. Detailed histopathological descriptions of COVID-19 chilblains have not been reported, and causality of SARS-CoV-2 has not been established yet. OBJECTIVE: To describe histopathological features of Covid-19 chilblains and explore the presence of SARS-CoV-2 in the tissue. METHODS: We examined skin biopsies from 7 paediatric patients presenting with chilblains during the COVID-19 pandemic. Immunohistochemistry for SARS-CoV-2 was performed in all cases and electron microscopy in one. RESULTS: Histopathology showed variable degrees of lymphocytic vasculitis ranging from endothelial swelling and endothelialitis to fibrinoid necrosis and thrombosis. Purpura, superficial and deep perivascular lymphocytic inflammation with perieccrine accentuation,​ oedema, and mild vacuolar interface damage were also seen. SARS-CoV-2 immunohistochemistry was positive in endothelial cells and epithelial cells of eccrine glands. Coronavirus particles were found in the cytoplasm of endothelial cells on electron microscopy. CONCLUSIONS:​ Although the clinical and histopathological features were similar to other forms of chilblains, the presence of viral particles in the endothelium and the histological evidence of vascular damage, support a causal relation of the lesions with SARS-CoV-2. Endothelial damage induced by the virus could be the key mechanism in the pathogenesis of COVID-19 chilblains and perhaps also in a group of patients severely affected by COVID-19 presenting with features of microangiopathic damage.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[31] Title: </​b>​High-Dose Intravenous Immunoglobulin as a Therapeutic Option for Deteriorating Patients With Coronavirus Disease 2019.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​237.9<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-03-21<​br>​
 +<​b>​Publisher:​ </​b>​Open Forum Infectious Diseases<​br>​
 +<​b>​Keywords:​ </b>, coronavirus disease 2019, high-dose intravenous immunoglobulin,​ immunomodulation<​br>​
 +<​b>​DOI:​ </​b><​a href="​http://​doi.org/​10.1093/​ofid/​ofaa102">​http://​doi.org/​10.1093/​ofid/​ofaa102</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The outbreak of coronavirus disease 2019 (COVID-19) has spread rapidly in China. Until now, no definite effective treatment has been identified. We reported on 3 patients with severe COVID-19 who received high-dose intravenous immunoglobulin (IVIg) with satisfactory recovery. Based on these observations,​ randomized studies of high-dose IVIg should be considered in deteriorating patients infected with COVID-19.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[32] Title: </​b>​Keratoconjunctivitis as the initial medical presentation of the novel coronavirus disease 2019 (COVID-19).<​br><​br>​
 +<​b>​Altmetric Score: </​b>​225.03<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-01<​br>​
 +<​b>​Publisher:​ </​b>​Canadian Journal of Ophthalmology<​br>​
 +<​b>​Keywords:​ </​b>​Ophthalmology And Optometry, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0008418220303057">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0008418220303057</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We present a case of coronavirus disease 2019 (COVID-19) with an initial medical presentation of keratoconjunctivitis,​ the first such reported case in North America. The patient'​s primary symptom was a red eye with watery discharge, though she did have mild respiratory symptoms, without fever. She was diagnosed with keratoconjunctivitis;​ evolving corneal findings were characterized through repeat visits to ophthalmology. A conjunctival swab of the affected eye was positive for the SAR-CoV-2 virus. This case emphasizes the importance of ensuring that first-line health care providers, including ophthalmologists,​ optometrists,​ emergency physicians, and family physicians, consider COVID-19 on the differential for any patient with recent travel who presents with acute conjunctivitis. Having a high index of suspicion with this presentation would allow for appropriate precautions to be taken to prevent further spread of COVID-19.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[33] Title: </b>A Hemodialysis Patient with Severe COVID-19 Pneumonia.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​215.95<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-06<​br>​
 +<​b>​Publisher:​ </​b>​Cureus<​br>​
 +<​b>​Keywords:​ </b>, coronavirus,​ covid-19, hemodialysis<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.cureus.com/​articles/​31511-a-hemodialysis-patient-with-severe-covid-19-pneumonia">​https://​www.cureus.com/​articles/​31511-a-hemodialysis-patient-with-severe-covid-19-pneumonia</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Coronavirus disease 2019 (COVID-19) is an infectious disease caused by a novel coronavirus that has spread rapidly, resulting in a worldwide pandemic. Even though end-stage renal disease (ESRD) patients are particularly susceptible to COVID-19 infection and can develop severe to critical disease, there are limited studies and case reports about COVID-19 in ESRD patients. We report a case of a 63-year-old gentleman with ESRD on regular hemodialysis. We describe the clinical presentation of this patient, the diagnostic process, the laboratory and imaging investigations,​ as well as the course of treatment. He positively responded to a 14-day course of Lopinavir-Ritonavir,​ Ribavirin, Azithromycin,​ and Hydroxychloroquine.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[34] Title: </​b>​Tissue plasminogen activator (tPA) treatment for COVID-19 associated acute respiratory distress syndrome (ARDS): A case series.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​210.4<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-11<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Thrombosis & Haemostasis<​br>​
 +<​b>​Keywords:​ </​b>​Cardiovascular Medicine And Haematology,​ covid-19, acute respiratory distress syndrome (ards), case report, fibrinolysis,​ tissue plasminogen activator (tpa), Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​jth.14828">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​jth.14828</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +A prothrombotic coagulopathy is commonly found in critically ill COVID-19 patients with acute respiratory distress syndrome (ARDS). A unique feature of COVID-19 respiratory failure is a relatively preserved lung compliance and high Alveolar-arterial oxygen gradient, with pathology reports consistently demonstrating diffuse pulmonary microthrombi on autopsy, all consistent with a vascular occlusive etiology of respiratory failure rather than the more classic findings of low-compliance in ARDS. The COVID-19 pandemic is overwhelming the world'​s medical care capacity with unprecedented needs for mechanical ventilators and high rates of mortality once patients progress to needing mechanical ventilation,​ and in many environments including in parts of the United States the medical capacity is being exhausted. Fibrinolytic therapy has previously been used in a Phase 1 clinical trial that led to reduced mortality and marked improvements in oxygenation. Here we report a series of three patients with severe COVID-19 respiratory failure who were treated with tissue plasminogen activator. All three patients had a temporally related improvement in their respiratory status, with one of them being a durable response.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[35] Title: </​b>​Asymptomatic novel coronavirus pneumonia patient outside Wuhan: The value of CT images in the course of the disease.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​203.99<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-07-01<​br>​
 +<​b>​Publisher:​ </​b>​Clinical Imaging<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, 2019-ncov, covid-19, ground glass opacities, novel coronavirus pneumonia, pleural effusion, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0899707120300565">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0899707120300565</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The purpose of this case report is to describe the imaging and associated clinical features of an asymptomatic novel coronavirus pneumonia (COVID-19) patient outside Wuhan, China. The principle findings are that in this patient with laboratory-confirmed COVID-19, CT findings preceded symptoms and included bilateral pleural effusions, previously not reported in association with COVID-19. The role of this case report is promotion of potential recognition amongst radiologists of this new disease, which has been declared a global health emergency by the World Health Organization (WHO).<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[36] Title: </​b>​Inoculum at the time of SARS-CoV-2 exposure and risk of disease severity.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​203.55<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-01<​br>​
 +<​b>​Publisher:​ </​b>​International Journal of Infectious Diseases<​br>​
 +<​b>​Keywords:​ </​b>​Microbiology,​ covid-19, coronavirus,​ disease severity, epidemiology,​ inoculum, outbreak, transmission,​ Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S1201971220304707">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S1201971220304707</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +A relationship between the infecting dose and the risk of disease severity has not been demonstrated for SARS-CoV-2 infection. Here, we report three clusters of individuals that were exposed to diverse inoculi in Madrid and overall developed divrgent clinical forms of COVID-19. Our data support that a greater SARS-CoV-2 inoculi at the time of exposure might determine a higher risk of severe COVID-19.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[37] Title: </​b>​Pulmonary Embolism and Increased Levels of d-Dimer in Patients with Coronavirus Disease.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​200.17<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-08-01<​br>​
 +<​b>​Publisher:​ </​b>​Emerging Infectious Diseases<​br>​
 +<​b>​Keywords:​ </​b>​Medical Microbiology,​ covid-19, sars-cov-2, coronavirus disease, d-dimer, deep vein thrombosis, hypercoagulability,​ prophylaxis,​ pulmonary embolism, respiratory infections, sequelae, severe acute respiratory syndrome coronavirus 2, thromboembolic,​ viruses, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​wwwnc.cdc.gov/​eid/​404.html?​aspxerrorpath=/​eid/​article/​26/​8/​20-1477_article">​https://​wwwnc.cdc.gov/​eid/​404.html?​aspxerrorpath=/​eid/​article/​26/​8/​20-1477_article</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We report 3 patients with coronavirus disease who had a decline in respiratory status during their hospital course that responded well to intravenous steroids and interleukin-6 receptor antagonist therapy. These patients later showed development of persistent hypoxia with increased levels of d-dimer levels and were given a diagnosis of pulmonary embolisms.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[38] Title: </​b>​Case of the Index Patient Who Caused Tertiary Transmission of COVID-19 Infection in Korea: the Application of Lopinavir/​Ritonavir for the Treatment of COVID-19 Infected Pneumonia Monitored by Quantitative RT-PCR.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​191.95<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-01-01<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Korean Medical Science<​br>​
 +<​b>​Keywords:​ </b>, covid-19, coronavirus,​ pneumonia, real-time reverse-transcriptase polymerase chain reaction, tertiary infection, viral load, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​jkms.org/​DOIx.php?​id=10.3346/​jkms.2020.35.e79">​https://​jkms.org/​DOIx.php?​id=10.3346/​jkms.2020.35.e79</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Since mid-December of 2019, coronavirus disease 2019 (COVID-19) infection has been spreading from Wuhan, China. The confirmed COVID-19 patients in South Korea are those who came from or visited China. As secondary transmissions have occurred and the speed of transmission is accelerating,​ there are rising concerns about community infections. The 54-year old male is the third patient diagnosed with COVID-19 infection in Korea. He is a worker for a clothing business and had mild respiratory symptoms and intermittent fever in the beginning of hospitalization,​ and pneumonia symptoms on chest computerized tomography scan on day 6 of admission. This patient caused one case of secondary transmission and three cases of tertiary transmission. Hereby, we report the clinical findings of the index patient who was the first to cause tertiary transmission outside China. Interestingly,​ after lopinavir/​ritonavir (Kaletra, AbbVie) was administered,​ beta-coronavirus viral loads significantly decreased and no or little coronavirus titers were observed.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[39] Title: </​b>​Features of COVID-19 post-infectious cytokine release syndrome in children presenting to the emergency department.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​190.55<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-01<​br>​
 +<​b>​Publisher:​ </​b>​American Journal of Emergency Medicine<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19, children, cytokine storm, kawasaki disease, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0735675720304034">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S0735675720304034</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The 2019 coronavirus disease (COVID-19) has not appeared to affect children as severely as adults. However, approximately 1 month after the COVID-19 peak in New York City in April 2020, cases of children with prolonged fevers abruptly developing inflammatory shock-like states have been reported in Western Europe and the United States. This case series describes four previously healthy children with COVID-19 infection confirmed by serologic antibody testing, but negative by nasopharyngeal RT-PCR swab, presenting to the Pediatric Emergency Department (PED) with prolonged fever (5 or more days) and abrupt onset of hemodynamic instability with elevated serologic inflammatory markers and cytokine levels (IL-6, IL-8 and TNF-alpha). Emergency physicians must maintain a high clinical suspicion for this COVID-19 associated post-infectious cytokine release syndrome, with features that overlap with Kawasaki Disease (KD) and Toxic Shock Syndrome (TSS) in children with recent or current COVID-19 infection, as patients can decompensate quickly.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[40] Title: </b>A case report of COVID-19 with false negative RT-PCR test: necessity of chest CT.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​176.7<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-07<​br>​
 +<​b>​Publisher:​ </​b>​Japanese Journal of Radiology<​br>​
 +<​b>​Keywords:​ </​b>​Imaging / Radiology, covid-19, 2019 corona virus disease, ct, computed tomography, cxr, chest radiography,​ rt-pcr, real-time fluorescence polymerase chain reaction, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​link.springer.com/​article/​10.1007/​s11604-020-00967-9">​https://​link.springer.com/​article/​10.1007/​s11604-020-00967-9</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The definite diagnosis of corona virus disease 2019 (COVID-19) is based on the viral isolation or positive result of polymerase chain reaction (PCR) from sputum, or nasal swab, or throat swab. However, the sensitivity to detect COVID-19 of real time (RT)-PCR is reported to be lower than that of chest CT. We report a case of 34-year-old man who was diagnosed as negative for COVID-19 based on the four sequential RT-PCR tests of his pharyngeal swab. Chest CT showed patchy ground-glass opacity on admission, and it rapidly progressed to segmental mixed consolidation and ground-glass opacity 3 days after admission, and it resolved in left upper lobe, but showed multifocal ground-glass opacities 7 days after admission, and they resolved within 2 weeks. The fifth RT-PCR test finally revealed positive results at the fifth day after admission. It is difficult to distinguish COVID-19 pneumonia from other viral pneumonia on CT findings alone; however, we emphasize the utility of chest CT to detect early change of COVID-19 in cases which RT-PCR tests show negative results.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[41] Title: </​b>​Coronavirus disease 2019 in pregnancy: early lessons.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​173.5<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-01<​br>​
 +<​b>​Publisher:​ </​b>​American Journal of Obstetrics & Gynecology MFM<​br>​
 +<​b>​Keywords:​ </b>, covid-19, novel coronavirus,​ pregnancy<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2589933320300410">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S2589933320300410</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The worldwide incidence of coronavirus disease 2019 (COVID-19) infection is rapidly increasing, but there exists limited information on coronavirus disease 2019 in pregnancy. Here, we present our experience with 7 confirmed cases of coronavirus disease 2019 in pregnancy presenting to a single large New York City tertiary care hospital. Of the 7 patients, 5 presented with symptoms of coronavirus disease 2019, including cough, myalgias, fevers, chest pain, and headache. Of the 7 patients, 4 were admitted to the hospital, including 2 who required supportive care with intravenous hydration. Of note, the other 2 admitted patients who were asymptomatic on admission to the hospital, presenting instead for obstetrically indicated labor inductions, became symptomatic after delivery, each requiring intensive care unit admission.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[42] Title: </​b>​First cases of coronavirus disease 2019 (COVID-19) in the WHO European Region, 24 January to 21 February 2020.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​169.78<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-03-05<​br>​
 +<​b>​Publisher:​ </​b>​Eurosurveillance<​br>​
 +<​b>​Keywords:​ </b>, covid-19, novel coronavirus,​ sars, sars-cov-2, coronavirus disease 2019, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.eurosurveillance.org/​content/​10.2807/​1560-7917.ES.2020.25.9.2000178">​https://​www.eurosurveillance.org/​content/​10.2807/​1560-7917.ES.2020.25.9.2000178</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +In the WHO European Region, COVID-19 surveillance was implemented 27 January 2020. We detail the first European cases. As at 21 February, nine European countries reported 47 cases. Among 38 cases studied, 21 were linked to two clusters in Germany and France, 14 were infected in China. Median case age was 42 years; 25 were male. Late detection of the clusters'​ index cases delayed isolation of further local cases. As at 5 March, there were 4,250 cases.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[43] Title: </​b>​Miller Fisher Syndrome and polyneuritis cranialis in COVID-19.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​165.28<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-17<​br>​
 +<​b>​Publisher:​ </​b>​Neurology<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​n.neurology.org/​content/​early/​2020/​04/​17/​WNL.0000000000009619">​https://​n.neurology.org/​content/​early/​2020/​04/​17/​WNL.0000000000009619</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +OBJECTIVE: To report two patients infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) who acutely presented with Miller Fisher syndrome and polyneuritis cranialis, respectively. METHODS: Patient data were obtained from medical records from the University Hospital "​Principe de Asturias",​ Alcala de Henares, Madrid, Spain and from the University Hospital "12 de Octubre",​ Madrid, Spain. RESULTS: The first patient was a 50-year-old man who presented with anosmia, ageusia, right internuclear ophthalmoparesis,​ right fascicular oculomotor palsy, ataxia, areflexia, albuminocytologic dissociation and positive testing for GD1b-IgG antibodies. Five days before, he had developed a cough, malaise, headache, low back pain, and a fever. The second patient was a 39-year-old man who presented with ageusia, bilateral abducens palsy, areflexia and albuminocytologic dissociation. Three days before, he had developed diarrhea, a low-grade fever, and a poor general condition. The oropharyngeal swab test for coronavirus disease 2019 (COVID-19) by qualitative real-time reverse-transcriptase-polymerase-chain-reaction assay was positive in both patients and negative in the cerebrospinal fluid. The first patient was treated with intravenous immunoglobulin and the second, with acetaminophen. Two weeks later, both patients made a complete neurological recovery, except for residual anosmia and ageusia in the first case. CONCLUSIONS:​ Our two cases highlight the rare occurrence of Miller Fisher syndrome and polyneuritis cranialis during the COVID-2 pandemic. Neurological manifestations may occur because of an aberrant immune response to COVID-19. The full clinical spectrum of neurological symptoms in patients with COVID-19 remains to be characterized.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[44] Title: </​b>​Serological and molecular findings during SARS-CoV-2 infection: the first case study in Finland, January to February 2020.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​154.75<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-03-19<​br>​
 +<​b>​Publisher:​ </​b>​Eurosurveillance<​br>​
 +<​b>​Keywords:​ </b>, covid-19, sars-cov-2, antibodies, coronavirus,​ humoral immunity, immunofluorescence assay, microneutralisation test, western blotting, whole-genome sequencing, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.eurosurveillance.org/​content/​10.2807/​1560-7917.ES.2020.25.11.2000266">​https://​www.eurosurveillance.org/​content/​10.2807/​1560-7917.ES.2020.25.11.2000266</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The first case of coronavirus disease (COVID-19) in Finland was confirmed on 29 January 2020. No secondary cases were detected. We describe the clinical picture and laboratory findings 3-23 days since the first symptoms. The SARS-CoV-2/​Finland/​1/​2020 virus strain was isolated, the genome showing a single nucleotide substitution to the reference strain from Wuhan. Neutralising antibody response appeared within 9 days along with specific IgM and IgG response, targeting particularly nucleocapsid and spike proteins.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[45] Title: </​b>​Atypical presentation of COVID-19 in a frail older person.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​149<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-21<​br>​
 +<​b>​Publisher:​ </​b>​Age & Ageing<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, covid-19, atypical presentation,​ older people, pandemic, pneumonia, Biochemistry,​ Genetics and Molecular Biology, Health Sciences, Life Sciences, Medicine<​br>​
 +<​b>​DOI:​ </​b><​a href="​http://​doi.org/​10.1093/​ageing/​afaa068">​http://​doi.org/​10.1093/​ageing/​afaa068</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Common symptoms of pandemic coronavirus disease (COVID-19) include fever and cough. We describe a 94-year-old man with well-controlled schizoaffective disorder, who presented with non-specific and atypical symptoms: delirium, low-grade pyrexia and abdominal pain. He was given antibiotics for infection of unknown source, subsequently refined to treatment for community-acquired pneumonia. Despite active treatment, he deteriorated with oxygen desaturation and tachypnoea. A repeat chest X-ray showed widespread opacification. A postmortem throat swab identified COVID-19 infection. He was treated in three wards over 5 days with no infection control precautions. This has implications for the screening, assessment and isolation of frail older people to COVID-specific clinical facilities and highlights the potential for spread among healthcare professionals and other patients.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[46] Title: </​b>​COVID-19 presenting with ophthalmoparesis from cranial nerve palsy.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​146.55<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-01<​br>​
 +<​b>​Publisher:​ </​b>​Neurology<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​n.neurology.org/​content/​early/​2020/​04/​28/​WNL.0000000000009700">​https://​n.neurology.org/​content/​early/​2020/​04/​28/​WNL.0000000000009700</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Neurological complications of COVID-19 are not well described. We report two patients who were diagnosed with COVID-19 after presenting with diplopia and ophthalmoparesis.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[47] Title: </​b>​Severe COVID-19 during Pregnancy and Possible Vertical Transmission.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​141.2<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-18<​br>​
 +<​b>​Publisher:​ </​b>​American Journal of Perinatology<​br>​
 +<​b>​Keywords:​ </​b>​Clinical Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.thieme-connect.de/​products/​ejournals/​abstract/​10.1055/​s-0040-1710050">​https://​www.thieme-connect.de/​products/​ejournals/​abstract/​10.1055/​s-0040-1710050</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +There are few cases of pregnant women with novel corona virus 2019 (COVID-19) in the literature, most of them with a mild illness course. There is limited evidence about in utero infection and early positive neonatal testing. A 41-year-old G3P2 with a history of previous cesarean deliveries and diabetes mellitus presented with a 4-day history of malaise, low-grade fever, and progressive shortness of breath. A nasopharyngeal swab was positive for COVID-19, COVID-19 serology was negative. The patient developed respiratory failure requiring mechanical ventilation on day 5 of disease onset. The patient underwent a cesarean delivery, and neonatal isolation was implemented immediately after birth, without delayed cord clamping or skin-to-skin contact. The neonatal nasopharyngeal swab, 16 hours after delivery, was positive for severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) real-time polymerase chain reaction (RT-PCR), and immunoglobulin (Ig)-M and IgG for SARS-CoV-2 were negative. Maternal IgM and IgG were positive on postpartum day 4 (day 9 after symptom onset). We report a severe presentation of COVID-19 during pregnancy. To our knowledge, this is the earliest reported positive PCR in the neonate, raising the concern for vertical transmission. We suggest pregnant women should be considered as a high-risk group and minimize exposures for these reasons. KEY POINTS: . We report a severe presentation of COVID-19 in pregnancy requiring invasive ventilatory support.. . This is a case of positive RT-PCR in first day of life, suggesting possible vertical transmission.. . There were no detectable maternal antibodies for COVID-19 until after delivery..<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[48] Title: </​b>​Recurrence of positive SARS-CoV-2 RNA in COVID-19: A case report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​133.2<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-01<​br>​
 +<​b>​Publisher:​ </​b>​International Journal of Infectious Diseases<​br>​
 +<​b>​Keywords:​ </​b>​Microbiology,​ covid-19, infectivity,​ ncp, novel coronavirus,​ sars-cov-2, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​linkinghub.elsevier.com/​retrieve/​pii/​S1201971220301223">​https://​linkinghub.elsevier.com/​retrieve/​pii/​S1201971220301223</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The ongoing outbreak of COVID-19 that began in Wuhan, China, has constituted a Public Health Emergency of International Concern, with cases confirmed in multiple countries. Currently, patients are the primary source of infection. We report a confirmed case of COVID-19 whose oropharyngeal swab test of SARS-CoV-2 RNA turned positive in convalescence. This case highlights the importance of active surveillance of SARS-CoV-2 RNA for infectivity assessment.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[49] Title: </​b>​Pathological study of the 2019 novel coronavirus disease (COVID-19) through postmortem core biopsies.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​124.61<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-04-14<​br>​
 +<​b>​Publisher:​ </​b>​Modern Pathology<​br>​
 +<​b>​Keywords:​ </​b>​Medical And Health Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.nature.com/​articles/​s41379-020-0536-x">​https://​www.nature.com/​articles/​s41379-020-0536-x</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Data on pathologic changes of the 2019 novel coronavirus disease (COVID-19) are scarce. To gain knowledge about the pathology that may contribute to disease progression and fatality, we performed postmortem needle core biopsies of lung, liver, and heart in four patients who died of COVID-19 pneumonia. The patients'​ ages ranged from 59 to 81, including three males and one female. Each patient had at least one underlying disease, including immunocompromised status (chronic lymphocytic leukemia and renal transplantation) or other conditions (cirrhosis, hypertension,​ and diabetes). Time from disease onset to death ranged from 15 to 52 days. All patients had elevated white blood cell counts, with significant rise toward the end, and all had lymphocytopenia except for the patient with leukemia. Histologically,​ the main findings are in the lungs, including injury to the alveolar epithelial cells, hyaline membrane formation, and hyperplasia of type II pneumocytes,​ all components of diffuse alveolar damage. Consolidation by fibroblastic proliferation with extracellular matrix and fibrin forming clusters in airspaces is evident. In one patient, the consolidation consists of abundant intra-alveolar neutrophilic infiltration,​ consistent with superimposed bacterial bronchopneumonia. The liver exhibits mild lobular infiltration by small lymphocytes,​ and centrilobular sinusoidal dilation. Patchy necrosis is also seen. The heart shows only focal mild fibrosis and mild myocardial hypertrophy,​ changes likely related to the underlying conditions. In conclusion, the postmortem examinations show advanced diffuse alveolar damage, as well as superimposed bacterial pneumonia in some patients. Changes in the liver and heart are likely secondary or related to the underlying diseases.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[50] Title: </​b>​First cases of coronavirus disease 2019 (COVID-19) in France: surveillance,​ investigations and control measures, January 2020.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​119.65<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-02-13<​br>​
 +<​b>​Publisher:​ </​b>​Eurosurveillance<​br>​
 +<​b>​Keywords:​ </b>, covid-19, sars-cov-2, 2019-ncov, france, surveillance,​ contact tracing, containment,​ coronavirus,​ Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​www.eurosurveillance.org/​content/​10.2807/​1560-7917.ES.2020.25.6.2000094">​https://​www.eurosurveillance.org/​content/​10.2807/​1560-7917.ES.2020.25.6.2000094</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +A novel coronavirus (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) causing a cluster of respiratory infections (coronavirus disease 2019, COVID-19) in Wuhan, China, was identified on 7 January 2020. The epidemic quickly disseminated from Wuhan and as at 12 February 2020, 45,179 cases have been confirmed in 25 countries, including 1,116 deaths. Strengthened surveillance was implemented in France on 10 January 2020 in order to identify imported cases early and prevent secondary transmission. Three categories of risk exposure and follow-up procedure were defined for contacts. Three cases of COVID-19 were confirmed on 24 January, the first cases in Europe. Contact tracing was immediately initiated. Five contacts were evaluated as at low risk of exposure and 18 at moderate/​high risk. As at 12 February 2020, two cases have been discharged and the third one remains symptomatic with a persistent cough, and no secondary transmission has been identified. Effective collaboration between all parties involved in the surveillance and response to emerging threats is required to detect imported cases early and to implement adequate control measures.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[51] Title: </​b>​COVID-19 vaginal delivery - A case report.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​112.43<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-28<​br>​
 +<​b>​Publisher:​ </​b>​Australian & New Zealand Journal of Obstetrics & Gynaecology<​br>​
 +<​b>​Keywords:​ </​b>​Paediatrics And Reproductive Medicine, covid-19, breastfeeding,​ coronavirus,​ neonatal, vaginal delivery, Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​ajo.13173">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1111/​ajo.13173</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +The novel coronavirus termed SARS-CoV-2 (COVID-19) is a major public health challenge. Many maternity units around the country are currently considering management protocols for these patients. We report a case from a tertiary Australian hospital describing an uncomplicated vaginal birth in a COVID-19 positive mother. To our knowledge this is also the first case described of a mother with COVID-19 not separated from her infant. Management provided supports the current Royal College of Obstetricians and Gynaecologists and World Health Organization guidelines suggesting that it is possible to consider rooming in post-delivery for COVID-19 positive parents. Encouragement of breastfeeding appears possible and safe when viral precautions are observed.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[52] Title: </​b>​Clinical and Epidemiological Features of a Family Cluster of Symptomatic and Asymptomatic SARS-CoV-2 Infection.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​111.85<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-22<​br>​
 +<​b>​Publisher:​ </​b>​Journal of the Pediatric Infectious Diseases Society<​br>​
 +<​b>​Keywords:​ </b>, covid-19, rna-persistence,​ sars, sars-cov2, children, gastrointestinal<​br>​
 +<​b>​DOI:​ </​b><​a href="​http://​doi.org/​10.1093/​jpids/​piaa060">​http://​doi.org/​10.1093/​jpids/​piaa060</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +This report describes the clinical and virological characteristics of three children in a family cluster experiencing infection with SARS-CoV2. While the youngest child was not infected, both parents and the two 2- and 5 years-old children became infected. The children were only briefly symptomatic with predominant gastrointestinal symptoms. They initially shed infectious virus from the upper respiratory tract, but cleared the virus after five to six days in the nasopharynx. However, SARS-CoV2 RNA was continuously detected in the stools of the children for more than 4 weeks indicating a predominant replication within the gastrointestinal tract.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[53] Title: </​b>​Central nervous system involvement by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).<​br><​br>​
 +<​b>​Altmetric Score: </​b>​110.97<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-06-09<​br>​
 +<​b>​Publisher:​ </​b>​Journal of Medical Virology<​br>​
 +<​b>​Keywords:​ </​b>​Medical Microbiology,​ cns infection, sars-cov-2, endothelium,​ neuroinvasion,​ neurotropism,​ Health Sciences, Life Sciences, Medicine, Immunology and Microbiology<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​jmv.25915">​https://​onlinelibrary.wiley.com/​doi/​abs/​10.1002/​jmv.25915</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +Neurologic sequelae can be devastating complications of respiratory viral infections. We report the presence of virus in neural and capillary endothelial cells in frontal lobe tissue obtained at postmortem examination from a patient infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Our observations of virus in neural tissue, in conjunction with clinical correlates of worsening neurologic symptoms, pave the way to a closer understanding of the pathogenic mechanisms underlying central nervous system involvement by SARS-CoV-2.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[54] Title: </​b>​3D CT of Novel Coronavirus (COVID-19) Pneumonia.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​110<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-03-31<​br>​
 +<​b>​Publisher:​ </​b>​Radiological Society of North America<​br>​
 +<​b>​Keywords:​ </​b>​Medical And Health Sciences, , Medicine, Health Sciences<​br>​
 +<​b>​DOI:​ </​b><​a href="​https://​pubs.rsna.org/​doi/​10.1148/​radiol.2020201183">​https://​pubs.rsna.org/​doi/​10.1148/​radiol.2020201183</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +This article has online supplemental material.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +----------------------------------------------------------------------<​br>​
 +<​b>​[55] Title: </​b>​Multisystem Inflammatory Syndrome in Children during the COVID-19 pandemic: a case series.<​br><​br>​
 +<​b>​Altmetric Score: </​b>​108.87<​br>​
 +<​b>​Pub_Date:​ </​b>​2020-05-28<​br>​
 +<​b>​Publisher:​ </​b>​Journal of the Pediatric Infectious Diseases Society<​br>​
 +<​b>​Keywords:​ </b>, covid-19, kawasaki disease, sars-cov-2, multisystem inflammatory syndrome in children<​br>​
 +<​b>​DOI:​ </​b><​a href="​http://​doi.org/​10.1093/​jpids/​piaa069">​http://​doi.org/​10.1093/​jpids/​piaa069</​a><​br><​br>​
 +<​b>​Abstract:​ </b>
 +We present a series of six critically ill children with Multisystem Inflammatory Syndrome in Children (MIS-C). Key findings of this syndrome include fever, diarrhea, shock, and variable presence of rash, conjunctivitis,​ extremity edema, and mucous membrane changes.<​br>​
 +----------------------------------------------------------------------<​br><​br>​
 +
 +</​html>​
oa_db/covid19_case_reports_abstracts_pg1.txt · Last modified: 2020/06/28 02:39 by bpwhite